How Do Women Who Are Violent In Couple Relationships Understand Their Violent Behaviour?

This study analyses the in-depth accounts of women who are aggressors in intimate partner violence in France. These female high-risk offenders give a rich and detailed description of their understanding of their violence. It seems it is a re-enactment from past traumas and is repetitive and transgenerational. For many years research and public policy in many countries have assumed that men are aggressors and women victims. Often citing self-protection as the explanation used to explain women’s violence, a reaction to their male partner who is aggressive. However, I show that women’s intimate partner violence isn’t always in self-defence. I also show that bidirectional violence, where both men and women are aggressors and victims, is also present. Using a qualitative methodology the data was studied through interpretative phenomenological analysis, with six one-hour interviews from three participants in this sparsely researched area. Three superordinate themes with eight subordinate themes were produced. Superordinate themes were: impact of early family violence; searching for a couple relationship without violence; an urgent need for change, internal world leads to acting-out. The discussion of the results highlights psychodynamic theories, including attachment theory, object relations, and mentalization to understand the women’s violence in a couple context. Psychodynamic couple therapy will benefit from this research as there are few qualitative studies that give a voice to women who are violent in their couple. Deepening our understanding of a woman’s experience of being violent in couple relationships is an original contribution to knowledge, and contributes to the broader understanding of the increasing numbers of domestic violence cases beyond gender stereotypes. The limitations of the study are also discussed as is the need for further qualitative psychodynamic investigation to look at other types of female perpetrated violence in a similar rich and in-depth way

Numerical Analysis Of A Circulation Control Wing

The objective of this thesis was to develop an experimental method to research circulation control wings using numerical analysis. Specifically, it is of interest to perform 3D wind tunnel testing on a circulation control wing in the Cal Poly Low Speed Wind Tunnel (CPLSWT). A circulation control wing was designed and analyzed to determine the feasibility of this testing. This study relied on computational fluid dynamics (CFD) simulations as a method to predict the flow conditions that would be seen in a wind tunnel test. A CFD simulation was created of a wing model in a wind tunnel domain. Due to high computational requirements, reliable 3D CFD results were not obtained. This led to utilizing 2D CFD models to make estimations about the flow conditions that would be encountered in an experimental environment. The 2D CFD model was validated with previous experimental data on circulation control wings and was shown to accurately capture the flow physics. These 2D CFD results were used to create a set of guidelines to help improve the effectiveness of a future wind tunnel test campaign and demonstrate where further design work needs to be done. The key finding is that it is feasible to perform circulation control testing in the CPLSWT with limitations on the maximum momentum coefficient. Due to internal plenum pressures reaching 66 psi at Cμ=0.35, a limitation should be placed on experimental testing below the choked condition of at Cμ=0.15. This provides a more feasible operating range for the equipment available. The main performance parameter of the airfoil was met with CLMAX=5.01 at Cμ=0.35 which required 0.9 lb/s/m mass flow rate for the 2D model

Wearable devices with two stage of use

A two-statewearable device may include a wearable band (e.g., a watch band) and a displaymodule (e.g. ̧ a watch face).In a "detached" state, the wearable band and display module act as separate devices, and the display module can be charging its battery while the wearable band gathers sensor data (e.g., sleep tracking data) and provides a vibrating/audio alarm clock function. In an "attached" state, the wearable band and display module act together as a single device, meaning that the data collected by the wearable band during the "detached" state is sent to and stored at the display module, and that sleep settings input at a user interface of the display module impact the wearable band's alarm function. The display module may also use its newly-recharged battery to recharge the wearable band's battery so that it can be used the next night.</p

Assessment of Hydration Thermodynamics at Protein Interfaces with Grid Cell Theory

Molecular dynamics simulations have been analyzed with the Grid Cell Theory (GCT) method to spatially resolve the binding enthalpies and entropies of water molecules at the interface of 17 structurally diverse proteins. Correlations between computed energetics and structural descriptors have been sought to facilitate the development of simple models of protein hydration. Little correlation was found between GCT-computed binding enthalpies and continuum electrostatics calculations. A simple count of contacts with functional groups in charged amino acids correlates well with enhanced water stabilization, but the stability of water near hydrophobic and polar residues depends markedly on its coordination environment. The positions of X-ray-resolved water molecules correlate with computed high-density hydration sites, but many unresolved waters are significantly stabilized at the protein surfaces. A defining characteristic of ligand-binding pockets compared to nonbinding pockets was a greater solvent-accessible volume, but average water thermodynamic properties were not distinctive from other interfacial regions. Interfacial water molecules are frequently stabilized by enthalpy and destabilized entropy with respect to bulk, but counter-examples occasionally occur. Overall detailed inspection of the local coordinating environment appears necessary to gauge the thermodynamic stability of water in protein structures

The Union of Hearts Depicted: Gladstone, Home Rule and United Ireland

First paragraph: William Ewart Gladstone detested political cartoons. They embodied caricature, the exaggeration of a particular feature into a deformity to excite ridicule or hatred. Cartoons, Gladstone once pointed out, had not existed in ancient Greece. There the ideal of human beauty was so deeply cherished that its distortion was not tolerated. Yet cartoons did the statesman powerful service during his long career. Their very frequency consolidated his image as a popular politician, bringing out qualities such as courage and tenacity that he was happy to have publicised. Nowhere, however, did they advance his cause more than in Ireland after the introduction of Home Rule. The nationalist journal United Ireland, as the illustrations in this paper will show, gave currency to striking depictions of Gladstone; and they vividly portrayed the union of hearts between England and Ireland that he preached so persistently in the late 1880s. The purpose of this article is to examine a sample of the cartoons, but first they need to be placed in their context

Future Directions in Sea Otter Research and Management

The conservation and management of sea otters has benefited from a dedicated research effort over the past 60 years enabling this species to recover from a few thousand in the early 20th century to about 150,000 today. Continued research to allow full, pre-exploitation recovery and restoration of nearshore ecosystems should focus on at least seven key challenges: (1) Defining sea otter populations at smaller spatial scales that reflect this species’ life history and dispersal patterns; (2) Understanding factors that regulate sea otter population density with a focus on index sites that are representative of the variety of littoral habitats occupied by sea otters around the North Pacific Rim; (3) Quantifying the effects of sea otters on the littoral community with a focus on how food availability limits population and ecosystem recovery and on predicting the effect of sea otter reoccupation on commercially valuable invertebrates; (4) Making sea otter monitoring programs comparable across geo-political boundaries through international collaboration to optimize survey efforts both spatially and temporally and to determine the cause of changes in sea otter demographics; (5) Evaluating the conservation benefits of sea otter reintroductions into historical habitat; (6) Assessing the socioeconomic costs and benefits of sea otter range expansion to anticipate and mitigate conflicts; (7) Recognizing in conservation and management plans that sea otters can be significantly affected by higher level predators in some circumstances. Many of these challenges will require new tools including the next generation geolocation tag technology that will allow assessments of long-range movements, dispersal and gene flow in various populations

TRPA1- FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p

YesRecent evidence suggests that the ion channel TRPA1 is implicated in lung adenocarcinoma (LUAD) where its role and mechanism of action remain unknown. We have previously established that the membrane receptor FGFR2 drives LUAD progression through aberrant protein-protein interactions mediated via its C-terminal proline rich motif. Here, we report that the N-terminal ankyrin repeats of TRPA1 directly bind to the C-terminal proline rich motif of FGFR2 inducing the constitutive activation of the receptor, thereby prompting LUAD progression and metastasis. Furthermore, we show that upon metastasis to the brain, TRPA1 gets depleted, an effect triggered by the transfer of TRPA1-targeting exosomal microRNA (miRNA-142-3p) from brain astrocytes to cancer cells. This downregulation, in turn, inhibits TRPA1-mediated activation of FGFR2 hindering the metastatic process. Our study reveals a direct binding event and characterizes the role of TRPA1 ankyrin repeats in regulating FGFR2-driven oncogenic process; a mechanism that is hindered by miRNA-142-3p.Faculty of Biological Sciences at the University of Leeds, Wellcome Trust Seed Award, Royal Society Research Grant RG150100, MR/K021303/1, Swedish Research Council (2014-3801) and the Medical Faculty at Lund University