Eje urbano Moro Zeit, Valencia

In 1992 public Institutions thought about the recovery of Valencia Old Town. with an important built heritage and some of their quarters in a situation of deep social, economic and architectural degradation. Into that scene it was signed an Agreement between the City Council and Regional Government (RlVA), in order lo create Plan RIVA. This one outlines a series of social. economic, urban and architectural objectives lo improve the quality of the residents' life and lo attract new neighbours, lo energize trade and associations and lo preserve the existent built heritage. The Plan RI VA is rewarded in 1998 such as one of the 100 Best Practices, as a complete performance in the old town of Valencia. It’s continuous development along the years goes configuring environments that can be defined as finished. With this appellative they define areas that have finish ed their physical rehabilitation and their social and economic regeneration. As upgrade of the Plan already presented, u intends now the result of one of those completed areas, which is the Moro Zeit Urban Axis. The great scale urban renovation began in 1996 in the centre of the Barrio de Velluters, in the scene of the European operative program URBAN. 11is now completed with the realization of the proposed area, as an important artery 01 connection of this quarter with the rest of the historical centre. The initiative has required the coordination of all the agents interveners, public and private, with periodic meetings of different work groups that have adjusted the final quantitative and qualitative parameters .En 1992 las Instituciones Públicas se plantean la recuperación del Centro Histórico de Valencia, con un importan le patrimonio edificado y algunos de sus barrios en una situación de profunda degradación social, económica y arquitectónica, mediante la firma de un Convenio entre el Ayuntamiento y la Generalitat Valenciana (RIVA), creando el Plan RIVA. Éste plantea una serie de objetivos sociales, económicos, urbanísticos y arquitectónicos para mejorar la calida d de vida de los residentes y atraer nuevos vecinos , dinamizar comercio y asociaciones y preservar el patrimonio construido existente. El Plan RI VA resulta premiado el¡ 1998 como una de las 100 Mejores Prácticas. como actuación completa en el centro histórico de Valencia . Su desarrollo continua do a lo largo de los alias va configurando entornos que se pueden definir como acabados. Con este apelativo se definen los ámbitos que han terminado su rehabilitación física y comienza su regeneración social y económica. Como actualización del Plan ya presenta do, se propone ahora el resultado de uno de esos ámbitos completados, como es el Eje Urbano Moro Zeil. La renovación urbana de gran escala iniciada en 1996 en el centro del Barrio de Velluters, en el marco del programa operativo europeo URBAN. se completa con la realización del enlomo propuesto, como importante arteria de conexión de dicho barrio con el resto del centro histórico. La iniciativa ha requerido la coordinación de lodos los agentes intervinientes, públicos y privados, con reuniones periódicas de distintos grupos de trabajo que han servido para ajustar los parámetros cuantitativos y cualitativos finales

Inference of the life cycle of environmental phages from genomic signature distances to their hosts

The environmental impact of uncultured phages is shaped by their preferred life cycle (lytic or lysogenic). However, our ability to predict it is very limited. We aimed to discriminate between lytic and lysogenic phages by comparing the similarity of their genomic signatures to those of their hosts, reflecting their co-evolution. We tested two approaches: (1) similarities of tetramer relative frequencies, (2) alignment-free comparisons based on exact k = 14 oligonucleotide matches. First, we explored 5126 reference bacterial host strains and 284 associated phages and found an approximate threshold for distinguishing lysogenic and lytic phages using both oligonucleotide-based methods. The analysis of 6482 plasmids revealed the potential for horizontal gene transfer between different host genera and, in some cases, distant bacterial taxa. Subsequently, we experimentally analyzed combinations of 138 Klebsiella pneumoniae strains and their 41 phages and found that the phages with the largest number of interactions with these strains in the laboratory had the shortest genomic distances to K. pneumoniae. We then applied our methods to 24 single-cells from a hot spring biofilm containing 41 uncultured phage-host pairs, and the results were compatible with the lysogenic life cycle of phages detected in this environment. In conclusion, oligonucleotide-based genome analysis methods can be used for predictions of (1) life cycles of environmental phages, (2) phages with the broadest host range in culture collections, and (3) potential horizontal gene transfer by plasmids

Gene expression profile of cervical and skin tissues from human papillomavirus type 16 E6 transgenic mice

<p>Abstract</p> <p>Background</p> <p>Although K14E6 transgenic mice develop spontaneous tumors of the skin epithelium, no spontaneous reproductive tract malignancies arise, unless the transgenic mice were treated chronically with 17β-estradiol. These findings suggest that E6 performs critical functions in normal adult cervix and skin, highlighting the need to define E6-controlled transcriptional programs in these tissues.</p> <p>Methods</p> <p>We evaluated the expression profile of 14,000 genes in skin or cervix from young K14E6 transgenic mice compared with nontransgenic. To identify differentially expressed genes a linear model was implemented using R and the LIMMA package. Two criteria were used to select the set of relevant genes. First a set of genes with a Log-odds ≥ 3 were selected. Then, a hierarchical search of genes was based on Log Fold Changes.</p> <p>Results</p> <p>Microarray analysis identified a total of 676 and 1154 genes that were significantly up and down-regulated, respectively, in skin from K14E6 transgenic mice. On the other hand, in the cervix from K14E6 transgenic mice we found that only 97 and 252 genes were significantly up and down-regulated, respectively. One of the most affected processes in the skin from K14E6 transgenic mice was the cell cycle. We also found that skin from transgenic mice showed down-regulation of pro-apoptotic genes and genes related to the immune response. In the cervix of K14E6 transgenic mice, we could not find affected any gene related to the cell cycle and apoptosis pathways but did observe alterations in the expression of immune response genes. Pathways such as angiogenesis, cell junction and epidermis development, also were altered in their gene expression profiles in both tissues.</p> <p>Conclusion</p> <p>Expression of the HPV16 E6 oncoprotein in our model alters expression of genes that fell into several functional groups providing insights into pathways by which E6 deregulate cell cycle progression, apoptosis, the host resistance to infection and immune function, providing new opportunities for early diagnostic markers and therapeutic drug targets.</p

Checkrein Deformity of the Hallux and Second Toe after Soft-Tissue Injury

We report the case of a patient who developed a checkrein deformity of the hallux and of the second toe following a direct soft tissue trauma to his right leg, with no associated fracture. This dynamic deformity caused the patient significant trouble walking and prevented him from playing any sport as in the stance phase of gait the toes were forced into maximum plantar flexion and ended up trapped under the foot. An MRI study did not show any bone injury or tendinous tethering. So the cause could be a subclinical compartment syndrome. Treatment consisted of a z-plasty and application of a pulvertaft suture to the flexor hallucis longus. Following a short rehabilitation program (2 weeks), the patient made a full recovery

Impact of hip fracture on health-related quality of life and activities of daily living: the SPARE-HIP prospective cohort study

There is a scarcity of prospectively collected data on functional and patient-reported outcomes following hip fracture. We therefore aimed to measure health-related quality of life (HRQoL) and activities of daily living activities (ADL) before, during index admission for a hip/proximal femur fracture, and at 1 and 4 months later

The impact of hip fracture on health-related quality of life and activities of daily living: the SPARE-HIP prospective cohort study

PURPOSE: The medical morbidity and mortality associated with neck of femur fractures is well-documented, whereas there is limited data for patient-reported outcomes. The aim of this study was to characterize the impact of neck of femur fractures on activities of daily living and patient-reported health-related quality of life. METHODS: Design and participants: Multicentric prospective cohort study. Consecutive sample patients with fragility hip fracture over 50 years old admitted in 48 hospitals in Spain. OUTCOMES: daily living activity function (Barthel Index) and health-related quality of life (EQ-5D) pre-fracture, admission to hospital and at 1- and 4-month follow-up post-fracture. STATISTICS: Barthel and EQ-5D over time are described as mean (SD) and median (interquartile range). RESULTS: A total of 997 patients were recruited at baseline with 4-month outcomes available for, and 856 patients (89.5%). Barthel Index fell from 78.77 (23.75) at baseline to 43.62 (19.86) on admission to hospital with the fracture. Scores partially recovered to 54.89 (25.40) and 64.09 (21.35) at 1- and 4-month post-fracture, respectively. EQ-5D fell from a median of 0.75 (0.47-0.91) to - 0.01 (- 0.03 to 0.51) on admission. Partial recovery was observed again to (0.51 (- 0.06 to 0.67)) and (0.60 (0.10 to 0.80)) at 1- and 4-month post-fracture, respectively. CONCLUSIONS: Hip fracture results in a large decline in the ability to perform activities of daily living and patient-reported health-related quality of life with only partial recovery amongst survivors 4-month post-fracture