Economic Topology Optimization of District Heating Networks using a Pipe Penalization Approach

In the presented study, a pipe penalization approach for the economic topology optimization of District Heating Networks is proposed, drawing inspiration from density-based topology optimization. For District Heating Networks, the upfront investment is a crucial factor for the rollout of this technology. Today, the pipe routing is usually designed relying on a linearization of the underlying heat transport problem. This study proposes to solve the optimal pipe routing problem as a non-linear topology optimization problem, drawing inspiration from density-based topology optimization. The optimization problem is formulated around a non-linear heat transport model and minimizes a detailed net present value representation of the heating network cost. By relaxing the combinatorial problem of pipe placement, this approach remains scalable for large-scale applications. A discrete network topology and near-discrete pipe design is achieved by using an intermediate pipe penalization strategy. For a realistic test case, the proposed algorithm achieves a discrete network topology and near-discrete pipe design that outperforms simple post-processing steps.Comment: Changed article template and minor reformulations in abstract, introduction and conclusio

Towards automated magnetic divertor design for optimal heat exhaust

International audienceAvoiding excessive structure heat loads in future fusion tokamaks is regarded as one of the greatest design challenges. In this paper, we aim at developing a tool to study how the severe divertor heat loads can be mitigated by reconfiguring the magnetic confinement. For this purpose, a free boundary equilibrium code is integrated with a plasma edge transport code to work in an automated fashion. Next, a practical and efficient adjoint based sensitivity calculation is proposed to evaluate the sensitivities of the integrated code. The sensitivity calculation is finally applied to a realistic test case and compared with finite difference sensitivity calculations

METIS - the Mid-infrared E-ELT Imager and Spectrograph

METIS, the Mid-infrared ELT Imager and Spectrograph (formerly called MIDIR), is a proposed instrument for the European Extremely Large Telescope (E-ELT), currently undergoing a phase-A study. The study is carried out within the framework of the ESO-sponsored E-ELT instrumentation studies. METIS will be designed to cover the E-ELT science needs at wavelengths longward of 3um, where the thermal background requires different operating schemes. In this paper we discuss the main science drivers from which the instrument baseline has been derived. Specific emphasis has been given to observations that require very high spatial and spectral resolution, which can only be achieved with a ground-based ELT. We also discuss the challenging aspects of background suppression techniques, adaptive optics in the mid-IR, and telescope site considerations. The METIS instrument baseline includes imaging and spectroscopy at the atmospheric L, M, and N bands with a possible extension to Q band imaging. Both coronagraphy and polarimetry are also being considered. However, we note that the concept is still not yet fully consolidated. The METIS studies are being performed by an international consortium with institutes from the Netherlands, Germany, France, United Kingdom, and Belgium.Comment: 15 pages, to be published in Proc SPIE 7014: Ground-based & Airborne Instrumentation for Astronomy I

A stubbornly large mass of cold dust in the ejecta of Supernova 1987A

We present new Herschel photometric and spectroscopic observations of Supernova 1987A, carried out in 2012. Our dedicated photometric measurements provide new 70 mu m data and improved imaging quality at 100 and 160 mu m compared to previous observations in 2010. Our Herschel spectra show only weak CO line emission, and provide an upper limit for the 63 mu m [O-I] line flux, eliminating the possibility that line contaminations distort the previously estimated dustmass. The far-infrared spectral energy distribution (SED) is well fitted by thermal emission from cold dust. The newly measured 70 mu m flux constrains the dust temperature, limiting it to nearly a single temperature. The far-infrared emission can be fitted by 0.5 +/- 0.1M(circle dot) of amorphous carbon, about a factor of two larger than the current nucleosynthetic mass prediction for carbon. The observation of SiO molecules at early and late phases suggests that silicates may also have formed and we could fit the SED with a combination of 0.3M(circle dot) of amorphous carbon and 0.5M(circle dot) of silicates, totalling 0.8M(circle dot) of dust. Our analysis thus supports the presence of a large dust reservoir in the ejecta of SN 1987A. The inferred dust mass suggests that supernovae can be an important source of dust in the interstellar medium, from local to high-redshift galaxies

Tryptophan depletion results in tryptophan-to-phenylalanine substitutants

Activated T cells secrete interferon-γ, which triggers intracellular tryptophan shortage by upregulating the indoleamine 2,3-dioxygenase 1 (IDO1) enzyme1–4. Here we show that despite tryptophan depletion, in-frame protein synthesis continues across tryptophan codons. We identified tryptophan-to-phenylalanine codon reassignment (W>F) as the major event facilitating this process, and pinpointed tryptophanyl-tRNA synthetase (WARS1) as its source. We call these W>F peptides ‘substitutants’ to distinguish them from genetically encoded mutants. Using large-scale proteomics analyses, we demonstrate W>F substitutants to be highly abundant in multiple cancer types. W>F substitutants were enriched in tumours relative to matching adjacent normal tissues, and were associated with increased IDO1 expression, oncogenic signalling and the tumour-immune microenvironment. Functionally, W>F substitutants can impair protein activity, but also expand the landscape of antigens presented at the cell surface to activate T cell responses. Thus, substitutants are generated by an alternative decoding mechanism with potential effects on gene function and tumour immunoreactivity

Elucidation of the Mode of Action of a New Antibacterial Compound Active against Staphylococcus aureus and Pseudomonas aeruginosa.

Nosocomial and community-acquired infections caused by multidrug resistant bacteria represent a major human health problem. Thus, there is an urgent need for the development of antibiotics with new modes of action. In this study, we investigated the antibacterial characteristics and mode of action of a new antimicrobial compound, SPI031 (N-alkylated 3, 6-dihalogenocarbazol 1-(sec-butylamino)-3-(3,6-dichloro-9H-carbazol-9-yl)propan-2-ol), which was previously identified in our group. This compound exhibits broad-spectrum antibacterial activity, including activity against the human pathogens Staphylococcus aureus and Pseudomonas aeruginosa. We found that SPI031 has rapid bactericidal activity (7-log reduction within 30 min at 4x MIC) and that the frequency of resistance development against SPI031 is low. To elucidate the mode of action of SPI031, we performed a macromolecular synthesis assay, which showed that SPI031 causes non-specific inhibition of macromolecular biosynthesis pathways. Liposome leakage and membrane permeability studies revealed that SPI031 rapidly exerts membrane damage, which is likely the primary cause of its antibacterial activity. These findings were supported by a mutational analysis of SPI031-resistant mutants, a transcriptome analysis and the identification of transposon mutants with altered sensitivity to the compound. In conclusion, our results show that SPI031 exerts its antimicrobial activity by causing membrane damage, making it an interesting starting point for the development of new antibacterial therapies

EUROfusion Integrated Modelling (EU-IM) capabilities and selected physics applications

International audienceRecent developments and achievements of the EUROfusion Code Development for Integrated Modelling project (WPCD), which aim is to provide a validated integrated modelling suite for the simulation and prediction of complete plasma discharges in any tokamak, are presented. WPCD develops generic complex integrated simulations, workflows, for physics applications, using the standardized European Integrated Modelling (EU-IM) framework. Selected physics applications of EU-IM workflows are illustrated in this paper

Automated Magnetic Divertor Design for Optimal Power Exhaust

The so-called divertor is the standard particle and power exhaust system of nuclear fusion tokamaks. In essence, the magnetic configuration hereby `diverts' the plasma to a specific divertor structure. The design of this divertor is still a key issue to be resolved to evolve from experimental fusion tokamaks to commercial power plants. The focus of this dissertation is on one particular design requirement: avoiding excessive heat loads on the divertor structure. The divertor design process is assisted by plasma edge transport codes that simulate the plasma and neutral particle transport in the edge of the reactor. These codes are computationally extremely demanding, not in the least due to the complex collisional processes between plasma and neutrals that lead to strong radiation sinks and macroscopic heat convection near the vessel walls. One way of improving the heat exhaust is by modifying the magnetic confinement that governs the plasma flow. In this dissertation, automated design of the magnetic configuration is pursued using adjoint based optimization methods. A simple and fast perturbation model is used to compute the magnetic field in the vacuum vessel. A stable optimal design method of the nested type is then elaborated that strictly accounts for several nonlinear design constraints and code limitations. Using appropriate cost function deffnitions, the heat is spread more uniformly over the high-heat load plasma-facing components in a practical design example. Furthermore, practical in-parts adjoint sensitivity calculations are presented that provide a way to an efficient optimization procedure. Results are elaborated for a fictituous JET (Joint European Torus) case [...

An efficient methodology to analyze plasma edge model parameter sensitivities

Quantifying uncertainties on code outputs is an important step for code-based design and scenario development. Because of the high computational cost of plasma edge transport simulations, the propagation of uncertainties on input parameters quickly becomes intractable. The paper starts with a short overview of current concepts to deal with this issue. A practical in-parts adjoint approach to sensitivity calculation is then applied for computationally efficient uncertainty propagation. The cumbersome derivation-by-hand of the sensitivity expressions is avoided, while the computational cost is roughly kept independent of the number of uncertain parameters. Exemplarily sensitivities of the outer strike point temperature and a heat load objective are calculated for a WEST case. Transport coefficients, boundary condition parameters, rate coefficients, as well as uncertain parameters in the magnetic equilibrium calculation are considered. The sensitivities are verified to be accurate, while the computational cost to compute the entire sensitivity matrix is equivalent to only one additional plasma edge simulation for each output quantity of interest. Furthermore, several logical trends are observed in the sensitivities. Keywords: Plasma edge simulation, Sensitivity calculation, Continuous adjoint metho

An adjoint optimization approach for the topological design of large-scale district heating networks based on nonlinear models

This article deals with the problem of finding the best topology, pipe diameter choices, and operation parameters for realistic district heating networks. Present design tools that employ non-linear flow and heat transport models for topological design are limited to small heating networks with up to 20 potential consumers. We introduce an alternative adjoint-based numerical optimization strategy to enable large-scale nonlinear thermal network optimization. In order to avoid a strong computational cost scaling with the network size, we aggregate consumer constraints with a constraint aggregation strategy. Moreover, to align this continuous optimization strategy with the discrete nature of topology optimization and pipe size choices, we present a numerical continuation strategy that gradually forces the design variables towards discrete design choices. As such, optimal network topology and pipe sizes are determined simultaneously. Finally, we demonstrate the scalability of the algorithm by designing a fictitious district heating network with 160 consumers. As a proof-of-concept, the network is optimized for minimal investment cost and pumping power, while keeping the heat supplied to the consumers within a thermal comfort range of 5 %. Starting from a uniform distribution of 15 cm wide piping throughout the network, the novel algorithm finds a network lay-out that reduces piping investment by 23 % and pump-related costs by a factor of 14 in less than an hour on a standard laptop. Moreover, the importance of embedding the non-linear transport model is clear from a temperature-induced variation in the consumer flow rates of 72 %.status: publishe