A Review: Novel Granulation Technology

All the pharmaceutical Active pharmaceutical Ingredients (API) and Pharmaceutical excipients will have different particle size.  While formulating a dosage form, particles from raw materials will tend to separate from other due to their rheological properties. There could be a condition where fine particles separate from the larger particles causing demixing or uneven distribution of active with its excipients leading to tablet content uniformity issue. To overcome this problem, particle enlargement or particle cohesiveness with or without additional aid is necessary, which could be achieved by granulation. Hence granulation technology is important in the formulation of pharmaceutical oral solid dosage form. Granulation is the process of adhering fine particles agglomerate into a large particle using two most common methods i.e. wet granulation and dry granulation/compaction. Day by day technological innovation is happening in all fields and pharmaceutical granulation process is also not an exemption. The objective of present review is to focus the novel granulation technology and how it is differing from the conventional granulation technology

Study of rainfall pattern in Chaksu Tehsil, Jaipur, Rajasthan, India

The water storage beneath the ground surface is the function of the Rainfall in an area. The underground water is the main source of irrigation and effect the agriculture production. So directly or indirectly the rainfall influences the agriculture. The years with the good rainfall enjoy the high agriculture production as the requirement of water is facilitated. The paper presents the rainfall pattern for last 25 years in study area with the analysis of variation of rainfall year by year. For the study, different techniques and tools are employed so the variation where it is seasonal or annual can be shown

Efficacy of animal origin products and ajwain powder against honey bee diseases in Apis mellifera (Linnaeus) colonies in Uttarakhand-A novel eco-friendly approach

The studies to manage the honey bee bacterial European foul brood ( EFB) disease caused by Melisococcus plutonius and ectoparasitic brood mite disease caused by Varroa destructor in the colonies of Apis mellifera (L.) at different locations of Uttarakhand were conducted during 2012- 2013 by applying eco-friendly formulations i.e. spraying of cow urine (desi cow breed), plant decoctions prepared in cow urine, cow dung cake and cow dung ash powders , ajwain seed powder and compared to an antibiotic, terramycin sugar syrup and synthetic chemicals, sulphur and thymol powder with two applications in a month. The data revealed that the cow urine sprays @ 50, 75 and 100% reduced the disease infection to below detectable limit in 10 to 14 days, respectively, as terramycin treated infected colonies where only 50-55% recovery was seen in EFB infection with highest sealed worker brood areas ( SWBA) in cow urine treated honeybee colonies in comparison to terramycin and untreated colonies. Similarly, on the other hand, cow urine (100%) significantly reduced brood mite infestation (72.10%) with highest mean mite fall (48.73) and highest (SWBA) (854.00 cm2) followed by ajwain powder with reduction in brood mi te infestation(65.84%) with mite fall (46.39) and SWBA (749.00 cm2), cow dung powder with reduction in brood mite infestation (71.35%) ,mite fall ( 42.87), SWBA (682.33 cm2), , followed by cow dung ash powder, cow urine @ 25%, in comparison to plant decoctions prepared in cow urine, synthetic chemicals i.e. thymol and sulphur powder after 4 weeks of treatments. Thus, the animal origin products and ajwain powder can serve as apotential eco- friendly measure for management of honeybee diseases in A. mellifera colonies at different locations of Uttarakhand as they significantly increased sealed worker brood area without affecting the activities of workers, queen bee and bee brood in comparison to chemicals and plant decoctions

The Role of Ionic Liquids in Protein Folding/Unfolding Studies

Ionic liquids (ILs) have emerged as novel solvent medium for several biotechnological processes in vitro. The use of ILs starts from protein extraction to catalysis to folding/unfolding studies. ILs are becoming the most favorite non-aqueous medium for protein studies due to their unique ionic combinations (cation + anion) and tunable physical properties. In this context, several research results have been published that use of pure or aqueous IL solutions as stabilizer for proteins. Hence, herein, in this chapter, we present a collection of research work that focuses on the importance of ILs (and their mixture) in protein stabilities. In addition, we have also reviewed the unique properties of ILs as counteracting solvents for cold-induced denaturation and also their refolding properties. This report will definitely generate a new understanding for the ILs, their importance and applicability in protein folding studies

Estudio del modelo de lluvia en Chaksu tehsil, Jaipur, Rajasthan, India

Underground water is the main source of irrigation which depends on the rainfall. Inconsistency and irregularity in the occurrence and intensity of rainfall influence adversely the agriculture and allied activities. The years in which an area received good rainfall yield high agriculture production as water is available in abundant. This paper is an attempt to analysis the rainfall pattern for last 30 years in study area by calculating the rainfall deviationEl agua subterránea es la principal fuente de riego que depende de la lluvia. Se encuentra la inconsistencia e irregularidad en la ocurrencia e intensidad de la lluvia que influyen negativamente en la agricultura y las actividades aliadas. Los años con buenas precipitaciones disfrutan de la alta producción agrícola ya que el agua está disponible en abundancia. Este documento es un intento de analizar el patrón de lluvia durante los últimos 30 años en el área de estudio calculando la desviación de lluvi

Sustainable Agroecosystems for Livelihood Security in Indian Himalayas

Agroforestry systems are an age-old practice in the Indian Himalayan region. Agroforestry deals with the combination of tree species with crop plants, fisheries, animals, bee keeping, and so on, and it is based on the principle of optimum utilization of land. Agrihorticulture, silvihorticulture, hortipastoral, and silvipastoral systems are diversified land use options for agroforestry in the hill region. The study was conducted at experimental farm Hawalbagh (29o36′N and 79o 40′ E, 1250 m amsl) of Vivekananda Parvatiya Krishi Anusandhan Sansthan, Almora, India. Study in an agri-horti system revealed that ragi (Eluesine coracana) and soybean (Glysine max) during kharif (rainy season) and wheat (Triticum estivum) and lentil (Lens esculenta) during rabi (winter season) can be grown successfully with pecan nut (Carya illinoinensis) tree without significant reduction in the yield of the crop. However, grain yield of these crops was numerically higher in the field without pecan nut tree. In fruit-based agri-horti system four fruit crops, hill lemon (Citrus limon), pear (Pyrus communis), plum (Prunus domestica), and apricot (Prunus armeniaca) were planted with soybean in kharif and dual purpose wheat during rabi season. During initial years, no significant effect on grain yield was observed with the presence of different fruit trees. Green forage yield varied from 4600 to 5900 kg/ha in different treatments. In different treatments, ginger (Zingiber officinale) and turmeric (Curcuma longa), turmeric and taro (Colocasia esculenta), and two varieties of turmeric (Pant Pitabh and Swarna) were grown under Grewia optiva, Quercus leucotrichophora, Bauhinia variegata, and Celtis australis. Turmeric and ginger produced significantly higher yield (12.04 and 7.99 t/ha) under oak. The highest rhizome yield was obtained under Quercus leucotrichophora (11,738 kg/ha) followed by Bauhinia variegata. Pant Pitabh gave significantly higher yield (10,860 kg/ha) than swarna. Improved systems with five tree species, that is, Grewia optiva, Quercus leucotrichophora, Bauhinia retusa, Melia azedarach, and Morus alba and four grasses, that is, Setaria kazugulla, Setaria nandi, Congo signal, and Broad leaf paspalum (Paspalum spp.) were tested under the silvipastoral system. Quercus leucotrichophora yielded (10,675 kg/ha) significantly higher green biomass than others, and the lowest green biomass was harvested from Grewia optiva. Among grasses, Setaria nandi produced the highest green forage (6234 kg/ha). Thus, in hilly terrain, planting of interspatial woody perennials, with least negative influences on the agronomic crops, seems productive in agroforestry system for settled farming. Therefore, agroforestry is a set of land use alternative, which if developed for resource poor farmers, can provide increased values and reduced risks and it should be made more popular in the rural areas

Soil Enzymes: Indicator for Soil Health under Fruit based Agri-Horti System

Agroforestry as a sustainable land management system, which increases the yield of the land, combines production of crops (including tree crops) and forest plants and/or animals simultaneously or sequentially. Among the different agroforestry system practices in hill area agri-horti system is one of the most important system because of its specific environmental conditions and natural availability of wide range of fruit trees (citrus, apple, walnut, plum, peach, pear, apricot etc.). In Northwestern hill region viz. Uttarakhand, Himachal Pradesh and Jammu and Kashmir horticulture is the backbone of these states economy which supports about 1.5-2.0 million families and, provides direct or indirect employment to 8-10 million peoples with revenue of more than 1 billion $ (USD) annually. In several studies it was reported that plant’s active root system releases about 17% of photosynthate detained in the form of organic compounds into the rhizosphere, most of which is available to the plant by the different soil microbial activities. The soil enzymatic activity play a significant role in efficient utilization of natural resources through agri-horti production system to enhance the soil sustainability and system productivity by the mechanisms of organic matter decomposition, soil stabilization, nutrient cycling, catalyzing several biochemical reactions in the soil system1,2. In recent years, studies soil enzymes activity have engaged the attention of many researchers. However, most of these studies are confined to agricultural cropping systems3 and forest ecosystems but, information regarding those under temperate fruit crops like peach, pear, apricot, lemon, plum etc., are very limited. The hypothesis of this experiment was that the different temperate fruit crops could have differential microbial activity in the rhizospheric soil (surface and sub-surface), influenced by management practice as well as quality of litter fall and root exudates. We assume that information produced from this study will help in understanding of microbial mediated nutrient dynamics and their management under temperate fruit crops in N-W hilly area

Evaluation of digital elevation model in hilly region of Uttarakhand: A case study of experimental farm Hawalbagh

Not AvailableDigital Elevation Model (DEM) is used to display terrestrial information on map. Moreover, DEMs are often used in geographic information systems (GIS), and serve as a basis for generation of relief map. The present study was conducted to evaluate the google earth (GE) derived DEM with three established open source DEMs such as, shuttle radar topographic mission (SRTM) DEM, advanced space borne thermal emission and reflection radiometer (ASTER) DEM and advanced land observing satellite phased array type l−band synthetic aperture radar (ALOS PALSAR) DEM. The study area of present research is experimental farm, Hawalbagh of the ICAR− Vivekananda Parvatiya Krishi Anusandhan Sansthan (VPKAS), Almora, India which lies in middle Himalayas using online tool (GPS visualizer). The accuracy statistics were evaluated using 100 points in the study area having varying topography with three DEMs such as, SRTM DEM, ASTER DEM and ALOS PALSAR DEM. The result showed that google earth data was positively correlated with all established 2 DEM with r value of 0.88 for SRTM, 0.92 for ALOS PALSAR Dem and 0.83 for ASTER DEM. The result showed that the accuracies for the google earth derived DEM is suitable for hydrological and other water resources modelling.Not Availabl

Climatic Variation and Its Impacts on Yield and Water Requirement of Crops in Indian Central Himalaya

Climate is most important factor affecting agriculture, and issues related to climate and its implications have attracted attention of policy makers globally. The farm sector, particularly marginal ecosystems in mountains are vulnerable because of unpredictable variation and severe sink limitations. Efforts to impart resilience to farm and its allied sector are an urgent need. The climatic parameters play very important role to determine type of crops, cattle rearing and the life style adopted by the people. Moreover, weather has a significant impact on crop growth and development. Weather plays a vital role and affects the production and productivity of the crops. According to an estimate, weather contributes 67% variation in productivity and rest of the factors (soil, nutrient and management practices etc.) accounts for 33%. Therefore, there is a need of in-depth analysis of each meteorological parameters and identification of their trend over the years in order to identify and adapt suitable agriculture practices, better adaptable crops, varieties and their duration, time of field preparation, sowing time and irrigation as per the climatic conditions of the region. This will lead farming community to plan strategies of agriculture operation to obtain optimum yield. The climatic data from the meteorological observatory of ICAR-VPKAS, Hawalbagh located at mid hill condition (1250 m amsl) were analyzed for different periods (annual, seasonal, monthly, weekly). It was revealed that rainfall is decreasing over the years but significant (P < 0.05) decrease was recorded at mid hills. The maximum temperature is increasing significantly (P < 0.05) during post-monsoon and winter season however decreasing in monsoon season whereas minimum temperature is decreasing round the year. These changes in rainfall and temperatures are affecting production and productivity of the crops, as hills are largely rainfed. In terms of crop water demand, there is no need to apply irrigation during the rainy season except the transplanted rice. However, during the winter season as there is more than 60% of water deficit to irrigate the crops. The proper understanding of climate is necessary to bring sustainability in hill agriculture by adjusting crop sowing window and other operations as per suitability of the climate

Protein-olive oil-in-water nanoemulsions as encapsulation materials for curcumin acting as anticancer agent towards MDA-MB-231 cells

The sustainable cellular delivery of the pleiotropic drug curcumin encounters drawbacks related to its fast autoxidation at the physiological pH, cytotoxicity of delivery vehicles and poor cellular uptake. A biomaterial compatible with curcumin and with the appropriate structure to allow the correct curcumin encapsulation considering its poor solubility in water, while maintaining its stability for a safe release was developed. In this work, the biomaterial developed started by the preparation of an oil-in-water nanoemulsion using with a cytocompatible copolymer (Pluronic F 127) coated with a positively charged protein (gelatin), designed as G-Cur-NE, to mitigate the cytotoxicity issue of curcumin. These G-Cur-NE showed excellent capacity to stabilize curcumin, to increase its bio-accessibility, while allowing to arrest its autoxidation during its successful application as an anticancer agent proved by the disintegration of MDA-MB-231 breast cancer cells as a proof of concept