Numerical evaluation of multiple polylogarithms

Multiple polylogarithms appear in analytic calculations of higher order corrections in quantum field theory. In this article we study the numerical evaluation of multiple polylogarithms. We provide algorithms, which allow the evaluation for arbitrary complex arguments and without any restriction on the weight. We have implemented these algorithms with arbitrary precision arithmetic in C++ within the GiNaC framework.Comment: 23 page

Scattering amplitudes for e^+e^- --> 3 jets at next-to-next-to-leading order QCD

We present the calculation of the fermionic contribution to the QCD two-loop amplitude for e^+e^- --> q qbar g.Comment: 5 pages, 4 figures, espcrc2.sty (included), Talk given at QCD '02, Montpellier, France, 2-9th July 200

Subtraction terms for one-loop amplitudes with one unresolved parton

Fully differential next-to-next-to-leading order calculations require a method to cancel infrared singularities. In a previous publication, I discussed the general setup for the subtraction method at NNLO. In this paper I give all subtraction terms for electron-positron annihilation associated with one-loop amplitudes with one unresolved parton. These subtraction terms are integrated within dimensional regularization over the unresolved one-particle phase space. The results can be used with all variants of dimensional regularization (conventional dimensional regularization, the 't Hooft-Veltman scheme and the four-dimensional scheme).Comment: 27 page

The use of routine outcome measures in two child and adolescent mental health services: a completed audit cycle

Background: Routine outcome measurement (ROM) is important for assessing the clinical effectiveness of health services and for monitoring patient outcomes. Within Child and Adolescent Mental Health Services (CAMHS) in the UK the adoption of ROM in CAMHS has been supported by both national and local initiatives (such as government strategies, local commissioning policy, and research). Methods: With the aim of assessing how these policies and initiatives may have influenced the uptake of ROM within two different CAMHS we report the findings of two case-note audits: a baseline audit conducted in January 2011 and a re-audit conducted two years later in December 2012-February 2013. Results: The findings show an increase in both the single and repeated use of outcome measures from the time of the original audit, with repeated use (baseline and follow-up) of the Health of the Nation Outcome Scale for Children and Adolescents (HoNOSCA) scale increasing from 10% to 50% of cases. Re-audited case-notes contained more combined use of different outcome measures, with greater consensus on which measures to use. Outcome measures that were applicable across a wide range of clinical conditions were more likely to be used than symptom-specific measures, and measures that were completed by the clinician were found more often than measures completed by the service user. Conclusions: The findings show a substantial improvement in the use of outcome measures within CAMHS. These increases in use were found across different service organisations which were subject to different types of local service priorities and drivers

Two-loop amplitudes with nested sums: Fermionic contributions to e+ e- --> q qbar g

We present the calculation of the nf-contributions to the two-loop amplitude for e+ e- --> q qbar g and give results for the full one-loop amplitude to order eps^2 in the dimensional regularization parameter. Our results agree with those recently obtained by Garland et al.. The calculation makes extensive use of an efficient method based on nested sums to calculate two-loop integrals with arbitrary powers of the propagators. The use of nested sums leads in a natural way to multiple polylogarithms with simple arguments, which allow a straightforward analytic continuation.Comment: 31 pages, a file "coefficients.h" with the results in FORM format is include

NNLO soft function for electroweak boson production at large transverse momentum

The soft function relevant for the production of an electroweak boson (photon, W, Z or H) with large transverse momentum at a hadron collider is computed at next-to-next-to-leading order. This is the first two-loop computation of a soft function involving three light-cone directions. With the result, the threshold resummation for these processes can now be performed at next-to-next-to-next-to-leading logarithmic accuracy.Comment: 16 pages, 3 figure

Identifying core features of adaptive metabolic mechanisms for chronic heat stress attenuation contributing to systems robustness

The contribution of metabolism to heat stress may play a significant role in defining robustness and recovery of systems; either by providing the energy and metabolites required for cellular homeostasis, or through the generation of protective osmolytes. However, the mechanisms by which heat stress attenuation could be adapted through metabolic processes as a stabilizing strategy against thermal stress are still largely unclear. We address this issue through metabolomic and transcriptomic profiles for populations along a thermal cline where two seagrass species, Zostera marina and Zostera noltii, were found in close proximity. Significant changes captured by these profile comparisons could be detected, with a larger response magnitude observed in northern populations to heat stress. Sucrose, fructose, and myo-inositol were identified to be the most responsive of the 29 analyzed organic metabolites. Many key enzymes in the Calvin cycle, glycolysis and pentose phosphate pathways also showed significant differential expression. The reported comparison suggests that adaptive mechanisms are involved through metabolic pathways to dampen the impacts of heat stress, and interactions between the metabolome and proteome should be further investigated in systems biology to understand robust design features against abiotic stress

Investigating a cluster of vulvar cancer in young women: a cross-sectional study of genital human papillomavirus prevalence

The electronic version of this article is the complete one and can be found online at: http://www.biomedcentral.com/1471-2334/12/243 Extent: 8p.Background: Vulvar cancer is a relatively rare malignancy, which occurs most often in postmenopausal women. We have previously identified a geographic cluster of vulvar cancer in young Indigenous women living in remote communities in the Arnhem Land region of Australia. In this population, we investigated the prevalence of oncogenic human papillomavirus (HPV) infection in anogenital samples (vulvar/vaginal/perianal area and cervix) and compared the overall, type-specific and multiple infection prevalence between sites. Methods: A cross-sectional survey of 551 Indigenous women aged 18–60 years was undertaken in 9 Arnhem Land communities. Women were consented for HPV detection and genotyping collected by a combined vulvar/vaginal/perianal (VVP) sweep swab and a separate PreservCyt endocervical sample collected during Pap cytology screening. HPV DNA testing was undertaken using PCR with broad spectrum L1 consensus PGMY09/11 primers with genotyping of positive samples by Roche Linear Array. The primary outcomes were the prevalence of cervical and VVP high-risk (HR) HPV. Results: The prevalence of VVP HR-HPV was 39%, which was significantly higher than the cervical HR-HPV prevalence (26%, p<0.0001). HPV-16 was the most common genotype detected in both sites (VVP 11%, cervical 6%). HPV-16 infection peaked in women aged <20 years; however, there was a marked decline in cervical HPV-16 prevalence with age (p=0.007), whereas following an initial decline, the prevalence of VVP HPV-16 remained constant in subsequent age-groups (p=0.835). Conclusions: In this population experiencing a cluster of vulvar cancer, the prevalence of cervical oncogenic HPV infection was similar to that reported by studies of other Australian women; however there was a significantly higher prevalence of vulvar/vaginal/perianal infection to cervical. The large discrepancy in HPV prevalence between anogenital sites in this population may represent more persistent infection at the vulva. This needs further investigation, including the presence of possible environmental and/or genetic factors that may impair host immunity.Alice R Rumbold, Sarah E Tan, John R Condon, Debbie Taylor-Thomson, Maria Nickels, Sepehr N Tabrizi, Margaret LJ Davy, Margaret M O’Brien, Christine M Connors, Ibrahim Zardawi, Jim Stankovich and Suzanne M Garlan