AIDA-DB: a data management architecture for the edge and cloud continuum

There is an increasing demand for stateful edge computing for both complex Virtual Network Functions (VNFs) and application services in emerging 5G networks. Managing a mutable persistent state in the edge does however bring new architectural, performance, and dependability challenges. Not only it has to be integrated with existing cloud-based systems, but also cope with both operational and analytical workloads and be compatible with a variety of SQL and NoSQL database management systems. We address these challenges with AIDA-DB, a polyglot data management architecture for the edge and cloud continuum. It leverages recent development in distributed transaction processing for a reliable mutable state in operational workloads, with a flexible synchronization mechanism for efficient data collection in cloud-based analytical workloads.Partially funded by project AIDA – Adaptive, Intelligent and Distributed Assurance Platform (POCI-01-0247- FEDER-045907) co-financed by the European Regional Development Fund (ERDF) through the Operational Program for Competitiveness and Internationalisation (COMPETE 2020) and by the Portuguese Foundation for Science and Technology (FCT) under CMU Portugal

Caracterização agronômica de acessos de cevada de alta produtividade sob irrigação no Cerrado

O objetivo deste trabalho foi estimar parâmetros genéticos, fenotípicos e ambientais de 113 acessos de cevada (Hordeum vulgare), previamente selecionados com base em alta produtividade, em sistema de produção irrigado no Cerrado, para uso em programas de melhoramento no Brasil. O experimento foi realizado em 2013, em dois locais no Distrito Federal, tendo-se utilizado o delineamento experimental de blocos ao acaso, com três repetições. Avaliaram-se as características: rendimento de grãos, classificação comercial de primeira, peso de mil grãos, altura de plantas, acamamento e dias para espigamento. Foram observadas diferenças significativas entre ambientes e acessos para todas as características avaliadas, além de interação genótipo x ambiente. Os acessos MCU 3832 PI 402310, MCU 3484 PI 401962, CI 08053 Custer, MCU 3634 PI 402112 e MCU 3816 PI 402294 destacaram-se em relação ao rendimento de grãos e à classificação comercial de primeira. É possível obter altos ganhos de seleção com altos valores de herdabilidade. No entanto, a seleção indireta não é recomendada nas condições experimentais, em razão das baixas correlações genotípicas e fenotípicas obtidas. Também é possível a seleção simultânea de acessos de cevada com alto rendimento e ciclo de espigamento precoce, fator decisivo no processo de escolha de genótipos para futuros experimentos. Os acessos colombianos são os mais adaptados às condições de Cerrado.The objective of this work was to estimate the genetic, phenotypic, and environmental parameters of 113 barley accessions (Hordeum vulgare), previously selected based on high yield, in an irrigated production system in the Cerrado (Brazilian savanna), for use in breeding programs in Brazil. The experiment was conducted in 2013 at two sites in the Federal District, using a randomized complete block design with three replicates. The evaluated traits were: grain yield, kernel plumpness, thousand grain weight, plant height, lodging, and days to heading. Significant differences were observed between environment and accessions for all studied traits, as well as genotype x environment interaction. The MCU 3832 PI 402310, MCU 3484 PI 401962, CI 08053 Custer, MCU 3634 PI 402112, and MCU 3816 PI 402294 accessions stood out regarding grain yield and kernel plumpness. It is possible to obtain high selection gains with high heritability values. However, indirect selection is not recommended in the experimental conditions due to the low genotypic and phenotypic correlations obtained. It is also possible to select barley accessions with high yield and early heading date simultaneously, an important factor in the genotype selection process for future experiments. The accessions from Colombia are the most adapted to the Cerrado conditions

Genetic parameters and agronomic characterization of elite barley accessions under irrigation in the cerrado

There is a demand for barley cultivars that are suitable for the malt industry as well as genotypes that are stable and better adapted for irrigation in the Cerrado. This study aimed to estimate the genetic parameters by assessing 69 barley genotypes from different countries, from 2012 to 2014, under irrigation in the Cerrado. Six agronomic characteristics were assessed: grain yield, plumpness kernel, thousand seeds weight, plant height, degree of plant lodging and days to heading. Analysis of variance, cluster test and phenotypic, genotypic and environmental correlations were performed. Significant effects were observed for genotypes, years and the G x E interaction. High values of broad-sense heritability (> 86%) were found for all the characteristics, which enabled direct selection. The Colombian accession MCU363PI402112 stood out for its agronomic characteristics. Genotype selection based on the phenotypic evaluations was possible due to their good experimental accuracy and precision. Precocious genotypes with high grain yields and homogeneous grain sizes were selected. Due to the environmental influence on the grain yield, additional studies concerning the components of yield in this environment are necessary to facilitate the selection of more productive genotypes

Cross-layer QoS-Aware Resource Allocation for IoT-Enabled Service Choreographies

International audienceResource allocation for distributed systems is a well-known approach to deal with quality of service requirements. However, existing approaches do not consider the effects of resource allocation at the different levels of a system, especially when considering the end-to-end behavior of distributed compositions such as service choreographies. Based on our previous research on the optimized and QoS-aware resource allocation for service choreographies and publish-subscribe brokers, we outline a novel approach that integrates the treatment of resource allocation at both levels in orderto yield a more precise control over end-to-end QoS. The paper presents an early architecture and discusses some of the main challenges towards realizing the approach

Increased Rho-kinase-mediated prostate contractions associated with impairment of β-adrenergic-cAMP-signaling pathway by chronic nitric oxide deficiency

AbstractImpairment of nitric oxide (NO) – cyclic GMP signaling pathway is likely to contribute to human begnin prostate hyperplasia (BPH). In the present study we have used a model of chronic NO synthesis inhibition to evaluate the functional alterations of prostate smooth muscle (PSM) machinery, and involvement of Rho-kinase pathway. Wistar rats were treated with the NO inhibitor Nω-nitro-l-arginine methyl ester (L-NAME, 20mg/kg/day; 4 weeks), after which contractile responses to phenylephrine (α1-adrenoceptor agonist; 1nM to 100µM), carbachol (muscarinic agonist; 1nM to 1mM) and α,β-methylene ATP (P2X receptor agonist; 1–10µM), as well as to electrical-field stimulation (EFS; 1–32Hz) were evaluated. PSM relaxations to isoproterenol (non-selective β-adrenoceptor agonist, 0.1nM to 10µM) and sodium nitroprusside (NO donor, 1nM to 10mM) were also evaluated. The ratio prostate weight/body weight was 22% greater (P<0.05) in L-NAME compared with control group. The PSM contractions to phenylephrine, carbachol and α,β-methylene ATP were higher in L-NAME (Emax: 3.85±0.25, 3.52±0.35 and 2.03±0.2mN, respectively) compared with control group (Emax: 3.08±0.17, 2.37±0.18 and 1.57±0.18mN, respectively). The PSM contractions induced by EFS were also significantly greater in L-NAME group. Prior incubation with the Rho-kinase inhibitor Y27632 (1µM) fully reversed the enhanced contractions to phenylephrine and carbachol. Isoproterenol-induced PSM relaxations were 34% lower in L-NAME group, which was associated with reduced levels of cAMP in prostate tissue. The relaxations to sodium nitroprusside remained unaltered in L-NAME group. In summary, chronic NO deficiency leads to increased Rho-kinase-mediated PSM contractile responses accompanied by impairment of β-adrenergic-cAMP-signaling pathway

Investigation of stress, anxiety and depression in women with fibromyalgia: a comparative study

Introduction:Depression has emerged as the most prevalent mental disorder in patients with fibromyalgia. Stress, whose stages are alarm, resistance, near-exhaustion and exhaustion, constitutes a physical reaction to a threatening situation.Objective:To investigate the levels of stress, anxiety and depression in women with fibromyalgia, comparing them with those of healthy women.Patients and methods:Participants were 50 women, 25 with a diagnosis of fibromyalgia according to the criteria of the American College of Rheumatology, and 25 without this diagnosis, matched for age. Instruments used: Lipp Inventory of Stress Symptoms for Adults (LISS), State-Trait Anxiety Inventory (STAI) and Beck Depression Inventory (BDI).Results:The mean age was 49.36 years for the group with fibromyalgia (FM) and 49.20 years for the group without fibromyalgia (non-FM). FM showed a higher incidence of stress (96%) compared with non-FM (5%). The resistance phase was predominant in both groups, FM (42%) and non-FM (100%). In FM there was distribution of the four stages (alarm, resistance, near-exhaustion and exhaustion). The differences between phases in the analyzed groups were significant (p < 0.001). FM showed predominance of psychological symptoms (54%); non-FM did show the same frequency of psychological and physical/psychological (40%) symptoms. Symptoms of state and trait anxiety and of depression in FM were significantly higher, when compared with non-FM (p < 0.01).Conclusion:Stress index (96%), trait anxiety (over 50) and clinically relevant depression (greater than 20) in FM were relevant. The understanding of the emotional variables involved in fibromyalgia is important to define the therapeutic strategy.Introdução:A depressão tem se apresentado como o transtorno mental mais prevalente em pacientes com fibromialgia. O estresse, cujas fases são alarme, resistência, quase-exaustão e exaustão, constitui importante reação do organismo frente a uma situação ameaçadora.Objetivo:Investigar os índices de estresse, ansiedade e depressão em mulheres com fibromialgia, comparando-os com os de mulheres saudáveis.Pacientes e métodos:Participaram 50 mulheres, 25 com o diagnóstico de fibromialgia, segundo os critérios do American College of Rheumatology, e 25 sem o diagnóstico, pareadas por idade. Instrumentos utilizados: Inventário de Sintomas de Stress para Adultos de Lipp (ISSL), Inventário de Ansiedade Traço-Estado (IDATE) e Inventário de Depressão Beck (BDI).Resultados:Idade média de 49,36 anos para o grupo com fibromialgia (FM) e 49,20 anos para o grupo sem fibromialgia (não FM). O FM apresentou maior incidência de estresse (96%) quando comparado com o não FM (5%). A fase de resistência foi predominante nos dois grupos, FM (42%) e não FM (100%). No FM verificou-se distribuição nas quatro fases (alerta, resistência, quase-exaustão e exaustão). As diferenças entre as fases nos grupos analisados foram significativas (p<0,001). O FM apresentou predominância de sintomas psicológicos (54%), o não FM apresentou a mesma frequência de sintomas psicológico e físico/psicológico (40%). Os sintomas de ansiedade estado e traço e depressão do FM foram significativamente superiores, quando comparados com o não FM (p<0,01).Conclusão:Constatou-se índice de estresse (96%), traço de ansiedade (superior a 50) e depressão clinicamente (superior a 20) relevantes no FM. O entendimento das variáveis emocionais envolvidas na fibromialgia é importante na definição da terapêutica.Universidade Federal de São Paulo (UNIFESP)Universidade Federal de São Paulo (UNIFESP) Departamento de Ciências do Movimento HumanoUniversidade Federal de São Paulo (UNIFESP) Departamento de BiociênciasUniversidade Metropolitana de SantosUniversidade Federal de São Paulo (UNIFESP) Departamento de Saúde, Educação e SociedadeUNIFESP, Depto. de Ciências do Movimento HumanoUNIFESP, Depto. de BiociênciasUNIFESP, Depto. de Saúde, Educação e SociedadeSciEL

Caracterização agronômica de acessos de cevada de alta produtividade sob irrigação no Cerrado

The objective of this work was to estimate the genetic, phenotypic, and environmental parameters of 113 barley accessions (Hordeum vulgare), previously selected based on high yield, in an irrigated production system in the Cerrado (Brazilian savanna), for use in breeding programs in Brazil. The experiment was conducted in 2013 at two sites in the Federal District, using a randomized complete block design with three replicates. The evaluated traits were: grain yield, kernel plumpness, thousand grain weight, plant height, lodging, and days to heading. Significant differences were observed between environment and accessions for all studied traits, as well as genotype x environment interaction. The MCU 3832 PI 402310, MCU 3484 PI 401962, CI 08053 Custer, MCU 3634 PI 402112, and MCU 3816 PI 402294 accessions stood out regarding grain yield and kernel plumpness. It is possible to obtain high selection gains with high heritability values. However, indirect selection is not recommended in the experimental conditions due to the low genotypic and phenotypic correlations obtained. It is also possible to select barley accessions with high yield and early heading date simultaneously, an important factor in the genotype selection process for future experiments. The accessions from Colombia are the most adapted to the Cerrado conditions.O objetivo deste trabalho foi estimar parâmetros genéticos, fenotípicos e ambientais de 113 acessos de cevada (Hordeum vulgare), previamente selecionados com base em alta produtividade, em sistema de produção irrigado no Cerrado, para uso em programas de melhoramento no Brasil. O experimento foi realizado em 2013, em dois locais no Distrito Federal, tendo-se utilizado o delineamento experimental de blocos ao acaso, com três repetições. Avaliaram-se as características: rendimento de grãos, classificação comercial de primeira, peso de mil grãos, altura de plantas, acamamento e dias para espigamento. Foram observadas diferenças significativas entre ambientes e acessos para todas as características avaliadas, além de interação genótipo x ambiente. Os acessos MCU 3832 PI 402310, MCU 3484 PI 401962, CI 08053 Custer, MCU 3634 PI 402112 e MCU 3816 PI 402294 destacaram-se em relação ao rendimento de grãos e à classificação comercial de primeira. É possível obter altos ganhos de seleção com altos valores de herdabilidade. No entanto, a seleção indireta não é recomendada nas condições experimentais, em razão das baixas correlações genotípicas e fenotípicas obtidas. Também é possível a seleção simultânea de acessos de cevada com alto rendimento e ciclo de espigamento precoce, fator decisivo no processo de escolha de genótipos para futuros experimentos. Os acessos colombianos são os mais adaptados às condições de Cerrado

Fibromialgia e atividade física: benefícios e fatores de não adesão

The objective of this study was to analyze the benefits and non-adherence factors of the practice of physical activity in people with Fibromyalgia Syndrome. It is an integrative review study with a qualitative and descriptive bias. We searched the BVS, SciELO and LILACS, grouping the published works from January 2010 to March 2019, using the following descriptors: Fibromyalgia, exercise and physical activity. Of the 252 papers found, 29 were used, according to the criteria adopted. The reviewed studies point to several types of physical activity as beneficial: aerobic, aquatic, rhythmic, strength, flexibility and associated activities. In the results there were more benefits (sleep, autonomy, psychological aspect, emotional aspect and well-being) than factors of non-adherence (fear, studies, avoidance and health) for the practice of physical activity, such results suggest the importance of the study population become physically active.O estudo objetiva analisar os benefícios e fatores de não adesão da prática da atividade física em pessoas com a Síndrome de Fibromialgia. Trata-se de um estudo de revisão integrativa com viés qualitativo e caráter descritivo. Foram realizadas buscas na BVS, Scielo e LILACS, agrupando os trabalhos publicados no período de janeiro de 2010 até março de 2019, utilizou-se os seguintes descritores: Fibromialgia, exercício e atividade física. Dos 252 trabalhos encontrados, 29 foram utilizados, conforme os critérios adotados. Os estudos revisados apontam vários tipos de atividades físicas como benéficas: atividades aeróbicas, aquáticas, rítmicas, de força, flexibilidade e associadas com outras. Nos resultados houve mais benefícios (sono, autonomia, aspecto psicológico, aspecto emocional e bem-estar) do que fatores de não adesão (medo, estudos, evasão e saúde) para a prática da atividade física, tais resultados sugerem a importância da população estudada se tornar fisicamente ativa

DEVELOPMENT AND VALIDATION OF TECHNOLOGY FOR TEACHING BASIC LIFE SUPPORT IN CARDIO-RESPIRATORY ARREST

Objective: to develop and validate a multimedia application on a mobile platform for teaching basic support in cardiac arrest to undergraduate health care students.Method: methodological study conducted in two stages: development of the application and content validation by experts. The application was developed based on Contextualized Instructional Design, following the stages of analysis, design, development, and implementation. For the content validation, 11 experts evaluated the application regarding relevance, clarity, coherence, information, presentation, navigability, accessibility, and design.Results: The SBVida application was developed for mobile devices on the Android platform. An overall Content Validity Index of 0.87 was achieved.Conclusion: The SBVida application was developed and validated and can contribute to the preparation and further training of students and professionals from Nursing and other health fields

ERICA: prevalência de asma em adolescentes brasileiros

OBJETIVO Descrever a prevalência de asma ativa e de diagnóstico médico de asma em adolescentes brasileiros. MÉTODOS Estudo transversal, nacional, de base escolar com adolescentes de 12 a 17 anos, participantes do Estudo de Riscos Cardiovasculares em adolescentes (ERICA). A amostra foi estratificada por região e conglomerada por escolas e turmas com representatividade para o conjunto de municípios com mais de 100 mil habitantes do País, macrorregiões, capitais e Distrito Federal. Os dados foram coletados em questionário autopreenchível. Foram calculadas as prevalências e respectivos intervalos de confiança de 95% (IC95%) segundo sexo, faixa etária, tipo de escola e cor da pele. RESULTADOS Entre 2013 e 2014 foram avaliados 74.589 adolescentes, 55,3% do sexo feminino. A prevalência total de asma ativa foi 13,1% (IC95% 12,1-13,9), sendo superior nas meninas (14,8%; IC95% 13,7-16,0) em relação aos meninos (11,2%; IC95% 10,3-12,2) em todos estratos geográficos analisados, e também entre os alunos da rede privada (15,9%; IC95% 14,2-17,7) em relação aos de escolas públicas (12,4%; IC95% 11,4-13,4). Foi mais elevada na região Sudeste (14,5%; IC95% 12,9-16,1) e na cidade de São Paulo (16,7%; IC95% 14,7-18,7). A menor prevalência foi observada na região Norte (9,7%; IC95% 9,7-10,5) e em Teresina (6,3%; IC95% 4,9-7,7). A prevalência de diagnóstico médico de asma foi 8,7% (IC95% 8,2-9,1); mais elevada na região Norte (13,5%; IC95% 12,7-14,2) e em Porto Alegre (19,8%; IC95% 17,5-22,3) e mais baixa no Centro-Oeste (6,9%; IC95% 6,0-7,8) e em Cuiabá (4,8%; IC95% 3,8-5,9). Não ocorreu diferença significativa na expressão desta taxa entre os sexos, assim como nas outras variáveis avaliadas pelo estudo. CONCLUSÕES A prevalência de asma em adolescentes brasileiros é alta. As taxas de asma ativa e de diagnóstico médico variam amplamente nas diferentes regiões e capitais avaliadas pelo ERICA. Estes resultados poderão auxiliar na elaboração de programas preventivos e de políticas de saúde e no melhor entendimento sobre os fatores associados à asma nessa faixa etária.OBJECTIVE To describe the prevalence of asthma and physician-diagnosed asthma in Brazilian adolescents. METHODS Cross-sectional, national, school-based study with adolescents from 12 to 17 years old, participants in the Study of Cardiovascular Risks in Adolescents (ERICA). The study stratified the sample by region and grouped according to schools and classes with representativeness to the set of cities with more than 100,000 inhabitants of the Country, macro-regions, capitals, and Federal District. A questionnaire collected data through a self-filled in method. We calculated the prevalences and their confidence intervals of 95% (95%CI) according to sex, age group, type of school and skin color. RESULTS Between 2013 and 2014, 74,589 adolescents were evaluated, 55.3% of the female sex. The total prevalence of active asthma was of 13.1% (95%CI 12.1-13.9), being higher in girls (14.8%; 95%CI 13.7-16.0) when compared to boys (11.2%; 95%CI 10.3-12.2) in all geographical strata examined. It was also higher between students of private schools (15.9%; 95%CI 14.2-17.7) when compared to public ones (12.4%; 95%CI 11.4-13.4). It was higher in the Southeast region (14.5%; 95%CI 12.9-16.1), and in the city of Sao Paulo (16.7%; 95%CI 14.7-18.7). The lowest prevalence was observed in North region (9.7%; 95%CI 9.7-10.5), and in Teresina (6.3%; 95%CI 4.9-7.7). The prevalence of physician-diagnosed asthma was of 8.7% (95%CI 8.2-9.1); higher in the North region (13.5%; 95%CI 12.7-14.2), and in Porto Alegre (19.8%; 95%CI 17.5-22.3). It was lower in the Midwest (6.9%; 95%CI 6.0-7.8), and in Cuiaba (4.8%; 95%CI 3.8-5.9). We found no significant difference in the expression of this rate between the sexes, as well as in other variables evaluated by the study. CONCLUSIONS The prevalence of asthma in Brazilian adolescents is high. Rates of active asthma and physician-diagnosed asthma vary widely in different regions and capitals evaluated by the ERICA. These results may assist in the preparation of preventive programs and policies on health and a better understanding of the factors associated with asthma in this age group