Magnetic field structure of the extended 3C 380 jet

An earlier study of the complex jet of 3C 380 by Papageorgiou et al. revealed total intensity and polarization structure associated with a bright knot K1 about 0.7 arcsec from the core that was reminiscent of that expected for a conical shock wave. In this new study, 1.42, 1.66 and 4.99 GHz total intensity, polarization and Faraday rotation images are presented and analysed. These images were derived from observations with the Very Long Baseline Array plus one antenna of the Very Large Array, obtained in 2006 March. These new images confirm the overall magnetic field structure of the knot K1 indicated in the earlier observations. In addition, a clear Faraday rotation gradient has been detected across the jet, extending roughly from 10 to 30 mas (70–200 pc) along the jet from the core (a radial distance of approximately two beamwidths). The gradient spans roughly 3.5 beamwidths in the transverse direction, and the difference in the rotation measures on either side of the jet is 4–5σ, demonstrating that the detection of the gradient is firm. We interpret this transverse Faraday rotation gradient as reflecting systematic variation of the line-of-sight component of a helical or toroidal magnetic field (B) associated with the jet of 3C 380. These results provide evidence that the helical field arising due to the joint action of the rotation of the central black hole and its accretion disc and the jet outflow can survive to distances of hundreds of parsecs from the central engine

Audio Tactile Maps (ATM) System for the Exploration of Digital Heritage Buildings by Visually-impaired Individuals - First Prototype and Preliminary Evaluation

P.I. Dr. Lorenzo Piccinali, Faculty of Technology, DMUNavigation within historic spaces requires analysis of a variety of acoustic, proprioceptive and tactile cues; a task that is well-developed in many visually-impaired individuals but for which sighted individuals rely almost entirely on vision. For the visually-impaired, the creation of a cognitive map of a space can be a long process for which the individual may repeat various paths numerous times. While this action is typically performed by the individual on-site, it is of some interest to investigate to what degree this task can be performed off-site using a virtual simulator. We propose a tactile map navigation system with interactive auditory display. The system is based on a paper tactile map upon which the user’s hands are tracked. Audio feedback provides; (i) information on user-selected map features, (ii) dynamic navigation information as the hand is moved, (iii) guidance on how to reach the location of one hand (arrival point) from the location of the other hand (departure point) and (iv) additional interactive 3D-audio cues useful for navigation. This paper presents an overview of the initial technical development stage, reporting observations from preliminary evaluations with a blind individual. The system will be beneficial to visually impaired visitors to heritage sites; we describe one such site which is being used to further assess our prototype

Analysing the Transverse Structure of the Relativistic Jets of AGN

This paper describes a method of fitting total intensity and polarization profiles in VLBI images of astrophysical jets to profiles predicted by a theoretical model. As an example, the method is used to fit profiles of the jet in the Active Galactic Nucleus Mrk501 with profiles predicted by a model in which a cylindrical jet of synchrotron plasma is threaded by a magnetic field with helical and disordered components. This fitting yields model Stokes Q profiles that agree with the observed profiles to within the 1-2 \sigma uncertainties; the I model and observed profiles are overall not in such good agreement, with the model I profiles being generally more symmetrical than the observed profiles. Consistent fitting results are obtained for profiles derived from 6cm VLBI images at two distances from the core, and also for profiles obtained for different wavelengths at a single location in the VLBI jet. The most striking success of the model is its ability to reproduce the spine-sheath polarization structure observed across the jet. Using the derived viewing angle in the jet rest frame, \delta' approximately 83 degrees, together with a superluminal speed reported in the literature, \beta apparent = 3.3, yields a solution for the viewing angle and velocity of the jet in the observer's frame \delta degrees and \beta approximately 0.96. Although these results for Mrk501 must be considered tentative, the combined analysis of polarization profiles and apparent component speeds holds promise as a means of further elucidating the magnetic field structures and other parameters of parsec-scale AGN jets

A caspase-3 'death-switch' in colorectal cancer cells for induced and synchronous tumor apoptosis in vitro and in vivo facilitates the development of minimally invasive cell death biomarkers

Novel anticancer drugs targeting key apoptosis regulators have been developed and are undergoing clinical trials. Pharmacodynamic biomarkers to define the optimum dose of drug that provokes tumor apoptosis are in demand; acquisition of longitudinal tumor biopsies is a significant challenge and minimally invasive biomarkers are required. Considering this, we have developed and validated a preclinical 'death-switch' model for the discovery of secreted biomarkers of tumour apoptosis using in vitro proteomics and in vivo evaluation of the novel imaging probe [ 18 F]ML-10 for non-invasive detection of apoptosis using positron emission tomography (PET). The 'death-switch' is a constitutively active mutant caspase-3 that is robustly induced by doxycycline to drive synchronous apoptosis in human colorectal cancer cells in vitro or grown as tumor xenografts. Deathswitch induction caused caspase-dependent apoptosis between 3 and 24 hours in vitro and regression of 'death-switched' xenografts occurred within 24 h correlating with the percentage of apoptotic cells in tumor and levels of an established cell death biomarker (cleaved cytokeratin-18) in the blood. We sought to define secreted biomarkers of tumor apoptosis from cultured cells using Discovery Isobaric Tag proteomics, which may provide candidates to validate in blood. Early after caspase-3 activation, levels of normally secreted proteins were decreased (e.g. Gelsolin and Midkine) and proteins including CD44 and High Mobility Group protein B1 (HMGB1) that were released into cell culture media in vitro were also identified in the bloodstream of mice bearing death-switched tumors. We also exemplify the utility of the death-switch model for the validation of apoptotic imaging probes using [ 18 F]ML-10, a PET tracer currently in clinical trials. Results showed increased tracer uptake of [ 18 F]ML-10 in tumours undergoing apoptosis, compared with matched tumour controls imaged in the same animal. Overall, the death-switch model represents a robust and versatile tool for the discovery and validation of apoptosis biomarkers. © 2013 Macmillan Publishers Limited. All rights reserved

iShocks: X-ray binary jets with an internal shocks model

In the following paper we present an internal shocks model, iShocks, for simulating a variety of relativistic jet scenarios; these scenarios can range from a single ejection event to an almost continuous jet, and are highly user configurable. Although the primary focus in the following paper is black hole X-ray binary jets, the model is scale and source independent and could be used for supermassive black holes in active galactic nuclei or other flows such as jets from neutron stars. Discrete packets of plasma (or `shells') are used to simulate the jet volume. A two-shell collision gives rise to an internal shock, which acts as an electron re-energization mechanism. Using a pseudo-random distribution of the shell properties, the results show how for the first time it is possible to reproduce a flat/inverted spectrum (associated with compact radio jets) in a conical jet whilst taking the adiabatic energy losses into account. Previous models have shown that electron re-acceleration is essential in order to obtain a flat spectrum from an adiabatic conical jet: multiple internal shocks prove to be efficient in providing this re-energization. We also show how the high frequency turnover/break in the spectrum is correlated with the jet power, $\nu_b \propto L_{\textrm W}^{\sim 0.6}$, and the flat-spectrum synchrotron flux is correlated with the total jet power, $F_{\nu}\propto L_{\textrm W}^{\sim 1.4}$. Both the correlations are in agreement with previous analytical predictions.Comment: 13 pages, 17 figures, 5 tables. Accepted for publication in MNRA

X-ray Properties of the GigaHertz-Peaked and Compact Steep Spectrum Sources

We present {\it Chandra} X-ray Observatory observations of Giga-Hertz Peaked Spectrum (GPS) and Compact Steep Spectrum (CSS) radio sources. The {\it Chandra} sample contains 13 quasars and 3 galaxies with measured 2-10 keV X-ray luminosity within $10^{42} - 10^{46}$ erg s$^{-1}$. We detect all of the sources, five of which are observed in X-ray for the first time. We study the X-ray spectral properties of the sample. The measured absorption columns in the quasars are different than those in the galaxies in the sense that the quasars show no absorption (with limits $\sim 10^{21} \rm cm^{-2}$) while the galaxies have large absorption columns ($> 10^{22} \rm cm^{-2}$) consistent with previous findings. The median photon index of the sources with high S/N is $\Gamma=1.84 \pm0.24$ and it is larger than the typical index of radio loud quasars. The arcsec resolution of {\it Chandra} telescope allows us to investigate X-ray extended emission, and look for diffuse components and X-ray jets. We found X-ray jets in two quasars (PKS 1127-145, B2 0738+32), an X-ray cluster surrounding a CSS quasar (z=1.1, 3C 186), detected a possible binary structure in 0941-080 galaxy and an extended diffuse emission in galaxy PKS B2 1345+12. We discuss our results in the context of X-ray emission processes and radio source evolution. We conclude that the X-ray emission in these sources is most likely unrelated to a relativistic jet, while the sources' radio-loudness may suggest a high radiative efficiency of the jet power in these sources.Comment: 15 pages, to be published in Ap

A practical microwave method for the synthesis of fluoromethy 4-methylbenzenesulfonate in tert-amyl alcohol

YesFluorine substitution is an established tool in medicinal chemistry to favourably alter the molecular properties of a lead compound of interest. However, gaps still exist in the library of synthetic methods for accessing certain fluorine-substituted motifs. One such area is the fluoromethyl group, particularly when required in a fluoroalkylating capacity. The cold fluorination of methylene ditosylate is under evaluated in the literature, often proceeding with low yields or harsh conditions. This report describes a novel microwave method for the rapid nucleophilic fluorination of methylene ditosylate using inexpensive reagents in good isolated yield (65%)

Analysis of l 6 cm VLBI polarization observations of a complete sample of northern BL Lacertae objects

A B S T R A C T The results of very long baseline interferometry (VLBI) total intensity (I) and linear polarization (P) observations at l 6 cm are presented for 10 radio bright BL Lacertae objects. These images complete first-epoch polarization observations for the 1-Jy sample of northern BL Lacertae objects defined by Ku Èhr & Schmidt. Estimates of superluminal speeds are presented for several sources, bringing the total number of sources in the sample for which such estimates are available to 16. Second-epoch observations currently being reduced should yield speed estimates for VLBI features in essentially all the sources in the sample. The jet magnetic fields of these BL Lacertae objects are usually transverse to the local jet direction, but a sizeable minority (about 30 per cent) have VLBI jet components with longitudinal magnetic fields. This may suggest that the conditions in the VLBI jets of BL Lacertae objects are favourable for the formation of relativistic shocks; alternatively, it may be that the toroidal component of the intrinsic jet magnetic field is characteristically dominant in these sources

Resonant-Cavity-Induced Phase Locking and Voltage Steps in a Josephson Array

We describe a simple dynamical model for an underdamped Josephson junction array coupled to a resonant cavity. From numerical solutions of the model in one dimension, we find that (i) current-voltage characteristics of the array have self-induced resonant steps (SIRS), (ii) at fixed disorder and coupling strength, the array locks into a coherent, periodic state above a critical number of active Josephson junctions, and (iii) when $N_a$ active junctions are synchronized on an SIRS, the energy emitted into the resonant cavity is quadratic with $N_a$. All three features are in agreement with a recent experiment [Barbara {\it et al}, Phys. Rev. Lett. {\bf 82}, 1963 (1999)]}.Comment: 4 pages, 3 eps figures included. Submitted to PRB Rapid Com