Measurement of the derivative 'ZW' for an oscillating aerofoil

This report presents the results of experimental measurements of the damping derivative coefficient zw for constant chord rigid wings of various aspect ratios having sweepback angles of zero and 450. The results for the rectangular wings Flow substantial agreement with the unsteady aerofoil theory developed by TI.P. Jones $2) The dependence of Zvi upon frequency parameter is as given by theory and is much less than for two dimensional flow, but the numerical results are approximately 10 per cent below the theoretical. This is attributed to the large trailing edge angle 22° of the N.A.C.A. 0020 section used for the model aerofoils. The effect of sweepback is to decrease the numerical value of z , but this effect is much less pronounced, for low than for high aspect ratios. For aspect ratios 5 and 3 the numerical value is greater than would be given by a factor of proportionality equal to the cosine of the angle of sweepback. The measurements were corrected for tunnel interference by a method based on the theoretical work of 7.P.Jones.(1

Understanding Class-level Testability Through Dynamic Analysis

It is generally acknowledged that software testing is both challenging and time-consuming. Understanding the factors that may positively or negatively affect testing effort will point to possibilities for reducing this effort. Consequently there is a significant body of research that has investigated relationships between static code properties and testability. The work reported in this paper complements this body of research by providing an empirical evaluation of the degree of association between runtime properties and class-level testability in object-oriented (OO) systems. The motivation for the use of dynamic code properties comes from the success of such metrics in providing a more complete insight into the multiple dimensions of software quality. In particular, we investigate the potential relationships between the runtime characteristics of production code, represented by Dynamic Coupling and Key Classes, and internal class-level testability. Testability of a class is consider ed here at the level of unit tests and two different measures are used to characterise those unit tests. The selected measures relate to test scope and structure: one is intended to measure the unit test size, represented by test lines of code, and the other is designed to reflect the intended design, represented by the number of test cases. In this research we found that Dynamic Coupling and Key Classes have significant correlations with class-level testability measures. We therefore suggest that these properties could be used as indicators of class-level testability. These results enhance our current knowledge and should help researchers in the area to build on previous results regarding factors believed to be related to testability and testing. Our results should also benefit practitioners in future class testability planning and maintenance activities

The experiences and perspectives of overseas trained speech and language therapists working in the United Kingdom

There is a growing body of research which has investigated the experience of the migrant health worker. However, only one of these studies has included speech and language therapists thus far, and then only with extremely small numbers. The aim of this study was to explore the experiences and perspectives of migrant speech and language therapists living in the UK. Twenty-three overseas qualified speech and language therapists living in the UK completed an online survey consisting of 36 questions (31 closed question, 5 open-ended questions). The majority of participants came from Australia or the USA and moved to the UK early in their careers. Participants reported a range of benefits from working in another country and more specifically working in the UK. The findings were consistent with other research on migrant health workers regarding known pull factors of travel, finance, and career. This study suggests additional advantages to working in the UK were realised once participants had started working in the UK, such as the UK job lifestyle. Finally, the migrant speech and language therapists were similar in profile to other migrant health workers in terms of age and country of origin previously reported in the literature

What are the priorities for improving cataract surgical outcomes in Africa? Results of a Delphi exercise.

PURPOSE: The quality of cataract surgery delivered in sub-Saharan Africa (SSA) is a significant constraint to achieving the elimination of avoidable blindness. No published reports from routine SSA cataract services attain the WHO benchmarks for visual outcomes; poor outcomes (<6/60) often comprise 20% in published case series. This Delphi exercise aimed to identify and prioritise potential interventions for improving the quality of cataract surgery in SSA to guide research and eye health programme development. METHODS: An initial email open-question survey created a ranked list of priorities for improving quality of surgical services. A second-round face-to-face discussion facilitated at a Vision 2020 Research Mentorship Workshop in Tanzania created a refined list for repeated ranking. RESULTS: Seventeen factors were agreed that might form target interventions to promote quality of cataract services. Improved training of surgeons was the top-ranked item, followed by utilisation of biometry, surgical equipment availability, effective monitoring of outcomes of cataract surgery by the surgeon, and well-trained support staff for the cataract pathway (including nurses seeing post-operative cases). CONCLUSION: Improving the quality of cataract surgery in SSA is a clinical, programmatic and public health priority. In the absence of other evidence, the collective expert opinion of those involved in ophthalmic services regarding the ranking of factors to promote quality improvement, refined through this Delphi exercise, provides us with candidate intervention areas to be evaluated

Access and non–access site bleeding after percutaneous coronary intervention and risk of subsequent mortality and major adverse cardiovascular events:Systematic review and meta-analysis

Background: The prognostic impact of site-specific major bleeding complications after percutaneous coronary intervention (PCI) has yielded conflicting data. The aim of this study is to provide an overview of site-specific major bleeding events in contemporary PCI and study their impact on mortality and major adverse cardiovascular event outcomes. Methods and Results: We conducted a meta-analysis of PCI studies that evaluated site-specific periprocedural bleeding complications and their impact on major adverse cardiovascular events and mortality outcomes. A systematic search of MEDLINE and Embase was conducted to identify relevant studies and random effects meta-analysis was used to estimate the risk of adverse outcomes with site-specific bleeding complications. Twenty-five relevant studies including 2 400 645 patients that underwent PCI were identified. Both non–access site (risk ratio [RR], 4.06; 95% confidence interval [CI], 3.21–5.14) and access site (RR, 1.71; 95% CI, 1.37–2.13) related bleeding complications were independently associated with an increased risk of periprocedural mortality. The prognostic impact of non–access site–related bleeding events on mortality related to the source of anatomic bleeding, for example, gastrointestinal RR, 2.78; 95% CI, 1.25 to 6.18; retroperitoneal RR, 5.87; 95% CI, 1.63 to 21.12; and intracranial RR, 22.71; 95% CI, 12.53 to 41.15. Conclusions: The prognostic impact of bleeding complications after PCI varies according to anatomic source and severity. Non–access site-related bleeding complications have a similar prevalence to those from the access site but are associated with a significantly worse prognosis partly related to the severity of the bleed. Clinicians should minimize the risk of major bleeding complications during PCI through judicious use of bleeding avoidance strategies irrespective of the access site used

What difference does ("good") HRM make?

The importance of human resources management (HRM) to the success or failure of health system performance has, until recently, been generally overlooked. In recent years it has been increasingly recognised that getting HR policy and management "right" has to be at the core of any sustainable solution to health system performance. In comparison to the evidence base on health care reform-related issues of health system finance and appropriate purchaser/provider incentive structures, there is very limited information on the HRM dimension or its impact. Despite the limited, but growing, evidence base on the impact of HRM on organisational performance in other sectors, there have been relatively few attempts to assess the implications of this evidence for the health sector. This paper examines this broader evidence base on HRM in other sectors and examines some of the underlying issues related to "good" HRM in the health sector. The paper considers how human resource management (HRM) has been defined and evaluated in other sectors. Essentially there are two sub-themes: how have HRM interventions been defined? and how have the effects of these interventions been measured in order to identify which interventions are most effective? In other words, what is "good" HRM? The paper argues that it is not only the organisational context that differentiates the health sector from many other sectors, in terms of HRM. Many of the measures of organisational performance are also unique. "Performance" in the health sector can be fully assessed only by means of indicators that are sector-specific. These can focus on measures of clinical activity or workload (e.g. staff per occupied bed, or patient acuity measures), on measures of output (e.g. number of patients treated) or, less frequently, on measures of outcome (e.g. mortality rates or rate of post-surgery complications). The paper also stresses the need for a "fit" between the HRM approach and the organisational characteristics, context and priorities, and for recognition that so-called "bundles" of linked and coordinated HRM interventions will be more likely to achieve sustained improvements in organisational performance than single or uncoordinated interventions

Revisiting the bulge-halo conspiracy I: Dependence on galaxy properties and halo mass

We carry out a systematic investigation of the total mass density profile of massive (Mstar>2e11 Msun) early-type galaxies and its dependence on galactic properties and host halo mass with the aid of a variety of lensing/dynamical data and large mock galaxy catalogs. The latter are produced via semi-empirical models that, by design, are based on just a few basic input assumptions. Galaxies, with measured stellar masses, effective radii and S\'{e}rsic indices, are assigned, via abundance matching relations, host dark matter halos characterized by a typical LCDM profile. Our main results are as follows: (i) In line with observational evidence, our semi-empirical models naturally predict that the total, mass-weighted density slope at the effective radius gamma' is not universal, steepening for more compact and/or massive galaxies, but flattening with increasing host halo mass. (ii) Models characterized by a Salpeter or variable initial mass function and uncontracted dark matter profiles are in good agreement with the data, while a Chabrier initial mass function and/or adiabatic contractions/expansions of the dark matter halos are highly disfavored. (iii) Currently available data on the mass density profiles of very massive galaxies (Mstar>1e12 Msun), with Mhalo>3e14 Msun, favor instead models with a stellar profile flatter than a S\'{e}rsic one in the very inner regions (r<3-5 kpc), and a cored NFW or Einasto dark matter profile with median halo concentration a factor of ~2 or <1.3, respectively, higher than those typically predicted by N-body numerical simulations.Comment: 23 pages, 10 figures, 3 Appendices (with an extra 7 figures). ApJ, accepted. Main results in Figures 3, 5, 6,

Prolonged PR interval, first-degree heart block and adverse cardiovascular outcomes: a systematic review and meta-analysis

Objective: First-degree atrioventricular block is frequently encountered in clinical practice and is generally considered a benign process. However, there is emerging evidence that prolonged PR interval may be associated with adverse outcomes. This study aims to determine if prolonged PR interval is associated with adverse cardiovascular outcomes and mortality. Methods: We searched MEDLINE and EMBASE for studies that evaluated clinical outcomes associated with prolonged and normal PR intervals. Relevant studies were pooled using random effects meta-analysis for risk of mortality, cardiovascular mortality, heart failure, coronary heart disease, atrial fibrillation and stroke or transient ischaemic attack (TIA). Sensitivity analyses were performed considering the population type and the use of adjustments. Results: Our search yielded 14 studies that were undertaken between 1972 and 2011 with 400 750 participants. Among the studies that adjusted for potential confounders, the pooled results suggest an increased risk of mortality with prolonged PR interval risk ratio (RR) 1.24 95% CI 1.02 to 1.51, five studies. Prolonged PR interval was associated with significant risk of heart failure or left ventricular dysfunction (RR 1.39 95% CI 1.18 to 1.65, three studies) and atrial fibrillation (RR 1.45 95% CI 1.23 to 1.71, eight studies) but not cardiovascular mortality, coronary heart disease or myocardial infarction or stroke or TIA. Similar observations were recorded when limited to studies of first-degree heart block. Conclusions: Data from observational studies suggests a possible association between prolonged PR interval and significant increases in atrial fibrillation, heart failure and mortality. Future prospective studies are needed to confirm the relationships reported, consider possible mechanisms and define the optimal monitoring strategy for such patients

Reprint: Good laboratory practice: preventing introduction of bias at the bench

As a research community, we have failed to show that drugs, which show substantial efficacy in animal models of cerebral ischemia, can also improve outcome in human stroke. Accumulating evidence suggests this may be due, at least in part, to problems in the design, conduct, and reporting of animal experiments which create a systematic bias resulting in the overstatement of neuroprotective efficacy. Here, we set out a series of measures to reduce bias in the design, conduct and reporting of animal experiments modeling human stroke.</p

Reprint: Good laboratory practice: preventing introduction of bias at the bench

As a research community, we have failed to show that drugs, which show substantial efficacy in animal models of cerebral ischemia, can also improve outcome in human stroke. Accumulating evidence suggests this may be due, at least in part, to problems in the design, conduct, and reporting of animal experiments which create a systematic bias resulting in the overstatement of neuroprotective efficacy. Here, we set out a series of measures to reduce bias in the design, conduct and reporting of animal experiments modeling human stroke