The Institutional Fan-Made Paratext: the Case of the Van Der Memes

This paper discusses the case of the Van Der Memes, internet memes based on close-ups of actor James Van Der Beek emoting feelings which, born as user-generated content (UGC), end up working as marketing tools for a rebranding campaign of the actor. Framing the case study into the complexity of contemporary mediascape, a digital environment where corporate branding strategies progress alongside remix culture, the analysis will unfold along two main directions: on the one hand, we will see how the same content undertakes constant reworks and repurposes, as the duration and circulation of the media objects involved gets inevitably altered. On the other, we shall see how the case of the Van Der Memes calls into question the conflict between bottom/up and top/down productions, as it exemplifies a profitable relation between the notoriously unruly world of UGC and the institutional environment of television industry

Straight-to-Series in Broadcast Television: Causes, Issues and Consequences

In the last few years, Netflix has set itself as a true player in U.S. television industry, fostering new competitive dynamics that have contributed to redefine television's production and distribution models. This paper aims to discuss one of the effects of this competition: the rethinking of the pilot process in favour of the straight-to-series commitment in broadcast television. The analysis will unfold along three main directions: 1. Causes: we will argue that Netflix, through its high financial commitments, has launched a speculative bubble that has shaken up the traditional structure of competitive forces, pushing competitors to outbid its offers to hit-producers. 2. Issues: we will see whether the straight-to-series model could prove economically viable for broadcast television. 3. Consequences: we will ultimately analyse the consequences on narrative forms of network series, focusing in particular on writing processes and modes of storytelling

Dalla segregazione al diritto all’abitare

Questo capitolo introduce la quarta parte del volume, relativa a casi di politiche locali finalizzate a superare la formula del “campo nomadi” e aumentare la varietà delle misure di inserimento abitativo1. L’abitare è una dimensione cruciale della vita in società, e il fatto che a partire dagli anni Settanta i gruppi zigani siano stati forzati dentro un’unica tipologia abitativa, il campo nomadi, ha avuto grandi conseguenze non solo sulla qualità di vita delle persone lì residenti, ma anche sui rapporti fra questi gruppi e le società urbane in cui risiedono (...)

Evaluation of the patients with syncope during the first month after coronary artery bypass graft

Background: Syncope is a well-known risk factor for adverse cardiovascular event in patients with coronary artery disease, especially those with previous myocardial infarction (MI) or left ventricular dysfunction. The aim of this study was to assess electrophysiologic findings and results of head-up tilt test (HUTT) in patients with syncope and without orthostatic changes in blood pressure during the first month after coronary artery bypass graft (CABG). Materials and Methods: A total of 20 patients with syncope during the first month after CABG were prospectively enrolled in this study from June 2002 to April 2006. Electrophysiologic study (EPS) was performed in all of them. HUTT was performed in all of the patients regardless of the result of EPS. Results: The mean age of patients was 60.311 years. Twelve patients were males. EPS was negative in 18 patients. HUTT was positive in 10 patients. Six patients had old MI. Ischemic insult occurred in one patient after CABG. Left bundle branch was present in two patients. There was a significant relationship between the duration of bed rest after CABG and positive HUTT (P value = 0.021). All of the patients except one did not experience syncope during the follow-up period. Conclusion: In patients with syncope during the first month post CABG, in whom an arrhythmic cause is suspected, the other cause of syncope like orthostatic intolerance should be considered. Being bedridden for an extended period of time post CABG can be a predisposing factor

Identification of a novel PPARβ/δ/miR-21-3p axis in UV-induced skin inflammation.

Although excessive exposure to UV is widely recognized as a major factor leading to skin perturbations and cancer, the complex mechanisms underlying inflammatory skin disorders resulting from UV exposure remain incompletely characterized. The nuclear hormone receptor PPARβ/δ is known to control mouse cutaneous repair and UV-induced skin cancer development. Here, we describe a novel PPARβ/δ-dependent molecular cascade involving TGFβ1 and miR-21-3p, which is activated in the epidermis in response to UV exposure. We establish that the passenger miRNA miR-21-3p, that we identify as a novel UV-induced miRNA in the epidermis, plays a pro-inflammatory function in keratinocytes and that its high level of expression in human skin is associated with psoriasis and squamous cell carcinomas. Finally, we provide evidence that inhibition of miR-21-3p reduces UV-induced cutaneous inflammation in ex vivo human skin biopsies, thereby underlining the clinical relevance of miRNA-based topical therapies for cutaneous disorders

Progressive age-associated activation of JNK associates with conduction disruption in the aged atrium.

Connexin43 (Cx43) is critical for maintaining electrical conduction across atrial muscle. During progressive aging cardiac conduction slows and becomes susceptible to disruption, predisposing to arrhythmias. Changes in Cx43 protein expression, or its phosphorylation status, can instigate changes in the conduction of the cardiac action potential. Our study investigated whether increased levels of activated c-jun N-terminal kinase (JNK) is the mechanism responsible for the decline of Cx43 protein and intercellular communication during progressive aging. We examined right atrial muscle from guinea pigs between 1 day and 38 months of age. The area of the intercalated disc increased with age concurrent with a 75% decline in total C43 protein expression and spatial re-organisation of the remaining protein. An age-dependent increase in activated-JNK correlated with a rise in phosphorylated Cx43. The data also correlated with slowing of the action potential conduction velocity across the right atria from 0.38±0.01 m/s at 1 month of age to 0.30±0.01 m/s at 38 months of age. The JNK activator anisomycin increased levels of activated JNK in myocytes and reduced Cx43 protein expression paralleling the aging effect The JNK inhibitor SP600125, was found to eradicate almost all trace of Cx43 protein from the intercalating discs. We conclude that in vivo activation of JNK increases with age leading to the loss of Cx43 protein from atrial myocytes. This progressive loss results in impaired conduction and is likely to contribute to the increasing risk of atrial arrhythmias with advancing age