In vitro transformation of lymphoid cells by Abelson murine leukemia virus

Cell cultures prepared from fetal murine liver were infected by Abelson murine leukemia virus. After about 2 weeks, proliferating cells of lymphoid morphology appeared in some of the cultures. Addition of 2-mercaptoethanol to the initial culture medium greatly enhanced the appearance of the lymphoid cells. Immunoglobulin determinants were evident on the cells in some cultures. Continuous passage of the cells in certain cultures was possible and the passaged cells could form tumors after animal inoculation. Because Abelson murine leukemia virus is able to induce in vitro malignant transformation of lymphoid cells, it probably causes leukemia by directly affecting cellular growth control

Low speed aerodynamic characteristics of an 0.075-scale F-15 airplane model at high angles of attack and sideslip

An 0.075 scale model representative of the F-15 airplane was tested in the Ames 12 foot pressure wind tunnel at a Mach number of 0.16 to determine static longitudinal and lateral directional characteristics at spin attitudes for Reynolds numbers from 1.48 to 16.4 million per meter (0.45 to 5.0 million per foot). Angles of attack ranged from 0 to +90 deg and from -40 deg to -80 deg while angles of sideslip were varied from -20 deg to +30 deg. Data were obtained for nacelle inlet ramp angles of 0 to 11 deg with the left and right stabilators deflected 0, -25 deg, and differentially 5 deg and -5 deg. The normal pointed nose and two alternate nose shapes were also tested along with several configurations of external stores. Analysis of the results indicate that at higher Reynolds numbers there is a slightly greater tendency to spin inverted than at lower Reynolds numbers. Use of a hemispherical nose in place of the normal pointed nose provided an over correction in simulating yawing moment effects at high Reynolds numbers

Low-speed aerodynamic characteristics of a 0.08-scale YF-17 airplane model at high angles of attack and sideslip

Data were obtained with and without the nose boom and with several strake configurations; also, data were obtained for various control surface deflections. Analysis of the results revealed that selected strake configurations adequately provided low Reynolds number simulation of the high Reynolds number characteristics. The addition of the boom in general tended to reduce the Reynolds number effects

Long-Tailed Trapping Times and Levy Flights in a Self-Organized Critical Granular System

We present a continuous time random walk model for the scale-invariant transport found in a self-organized critical rice pile [Christensen et al., Phys. Rev. Lett. 77, 107 (1996)]. From our analytical results it is shown that the dynamics of the experiment can be explained in terms of L\'evy flights for the grains and a long-tailed distribution of trapping times. Scaling relations for the exponents of these distributions are obtained. The predicted microscopic behavior is confirmed by means of a cellular automaton model.Comment: 4 pages, RevTex, includes 3 PostScript figures, submitted to Phys. Rev. Let

A non-perturbative determination of Z_V and b_V for O(a) improved quenched and unquenched Wilson fermions

By considering the local vector current between nucleon states and imposing charge conservation we determine, for $O(a)$ improved Wilson fermions, its renormalisation constant and quark mass improvement coefficient. The computation is performed for both quenched and two flavour unquenched fermions.Comment: 3 pages, 4 figures, Lattice(2002)(improve

Superdiffusion in Decoupled Continuous Time Random Walks

Continuous time random walk models with decoupled waiting time density are studied. When the spatial one jump probability density belongs to the Levy distribution type and the total time transition is exponential a generalized superdiffusive regime is established. This is verified by showing that the square width of the probability distribution (appropriately defined)grows as $t^{2/\gamma}$ with $0<\gamma\leq2$ when $t\to \infty$. An important connection of our results and those of Tsallis' nonextensive statistics is shown. The normalized q-expectation value of $x^2$ calculated with the corresponding probability distribution behaves exactly as $t^{2/\gamma}$ in the asymptotic limit.Comment: 9 pages (.tex file), 1 Postscript figures, uses revtex.st

Bulk Mediated Surface Diffusion: Non Markovian Desorption with Finite First Moment

Here we address a fundamental issue in surface physics: the dynamics of adsorbed molecules. We study this problem when the particle's desorption is characterized by a non Markovian process, while the particle's adsorption and its motion in the bulk are governed by a Markovian dynamics. We study the diffusion of particles in a semi-infinite cubic lattice, and focus on the effective diffusion process at the interface $z = 1$. We calculate analytically the conditional probability to find the particle on the $z=1$ plane as well as the surface dispersion as functions of time. The comparison of these results with Monte Carlo simulations show an excellent agreement.Comment: 16 pages, 7 figs. European Physical Journal B (in press

Favorable outcome of early treatment of new onset child and adolescent migraine-implications for disease modification.

There is evidence that the prevalence of migraine in children and adolescents may be increasing. Current theories of migraine pathophysiology in adults suggest activation of central cortical and brainstem pathways in conjunction with the peripheral trigeminovascular system, which ultimately results in release of neuropeptides, facilitation of central pain pathways, neurogenic inflammation surrounding peripheral vessels, and vasodilatation. Although several risk factors for frequent episodic, chronic, and refractory migraine have been identified, the causes of migraine progression are not known. Migraine pathophysiology has not been fully evaluated in children. In this review, we will first discuss the evidence that early therapeutic interventions in the child or adolescent new onset migraineur, may halt or limit progression and disability. We will then review the evidence suggesting that many adults with chronic or refractory migraine developed their migraine as children or adolescents and may not have been treated adequately with migraine-specific therapy. Finally, we will show that early, appropriate and optimal treatment of migraine during childhood and adolescence may result in disease modification and prevent progression of this disease