The influence of temperature and salinity on the impacts of lead in Mytilus galloprovincialis

Mussels, such as the marine bivalve Mytilus galloprovincialis are sentinels for marine pollution but they are also excellent bioindicators under laboratory conditions. For that, in this study we tested the modulation of biochemical responses under realistic concentrations of the toxic metal Lead (Pb) in water for 28 days under different conditions of salinity and temperature, including control condition (temperature 17 ± 1.0 °C and salinity 30 ± 1.0) as well as those within the range expected to occur due to climate change predictions (± 5 in salinity and + 4 °C in temperature). A comprehensive set of biomarkers was applied to search on modulation of biochemical responses in terms of energy metabolism, energy reserves, oxidative stress and damage occurrence in lipids, proteins as well as neurotoxicity signs. The application of an integrative Principal Coordinates Ordination (PCO) tool was successful and demonstrated that Pb caused an increase in the detoxification activity mainly evidenced by glutathione S-transferases and that the salinities 25 and 35 were, even in un-exposed mussels, responsible for cell damage seen as increased levels of lipid peroxidation (at salinity 25) and oxidised proteins (at salinity 35).publishe

Ecotoxicological effects of lanthanum in Mytilus galloprovincialis: biochemical and histopathological impacts

Inappropriate processing and disposal of electronic waste contributes to the contamination of aquatic systems by various types of pollutants such as the rare-earth elements (REE) in which lanthanum (La) is included. Knowledge on the toxicity of these elements in marine organisms is still scarce when compared to other metals such as mercury (Hg) and arsenic (As). Therefore, this study aims to assess the toxicity of La on the mussel Mytilus galloprovincialis, considered a good bioindicator of aquatic pollution, through the analysis of metabolic, oxidative stress, neurotoxicity and histopathological markers. Organisms were exposed to different concentrations of La for a period of 28 days (0, 0.1, 1, 10 mg/L) under controlled temperature (18 °C ± 1.0) and salinity (30 ± 1) conditions. La concentrations in mussels increased in higher exposure concentrations. La exposure demonstrated a biochemical response in mussels, evidenced by lowered metabolism and accumulation of energy reserves, activation of the antioxidant defences SOD and GPx as well as the biotransformation enzymes GSTs, especially at intermediate concentrations. Despite oxidative stress being shown by a decrease in GSH/GSSG, oxidative damage was avoided as evidenced by lower LPO and PC levels. Inhibition of the enzyme AChE demonstrated the neurotoxicity of La in this species. Histopathological indices were significantly different from the control group, indicating impacts in gonads, gills and digestive glands of mussels due to La. These results show that La can be considered a risk for marine organisms and thus its discharge into the environment should be monitored.publishe

Description and evaluation of the Earth System Regional Climate Model (Reg CM-ES)

We describe a new, state-of-the-art, Earth System Regional Climate Model (RegCM-ES), which includes the coupling between the atmosphere, ocean, and land surface, as well as a hydrological and ocean biogeochemistry model, with the capability of using a variety of physical parameterizations. The regional coupled model has been implemented and tested over some of the COordinated Regional climate Downscaling Experiment (CORDEX) domains and more regional settings featuring climatically important coupled phenomena. Regional coupled ocean-atmosphere models can be especially useful tools to provide information on the mechanisms of air-sea interactions and feedbacks occurring at fine spatial and temporal scales. RegCM-ES shows a good representation of precipitation and SST fields over the domains tested, as well as realistic simulations of coupled air-sea processes and interactions. The RegCM-ES model, which can be easily implemented over any regional domain of interest, is open source, making it suitable for usage by the broad scientific community

Hepatitis D double reflex testing of all hepatitis B carriers in low-HBV- and high-HBV/HDV-prevalence countries

Hepatitis D virus (HDV) infection occurs as a coinfection with hepatitis B and increases the risk of hepatocellular carcinoma, decompensated cirrhosis, and mortality compared to hepatitis B virus (HBV) monoinfection. Reliable estimates of the prevalence of HDV infection and disease burden are essential to formulate strategies to find coinfected individuals more effectively and efficiently. The global prevalence of HBV infections was estimated to be 262,240,000 in 2021. Only 1,994,000 of the HBV infections were newly diagnosed in 2021, with more than half of the new diagnoses made in China. Our initial estimates indicated a much lower prevalence of HDV antibody (anti-HDV) and HDV RNA positivity than previously reported in published studies. Accurate estimates of HDV prevalence are needed. The most effective method to generate estimates of the prevalence of anti-HDV and HDV RNA positivity and to find undiagnosed individuals at the national level is to implement double reflex testing. This requires anti-HDV testing of all hepatitis B surface antigen-positive individuals and HDV RNA testing of all anti-HDV-positive individuals. This strategy is manageable for healthcare systems since the number of newly diagnosed HBV cases is low. At the global level, a comprehensive HDV screening strategy would require only 1,994,000 HDV antibody tests and less than 89,000 HDV PCR tests. Double reflex testing is the preferred strategy in countries with a low prevalence of HBV and those with a high prevalence of both HBV and HDV. For example, in the European Union and North America only 35,000 and 22,000 cases, respectively, will require anti-HDV testing annually

VIII Encuentro de Docentes e Investigadores en Historia del Diseño, la Arquitectura y la Ciudad

Acta de congresoLa conmemoración de los cien años de la Reforma Universitaria de 1918 se presentó como una ocasión propicia para debatir el rol de la historia, la teoría y la crítica en la formación y en la práctica profesional de diseñadores, arquitectos y urbanistas. En ese marco el VIII Encuentro de Docentes e Investigadores en Historia del Diseño, la Arquitectura y la Ciudad constituyó un espacio de intercambio y reflexión cuya realización ha sido posible gracias a la colaboración entre Facultades de Arquitectura, Urbanismo y Diseño de la Universidad Nacional y la Facultad de Arquitectura de la Universidad Católica de Córdoba, contando además con la activa participación de mayoría de las Facultades, Centros e Institutos de Historia de la Arquitectura del país y la región. Orientado en su convocatoria tanto a docentes como a estudiantes de Arquitectura y Diseño Industrial de todos los niveles de la FAUD-UNC promovió el debate de ideas a partir de experiencias concretas en instancias tales como mesas temáticas de carácter interdisciplinario, que adoptaron la modalidad de presentación de ponencias, entre otras actividades. En el ámbito de VIII Encuentro, desarrollado en la sede Ciudad Universitaria de Córdoba, se desplegaron numerosas posiciones sobre la enseñanza, la investigación y la formación en historia, teoría y crítica del diseño, la arquitectura y la ciudad; sumándose el aporte realizado a través de sus respectivas conferencias de Ana Clarisa Agüero, Bibiana Cicutti, Fernando Aliata y Alberto Petrina. El conjunto de ponencias que se publican en este Repositorio de la UNC son el resultado de dos intensas jornadas de exposiciones, cuyos contenidos han posibilitado actualizar viejos dilemas y promover nuevos debates. El evento recibió el apoyo de las autoridades de la FAUD-UNC, en especial de la Secretaría de Investigación y de la Biblioteca de nuestra casa, como así también de la Facultad de Arquitectura de la UCC; va para todos ellos un especial agradecimiento

ECOSCALE: Reconfigurable Computing and Runtime System for Future Exascale Systems

In order to reach exascale performance, current HPC systems need to be improved. Simple hardware scaling is not a feasible solution due to the increasing utility costs and power consumption limitations. Apart from improvements in implementation technology, what is needed is to refine the HPC application development flow as well as the system architecture of future HPC systems. ECOSCALE tackles these challenges by proposing a scalable programming environment and architecture, aiming to substantially reduce energy consumption as well as data traffic and latency. ECOSCALE introduces a novel heterogeneous energy-efficient hierarchical architecture, as well as a hybrid many-core+OpenCL programming environment and runtime system. The ECOSCALE approach is hierarchical and is expected to scale well by partitioning the physical system into multiple independent Workers (i.e. compute nodes). Workers are interconnected in a tree-like fashion and define a contiguous global address space that can be viewed either as a set of partitions in a Partitioned Global Address Space (PGAS), or as a set of nodes hierarchically interconnected via an MPI protocol. To further increase energy efficiency, as well as to provide resilience, the Workers employ reconfigurable accelerators mapped into the virtual address space utilizing a dual stage System Memory Management Unit with coherent memory access. The architecture supports shared partitioned reconfigurable resources accessed by any Worker in a PGAS partition, as well as automated hardware synthesis of these resources from an OpenCL-based programming model

Noninvasive respiratory support in the hypoxaemic peri-operative/periprocedural patient: a joint ESA/ESICM guideline

Hypoxaemia is a potential life-threatening yet common complication in the peri-operative and periprocedural patient (e.g. during an invasive procedure at risk of deterioration of gas exchange, such as bronchoscopy). The European Society of Anaesthesiology (ESA) and the European Society of Intensive Care Medicine (ESICM) developed guidelines for the use of noninvasive respiratory support techniques in the hypoxaemic patient in the peri-operative and periprocedural period. The panel outlined five clinical questions regarding treatment with noninvasive respiratory support techniques [conventional oxygen therapy (COT), high flow nasal cannula, noninvasive positive pressure ventilation (NIPPV) and continuous positive airway pressure (CPAP)] for hypoxaemic patients with acute peri-operative/periprocedural respiratory failure. The goal was to assess the available literature on the various noninvasive respiratory support techniques, specifically studies that included adult participants with hypoxaemia in the peri-operative/periprocedural period. The literature search strategy was developed by a Cochrane Anaesthesia and Intensive Care trial search specialist in close collaboration with the panel members and the ESA group methodologist. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) system was used to assess the level of evidence and to grade recommendations. The final process was then validated by both ESA and ESICM scientific committees. Among 19 recommendations, the two grade 1B recommendations state that: in the peri-operative/periprocedural hypoxaemic patient, the use of either NIPPV or CPAP (based on local expertise) is preferred to COT for improvement of oxygenation; and that the panel suggests using NIPPV or CPAP immediately post-extubation for hypoxaemic patients at risk of developing acute respiratory failure after abdominal surgery

Linking ground-based data and satellite monitoring to understand the last two decades of eruptive activity at Sangay volcano, Ecuador

International audienceSangay is one of the most active volcanoes in Ecuador, as it has been almost continuously erupting at least since the seventeenth century. However, because of its remote location and low associated risk to human population, little is known about its eruptions. Here we summarize Sangay's volcanic activity from January 2001 to May 2020, based on ground-based data, satellite-derived observations and chemical analysis of its erupted products. During the analyzed period, Sangay's activity changed from continuous to episodic, as revealed by seismic, thermal and ash emission data. We identified three main eruptive periods: the first, from 2001 to 2013, extruded a cumulative volume of 100 ± 50 million m3 of lava through long-lived activity; the second emitted 54 ± 27 million m3 in four short-lived episodes, which occurred once every year from 2015 to 2018; and finally, a third period since 2019, which has continuous but fluctuating intensity, and shows a significant increase in the extruded lava volume (172 ± 86 million m3 until May 31, 2020). Our results show a marked change in the eruption frequency and a significant increase in average discharge rate over time, although surface activity remained similar, with lava flows, small explosions and ash venting. We propose that three magmatic processes acted to explain the observed changes: between 2001 and 2013 the long-living low-intensity eruptions were promoted by buoyancy, while since 2019 similar but more intense activity was triggered by mass injections. In contrast, the episodic activity in between probably resulted from volatile exsolution due to crystallization (second boiling). Transitions between these three regimes are presumably the result of varying mass inflow rates. Our results provide insights into eruptive style transitions commonly observed at volcanoes of intermediate composition, such as Sangay, over a timescale of several years

Scalable performance in solid-state single-photon sources

The desiderata for an ideal photon source are high brightness, high single-photon purity, and high indistinguishability. Defining brightness at the first collection lens, these properties have been simultaneously demonstrated with solid-state sources; however, absolute source efficiencies remain close to the 1% level and indistinguishability has only been demonstrated for photons emitted consecutively on the few-nanoseconds scale. Here, we employ deterministic quantum dot-micropillar devices to demonstrate solid-state single-photon sources with scalable performances. In one device, an absolute brightness at the output of a single-mode fiber of 14% and purities of 97.1%–99.0% are demonstrated. When nonresontantly excited, it emits a long stream of photons that exhibit indistinguishability up to 70%—above the classical limit of 50%—even after 33 consecutively emitted photons with a 400 ns separation between them. Resonant excitation in other devices results in near-optimal indistinguishability values: 96% at short timescales, remaining at 88% in timescales as large as 463 ns after 39 emitted photons. The performance attained by our devices brings solid-state sources into a regime suitable for scalable implementations