7 research outputs found
Fabrication, 3d finite element analysis and characterization of an optical passive microsensor
In this work we present the 3D Finite Element Analysis (FEA) of an optical passive microsensor for measuring pressure in biofluids and the simulation of the required characterization setup. Previously, we reported the design and analysis of a prototype where simulations were performed by using the Finite Element Method (FEM) in order to analyze the mechanical behavior of the grating;the results were exported to an optical software for diffraction analysis. The microsensor is based on a deformable diffraction grating made of an elastomeric polymer (PDMS); as the PDMS membrane containing the diffraction grating is subjected to a pressure, its optical properties are varied and an indirect measurement of the pressure is attainable. Now, we report the fabrication and characterization of the optical passive microsensor. The simulation of the setup required for characterization brings many advantages as it enables a rapid understanding of the optical properties of the microsensor without implementing it. Therefore, a correct model of both the optical and the mechanical model accelerates the development-time of the prototype so as to carry out possible re-designs in the future.Fil: Braggio, Luciano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico. Centro de Investigación de Métodos Computacionales; ArgentinaFil: Guarnieri, Fabio Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico. Centro de Investigación de Métodos Computacionales; Argentina. Universidad Nacional de Entre Rios; Argentin
Evaluation of different Bacillus thuringiensis sv kurstaki formulations against Lymantria dispar and Malacosoma neustria larvae infesting Quercus suber trees
Lepidopteran defoliators such as Lymantria dispar and Malacosoma neustria represent a major concern for cork oak forest, especially during population outbreaks. To contain their infestations over large areas, the use of entomopathogenic microorganisms such as Bacillus thuringiensis serovar kurstaki (Btk) is one of the available option. However, the features of the microbial control agent formulations represent a key factor for the success of application programs. The results of two years efficacy trials with different formulations of Btk, conducted in 2012 and 2013 in a cork oak forest in North-Western Sardinia, are reported. In the first year, trials were carried out on a M. neustria population, while in the second year a mixed population of L. dispar and M. neustria was involved. Trials included two formulations of Btk strain EG 2348 (Rapax® and Rapax Experimental) in comparison with two other commercial formulations (Foray 48B® and Delfin®). Both formulations of Btk strain EG 2348 proved to be effective in controlling the two pest species, showing a forest protection potential comparable to that of the reference products, Foray 48B® and Delfin®, containing spores and insecticidal Cry proteins of strains HD-1 and SA-11, respectively. Also the defoliation levels were significantly higher in untreated control trees than in treated ones
El devenir colonial del capitalismo en la Patagonia: la contemporaneidad de lo originario
En el presente artículo intentaremos reflexionar sobre el carácter trágico del desarrollo de la acumulación capitalista en la región y la lógica sacrificial que supone el mismo, tanto en su forma originaria como en las formas contemporáneas de la acumulación por desposesión. Sabido es que ya Marx concibió a la llamada “acumulación originaria” como una tragedia de escala global que supuso el sacrificio de las poblaciones americanas y de los pueblos africanos por medio de la explotación, la esclavitud y el trabajo servil. Este carácter trágico y la ubicación temporal de dicho proceso originario ha sido uno de los nudos problemáticos centrales del drama del marxismo frente al “problema” latinoamericano. Un drama que ha implicado en no pocas reflexiones la imposibilidad de comprender lo singular del desarrollo del capitalismo en nuestra región (y con ella nos referimos a Latinoamérica, pero también a la Patagonia). Nos interesa, por lo tanto, retomar y desarrollar algunas reflexiones que habitando ese drama, hicieron el esfuerzo por pensar con ciertas claves del marxismo y, al mismo tiempo, de forma situada. Quizá, porque ese drama, sigue siendo aún el nuestro y la trágica historia del capital en la Patagonia parece seguir acumulando ruinas sobre ruinas sin detenerse.Fil: Sacchi, Emiliano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Confluencia; Argentina. Universidad Nacional del Comahue; ArgentinaFil: Braggio, Luciano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Confluencia; Argentina. Universidad Nacional del Comahue; ArgentinaFil: Dall'Armellina, Pedro. Universidad Nacional del Comahue; Argentin
Leptogenesis via varying Weinberg operator
The Weinberg operator is a well-known solution to explain light neutrino masses. This operator violates lepton number and can provide non-equilibrium dynamics in the early Universe due to the suppression of tiny neutrino masses. A lot of underlying symmetries proposed in the lepton sector strongly motivate the existence of phase transitions at high scale. During the phase transition, the coupling of the Weinberg operator may be time-dependent, and the lepton asymmetry is generated by the interference of Weinberg operators at different times. This mechanism does not require any explicit new particles beyond the standard model or seesaw models
1,2,4-Triazolyl 5‑Azaspiro[2.4]heptanes: Lead Identification and Early Lead Optimization of a New Series of Potent and Selective Dopamine D3 Receptor Antagonists
A novel
series of 1,2,4-triazolyl 5-azaspiro[2.4]heptanes with high affinity
and selectivity at the dopamine (DA) D3 receptor (D3R) is described.
Some of these compounds also have high selectivity over the hERG channel
and were characterized with respect to their pharmacokinetic properties
both in vitro and in vivo during lead identification and early lead
optimization phases. A few derivatives with overall favorable developability
characteristics were selected for further late lead optimization studies