Transcription specificity of Xenopus laevis RNA polymerase A

Based on a combination of an Ugi four component reaction and a ring closing metathesis, a library of novel artificial macrocyclic inhibitors of the p53-MDM2 interaction was designed and synthesized. These macrocycles, alternatively to stapled peptides, target for the first time the large hydrophobic surface area formed by Tyr67, Gln72, His73, Val93, and Lys94 yielding derivatives with affinity to MDM2 in the nanomolar range. Their binding affinity with MDM2 was evaluated using fluorescence polarization (FP) assay and 1H-15N two-dimensional HSQC nuclear magnetic resonance experiments

Design of strapdown gyroscopes for a dynamic environment Semiannual report, 1 Dec. 1968 - 31 May 1969

Strapdown gyros which employ time modulation torquing techniqu

Epiphenomenalism for Functionalists

This chapter focuses on an assumption implicitly made by most recent attempts to solve the exclusion problem for mental causation, that mental (and so multiply realized) properties are ‘distinct existences’ from their alleged effects. Without that assumption, no such solution can work, since we have excellent grounds for thinking that there is no causation between entities that are not distinct from one another. But, assuming functionalism—which, after all, constitutes the grounds for thinking that mental properties are multiply realized in the first place—mental properties are not distinct from the effects to which they are alleged to bear causal relevance, since functional properties are defined in terms of the causal roles of their realizers. The chapter argues, however, that the natural consequence—epiphenomenalism with respect to mental properties—is not as problematic as many philosophers tend to assume

Necessary Connections and the Problem of Induction

In this paper Beebee argues that the problem of induction, which she describes as a genuine sceptical problem, is the same for Humeans than for Necessitarians. Neither scientific essentialists nor Armstrong can solve the problem of induction by appealing to IBE, for both arguments take an illicit inductive step