Closed geodesics on pairs of pants

We study the non-simple closed geodesics of the Riemann surfaces of signature (0, 3). In the aim of classifying them, we define one parameter: the number of strings. We show that for a given number of strings, a minimal geodesic exists; we then give its representation and its length which depends on the boundary geodesic

Control Modules for Scintillation Counters in the SPS Experimental Areas

The hardware used in the SPS Experimental Areas to control the beam instrumentation electronics and mechanics of the particle detectors is based on CAMAC and NIM modules. The maintenance of this hardware now presents very serious problems. The modules used to operate the Experimental Areas are numerous and older than 20 years so many of them cannot be repaired any more and CAMAC is no longer well supported by industry. The fast evolution of technology and a better understanding of the detectors allow a new equipment-oriented approach, which is more favourable for maintenance purposes and presents fewer data handling problems. VME and IP Modules were selected as standard components to implement the new electronics to control and read out the particle detectors. The first application implemented in this way concerns the instrumentation for the Scintillation Counters (formerly referred to as triggers). The fundamental options and the design features will be presented

Systemic inflammatory profile and response to anti-tumor necrosis factor therapy in chronic obstructive pulmonary disease

<p>Abstract</p> <p>Background</p> <p>Chronic obstructive pulmonary disease (COPD) is characterized by progressive worsening of airflow limitation associated with abnormally inflamed airways in older smokers. Despite correlative evidence for a role for tumor necrosis factor-alpha in the pathogenesis of COPD, the anti-tumor necrosis factor-alpha, infliximab did not show clinical efficacy in a double-blind, placebo-controlled, phase II clinical trial. This study sought to evaluate the systemic inflammatory profile associated with COPD and to assess the impact of tumor necrosis factor neutralization on systemic inflammation.</p> <p>Methods</p> <p>Serum samples (n = 234) from the phase II trial were collected at baseline and after 24 weeks of placebo or infliximab. Additionally, baseline serum samples were obtained from an independent COPD cohort (n = 160) and 2 healthy control cohorts (n = 50; n = 109). Serum concentrations of a broad panel of inflammation-associated analytes were measured using a 92-analyte multiplex assay.</p> <p>Results</p> <p>Twenty-five proteins were significantly elevated and 2 were decreased in COPD, including highly elevated CD40 ligand, brain-derived neurotrophic factor, epidermal growth factor, acute-phase proteins, and neutrophil-associated proteins. This profile was largely independent of smoking status, age, and clinical phenotype. The majority of these associations of serum analytes with COPD are novel findings. Increased serum creatine kinase-muscle/brain and myoglobin correlated modestly with decreased forced expiratory volume at 1 second, suggesting cardiac involvement. Infliximab did not affect this systemic inflammatory profile.</p> <p>Conclusions</p> <p>A robust systemic inflammatory profile was associated with COPD. This profile was generally independent of disease severity. Because anti-tumor necrosis factor-alpha did not influence systemic inflammation, how to control the underlying pathology beyond symptom suppression remains unclear.</p> <p>Trial Registration</p> <p>ClinicalTrials.gov, <it>No</it>.: <a href="http://www.clinicaltrials.gov/ct2/show/NCT00056264">NCT00056264</a>.</p

I_MDS: an inflammatory bowel disease molecular activity score to classify patients with differing disease-driving pathways and therapeutic response to anti-TNF treatment

Crohn's disease and ulcerative colitis are driven by both common and distinct underlying mechanisms of pathobiology. Both diseases, exhibit heterogeneity underscored by the variable clinical responses to therapeutic interventions. We aimed to identify disease-driving pathways and classify individuals into subpopulations that differ in their pathobiology and response to treatment. We applied hierarchical clustering of enrichment scores derived from gene set variation analysis of signatures representative of various immunological processes and activated cell types, to a colonic biopsy dataset that included healthy volunteers, Crohn's disease and ulcerative colitis patients. Patient stratification at baseline or after anti-TNF treatment in clinical responders and non-responders was queried. Signatures with significantly different enrichment scores were identified using a general linear model. Comparisons to healthy controls were made at baseline in all participants and then separately in responders and non-responders. Fifty-nine percent of the signatures were commonly enriched in both conditions at baseline, supporting the notion of a disease continuum within ulcerative colitis and Crohn's disease. Signatures included T cells, macrophages, neutrophil activation and poly:IC signatures, representing acute inflammation and a complex mix of potential disease-driving biology. Collectively, identification of significantly enriched signatures allowed establishment of an inflammatory bowel disease molecular activity score which uses biopsy transcriptomics as a surrogate marker to accurately track disease severity. This score separated diseased from healthy samples, enabled discrimination of clinical responders and non-responders at baseline with 100% specificity and 78.8% sensitivity, and was validated in an independent data set that showed comparable classification. Comparing responders and non-responders separately at baseline to controls, 43% and 70% of signatures were enriched, respectively, suggesting greater molecular dysregulation in TNF non-responders at baseline. This methodological approach could facilitate better targeted design of clinical studies to test therapeutics, concentrating on patient subsets sharing similar underlying pathobiology, therefore increasing the likelihood of clinical response

Inner Size of a Dust Torus in the Seyfert 1 Galaxy NGC 4151

The most intense monitoring observations yet made were carried out on the Seyfert 1 galaxy NGC 4151 in the optical and near-infrared wave-bands. A lag from the optical light curve to the near-infrared light curve was measured. The lag-time between the V and K light curves at the flux minimum in 2001 was precisely 48+2-3 days, as determined by a cross-correlation analysis. The correlation between the optical luminosity of an active galactic nucleus (AGN) and the lag-time between the UV/optical and the near-infrared light curves is presented for NGC 4151 in combination with previous lag-time measurements of NGC 4151 and other AGNs in the literature. This correlation is interpreted as thermal dust reverberation in an AGN, where the near-infrared emission from an AGN is expected to be the thermal re-radiation from hot dust surrounding the central engine at a radius where the temperature equals to that of the dust sublimation temperature. We find that the inner radius of the dust torus in NGC 4151 is $\sim$ 0.04 pc corresponding to the measured lag-time, well outside the broad line region (BLR) determined by other reverberation studies of the emission lines.Comment: Accepted for publication in ApJ Letters, 13 pages, 3 figures; Corrected typo

Long-term IR Photometry of Seyferts

Long-term (up to 10000d) monitoring has been undertaken for 41 Seyferts in the near-IR (JHKL). All but 2 showed variability, with K ampl in the range <0.1 to > 1.1 mags. The timescale for detectable change is from about one week to a few years. A simple cross-correlation study shows evidence for delays of up to several hundred days between the variations seen at the shortest wavelengths and the longest in many galaxies. In particular, the data for F9 now extend to twice the interval covered earlier and the delay between its UV and IR outputs persists. An analysis of the fluxes shows that, for any given galaxy, the colours of the variable component are usually independent of the level of activity. The state of activity can be parameterized. Taken over the whole sample, the colours of the variable components fall within moderately narrowly defined ranges. In particular, the H-K colour is appropriate to a black body of temperature 1600K. The H-K excess for a heavily reddened nucleus can be determined and used to find E_{B-V}, which can be compared to the values found from the visible region broad line fluxes. Using flux-flux diagrams, the flux within the aperture from the underlying galaxy can often be determined without the need for model surface brightness profiles. In many galaxies it is apparent that here must be an additional constant contribution from warm dust.Comment: Better quality available from ftp://ftp.saao.ac.za/pub/isg/seyf.pd

A transcriptome-driven analysis of epithelial brushings and bronchial biopsies to define asthma phenotypes in U-BIOPRED

RATIONALE AND OBJECTIVES: Asthma is a heterogeneous disease driven by diverse immunologic and inflammatory mechanisms. We used transcriptomic profiling of airway tissues to help define asthma phenotypes. METHODS: The transcriptome from bronchial biopsies and epithelial brushings of 107 moderate-to-severe asthmatics were annotated by gene-set variation analysis (GSVA) using 42 gene-signatures relevant to asthma, inflammation and immune function. Topological data analysis (TDA) of clinical and histological data was used to derive clusters and the nearest shrunken centroid algorithm used for signature refinement. RESULTS: 9 GSVA signatures expressed in bronchial biopsies and airway epithelial brushings distinguished two distinct asthma subtypes associated with high expression of T-helper type 2 (Th-2) cytokines and lack of corticosteroid response (Group 1 and Group 3). Group 1 had the highest submucosal eosinophils, high exhaled nitric oxide (FeNO) levels, exacerbation rates and oral corticosteroid (OCS) use whilst Group 3 patients showed the highest levels of sputum eosinophils and had a high BMI. In contrast, Group 2 and Group 4 patients had an 86% and 64% probability of having non-eosinophilic inflammation. Using machine-learning tools, we describe an inference scheme using the currently-available inflammatory biomarkers sputum eosinophilia and exhaled nitric oxide levels along with OCS use that could predict the subtypes of gene expression within bronchial biopsies and epithelial cells with good sensitivity and specificity. CONCLUSION: This analysis demonstrates the usefulness of a transcriptomic-driven approach to phenotyping that segments patients who may benefit the most from specific agents that target Th2-mediated inflammation and/or corticosteroid insensitivity

VLT diffraction-limited imaging at 11 and 18 micron of the nearest active galactic nuclei

Mid-infrared imaging at resolutions of 300 mas of the central kpc region of 13 nearby, well-known active galaxies is presented. The bulk of the mid-IR emission is concentrated on an unresolved central source within a size of less than 5 to 130 pc, depending on the object distance. Further resolved emission is detected in 70% of the sample in the form of circumnuclear star-forming rings or diffuse nuclear extended emission. In the three cases with circumnuclear star formation, the stellar contribution is at least as important as that of the AGN. In those with extended nuclear emission -- a third of the sample -- this emission represents a few per cent of the total measured; however, this contribution may be underestimated because of the chopped nature of these observations. This extended emission is generally collimated in a preferential direction often coinciding with that of the extended ionized gas or the jet. In all cases, the nuclear fluxes measured at 11.8 and 18.7 micron represent a minor contribution of the flux levels measured by large aperture IRAS data at the nearest energy bands of 12 and 25 micron. This contribution ranges from 30% to less than 10%. In only three cases do the AGN fluxes agree with IRAS to within a factor of 2. In the AGNs with strong circumnuclear star formation, this component can well account for most of the IRAS flux measured in these objects. But in all other cases, either a low surface brightness component extending over galactic scales or strong extra-nuclear IR sources -- e.g. HII regions in spiral arms -- have to be the main source of the IRAS emission. In either case, the contribution of these components dwarfs that of the AGN at mid-IR wavelengths.Comment: 17 pages, 10 figures. Accepted for publication in MNRA