3,175 research outputs found
Correlation of the South Pole 94 data with 100microns and 408 MHz maps
We present a correlation between the ACME/SP94 CMB anisotropy data at 25 to
45 GHz with the IRAS/DIRBE data and the Haslam 408 MHz data. We find a marginal
correlation between the dust and the Q-band CMB data but none between the CMB
data and the Haslam map. While the amplitude of the correlation with the dust
is larger than that expected from naive models of dust emission it does not
dominate the sky emission.Comment: 6 pages, 4 figures. Accepted for publication in Astronomy and
Astrophysic
Antimicrobial consumption in pediatric intensive care units during the first year of COVID-19 pandemic / Consumo antimicrobiano em unidades de cuidados intensivos pediátricos durante o primeiro ano da pandemia de COVID-19
Introduction: The absence of standardized treatment for critical children admitted in pediatric intensive care units (PICUs) with COVID could lead to an increase in antimicrobial consumption, as indirect effect. Aim: To describe trends of antimicrobial consumption in two PICUs before and during the COVID pandemic year.Methods: We did a retrospective study in children admitted in two PICUs of Rio de Janeiro city, between March 2019 and March 2021. The first year represented the pre-pandemic period and the last one the pandemic period. Trends of antimicrobial consumption were measured by days of therapy (DOT/1000 patient-days) and analyzed by linear regression for antibiotics, antivirals and antifungals Results: Number of patients-days in the PICU 1 was 3495 in the pre-pandemic period and 3600 in the pandemic period. The overall DOT/1000 PD of antibiotics, antivirals and antifungal was 15,308.1, 942.8 and 1,691.1, respectively in the pre-pandemic period and 13,481.5, 1,335.4 and 1,243.7, respectively in pandemic period. It was verified trend of reduction of antibiotic and antifungals and increase in antivirals consumption. Number of patients-days in the PICU 2 was 5029 in the pre-pandemic period and 4557 in the pandemic period and the overall DOT/1000 PD of antibiotics, antivirals and antifungal was 16,668.5, 1,385 and 1,966.7, respectively in the pre-pandemic period and 10,896.5, 830.7 and 677.3 in pandemic period. It was verified trend of reduction of antibiotic, antivirals and antifungals consumption. Conclusion: Trends of antimicrobial consumption reduction were verified for antibiotics and antifungals in two PICUs and reduction for antiviral in one of them
UGC 7388: a galaxy with two tidal loops
We present the results of spectroscopic and morphological studies of the
galaxy UGC7388 with the 8.1-m Gemini North telescope. Judging by its observed
characteristics, UGC7388 is a giant late-type spiral galaxy seen almost
edge-on. The main body of the galaxy is surrounded by two faint (\mu(B) ~ 24
and \mu(B) ~ 25.5) extended (~20-30 kpc) loop-like structures. A large-scale
rotation of the brighter loop about the main galaxy has been detected. We
discuss the assumption that the tidal disruption of a relatively massive
companion is observed in the case of UGC7388. A detailed study and modeling of
the observed structure of this unique galaxy can give important information
about the influence of the absorption of massive companions on the galactic
disks and about the structure of the dark halo around UGC7388.Comment: 8 pages, 5 figure
Spatial and temporal changes in Lutzomyia longipalpis abundance, a Leishmania infantum vector in an urban area in northeastern Argentina
Effects of pollution on adolescent mental health: a systematic review protocol.
BACKGROUND: Whilst there is little uncertainty about the deleterious impact of pollution on human and planetary health, pollution's impact on adolescent mental health is less well understood. This is particularly true for young people in underdeveloped and developing world contexts, about whom research is generally lacking. Furthermore, although adolescent resilience continues to be a research priority, little attention has been paid to adolescent pathways of resilience in the face or aftermath of pollution exposure. The objective of this study will be to examine the associations between pollution and mental health in 10- to 24-year-olds (i.e. adolescents). METHODS: We designed and registered a study protocol for a systematic review of studies which link pollution and mental health in adolescents. We will include observational studies (e.g. cohort, case-control, time series analyses) that assess the associations between exposure to any form of pollution and the mental health of 10- to 24-year-olds. The primary outcome will be symptoms associated with neurodevelopmental disorders; disruptive, impulse-control, and conduct disorders; depressive disorders; anxiety disorders; substance disorders; and schizophrenia. No secondary outcomes will be considered. Literature searches will be conducted in multiple electronic databases (from inception onwards), including PubMed, MEDLINE, SCOPUS, Web of Science, CINAHL, PsycINFO, SciELO, ERIC, and Africa-Wide. Two investigators will independently screen all citations, full-text articles, and abstract data. The methodological quality (or bias) of included studies will be appraised using appropriate tools. We will provide a narrative synthesis of the evidence. DISCUSSION: This systematic review will evaluate the evidence on the associations between pollution and the mental health of 10- to 24-year-olds. Our findings will be of potential interest to multiple audiences (including adolescent patients/clients, their families, caregivers, healthcare professionals, scientists, and policy makers) and could be used to develop prevention and intervention strategies as well as focus future research. Results will be published in a peer-reviewed journal. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42020176664
PD-1 Blockade Modulates Functional Activities of Exhausted-Like T Cell in Patients With Cutaneous Leishmaniasis
Patients infected by Leishmania braziliensis develop debilitating skin lesions. The role of inhibitory checkpoint receptors (ICRs) that induce T cell exhaustion during this disease is not known. Transcriptional profiling identified increased expression of ICRs including PD-1, PDL-1, PDL-2, TIM-3, and CTLA-4 in skin lesions of patients that was confirmed by immunohistology where there was increased expression of PD-1, TIM-3, and CTLA-4 in both CD4^{+} and CD8^{+} T cell subsets. Moreover, PDL-1/PDL-2 ligands were increased on skin macrophages compared to healthy controls. The proportions PD1^{+}, but not TIM-3 or CTLA-4 expressing T cells in the circulation were positively correlated with those in the lesions of the same patients, suggesting that PD-1 may regulate T cell function equally in both compartments. Blocking PD-1 signaling in circulating T cells enhanced their proliferative capacity and IFN-γ production, but not TNF-α secretion in response to L. braziliensis recall antigen challenge in vitro. While we previously showed a significant correlation between the accumulation of senescent CD8^{+}CD45RA^{+}CD27^{-} T cells in the circulation and skin lesion size in the patients, there was no such correlation between the extent of PD-1 expression by circulating on T cells and the magnitude of skin lesions suggesting that exhausted-like T cells may not contribute to the cutaneous immunopathology. Nevertheless, we identified exhausted-like T cells in both skin lesions and in the blood. Targeting this population by PD-1 blockade may improve T cell function and thus accelerate parasite clearance that would reduce the cutaneous pathology in cutaneous leishmaniasis
Astrobiological Complexity with Probabilistic Cellular Automata
Search for extraterrestrial life and intelligence constitutes one of the
major endeavors in science, but has yet been quantitatively modeled only rarely
and in a cursory and superficial fashion. We argue that probabilistic cellular
automata (PCA) represent the best quantitative framework for modeling
astrobiological history of the Milky Way and its Galactic Habitable Zone. The
relevant astrobiological parameters are to be modeled as the elements of the
input probability matrix for the PCA kernel. With the underlying simplicity of
the cellular automata constructs, this approach enables a quick analysis of
large and ambiguous input parameters' space. We perform a simple clustering
analysis of typical astrobiological histories and discuss the relevant boundary
conditions of practical importance for planning and guiding actual empirical
astrobiological and SETI projects. In addition to showing how the present
framework is adaptable to more complex situations and updated observational
databases from current and near-future space missions, we demonstrate how
numerical results could offer a cautious rationale for continuation of
practical SETI searches.Comment: 37 pages, 11 figures, 2 tables; added journal reference belo
Uptake of oxLDL and IL-10 production by macrophages requires PAFR and CD36 recruitment into the same lipid rafts
Macrophage interaction with oxidized low-density lipoprotein (oxLDL) leads to its differentiation into foam cells and cytokine production, contributing to atherosclerosis development. In a previous study, we showed that CD36 and the receptor for platelet-activating factor (PAFR) are required for oxLDL to activate gene transcription for cytokines and CD36. Here, we investigated the localization and physical interaction of CD36 and PAFR in macrophages stimulated with oxLDL. We found that blocking CD36 or PAFR decreases oxLDL uptake and IL-10 production. OxLDL induces IL-10 mRNA expression only in HEK293T expressing both receptors (PAFR and CD36). OxLDL does not induce IL-12 production. The lipid rafts disruption by treatment with βCD reduces the oxLDL uptake and IL-10 production. OxLDL induces co-immunoprecipitation of PAFR and CD36 with the constitutive raft protein flotillin-1, and colocalization with the lipid raft-marker GM1-ganglioside. Finally, we found colocalization of PAFR and CD36 in macrophages from human atherosclerotic plaques. Our results show that oxLDL induces the recruitment of PAFR and CD36 into the same lipid rafts, which is important for oxLDL uptake and IL-10 production. This study provided new insights into how oxLDL interact with macrophages and contributing to atherosclerosis development
First Detection of Polarization of the Submillimetre Diffuse Galactic Dust Emission by Archeops
We present the first determination of the Galactic polarized emission at 353
GHz by Archeops. The data were taken during the Arctic night of February 7,
2002 after the balloon--borne instrument was launched by CNES from the Swedish
Esrange base near Kiruna. In addition to the 143 GHz and 217 GHz frequency
bands dedicated to CMB studies, Archeops had one 545 GHz and six 353 GHz
bolometers mounted in three polarization sensitive pairs that were used for
Galactic foreground studies. We present maps of the I, Q, U Stokes parameters
over 17% of the sky and with a 13 arcmin resolution at 353 GHz (850 microns).
They show a significant Galactic large scale polarized emission coherent on the
longitude ranges [100, 120] and [180, 200] deg. with a degree of polarization
at the level of 4-5%, in agreement with expectations from starlight
polarization measurements. Some regions in the Galactic plane (Gem OB1,
Cassiopeia) show an even stronger degree of polarization in the range 10-20%.
Those findings provide strong evidence for a powerful grain alignment mechanism
throughout the interstellar medium and a coherent magnetic field coplanar to
the Galactic plane. This magnetic field pervades even some dense clouds.
Extrapolated to high Galactic latitude, these results indicate that
interstellar dust polarized emission is the major foreground for PLANCK-HFI CMB
polarization measurement.Comment: Submitted to Astron. & Astrophys., 14 pages, 12 Fig., 2 Table
Strong CH+ J=1-0 emission and absorption in DR21
We report the first detection of the ground-state rotational transition of
the methylidyne cation CH+ towards the massive star-forming region DR21 with
the HIFI instrument onboard the Herschel satellite. The line profile exhibits a
broad emission line, in addition to two deep and broad absorption features
associated with the DR21 molecular ridge and foreground gas. These observations
allow us to determine a CH+ J=1-0 line frequency of 835137 +/- 3 MHz, in good
agreement with a recent experimental determination. We estimate the CH+ column
density to be a few 1e13 cm^-2 in the gas seen in emission, and > 1e14 cm^-2 in
the components responsible for the absorption, which is indicative of a high
line of sight average abundance [CH+]/[H] > 1.2x10^-8. We show that the CH+
column densities agree well with the predictions of state-of-the-art C-shock
models in dense UV-illuminated gas for the emission line, and with those of
turbulent dissipation models in diffuse gas for the absorption lines.Comment: Accepted for publication in A&
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