Models in the delivery of depression care: a systematic review of randomised and controlled intervention trials

BACKGROUND: There is still debate as to which features, types or components of primary care interventions are associated with improved depression outcomes. Previous reviews have focused on components of collaborative care models in general practice settings. This paper aims to determine the effective components of depression care in primary care through a systematic examination of both general practice and community based intervention trials. METHODS: Fifty five randomised and controlled research trials which focused on adults and contained depression outcome measures were identified through PubMed, PsycInfo and the Cochrane Central Register of Controlled Trials databases. Trials were classified according to the components involved in the delivery of treatment, the type of treatment, the primary focus or setting of the study, detailed features of delivery, and the discipline of the professional providing the treatment. The primary outcome measure was significant improvement on the key depression measure. RESULTS: Components which were found to significantly predict improvement were the revision of professional roles, the provision of a case manager who provided direct feedback and delivered a psychological therapy, and an intervention that incorporated patient preferences into care. Nurse, psychologist and psychiatrist delivered care were effective, but pharmacist delivery was not. Training directed to general practitioners was significantly less successful than interventions that did not have training as the most important intervention. Community interventions were effective. CONCLUSION: Case management is important in the provision of care in general practice. Certain community models of care (education programs) have potential while others are not successful in their current form (pharmacist monitoring)

Electrodynamics of a Magnet Moving through a Conducting Pipe

The popular demonstration involving a permanent magnet falling through a conducting pipe is treated as an axially symmetric boundary value problem. Specifically, Maxwell's equations are solved for an axially symmetric magnet moving coaxially inside an infinitely long, conducting cylindrical shell of arbitrary thickness at nonrelativistic speeds. Analytic solutions for the fields are developed and used to derive the resulting drag force acting on the magnet in integral form. This treatment represents a significant improvement over existing models which idealize the problem as a point dipole moving slowly inside a pipe of negligible thickness. It also provides a rigorous study of eddy currents under a broad range of conditions, and can be used for precision magnetic braking applications. The case of a uniformly magnetized cylindrical magnet is considered in detail, and a comprehensive analytical and numerical study of the properties of the drag force is presented for this geometry. Various limiting cases of interest involving the shape and speed of the magnet and the full range of conductivity and magnetic behavior of the pipe material are investigated and corresponding asymptotic formulas are developed.Comment: 20 pages, 3 figures; computer program posted to http://www.csus.edu/indiv/p/partovimh/magpipedrag.nb Submitted to the Canadian Journal of Physic

Nonlinear resonant absorption of fast magnetoacoustic waves in strongly anisotropic and dispersive plasmas

The nonlinear theory of driven magnetohydrodynamics (MHD) waves in strongly anisotropic and dispersive plasmas, developed for slow resonance by Clack and Ballai [Phys. Plasmas 15, 2310 (2008)] and Alfvén resonance by Clack et al. [Astron. Astrophys. 494, 317 (2009)] , is used to study the weakly nonlinear interaction of fast magnetoacoustic (FMA) waves in a one-dimensional planar plasma. The magnetic configuration consists of an inhomogeneous magnetic slab sandwiched between two regions of semi-infinite homogeneous magnetic plasmas. Laterally driven FMA waves penetrate the inhomogeneous slab interacting with the localized slow or Alfvén dissipative layer and are partly reflected, dissipated, and transmitted by this region. The nonlinearity parameter defined by Clack and Ballai (2008) is assumed to be small and a regular perturbation method is used to obtain analytical solutions in the slow dissipative layer. The effect of dispersion in the slow dissipative layer is to further decrease the coefficient of energy absorption, compared to its standard weakly nonlinear counterpart, and the generation of higher harmonics in the outgoing wave in addition to the fundamental one. The absorption of external drivers at the Alfvén resonance is described within the linear MHD with great accuracy

Mean shear flows generated by nonlinear resonant Alfven waves

In the context of resonant absorption, nonlinearity has two different manifestations. The first is the reduction in amplitude of perturbations around the resonant point (wave energy absorption). The second is the generation of mean shear flows outside the dissipative layer surrounding the resonant point. Ruderman et al. [Phys. Plasmas 4, 75 (1997)] studied both these effects at the slow resonance in isotropic plasmas. Clack et al. [Astron. Astrophys. 494}, 317 (2009)] investigated nonlinearity at the Alfven resonance, however, they did not include the generation of mean shear flow. In this present paper, we investigate the mean shear flow, analytically, and study its properties. We find that the flow generated is parallel to the magnetic surfaces and has a characteristic velocity proportional to $\epsilon^{1/2}$, where $\epsilon$ is the dimensionless amplitude of perturbations far away from the resonance. This is, qualitatively, similar to the flow generated at the slow resonance. The jumps in the derivatives of the parallel and perpendicular components of mean shear flow across the dissipative layer are derived. We estimate the generated mean shear flow to be of the order of $10{\rm kms}^{-1}$ in both the solar upper chromosphere and solar corona, however, this value strongly depends on the choice of boundary conditions. It is proposed that the generated mean shear flow can produce a Kelvin--Helmholtz instability at the dissipative layer which can create turbulent motions. This instability would be an additional effect, as a Kelvin--Helmholtz instability may already exist due to the velocity field of the resonant Alfven waves. This flow can also be superimposed onto existing large scale motions in the solar upper atmosphere.Comment: 11 page

On the validity of nonlinear Alfvén resonance in space plasmas

Aims. In the approximation of linear dissipative magnetohydrodynamics (MHD), it can be shown that driven MHD waves in magnetic plasmas with high Reynolds number exhibit a near resonant behaviour if the frequency of the wave becomes equal to the local Alfvén (or slow) frequency of a magnetic surface. This behaviour is confined to a thin region, known as the dissipative layer, which embraces the resonant magnetic surface. Although driven MHD waves have small dimensionless amplitude far away from the resonant surface, this near-resonant behaviour in the dissipative layer may cause a breakdown of linear theory. Our aim is to study the nonlinear effects in Alfvén dissipative layer Methods. In the present paper, the method of simplified matched asymptotic expansions developed for nonlinear slow resonant waves is used to describe nonlinear effects inside the Alfvén dissipative layer. Results. The nonlinear corrections to resonant waves in the Alfvén dissipative layer are derived, and it is proved that at the Alfvén resonance (with isotropic/anisotropic dissipation) wave dynamics can be described by the linear theory with great accuracy

Landscape-Scale Implications of the Edge Effect on Soil Fauna Activity in a Temperate Forest

Although studies on edge effects on species richness and abundance are numerous, the responses of ecosystem processes to these effects have received considerably less attention. How ecosystem processes respond to edge effects is particularly important in temperate forests, where small fragments and edge habitats form a considerable proportion of the total forest area. Soil fauna are key contributors to decomposition and soil biogeochemical cycling processes. Using the bait lamina technique, we quantified soil fauna feeding activity, and its dependence on soil moisture and distance to the edge in a broad-leaved forest in Southern England. Feeding activity was 40% lower at the forest edge than in the interior, and the depth of edge influence was approximately 75 m. A watering treatment showed that moisture limitation was the main driver of the reduced feeding activity at the edge. In England, only 33% of the forest area is greater than 75 m from the edge. Therefore, assuming that the results from this single-site study are representative for the landscape, it implies that only one- third of the forest area in England supports activity levels typical for the forest core, and that edge effects reduce the mean feeding activity across the landscape by 17% (with lower and upper 90% confidence intervals of 1.3 and 23%, respectively). Changing climatic conditions, such as summer droughts may exacerbate such effects as edges lose water faster than the forest interior. The results highlight the importance of taking edge effects into account in ecological studies and forest management planning in highly fragmented landscapes.Peer reviewe

Nonlinear theory of resonant slow waves in anisotropic and dispersive plasmas

The solar corona is a typical example of a plasma with strongly anisotropic transport processes. The main dissipative mechanisms in the solar corona acting on slow magnetoacoustic waves are the anisotropic thermal conductivity and viscosity [Ballai et al., Phys. Plasmas 5, 252 (1998)] developed the nonlinear theory of driven slow resonant waves in such a regime. In the present paper the nonlinear behavior of driven magnetohydrodynamic waves in the slow dissipative layer in plasmas with strongly anisotropic viscosity and thermal conductivity is expanded by considering dispersive effects due to Hall currents. The nonlinear governing equation describing the dynamics of nonlinear resonant slow waves is supplemented by a term which describes nonlinear dispersion and is of the same order of magnitude as nonlinearity and dissipation. The connection formulas are found to be similar to their nondispersive counterparts

The Addition of Arachidin 1 or Arachidin 3 to Human Rotavirus-infected Cells Inhibits Viral Replication and Alters the Apoptotic Cell Death Pathway

Rotavirus (RV) infections are a leading cause of severe gastroenteritis in infants and children under the age of five. There are two vaccines available in the United States and one in India that can be administered early in childhood, however they only protect against specific strains1. From our previous work, both arachidin-1 (A1) and arachidin-3 (A3) from peanut (Arachis hypogaea) hairy root cultures significantly inhibit simian RV replication2,3,4. The purpose of this study was to determine if a human intestinal cell line, HT29.f8, infected with a human RV, Wa, was affected by A1 and A3. Cell viability assays were utilized to determine if A1 and A3 affect the HT29.f8 cells with/without RV infections. At eighteen hours post infection (hpi), supernatants from the RV-infected HT29.f8 cells with/without the arachidins were used in plaque forming assays to quantify and compare the amount of infectious RV particles that are produced during an infection. Transmission electron microscopy (TEM) was used to visualize cell ultrastructure and individual RV particles. Additionally, tunable resistive pulse sensing technology (TRPS) using the qNano system by IZON was employed to quantify and measure virus particle sizes, and display the size distribution of RV particles. Likewise, quantitative real time polymerase chain reactions (qRT-PCR) were performed to determine if A1 and A3 regulated cell death pathways in the HT29.f8 cell line. This data will guide our future studies to determine the antiviral mechanism(s) of action of A1 and A3

Enzymes as Feed Additive to Aid in Responses Against Eimeria Species in Coccidia-Vaccinated Broilers Fed Corn-Soybean Meal Diets with Different Protein Levels

This research aimed to evaluate the effects of adding a combination of exogenous enzymes to starter diets varying in protein content and fed to broilers vaccinated at day of hatch with live oocysts and then challenged with mixed Eimeria spp. Five hundred four 1-d-old male Cobb-500 chickens were distributed in 72 cages. The design consisted of 12 treatments. Three anticoccidial control programs [ionophore (IO), coccidian vaccine (COV), and coccidia-vaccine + enzymes (COV + EC)] were evaluated under 3 CP levels (19, 21, and 23%), and 3 unmedicated-uninfected (UU) negative controls were included for each one of the protein levels. All chickens except those in unmedicated-uninfected negative controls were infected at 17 d of age with a mixed oral inoculum of Eimeria acervulina, Eimeria maxima, and Eimeria tenella. Live performance, lesion scores, oocyst counts, and samples for gut microflora profiles were evaluated 7 d postinfection. Ileal digestibility of amino acids (IDAA) was determined 8 d postinfection. Microbial communities (MC) were analyzed by G + C%, microbial numbers were counted by flow cytometry, and IgA concentrations were measured by ELISA. The lowest CP diets had poorer (P ≤ 0.001) BW gain and feed conversion ratio in the preinfection period. Coccidia-vaccinated broilers had lower performance than the ones fed ionophore diets during pre- and postchallenge periods. Intestinal lesion scores were affected (P ≤ 0.05) by anticoccidial control programs, but responses changed according to gut section. Feed additives or vaccination had no effect (P ≥ 0.05) on IDAA, and diets with 23% CP had the lowest (P ≤ 0.001) IDAA. Coccidial infection had no effect on MC numbers in the ileum but reduced MC numbers in ceca and suppressed ileal IgA production. The COV + EC treatment modulated MC during mixed coccidiosis infection but did not significantly improve chicken performance. Results indicated that feed enzymes may be used to modulate the gut microflora of cocci-vaccinated broiler chickens

Bulk Band Gaps in Divalent Hexaborides

Complementary angle-resolved photoemission and bulk-sensitive k-resolved resonant inelastic x-ray scattering of divalent hexaborides reveal a >1 eV X-point gap between the valence and conduction bands, in contradiction to the band overlap assumed in several models of their novel ferromagnetism. This semiconducting gap implies that carriers detected in transport measurements arise from defects, and the measured location of the bulk Fermi level at the bottom of the conduction band implicates boron vacancies as the origin of the excess electrons. The measured band structure and X-point gap in CaB_6 additionally provide a stringent test case for proper inclusion of many-body effects in quasi-particle band calculations.Comment: 4 pages, 3 figures; new RIXS analysis; accepted for publication in PR