1,045 research outputs found
In vitro characterisation of the Leishmania : Dendritic cell interaction
- Author
- Publication venue
- The University of Edinburgh
- Publication date
- 01/01/2002
- Field of study
Healthy ageing for all? Comparisons of socioeconomic inequalities in health expectancies over two decades in the Cognitive Function and Ageing Studies I and II
- Author
- Publication venue
- Oxford University Press
- Publication date
- 09/01/2021
- Field of study
Background: Despite increasing life expectancy (LE), cross-sectional data show widening inequalities in disability-free LE (DFLE) by socioeconomic status (SES) in many countries. We use longitudinal data to better understand trends in DFLE and years independent (IndLE) by SES, and how underlying transitions contribute. Methods: The Cognitive Function and Ageing Studies (CFAS I and II) are large population-based studies of those aged ≥65 years in three English centres (Newcastle, Nottingham, Cambridgeshire), with baseline around 1991 (CFAS I, n = 7635) and 2011 (CFAS II, n = 7762) and 2-year follow-up. We defined disability as difficulty in activities of daily living (ADL), dependency by combining ADLs and cognition reflecting care required, and SES by area-level deprivation. Transitions between disability or dependency states and death were estimated from multistate models. Results: Between 1991 and 2011, gains in DFLE at age 65 were greatest for the most advantaged men and women [men: 4.7 years, 95% confidence interval (95% CI) 3.3-6.2; women: 2.8 years, 95% CI 1.3-4.3]. Gains were due to the most advantaged women having a reduced risk of incident disability [relative risk ratio (RRR):0.7, 95% CI 0.5-0.8], whereas the most advantaged men had a greater likelihood of recovery (RRR: 1.8, 95% CI 1.0-3.2) and reduced disability-free mortality risk (RRR: 0.4, 95% CI 0.3-0.6]. Risk of death from disability decreased for least advantaged men (RRR: 0.7, 95% CI 0.6-0.9); least advantaged women showed little improvement in transitions. IndLE patterns across time were similar. Conclusions: Prevention should target the most disadvantaged areas, to narrow inequalities, with clear indication from the most advantaged that reduction in poor transitions is achievable
2018: Art & Mobilities Network Inaugural Symposium Instant Journal (Peter Scott Gallery)
- Author
- Barry Kaya
- Baxter Tess
- Bennett Bruce
- Booker Clare
- Bowers Natalie
- Büscher Monika
- Chapman Owen
- Collier Mike
- Cunningham Jocelyn
- Ferguson Nick
- Guelton Bernard
- Jungnickel Kat
- Kesselring Sven
- Lopez Carlos
- Lujan Escalante Malé
- Merrington Peter
- Ntaousani Elia
- O Keeffe Linda
- Pollastri Serena
- Pugh Nikki
- Rose Emma
- Sawchuk Kim
- Sheller Mimi
- Smith Richard
- Southern Jen
- Syng Tan Kai
- Szerszynski Bron
- Thulin Sam
- Whittaker Emma
- Wilson Louise Ann
- Publication venue
- Centre for Mobilities Research, Lancaster University
- Publication date
- 03/07/2018
- Field of study
"Mobilities has been gaining momentum through networks, conferences, books, special issues, exhibitions and in the practices of artists, writers and curators. In recognition of this activity we are forming an Art & Mobilities network through which to consolidate, celebrate and develop this work.Inspired by the recent foregrounding of Mobility and the Humanities (Pearce & Merriman, 2018) and drawing on last November's successful Mobile Utopia Exhibition amongst others, the Centre for Mobilities Research (CEMORE) at Lancaster University are pleased to hold a UK Art & Mobilities Network Inaugural Symposium 2018 on the 3rd of July 2018.
The aim of the symposium is to bring together people in the UK who are active in the field of mobilities and art in order to discuss the distinctive contribution that art makes to mobilities research and vice versa. We would be delighted if you can join us for this one-day event to help shape the network, particularly in the context of a fast-changing world, not just socio-politically but in terms of the place of art in the academy and vice versa.
There are nearly 30 key international artists and researchers gathered on this day both locally and via Skype. We invite all participants in the symposium to bring with them an artwork, artefact, written statement or quote that can be displayed as a ‘pop up’ exhibition. These artefacts will be used during the day to focus discussion around different facets of mobilities and art." (Jen Southern, Kai Syng Tan, Emma Rose, Linda O'Keeffe Editors
Development and validation of a targeted gene sequencing panel for application to disparate cancers
- Author
- Aghmesheh Morteza
- Amor David
- Andrews Lesley
- Antill Yoland C.
- Armitage Shane
- Arnold Leanne
- Balleine Rosemary
- Bastik Patricia A.
- Beesley Jonathan
- Beilby John
- Bennett Ian
- Blackburn Anneke C.
- Bogwitz Michael R.
- Botes Leon P.
- Brennan Meagan
- Brown Melissa A.
- Buckley Michael
- Burgess Matthew J.
- Burke Jo
- Butow Phyllis
- Caldon Elizabeth
- Callen David F.
- Campbell Ian G.
- Chan Chialing
- Chauhan Deepa
- Chauhan Manisha
- Chenevix-Trench Georgia
- Christian Alice
- Cipponi Arcadi
- Clarke Christine L.
- Cohen Paul A.
- Colley Alison S.
- Crook Ashley
- Cui James
- Culling Bronwyn
- Cummings Margaret C.
- Dawson Sarah J.
- De Sousa Sunita M.
- DeFazio Anna
- Delatycki Martin B.
- Deng Niantao
- Dickson Rebecca
- Dixon Joanne W.
- Dobrovic Alexander
- Dudding Tracy
- Edkins Ted
- Edwards Stacey L.
- Eisenbruch Maurice
- et al .
- Farshid Gelareh
- Fellows Andrew
- Fenton Georgina
- Field Michael
- Flanagan James M.
- Fong Peter C.
- Forrest Laura
- Fox Stephen B.
- French Juliet D.
- Friedlander Michael
- Gaff Clara
- Gallego-Ortega David
- Gattas Michael R.
- Gauthier Marie-Emilie A.
- Gayevskiy Velimir
- George Peter M.
- Giles Graham G.
- Gill Grantley
- Grady John P.
- Greening Sian
- Haan Eric A.
- Harris Marion T.
- Hart Stewart
- Hayward Nicholas K.
- Heiniger Louise E.
- Hopper John L.
- Hunt Clare E.
- James Paul A.
- Jenkins Mark A.
- Johns Amber L.
- Kefford Rick F.
- Kidd Alexa M.
- Kirk Judy
- Koehler Jessica
- Kohonen-Corish Maija R.
- Kollias James
- Lakhini Sunil R.
- Lindeman Geoffrey J.
- Lipton Lara R.
- Lobb Liz
- Lord Reginald V.
- Mann Graham
- March Deborah J.
- McCabe Mark J.
- McLachaln Sue A.
- Meiser Bettina
- Milne Roger L.
- Nightingale Sophie S.
- O'Connell Shona
- O'Sullivan Sarah
- O'Toole Sandra A. (R17255)
- Pachter Nicholas S.
- Patterson Briony
- Phillips Kelly A.
- Pieper Ellen
- Puttick Clare
- Rickard Edwina
- Robinson Bridget
- Saleh Mona
- Salisbury Elizabeth
- Sambrook Joseph F.
- Saunders Christobel
- Saunus Jodi
- Scott Clare L.
- Scott Elizabeth
- Scott Rodney J.
- Sexton Adrienne C.
- Shelling Andrew N.
- Simpson Peter
- Southey Melissa C.
- Spurdle Amanda B.
- Swarbrick Alexander
- Tao Jiang
- Taylor Jessica A.
- Thomas Melissa L.
- Thompson Tanya J.
- Thorne Heather J.
- Trainer Alison H.
- Tucker Katherine
- Visvader Jane E.
- Walker Logan C.
- Williams Rachel A.
- Winship Ingrid
- Ying Kevin
- Young Mary A.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
Next generation sequencing has revolutionised genomic studies of cancer, having facilitated the development of precision oncology treatments based on a tumour’s molecular profile. We aimed to develop a targeted gene sequencing panel for application to disparate cancer types with particular focus on tumours of the head and neck, plus test for utility in liquid biopsy. The final panel designed through Roche/Nimblegen combined 451 cancer-associated genes (2.01 Mb target region). 136 patient DNA samples were collected for performance and application testing. Panel sensitivity and precision were measured using well-characterised DNA controls (n = 47), and specificity by Sanger sequencing of the Aryl Hydrocarbon Receptor Interacting Protein (AIP) gene in 89 patients. Assessment of liquid biopsy application employed a pool of synthetic circulating tumour DNA (ctDNA). Library preparation and sequencing were conducted on Illumina-based platforms prior to analysis with our accredited (ISO15189) bioinformatics pipeline. We achieved a mean coverage of 395x, with sensitivity and specificity of >99% and precision of >97%. Liquid biopsy revealed detection to 1.25% variant allele frequency. Application to head and neck tumours/cancers resulted in detection of mutations aligned to published databases. In conclusion, we have developed an analytically-validated panel for application to cancers of disparate types with utility in liquid biopsy
Act now against new NHS competition regulations: an open letter to the BMA and the Academy of Medical Royal Colleges calls on them to make a joint public statement of opposition to the amended section 75 regulations.
- Author
- Anson James
- Applebee Jackie
- Arnold Natasha
- Awsare Ninaad
- Bambra Clare
- Banks Ian
- Bareford David
- Basarab Adriana
- Beadsworth Mike
- Beer Naomi
- Bell David
- Bell David
- Bennett-Richards Phillip
- Bhatti Osman
- Boomla Kambiz
- Bossano David
- Bostock David
- Boswell John P
- Bratty Catherine
- Brearey Steve
- Brown Kirsten
- Brown Raymond
- Buhrs Ernst
- Burgess-Allen Jilla
- Bury Bob
- Buttivant Helen
- Caan Woody
- Cabot Kate
- Camilleri-Ferrante Corinne
- Carter Lucy
- Chamberlain MA
- Chandy Rajiv
- Cheeroth Sheila
- Clark Leon
- Clarke Aileen
- Clarke Edward
- Coates Jonathan
- Cole Jim
- Coleman Michel
- Colvin Deborah
- Cook Derek
- Cripwell Michael
- Crome Peter
- Cullinan Paul
- Currie Jonny
- Daley Helen
- Danby Jude
- Darling Jonathan
- Davies David
- Davies Gerry
- Davis Jacky
- Deveson Pete
- Dickinson Jane
- Dickson Harriet
- Domizio Paola
- Duncan John AT
- Edwards Mark
- Edwards Martin
- Ehrhardt Peter
- Eisner Maggie
- Erskine Jonathan
- Etherington Robert
- Evans David
- Evans-Jones John
- Farrelly George
- Feder Gene
- Feehally John
- Fell Henry
- Fellows Griffith
- Fielding Richard
- Finer Nick
- Finer Sarah
- Fisher Brian
- Fitchett Mike
- Fitzgerald Richard
- Fleming Peter
- Fleming Peter
- Fluxman Jonathan
- Folb Jonathan
- Folb Jonathan
- Ford Amy
- Ford Steven
- Franks Andrea
- Freud Kathy McAdam
- Gawler Jeff
- Gibbs John
- Gill Alison
- Godfrey Peter
- Goodger V
- Gore Jonathan
- Gould Derek A
- Greenhalgh Trisha
- Griffiths Alun
- Grunewald Richard
- Gurling Hugh
- Hall Alyson
- Hall Peter
- Hamlyn Adrian N
- Hawkins David
- Highton Clare
- Hirst Julie
- Hobson Esther
- Holland Walter
- Holt Kim
- Holt Victoria J
- Hopkinson Nicholas
- Hotchkiss Julie
- Hughes Richard
- Ingrams Grant
- Ireland Maggie
- Irvine Louise
- Irving William L
- Jacobson Bobbie
- Jeffreys Anne
- Jenner David
- Jenner David
- Johnson Guy
- Johnston Sally
- Johnstone Chris
- Jones Anna
- Jones Coral
- Jones Phil
- Kendall Bryony
- Kinmonth Ann-Louise
- Kirwin Simon
- Klonin Hilary
- Knight David
- Koperski M
- Kraemer Sebastian
- Landers Aileen
- Lau Alice
- Lawrence David
- Lee Alan
- Lefevre Dianne
- Leigh Martha
- Lewis David
- Lewis David
- Lewis Geoffrey
- Livingstone Anna
- Lockwood Kate
- Logan Jane
- Logan Mary
- Logan Stuart
- Lowes Simon
- Lyttelton Laura
- Ma Richard
- Macfarlane Alison
- Macgibbon Robert
- Macklon AF
- Maclennan Iain
- Macpherson Jamie
- Main John
- Mann Nick
- Marlowe Gary
- Marmot Saul
- Martin P
- Maryon-Davis Alan
- Mason Rebecca
- McCartney Margaret
- McCoy David
- McEewen J
- McElderry Elisabeth
- McKee Martin
- McPherson Klim
- Michael Benedict
- Middleton John
- Miller Jo
- Mindell Jennifer
- Mitchel Sarah
- Mitchison Sally
- Moore Robert
- Morrison Richard
- Mullen Paul
- Munday Pat
- Murphy E
- Newell Jo
- Nixon Jonathan
- Noor R
- Nsutebu Emmanuel
- Ormerod Julian
- Ormerod Oliver
- Paintin David
- Patel Anita
- Paul Ashish
- Peedell Clive
- Pollock Alyson
- Pride Neil
- Puntis John
- Rainbow Daniel
- Rawaf Salman
- Reeve Joanne
- Reissman Gerard
- Ross Wendy
- Rossiter Brian
- Salim Asad
- Savage Wendy
- Sayer Mel
- Schweiger Martin
- Scott Brian
- Scott-Samuel Alex
- Sharma Ajay
- Sharp Deborah J
- Sharvill John
- Sikorski Jim
- Silverman Ruth
- Singer Ron
- Singh G
- Singh Surinder
- Smailes Alison
- Smyth Alan
- Souza Richard de
- Stevenson Nicola
- Stobbart Kate
- Suckling Ruth
- Tallis Ray
- Tebboth Louise
- Timmis Alison
- Timms Philip
- Tomlinson Jonathon
- Tomlinson Laurie
- Tomson D
- Tomson Mike
- Torabi Payam
- Tulloch Alex
- Turner Gill
- Venning Helen
- Walker Jonathan
- Waterston Tony
- Wesby Barbara
- West Andrew
- West Robert
- West Robert
- Whincup Peter
- Wolfe Ingrid
- Wortley Pam
- Wrigley David
- Young Gail
- Young Jane
- Yudkin John S
- Zinkin Pam
- Publication venue
- 'BMJ'
- Publication date
- 20/03/2013
- Field of study
Children must be protected from the tobacco industry's marketing tactics.
- Author
- Abdallah Said
- Absalom Gareth
- Adams Nick
- Adeboyeku David
- Agate Rowan
- Agrawal Sanjay
- Ahmed Liju
- Allen Bev
- Anderson Paul
- Anwar Sadia
- Arabnia Gilda
- Ayres Jon
- Badman Ros
- Bafadhel Mona
- Baker Emma
- Banerjee Tushar
- Barker Jack
- Barnes Peter
- Barnett Emma
- Barnham Kate
- Barr Laura
- Barry Simon
- Bartoszewicz Charlotte
- Beasley Victoria
- Berry Matthew
- Bhowmik Angshu
- Bingham Lyn
- Bintcliffe Oliver
- Bloch Susannah
- Boland Alison
- Bolton Charlotte
- Booth Andrew
- Booton Richard
- Bothamley Graham
- Bott Julia
- Bourke Stephen
- Bradley Bethia
- Breen Ronan
- Brennan Amanda
- Bridges Diana
- Britton John
- Brown Joanna
- Brown Louise
- Brown Sarah
- Browne Emma
- Brunet Martin
- Burge Sherwood
- Burgin Karen
- Burke Hannah
- Bush Andrew
- Butcher Jane
- Buttery Robert
- Buxton Maria
- Calverley Peter
- Campbell Colin
- Campbell Ian
- Capstick Toby
- Carlin Chris
- Casswell Georgina
- Chaudhry Nauman
- Chavasse Richard
- Christensen Anne
- Christopher Anne
- Chua Felix
- Clarke Sarah
- Clive Amelia
- Colin Campbell
- Collett Anne
- Collins Andrea
- Collins Nicola
- Connell David
- Connellan Stephen
- Connelly Carol
- Connett Gary
- Connolly Bronwen
- Cookson John
- Cooper Angela
- Cooper David
- Costello Carol Ann
- Coutts Ian
- Cowie Calvin
- Cox Nicola
- Crawfurd Laura
- Creagh-Brown Ben
- Crooks Gillian
- Crooks Gillian
- Crooks Stephen
- Crossingham Iain
- Cullen Kathy
- Cummings Natalie
- Curry Denise
- Curtis Katrina
- Daniels Tracey
- Davey Claire
- Davidson Philip
- Davies Carol-Anne
- Davies Lisa
- Davies Peter
- Davies Sarah
- Davison John
- Davison Tony
- Dayer Mark
- Deegan Paul
- Denniston Sarah
- Deveson Pete
- Dewar Maria
- Diana Bridges
- Dobson Lee
- Docherty Marianne
- Dodd James
- Doe Simon
- Dow Claire
- Downs Janis
- Dowson Lee
- Durham Stephen
- Durrington Hannah
- Dutta P
- Dwarakanath Akshay
- Eaden James
- Edwards Adrian
- Edwards Catherine
- Edwards John
- Edwards Sheila
- Edwina Wooler
- Elizabeth Ringrose
- Elkin Sarah
- Elston Will
- Emerson Peter
- English Peter
- Esterbrook Georgina
- Everett Caroline
- Farmer Ray
- Feary Johanna
- Fern Karen
- Fleming Louise
- Fletcher Tim
- Ford David
- Ford Kate
- Forrest Ian
- Forster Georgia
- Fowler Robert William
- Fowler Stephen
- Fraser Una
- Freeman Debbie
- Fuld Jonathan
- Furness John
- Gaduzo Stephen
- Gardiner Karen
- Georgiadi Adamantia
- Ghosh Dipansu
- Gibson John
- Gill Alison
- Goldman Jon
- Goode Chris
- Graham Alison
- Graham Annika
- Graves Jennifer
- Gray Barry
- Gray Linda
- Greenhalgh Trish
- Greening Neil
- Griffiths Mark
- Griffiths Paul
- Griffiths Valerie
- Grove Alison
- Guadagno Alison
- Guyatt Fran
- Hailes Karen
- Haja Mydin Helmy
- Haney Sarah
- Hankinson Jenny
- Haqqee Raana
- Harle Amelie
- Harrison Brian
- Harrris Ann
- Hart Nicholas
- Harvey John
- Haslam Patricia L
- Heslop Karen
- Hewitt Lee
- Hickman Katherine
- Hicks Alex
- Higgins Bernard
- Hilton Kay
- Hoadley Jacky
- Hodgson Luke
- Hodson Matthew
- Holden Emma
- Holmes Steve
- Hopkinson Nicholas
- Hosker Harold
- Hough Alexandra
- Houghton Catherine
- Howell Tim
- Hughes John
- Hutchinson John
- Hynes Gareth
- Iftikhar Ahsan
- Iles Peter
- Ioakim Shona
- Janes Sam
- Jennings David
- Jha Akhilesh
- John Edwards
- Johnston Carol
- Jolley Caroline
- Jones Helen
- Kaul Sundeep
- Keaney Niall
- Keilty Sarah
- Kemp Samuel
- Ketchell Robert Ian
- Khan Katie
- Kim Randall
- Kowal Julia
- Kumar Sanjay
- Lacy-Colson Amruta
- Lane Amber
- Lane Ian
- Lebus Jenny
- Lenney Warren
- Lenney Warren
- Leonard Andrew
- Leonard Helen
- Lightbody Darren
- Lipman Marc
- Lithgow Anna
- Lloyd Jananee
- Lloyd Julie
- Lock Sara
- Lomas Dean David
- Long Alex
- Lord Victoria
- Lordan James
- Lowe Lesley
- Lyall Rebecca
- Lyons Elizabeth
- Lytton Stephen
- MacBean Vicky
- Macdonald Ian
- Mackenzie Nesta
- Mackinlay Carolyn
- Macmillan Alison Bennett
- Maddocks Matthew
- Majeed Azeem
- Malin Adam
- Mallia-Milanes Brendan
- Malone Sarah
- Man William
- Maqsood Usman
- Marsden Paul
- Marshall Robert
- Martin Katharine
- Martin Sarah
- Matthew Hodson
- Matusiewicz Simon
- Maxwell David
- McAuley Danny
- McCarvill Iona
- McHugh Martin
- McKee Martin
- McNicholl Diarmuid
- Meadows Chris
- Merritt Simon
- Milburn Heather
- Miller Joy
- Miller Lauren
- Mir Misbah
- Mitchell Sally
- Mitchelmore Philip
- Mohd Noh Mohd Shahrin
- Molloy Alanna
- Monaghan Valerie
- Montgomery Hugh
- Montgomery Mary
- Moore Caroline
- Moore-Gillon John
- Morgan David
- Morrison Douglas
- Moxham John
- Munday Maureen
- Mungall Sarah
- Murray Clare
- Mustfa Naveed
- Myerson James
- Narasimhan Divya
- Naveed Shams-un-nisa
- Nelson Christopher
- Newey Alison
- Nicholl David
- Nickol Annabel
- Nicoll Debby
- Nikolic Marko
- Nyman Cyril
- O'Callaghan Una
- O'Connor Sally
- O'Driscoll Ronan
- O'Hara Doreen
- O'Kane Cecilia
- Ohri Chandra
- Olive Sandra
- Olivier Sharon
- Olley Amy
- Ong Yee Ean
- Ormerod Lawrence
- Padmanaban Vijay
- Parker Samuel
- Parkes Marilyn
- Parmar Sonia
- Parry Diane
- Partridge Martyn
- Partridge Samuel
- Patel Anant
- Patel Irem
- Paterson Ian
- Paton James Y
- Pawulska Barbara
- Peedell Clive
- Pengo Martino
- Phitidis Elpida
- Pieri-Davies Sue
- Pillai Anilkumar
- Powell Helen
- Powrie Duncan
- Primhak Robert
- Prowse Keith
- Prowse Keith
- Purcell Helen
- Puthucheary Zudin
- Pye Kathy
- Quint Jennifer
- Radnan Paul
- Rafferty Gerrard
- Rajhan Ashwin
- Raju Raghu
- Ramsay Michelle
- Range Simon
- Redington Anthony
- Reilly Jacqui
- Restrick Louise
- Ridyard John
- Rigge Lucy
- Ringrose Elizabeth
- Robinson Grace
- Robinson Louise
- Rodman Anne
- Roots Debbie
- Roots Debbie
- Rosalind Backham
- Ross David
- Round Jonathan
- Ruiz Gary
- Russell Richard
- Ryan Helen
- Safavi Shahideh
- Saini Sarvesh
- Sapey Elizabeth
- Satia Imran
- Satkunam Karnan
- Scaffardi Anthony
- Scheele Kate
- Seaton Douglas
- Serlin Matthew
- Seymour John
- Shaheen Fizah
- Sharkey Emma
- Sharp Charles
- Sherrington Rebecca
- Shields Michael
- Shribman Jonathan
- Shrikrishna Dinesh
- Simon Ward
- Simonds Anita
- Simpson John
- Sloper Katherine
- Smith David
- Smith Peter
- Spencer Charlotte
- Spencer David
- Spiro Stephen
- Stableforth David
- Stanton Andrew
- Starren Elizabeth
- Steel Mark
- Steier Joerg
- Stern Myra
- Stewart Tara
- Stockley Robert
- Stocks Janet
- Stratford- Martin James
- Sturney Sharon
- Suh Eui-Sik
- Summers Geoffrey
- Sumner Helen
- Sutherland Tim
- Sylvester Karl
- Szram Joanna
- Tate Paul
- Taylor Amy
- Templeton-Wright Suzanne
- Thomas Ajit
- Thomas Angela
- Thomas Matt
- Thomson Fiona
- Thomson Neil
- Tilbrook Sean
- Timlett Amber
- Towns Rebecca
- Tracey Mathieson
- Treharne Jo
- Tunnicliffe Georgia
- Turner Sally
- Turner Steve
- Vaughan Sophie
- Voase Nia
- Walker Paul
- Walker Woolf
- Wallis Colin
- Walmsley Sandy
- Walters Nicola
- Ward Ann
- Ward Simon
- Warner John
- Warwick Geoffrey
- Watson John
- Wedzicha Wisia
- Wheatley Iain
- White John
- Whitfield Ruth
- Wicker Jacquelyne
- Wieboldt Jason
- Williams Ruth
- Williamson Kathryn
- Wilson Patrick
- Wilson Robert
- Winter Barbara
- Winter Robert
- Winter-Burke Alice
- Wood Fraser
- Wood Marion
- Woodcock Ashley
- Woodhead Mark
- Wooler Edwina
- Woolhouse Ian
- Wright Joanne
- Yasso Razouqi
- Zoumot Zaid
- Zurek Andrew
- Publication venue
- 'BMJ'
- Publication date
- 01/01/2013
- Field of study
The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer
- Author
- Aalfs Cora M.
- Adank Muriel A.
- Adenis Claude
- Adlard Julian
- Agata Simona
- Aghmesheh Morteza
- Agnarsson Bjarni A.
- Ahearn Thomas
- Aittomäki Kristiina
- Ambrosone Christine B.
- Amor David
- Andrews Lesley
- Andrulis Irene L.
- Antill Yoland
- Anton-Culver Hoda
- Antonenkova Natalia N.
- Antoniou Antonis C.
- Armitage Shane
- Arndt Volker
- Arnold Leanne
- Arnold Norbert
- Aronson Kristan J.
- Arun Banu K.
- Asseryanis Ella
- Auber Bernd
- Auvinen Päivi
- Azzollini Jacopo
- Balleine Rosemary
- Balmaña Judith
- Barkardottir Rosa B.
- Barnes Daniel R.
- Barouk-Simonet Emmanuelle
- Barrowdale Daniel
- Barwell Julian
- Bastick Patti
- Baurand Amandine
- Baxter Robert
- Beane Freeman Laura E.
- Beauparlant Charles Joly
- Beckmann Matthias W.
- Beesley Jonathan
- Behrens Sabine
- Beilby John
- Belotti Muriel
- Benitez Javier
- Bennett Ian
- Berger Raanan
- Bermisheva Marina
- Berthet Pascaline
- Bertolone Geoffrey
- Bertrand Ophélie
- Bignon Yves-Jean
- Birot Anne-Marie
- Blackburn Anneke
- Blanco Amie M.
- Blomqvist Carl
- Bogdanova Natalia V.
- Bogliolo Massimo
- Bogwitz Michael
- Bojesen Anders
- Bojesen Stig E.
- Bolla Manjeet K.
- Bonadona Valérie
- Bonanni Bernardo
- Bonnet Françoise
- Borg Ake
- Botes Leon
- Bourdon Violaine
- Boutry-Kryza Nadia
- Brady Angela F.
- Brauch Hiltrud
- Braye Stephen
- Brennan Meagan
- Brenner Hermann
- Bressac-de-Paillerets Brigitte
- Bronner Myriam
- Brown Melissa
- Brüning Thomas
- Bubien Virginie
- Buckley Michael
- Buecher Bruno
- Burgess Matthew
- Burke Jo
- Burwinkel Barbara
- Butow Phyllis
- Buys Saundra S.
- Bézieau Stéphane
- Cadoo Karen
- Caldon Liz
- Caldés Trinidad
- Caleca Laura
- Calender Alain
- Caliebe Almuth
- Caligo Maria A.
- Callen David
- Campa Daniele
- Campbell Ian G.
- Canzian Federico
- Caputo Sandrine
- Caron Olivier
- Carpenter Jane
- Castelao Jose E.
- Castera Laurent
- Catucci Irene
- Chang-Claude Jenny
- Chanock Stephen J.
- Chauhan Deepa
- Chauhan Manisha
- Chenevix-Trench Georgia
- Chiesa Jean
- Christian Alice
- Chung Wendy K.
- Claes Kathleen B. M.
- Clarke Christine L.
- Cohen Paul
- Colas Chrystelle
- Collavoli Anita
- Colley Alison
- Collonge-Rame Marie-Agnès
- Conner Thomas A.
- Coron Fanny
- Couch Fergus J.
- Coulet Florence
- Coupier Isabelle
- Cox David G.
- Crook Ashley
- Cui James
- Culling Bronwyn
- Cummings Margaret
- Cybulski Cezary
- Czene Kamila
- Dahlstrom Jane
- Daly Mary B.
- Damette Alexandre
- Dawson Sarah-Jane
- de la Hoya Miguel
- de Pauw Antoine
- DeFazio Anna
- Delatycki Martin
- Delnatte Capucine
- Dennis Joe
- Devilee Peter
- Dickson Rebecca
- Diez Orland
- Ding Yuan Chun
- Dite Gillian S.
- Ditsch Nina
- Dixon Joanne
- Dobrovic Alexander
- Domchek Susan M.
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- Shah Mitul
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- Tapper William J.
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- Thull Darcy L.
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- Troester Melissa A.
- Truong Thérèse
- Tucker Kathy
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- Untch Michael
- Vachon Celine M.
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- van Veen Elke M.
- Vaur Dominique
- Vega Ana
- Viel Alessandra
- Visvader Jane
- Vénat-Bouvet Laurence
- Walker Logan
- Wang Qin
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- Warcoin Mathilde
- Weitzel Jeffrey N.
- Wendt Camilla
- Wieme Greet
- Wilcken Nicholas
- Williams Rachael
- Winship Ingrid
- Wolk Alicja
- Yang Xiaohong R.
- Yip Desmond
- Young Mary Ann
- Zeps Nikolajs
- Zheng Wei
- Ziogas Argyrios
- Zorn Kristin K.
- Publication venue
- npj Breast Cancer
- Publication date
- 01/01/2019
- Field of study
Abstract: Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has been proposed as a breast cancer predisposition gene, with greater effects for the ER-negative and triple-negative breast cancer (TNBC) subtypes. We tested the three recurrent protein-truncating variants FANCM:p.Arg658*, p.Gln1701*, and p.Arg1931* for association with breast cancer risk in 67,112 cases, 53,766 controls, and 26,662 carriers of pathogenic variants of BRCA1 or BRCA2. These three variants were also studied functionally by measuring survival and chromosome fragility in FANCM−/− patient-derived immortalized fibroblasts treated with diepoxybutane or olaparib. We observed that FANCM:p.Arg658* was associated with increased risk of ER-negative disease and TNBC (OR = 2.44, P = 0.034 and OR = 3.79; P = 0.009, respectively). In a country-restricted analysis, we confirmed the associations detected for FANCM:p.Arg658* and found that also FANCM:p.Arg1931* was associated with ER-negative breast cancer risk (OR = 1.96; P = 0.006). The functional results indicated that all three variants were deleterious affecting cell survival and chromosome stability with FANCM:p.Arg658* causing more severe phenotypes. In conclusion, we confirmed that the two rare FANCM deleterious variants p.Arg658* and p.Arg1931* are risk factors for ER-negative and TNBC subtypes. Overall our data suggest that the effect of truncating variants on breast cancer risk may depend on their position in the gene. Cell sensitivity to olaparib exposure, identifies a possible therapeutic option to treat FANCM-associated tumors
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard Véronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
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- Ashcroft Kevin
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- Aslanidis Cara
- Asomugha Chinwe O.
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- Atkinson Andrea
- Atkinson Barry
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- Gench Stephanie L.
- Geng Jianing
- Georgescu Anca
- Geotina Amy
- Ghori Jilur
- Ghose Sayantan
- Gibbs Ben
- Gibbs Richard A.
- Gibson Diane
- Gibson Elizabeth
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- Gil Isaias
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- Golinveaux Kristen
- Gomez Maria
- Gong Guanghui
- Gong Jinying
- Gonzales Eidelyn
- Gonzalez Guillermo B.
- Gooderham April
- Goodstadt Leo
- Goodstein David
- Goodwin Lynne A.
- Gordon Catherine
- Gordon Laurie A.
- Gordon Seth
- Gorton Matthew
- Gorvad Ann
- Gould Christine
- Goyea Ernest
- Goyette Audra
- Grady Deborah I.
- Grady Michelle L.
- Grafham Darren
- Graham Joe
- Grandbois Edward
- Grant Jennifer
- Grant Michael
- Grant Susan
- Graves Tina A.
- Gray Bruce
- Gray Emma
- Gray Lain
- Green Lisa
- Greenhalgh James
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- Gregg Philippa
- Gregory Simon
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- Gribble Susan
- Griffith Jeffrey K.
- Griffiths Coline
- Griffiths Ed
- Griffiths Mark
- Griffiths-Jones Sam
- Grigoriev Igor
- Grimwood Jane
- Grocock Russell
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- Gu Jingli
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- Gu Wenyi
- Gu Wenyi
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- Guel Metzalli
- Guerra William
- Guevara Whitney V.
- Gui Qi
- Gunaratne Preethi
- Gunning Kate
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- Gustafson Erik
- Guthrie Ian
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- Hamilton Matt
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- Hamlett John
- Hammon Nancy
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- Hammond Sha
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- Hamza Khalid
- Han Guiqing
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- Hanak Vincent A.
- Hancock Julie
- Harbes Brandy A.
- Harding Adam
- Harkins C. Richard
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- Heyen Joshua
- Higgs Douglas
- Hildebrand Carl E.
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- Hillyard Guy
- Hines Sandra
- Hinkins Russell
- Hinrichs Angela S.
- Hitchens Matthew Edward
- Ho Issac
- Ho Sara-Jane
- Hodgson Anne V.
- Hodgson David
- Hoffman Susan M.G.
- Hoffs Michael
- Hogues Marilyn E.
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- Hynds Christopher
- Idlebird Devincent G.
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- Imbro Paula
- Imo Kelvin C.
- Inacio Nicole
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- Ince Michael
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- Ishibashi Akiko
- Ishikawa Sabine K.
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- Jaeger Sara
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- Jia Jia
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- Kosiura Anna
- Kou Zhaohui
- Kovar Christie L.
- Krawczyk Marie-Claude
- Kremitzki Colin
- Kremmidiotis Gabriel
- Krogh Anders
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- Kruchowski Scott S.
- Kube Michael
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- Lorensuhewa Lorna M.
- Lou Yunian
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- Lowenstein Michael G.
- Lowry Stephen
- Lozado Ryan J.
- Lu Lingfeng
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- Madabhushi Ramki
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- Marra Marco
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- McLeod Michael P.
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- McMurray Kimberly
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- McPherson John
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- Meidi Patrick
- Meier Elke
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- Meng Shanshan
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- Mercado Christian
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- Mercado Iracema C.
- Mercer Simon
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- Mesirov Jill P.
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- Munidasa Mala
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- Murayama Yuji
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- Nair Seema R.
- Naka Maho
- Nakagawa Masayo
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- Nazareth Lynne V.
- Neal Dearl D.
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- Nwaokelemeh Ogechi O.
- Nwokenkwo Stanley
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- O\u27Donovan Daniel
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- Pasternak Shiran
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- Patel Vishal V.
- Patrick James
- Paul Heidie A.
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- Perez Agapito
- Perez Lesette M.
- Perito Andrew
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- Quiles Miyo M.
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- Radionenko Maxim
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- Ridler Kerry
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- Yun Rui
- Zainoun Joanne
- Zembeck Lisa
- Zeng Yixin
- Zhai Dong
- Zhan Guoping
- Zhang Bo
- Zhang Caimin
- Zhang Fengmei
- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Genetic mechanisms of critical illness in COVID-19.
- Author
- A A Roger Thompson
- A Abraheem
- A Agasou
- A Ahmed
- A Ali
- A Allan
- A Altabaibeh
- A Alvaro
- A Aspinwall
- A Ayers
- A Bamford
- A Barron
- A Bashyal
- A Bellini
- A Bociek
- A Botello
- A Bowes
- A Brady
- A Brayne
- A Brown
- A Brown
- A Butler
- A Campbell
- A Carter
- A Collins
- A Cowley
- A Cowton
- A Cowton
- A Cox
- A Crew
- A Dance
- A Daniel
- A Daniels
- A Dela Rosa
- A Drummond
- A Durie
- A E Heron
- A Easthope
- A Easthope
- A Evans
- A Fofano
- A Gales
- A Ganesan
- A Gardner
- A Garg
- A Gherman
- A Gordon
- A Gratrix
- A Gulati
- A Gupta
- A Haigh
- A Haldeos
- A Harrison
- A Harvey
- A Hayes
- A Higham
- A Higham
- A Hilldrith
- A Holden
- A Hormis
- A Hutcheon
- A Javaid
- A Joseph
- A Kaliappan
- A Katary
- A Kay
- A Kayani
- A Kent
- A Kirkby
- A Knight
- A Kubisz-Pudelko
- A Kuravi
- A Lewis
- A Loveridge
- A Lyle
- A Mayer
- A McAlpine
- A McCarthy
- A McGregor
- A McGregor
- A Meikle
- A Mitchell
- A Mitra
- A Morris
- A Morrison
- A Naranjo
- A Nicholson
- A Nicholson
- A Nilsson
- A Noakes
- A Patel
- A Pickard
- A Poole
- A Price
- A Puxty
- A Quinn
- A Quinn
- A Raithatha
- A Rattray
- A Reddy
- A Reed
- A Reyes
- A Rose
- A Rose
- A Rostron
- A Roy
- A Roynon-Reed
- A S Raj
- A Salberg
- A Sanderson
- A Serrano-Ruiz
- A Solesbury
- A Sukha
- A Swain
- A Tariq
- A Thomas
- A Thomas
- A Todd
- A Tomas
- A Tridente
- A Tucci
- A Turnbull
- A Uriel
- A Ustianowski
- A Vochin
- A Vuylsteke
- A Waite
- A Walden
- A Whileman
- A Wilkinson
- A Williams
- A Williams
- A Wilson
- A Zak
- A Zaki
- Achille Iolascon
- Adam Auton
- Adam Brown
- Agnese Verzuri
- Agostino Ognibene
- Agostino Riva
- Ailsa Golightly
- Alan Maclean
- Alessandra
- Alessandra Stella
- Alessandra Vergori
- Alessia Giorli
- Alexander J Mentzer
- Alice Donati
- Alison M Meynert
- Alistair Nichol
- Ana da Silva Filipe
- Andrea Antinori
- Andrea Cossarizza
- Andrea Ganna
- Andrea Tommasi
- Andrew Rambaut
- Andrew Stenhouse
- Andy Law
- Anjali J Shastri
- Anna Canaccini
- Anna Maria Pinto
- Annarita Giliberti
- Annemarie B Docherty
- Antonella D'Arminio Monforte
- Antonia Ying Wai Ho
- Antonio Di Biagio
- Antony Symons
- Arianna Emiliozzi
- Arianna Gabrieli
- Audrey Coutts
- B Anwar
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- B Borislavova
- B Chandler
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- B Winter-Goodwin
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- Baillie J Kenneth
- Barbara Rossetti
- Beale Rupert
- Beatrice Alex
- Benjamin Bach
- Bretherick Andrew D
- Bruno Frediani
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- E Smith
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- E Stoddard
- E Stones
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- S Kimber
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- S Sathe
- S Selvanayagam
- S Shelton
- S Shepardson
- S Siddiqui
- S Smuts
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- S Spencer
- S Srikaran
- S Stone
- S Swann
- S Tilbey
- S Turki
- S Turney
- S Twiss
- S Wadd
- S Whiteley
- S Williams
- S Wood
- S Yussuf
- Sabino Scolletta
- Samreen Ijaz
- Sandro Mancarella
- Sandro Panese
- Sara Amitrano
- Sara McDonald
- Sarah Law
- Sarah McCafferty
- Saverio Giuseppe Parisi
- Saye Khoo
- Scott Richard
- Semple Malcolm G
- Serafina Valente
- Serena Ludovisi
- Sergio Daga
- Seán Keating
- Shankar-Hari Manu
- Shen Xia
- Shih Barbara
- Shiranee Sriskandan
- Shona C Moore
- Silvia Cappelli
- Simona Marcantonio
- Simone Furini
- Sophie Halpin
- Sophie Venturelli
- Stefania Mantovani
- Stefano Baratti
- Stefano Ceri
- Stefano Rusconi
- Stella Aslibekyan
- Stephanie Roberts
- Stephen R Knight
- Summers Charlotte
- Susanna Croci
- Susanna Guerrini
- T Anderson
- T Arden
- T Baird
- T Behan
- T Bemand
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- T Kannan
- T Lawton
- T Marsden
- T Martin
- T McHugh
- T Newman
- T Nortcliffe
- T O Jones
- T Pogreban
- T Rees
- T Samakomva
- T Smith
- T Smith
- T Szakmany
- T Varghes
- T Williams
- T Wood
- Tammy Gilchrist
- Tenesa Albert
- Teresa Filshtein-Sonmez
- Thomas M Drake
- Thushan de Silva
- Tim Walsh
- Tom Fletcher
- Tom Solomon
- Tony Wackett
- Trevor Paterson
- Tullio Trotta
- Turtle Lance
- U Poultney
- V Amin
- V Anumakonda
- V Bastion
- V Cannons
- V Crickmore
- V Gopal
- V Irvine
- V Kasipandian
- V Krishnamurthy
- V Lake
- V Linnett
- V Martinson
- V Nagarajan
- V Page
- V Parris
- V Parris
- V Pristopan
- V Ratnam
- V Rivers
- V Sarathy
- V Thomas
- V Thwaites
- V Tuckey
- V Turner
- V Wagstaff
- V Waugh
- Valentina Anemoli
- Vanessa Sancho-Shimizu
- Victoria Shaw
- Vitart Veronique
- W Harrison
- W Khaliq
- W Khaliq
- W McCormick
- W Woodyatt
- Walker Susan
- Walsh Timothy
- Wang Bo
- Wei Shen Lim
- Wendy S Barclay
- William A Paxton
- William Greenhalf
- Wilson James F
- Wrobel Nicola
- Wu Yang
- X Qiu
- Y Baird
- Y Choudhury
- Y Hussain
- Y Jackson
- Y Thirlwall
- Yang Jian
- Yang Zhijian
- Z Alldis
- Z Belagodu
- Z Bradshaw
- Z Coton
- Z Daly
- Z Farzad
- Z Fernandez
- Z Garland
- Z Maqsood
- Z Omar
- Z Prime
- Z Scott
- Zechner Marie
- Zhai Ranran
- Zheng Chenqing
- Publication venue
- Nature
- Publication date
- 01/01/2020
- Field of study
Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 × 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, P = 2.3 × 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, P = 3.98 × 10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, P = 4.99 × 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice
Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults
- Author
- Abbas Rezaianzadeh
- Abdonas Tamosiunas
- Abdul Basit
- Abdul Hamid Zargar
- Abdullah Alkandari
- Abdullatif Husseini
- Abhijit Sen
- Abla M Sibai
- Abu Am Hanif
- Adela Chirita-Emandi
- Adelheid Weber
- Adetoyeje Y Oyeyemi
- Adewale L Oyeyemi
- Adolfo Rubinstein
- Adoubi Kassi Anicet
- Adroaldo Cesar Araujo Gaya
- Afshin Ostovar
- Agnes L Kadvan
- Agneta Sjöberg
- Agneta Yngve
- Agnès Le Port
- Agustinus Soemantri
- Agustín Perez-Londoño
- Ahmad A Zainuddin
- Ahmad Faudzi Yusoff
- Ahmad Reza Dorosty
- Ahmed A Madar
- Aida Pilav
- Aïcha Soumaré
- Akaninyene Otu
- Akihiro Yoshihara
- Akkumis Salhanova
- Akram Pourshams
- Ala'a Alkerwi
- Alain Morejon
- Alanna G da Silva
- Albertino Damasceno
- Alberto Barceló
- Alberto Palloni
- Albina A Fakhretdinova
- Alejandro Diaz
- Aleksander Giwercman
- Aleksandra Gomula
- Aleksandra Piwonska
- Alessandro Gialluisi
- Aletta E Schutte
- Alexander D Deev
- Alexandra M Cucu
- Alexandre C Pereira
- Alfonso Siani
- Alfonso Sousa-Poza
- Ali Ahmadi
- Ali Akbar Shayesteh
- Ali Esmaeili
- Ali Ghanbari
- Ali Reza Safarpour
- Alice Bonilla-Vargas
- Alicia Matijasevich
- Alina G Platonova
- Alina Kerimkulova
- Aline Meirhaeghe
- Aline P Batista
- Alireza Ansari-Moghaddam
- Alireza Khosravi
- Alireza Moslem
- Alireza Sadjadi
- Alisha N Wade
- Alison J Hayes
- Alison J Price
- Allan G Hill
- Allan Linneberg
- Almaz Sharman
- Altan Onat
- Aluisio Jd Barros
- Alun Evans
- Amalia De Curtis
- Amanda G Thrift
- Amanda J Cross
- Amaneh Shayanrad
- Ambady Ramachandran
- Amelia C Crampin
- Amina Barkat
- Amir Houshang Mehrparvar
- Amirabbas Momenan
- Ana Azevedo
- Ana B Crujeiras
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- María José García Mérida
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- Vanessa Rouzier
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- Vasiliki Efthymiou
- Vassilis Zafiropulos
- Vayia Rarra
- Vedrana Sember
- Veikko Salomaa
- Vera Lanska
- Vera Musil
- Veronica Mocanu
- Vesna Juresa
- Vesselka L Duleva
- Victor M Herrera
- Victor Matsudo
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- Viviana Guajardo
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- Vladimir Kutsenko
- Wafaie W Fawzi
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- Wan Nazaimoon Wan Mohamud
- Wei Zheng
- Wei-Cheng Lo
- Wei-Yen Lim
- Weili Yan
- Wen-Harn Pan
- Wenbin Wei
- Wendy Van Lippevelde
- Wenhua Zhao
- Wichai Aekplakorn
- Willem A Hanekom
- William A Neal
- William R Tebar
- Wilma M Hopman
- Winsome R Parnell
- Wm Monique Verschuren
- Wojciech Drygas
- Wojciech Rusek
- Wolfgang Ahrens
- Wolfgang Kratzer
- Xenophon Theodoridis
- Xiangjun Wang
- Xiaoguang Yang
- Xiaotian Liu
- Ximena Berrios Carrasola
- Xinyi Gwee
- Xiu-Hua Guo
- Xu Lin
- Xu Ma
- Xueling Sim
- Xun Tang
- Ya Xing Wang
- Yadlapalli S Kusuma
- Yajaira Briceño
- Yang Yang
- Yanhui Dong
- Yanina Zocalo
- Yanitsa V Zhecheva
- Yannis Manios
- Yanping Li
- Yemane Berhane
- Yeunsook Rho
- Yeva Movsesyan
- Yi Song
- Yi Zeng
- Yih Chung Tham
- Yiling J Cheng
- Yin Guo
- Ying-Wei Wang
- Yingfeng Zheng
- Yn-Tz Sung
- Yong Tao
- Yonghua Hu
- Yosef Farzi
- Yoto Yotov
- Youcef Laid
- Young-Ho Khang
- Yousef Saleh Khader
- Yu-Ling Yu
- Yuan He
- Yufang Bi
- Yuki Fujita
- Yulia Balanova
- Yuliya V Solovieva
- Yuna He
- Yunjiang Yu
- Yury P Nikitin
- Yves Kameli
- Yves Martin-Prevel
- Yvonne T van der Schouw
- Zahra Mohammadi
- Zbigniew Gaciong
- Zbigniew Kulaga
- Zengchang Pang
- Zhamilya Battakova
- Zhamyila Usupova
- Zhanna Kalmatayeva
- Zhen-Yu Zhang
- Zhengming Chen
- Ziad A Abdeen
- Zivka Dika
- Zlatko Fras
- Zulfiqar A Bhutta
- Zulfiya Abdurrahmonova
- Zumin Shi
- Łukasz Kryst
- Publication venue
- Publication date
- 01/03/2024
- Field of study
Background Underweight and obesity are associated with adverse health outcomes throughout the life course. We
estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from
1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories.
Methods We used data from 3663 population-based studies with 222 million participants that measured height and
weight in representative samples of the general population. We used a Bayesian hierarchical model to estimate
trends in the prevalence of different BMI categories, separately for adults (age ≥20 years) and school-aged children
and adolescents (age 5–19 years), from 1990 to 2022 for 200 countries and territories. For adults, we report the
individual and combined prevalence of underweight (BMI <18·5 kg/m2) and obesity (BMI ≥30 kg/m2). For schoolaged children and adolescents, we report thinness (BMI <2 SD below the median of the WHO growth reference)
and obesity (BMI >2 SD above the median).
Findings From 1990 to 2022, the combined prevalence of underweight and obesity in adults decreased in
11 countries (6%) for women and 17 (9%) for men with a posterior probability of at least 0·80 that the observed
changes were true decreases. The combined prevalence increased in 162 countries (81%) for women and
140 countries (70%) for men with a posterior probability of at least 0·80. In 2022, the combined prevalence of
underweight and obesity was highest in island nations in the Caribbean and Polynesia and Micronesia, and
countries in the Middle East and north Africa. Obesity prevalence was higher than underweight with posterior
probability of at least 0·80 in 177 countries (89%) for women and 145 (73%) for men in 2022, whereas the converse
was true in 16 countries (8%) for women, and 39 (20%) for men. From 1990 to 2022, the combined prevalence of
thinness and obesity decreased among girls in five countries (3%) and among boys in 15 countries (8%) with a
posterior probability of at least 0·80, and increased among girls in 140 countries (70%) and boys in 137 countries (69%)
with a posterior probability of at least 0·80. The countries with highest combined prevalence of thinness and
obesity in school-aged children and adolescents in 2022 were in Polynesia and Micronesia and the Caribbean for
both sexes, and Chile and Qatar for boys. Combined prevalence was also high in some countries in south Asia, such
as India and Pakistan, where thinness remained prevalent despite having declined. In 2022, obesity in school-aged
children and adolescents was more prevalent than thinness with a posterior probability of at least 0·80 among girls
in 133 countries (67%) and boys in 125 countries (63%), whereas the converse was true in 35 countries (18%) and
42 countries (21%), respectively. In almost all countries for both adults and school-aged children and adolescents,
the increases in double burden were driven by increases in obesity, and decreases in double burden by declining
underweight or thinness.
Interpretation The combined burden of underweight and obesity has increased in most countries, driven by an
increase in obesity, while underweight and thinness remain prevalent in south Asia and parts of Africa. A healthy
nutrition transition that enhances access to nutritious foods is needed to address the remaining burden of
underweight while curbing and reversing the increase in obesit
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