Inter-Organizational Learning and Collective Memory in Small Firms Clusters: an Agent-Based Approach

Literature about Industrial Districts has largely emphasized the importance of both economic and social factors in determining the competitiveness of these particular firms\' clusters. For thirty years, the Industrial District productive and organizational model represented an alternative to the integrated model of fordist enterprise. Nowadays, the district model suffers from competitive gaps, largely due to the increase of competitive pressure of globalization. This work aims to analyze, through an agent-based simulation model, the influence of informal socio-cognitive coordination mechanisms on district\'s performances, in relation to different competitive scenarios. The agent-based simulation approach is particularly fit for this purpose as it is able to represent the Industrial District\'s complexity. Furthermore, it permits to develop dynamic analysis of district\'s performances according to different types of environment evolution. The results of this work question the widespread opinion that cooperative districts can answer to environmental changes more effectively that non-cooperative ones. In fact, the results of simulations show that, in the presence of turbulent scenarios, the best performer districts are those in which cooperation and competition, trust and opportunism balance out.Firm Networks, Collective Memory, Agent Based Models, Uncertainty

New Insights into the Geography and Modelling of Wind Erosion in the European Agricultural Land. Application of a Spatially Explicit Indicator of Land Susceptibility to Wind Erosion

The current state of the art in erosion research does not provide answers about the ‘where’ and ‘when’ of wind erosion in European agricultural lands. Questions about the implications for the agricultural productivity remain unanswered. Tackling this research gap, the study provides a more comprehensive understanding of the spatial patterns of land susceptibility to wind erosion in European agricultural lands. The Index of Land Susceptibility to Wind Erosion (ILSWE) was introduced in a GIS environment. A harmonised input dataset ranked following a fuzzy logic technique was employed. Within the 36 European countries under investigation, moderate (17.3 million ha) and high levels (8.8 million ha) of land susceptibility to wind erosion were predicted. This corresponds to 8.0% and 4.1 % of total agricultural land, respectively.JRC.H.5-Land Resources Managemen

Basic fibroblast growth factor mediates carotid plaque instability through metalloproteinase-2 and –9 expression

OBJECTIVE(S): We hypothesized that basic fibroblast growth factor (bFGF) may exert a role in carotid plaque instability by regulating the expression of matrix metalloproteinases (MMP). METHODS: Plaques obtained from 40 consecutive patients undergoing carotid endarterectomy were preoperatively classified as soft or hard. Serum bFGF was pre- and postoperatively measured. The release of MMP-2 and MMP-9 in the blood serum, and the activity, production and expression in the carotid specimens was analyzed. Specific anti-bFGF inhibition tests were performed in vitro on human umbilical artery smooth muscle cells (HUASMC) to evaluate the role of bFGF in the activity, production and expression of MMP-2 and -9. RESULTS: Twenty-one (53%) patients had a soft carotid plaque and 19 (48%) a hard plaque. Preoperative bFGF serum levels were higher in patients with soft plaques [soft=34 (28-39) pg/mL and hard=20 (17-22) pg/mL-p<0.001] and postoperatively returned to normal values (when compared to 10 healthy volunteers). The serum levels of MMP-2 in patients' with soft plaques were higher than those in patients' with hard plaques [soft=1222 (1190-1252) ng/mL and hard=748 (656-793)ng/mL-p<0.0001]. MMP-9 serum values were 26 (22-29) ng/mL for soft plaques and 18 (15-21) ng/mL for hard plaques (p<0.0001). We found increased activity, production and expression of MMP-2 and -9 in soft plaques compared to hard plaques (p<0.001). In vitro inhibition tests on HUASMC showed the direct influence of bFGF on the activity, production and expression of MMP-2 and -9 (p<0.001). CONCLUSIONS: bFGF seems to exert a key role in carotid plaque instability regulating the activity, production and expression of MMP thus altering the physiologic homeostasis of the carotid plaque

Growth factors and experimental arterial grafts

Background: The production of growth factors from several experimental arterial conduits was determined. Methods: We implanted 105 experimental arterial grafts that were 1 cm long in the abdominal aorta of Lewis rats (average weight, 250 g). Five different types of grafts were analyzed: arterial isografts, vein grafts, arterial allografts, and polytetrafluoroethylene (PTFE) grafts with normal or decreased compliance. Animals were killed humanely 4 weeks after surgery and the production of platelet-derived growth factor (PDGF), basic fibroblast growth factor (bFGF), transforming growth factor-b, tumor necrosis factor-a, and interleukin-1 was analyzed. Results: Myointimal hyperplasia (MH) was evident in vein grafts, arterial allografts, and PTFE grafts, but not in arterial isografts. Growth factor production was increased for grafts prone to develop MH like vein, PTFE grafts, and arterial allografts. PDGF and bFGF were increased significantly for PTFE and vein grafts, but not for arterial allografts. The importance of bFGF and PGDF was confirmed by the capability of antibody to PDGF and to bFGF to reduce the mitogenic activity of smooth muscle cells, in vivo and in vitro, for PTFE and vein grafts, but not for arterial allografts, in which a predominant role was played by interleukin-1 and tumor necrosis factor-a. Conclusions: Agents able to neutralize this increased production of growth factors, either directly or by competition with their receptors, can prevent MH formation. (J Vasc Surg 2016;64:1444-9.) Clinical Relevance: Arterial grafts release growth factors, which can lead to myointimal hyperplasia formation and atherosclerosis progression in the arterial tree. Both phenomena can cause graft occlusion. Inhibition of growth factor release by arterial grafts can improve their clinical effectiveness

A New Assessment of Soil Loss Due to Wind Erosion in European Agricultural Soils Using a Quantitative Spatially Distributed Modelling Approach

Field measurements and observations have shown that wind erosion is a threat for numerous arable lands in the European Union (EU). Wind erosion affects both the semi-arid areas of the Mediterranean region as well as the temperate climate areas of the northern European countries. Yet, there is still a lack of knowledge, which limits the understanding about where, when and how heavily wind erosion is affecting European arable lands. Currently, the challenge is to integrate the insights gained by recent pan-European assessments, local measurements, observations and field-scale model exercises into a new generation of regional-scale wind erosion models. This is an important step to make the complex matter of wind erosion dynamics more tangible for decision-makers and to support further research on a field-scale level. A geographic information system version of the Revised Wind Erosion Equation was developed to (i) move a step forward into the large-scale wind erosion modelling; (ii) evaluate the soil loss potential due to wind erosion in the arable land of the EU; and (iii) provide a tool useful to support field-based observations of wind erosion. The model was designed to predict the daily soil loss potential at a ca. 1 km2 spatial resolution. The average annual soil loss predicted by geographic information system Revised Wind Erosion Equation in the EU arable land totalled 0·53 Mg ha−1 y−1, with the second quantile and the fourth quantile equal to 0·3 and 1·9 Mg ha−1 y−1, respectively. The cross-validation shows a high consistency with local measurements reported in literature

Resistant Hypertension in Nondialysis Chronic Kidney Disease

Resistant hypertension (RH) is defined as blood pressure (BP) that remains above the target of less than 140/90 mmHg in the general population and 130/80 mmHg in people with diabetes mellitus or chronic kidney disease (CKD) in spite of the use of at least three full-dose antihypertensive drugs including a diuretic or as BP that reaches the target by means of four or more drugs. In CKD, RH is a common condition due to a combination of factors including sodium retention, increased activity of the renin-angiotensin system, and enhanced activity of the sympathetic nervous system. Before defining the hypertensive patient as resistant it is mandatory to exclude the so-called “pseudoresistance.” This condition, which refers to the apparent failure to reach BP target in spite of an appropriate antihypertensive treatment, is mainly caused by white coat hypertension that is prevalent (30%) in CKD patients. Recently we have demonstrated that “true” RH represents an independent risk factor for renal and cardiovascular outcomes in CKD patients

Insect Derived Lauric Acid as Promising Alternative Strategy to Antibiotics in the Antimicrobial Resistance Scenario

Antibiotic misuse is greatly contributing to an increase in antimicrobial resistance (AMR) in humans and animals. Natural and synthetic alternative strategies are being investigated in human and veterinary medicine, but little attention is paid to the antimicrobial effects of edible lipids, such as medium-chain fatty acids (MCFAs) and monoglycerides. Among MCFAs, lauric acid (LA) and its monoglyceride derivative, glycerol monolaurate (GML), exhibit the strongest antimicrobial activity. Coconut and palm kernel oils are considered the main sources of LA. On the other hand, some edible insects (e.g., Hermetia illucens) are gaining interest as novel feed ingredients, due to the high amount of LA they contain as well as their numerous bioactive components, which provide many additional benefits to animal health. Although the beneficial effect of both MCFAs and LA is gradually being recognized, their high content within insects and, consequently, their possible role as antimicrobials, has not been well-reported. This mini review focuses on the anti-infective effects of the insect-derived MCFAs LA and its derivatives. We emphasize the potential of insect lipids, compared to the other vegetable sources, in the current global scenario where a sustainable and circular economy is required. Finally, we critically discuss the use and the benefits of edible insects such as favorable options as feed and food from the perspective of animal and human nutrition

Nitrogen fertiliser value of digested dairy cow slurry, its liquid and solid fractions, and of dairy cow slurry

An understanding of crop availability of livestock slurry nitrogen (N) is necessary to maximise crop N use efficiency and to minimise environmental losses. Results from field and laboratory incubation experiments suggest that first-year crop availability of slurry N comes mainly from its ammonium fraction because net mineralisation of organic N is often negligible in the short term. A two-year field experiment during 2011 and 2012 in northern Italy was undertaken with several aims: to estimate the N fertiliser value of raw dairy cow slurry, digested dairy cow slurry, and the liquid and solid fractions of the digested slurry, and to verify if applied ammonium recovery was similar both among slurries and between slurries and inorganic N fertiliser (ammonium sulphate). Different fertilisers were applied before silage maize cultivation followed by an unfertilised Italian ryegrass crop. The results showed that ammonium recovery was significantly higher in mineral-fertilised (75%) versus slurry-fertilised (30%) treatments, except in digested slurry (65%). This indicates that ammonium applied with organic materials is less efficient than when applied with mineral fertiliser. For the digested slurry and its liquid fraction, most of the applied ammonium was available to the maize during its application year (55%) due to a low carbon (C)/organic N ratio. The apparent N recovery of the raw slurry and digested slurry solid fraction increased substantially between the first (-1.4%) and second (20%) years, as these materials had high C/organic N ratios; they likely immobilised N for several months post application, producing residual effects during the Italian ryegrass and next maize crops