Recurrence dynamics of particulate transport with reversible blockage: from a single channel to a bundle of coupled channels

We model a particulate flow of constant velocity through confined geometries, ranging from a single channel to a bundle of $N_c$ identical coupled channels, under conditions of reversible blockage. Quantities of interest include the exiting particle flux (or throughput) and the probability that the bundle is open. For a constant entering flux, the bundle evolves through a transient regime to a steady state. We present analytic solutions for the stationary properties of a single channel with capacity $N\le 3$ and for a bundle of channels each of capacity $N = 1$. For larger values of $N$ and $N_c$, the system's steady state behavior is explored by numerical simulation. Depending on the deblocking time, the exiting flux either increases monotonically with intensity or displays a maximum at a finite intensity. For large $N$ we observe an abrupt change from a state with few blockages to one in which the bundle is permanently blocked and the exiting flux is due entirely to the release of blocked particles. We also compare the relative efficiency of coupled and uncoupled bundles. For $N=1$ the coupled system is always more efficient, but for $N>1$ the behavior is more complex.Comment: 14 pages, 15 figure

Phenotypic spectrum of fetal Smith-Lemli-Opitz syndrome.

International audienceThe Smith-Lemli-Opitz syndrome (SLOS) is an autosomal recessive multiple congenital malformation syndrome caused by dehydrocholesterol reductase deficiency. The diagnosis is confirmed by high 7- and secondarily 8-dehydrocholesterol levels in plasma and tissues and/or by detection of biallelic mutations in the DHCR7 gene. The phenotypic spectrum of SLOS is broad, ranging from a mild phenotype combining subtle physical anomalies with behavioral and learning problems, to a perinatally lethal multiple malformations syndrome. The fetal phenotype of SLOS has been poorly described in the literature. We report a series of 10 fetuses with molecularly proven SLOS. Even in young fetuses, the facial dysmorphism appears characteristic. Genital abnormalities are rare in 46,XX subjects. Gonadal differentiation appears histologically normal and in agreement with the chromosomal sex, contrary to what has been previously stated. We observed some previously unreported anomalies: ulnar hypoplasia, vertebral segmentation anomalies, congenital pulmonary adenomatoid malformation, fused lungs, gastroschisis, holomyelia and hypothalamic hamartoma. This latter malformation proves that SLOS phenotypically overlaps with Pallister-Hall syndrome which remains clinically a major differential diagnosis of SLOS

Stochastic model of single-file flow with reversible blockage

We introduce a stochastic model for reversible blockage in particulate flow through a channel. A blockage forms whenever two particles are in the channel simultaneously. The process restarts after a waiting time $\tau_b$ and both particles exit the channel. We obtain exact expressions for the steady-state particle flux out of the channel, the probability that the channel is open at time t and the probability distribution that n particles have exited the channel at time t when the channel is closed

Image employeur, image de la ville et attractivité organisationnelle

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Label employer et/ou marque région: quels signaux privilégier dans la communication de recrutement pour renforcer l'attractivité organisationnelle?

International audienceCette recherche analyse les effets de la présence séparée ou simultanée de signaux relatifs au territoire et à l’employeur dans une annonce de recrutement sur l’attractivité organisationnelle. Les résultats montrent que marque employeur et marque territoire n’ont pas intérêt à être rapprochées dans la communication de recrutement. L’effet du logo région fonctionne en effet lorsqu’il n’est pas associé au label employeur et est d’autant plus fort que l’image de la ville est bonne

L’effet sur l'attractivité organisationnelle de l'association d'une marque région et d'un label employeur dans une publicité de recrutement

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THE EFFECT ON THE ORGANIZATIONAL ATTRACTIVENESS OF THE ASSOCIATION OF A REGION BRAND AND AN EMPLOYER CERTIFICATION IN A RECRUITMENT ADVERTISING

International audienceDans une perspective de marketing RH, cette recherche s'intéresse à l'effet de la présence, dans une publicité de recrutement, de signaux de qualité relatifs à l'entreprise (label employeur) et/ou au territoire d'implantation de celle-ci (logo de la marque région dans laquelle cet employeur est implanté) sur l'attractivité organisationnelle (AO). Un design expérimental montre que l'utilisation d'une marque région et/ou d'un label employeur permet de renforcer l'attractivité d'une organisation en tant qu'employeur. Plus précisément, chacun des deux logos renforce l'AO comparativement à une communication ne faisant apparaitre aucun logo. En revanche, la présence des deux logos (employeur et région) ne se traduit pas par une augmentation de l'AO de manière significative par rapport à une publicité de recrutement contenant un seul des deux logos. Cette recherche permet néanmoins de conclure à l'intérêt, pour une entreprise, de faire figurer des labels et/ou des marques dans sa communication de recrutement. Mots clefs : attractivité organisationnelle ; label employeur ; marketing RH ; marque région. Abstract: From an HR marketing perspective, this research focuses on the effect of the presence, in a recruitment advertisement, of quality signals relating to the company (employer certification) and the territory where it is located (logo of the region brand in which this employer is established) on organizational attractiveness (OA). An experimental design shows that the use of a regional brand and/or an employer certification enhances the attractiveness of an organization as an employer. Specifically, each of the two logos reinforces the OA compared to a communication without logo. On the other hand, the presence of the two logos (employer and region) does not translate into a significant increase in the OA compared to

Low correlation between Ki67 assessed by qRT-PCR in Oncotype Dx score and Ki67 assessed by Immunohistochemistry

International audienceAbstract Breast cancers expressing high levels of Ki67 are associated with poor outcomes. Oncotype DX test was designed for ER+/HER2− early-stage breast cancers to help adjuvant chemotherapy decision by providing a Recurrent Score (RS). RS measures the expression of 21 specific genes from tumor tissue, including Ki67 . The primary aim of this study was to assess the agreement between Ki67 RNA obtained with Oncotype DX RS and Ki67 IHC . Other objectives were to analyze the association between the event free survival (EFS) and the expression level of Ki67 RNA ; and association between RS and Ki67 RNA . Herein, we report a low agreement of 0.288 by Pearson correlation coefficient test between Ki67 IHC and Ki67 RNA in a cohort of 98 patients with early ER+/HER2− breast cancers. Moreover, Ki67 RNA high tumors were significantly associated with the occurrence of events ( p = 0.03). On the other hand, we did not find any association between Ki67 IHC and EFS ( p = 0.26). We observed a low agreement between expression level of Ki67 RNA and Ki67 protein labelling by IHC. Unlike Ki67 IHC and independently of the RS, Ki67 RNA could have a prognostic value. It would be interesting to better assess the prognosis and predictive value of Ki67 RNA measured by qRT-PCR. The Ki67 RNA in medical routine could be a good support in countries where Oncotype DX is not accessible