Idiopathic isolated clitoromegaly: A report of two cases

BACKGROUND: Clitoromegaly is a frequent congenital malformation, but acquired clitoral enlargement is relatively rare. METHODS: Two acquired clitoromegaly cases treated in Atatürk Training Hospital, Izmir, Turkey are presented. RESULTS: History from both patients revealed clitoromegaly over the last three years. Neither gynecological nor systemic abnormalities were detected in either patient. Karyotype analyses and hormonal tests were normal. Abdominal and gynaecological ultrasound did not show any cystic lesion or other abnormal finding. Computerized tomography scan of the adrenal glands was normal. Clitoroplasty with preservation of neurovascular pedicles was performed for the treatment of clitoromegaly. CONCLUSION: The patients were diagnosed as "idiopathic isolated" clitoromegaly. To the best of our knowledge, there has been no detailed report about idiopathic clitoromegaly in the literature

Biphasic calcium phosphate with submicron surface topography in an Ovine model of instrumented posterolateral spinal fusion.

As spinal fusions require large volumes of bone graft, different bone graft substitutes are being investigated as alternatives. A subclass of calcium phosphate materials with submicron surface topography has been shown to be a highly effective bone graft substitute. In this work, a commercially available biphasic calcium phosphate (BCP) with submicron surface topography (MagnetOs; Kuros Biosciences BV) was evaluated in an Ovine model of instrumented posterolateral fusion. The material was implanted stand-alone, either as granules (BCPgranules) or as granules embedded within a fast-resorbing polymeric carrier (BCPputty) and compared to autograft bone (AG). Twenty-five adult, female Merino sheep underwent posterolateral fusion at L2-3 and L4-5 levels with instrumentation. After 6, 12, and 26 weeks, outcomes were evaluated by manual palpation, range of motion (ROM) testing, micro-computed tomography, histology and histomorphometry. Fusion assessment by manual palpation 12 weeks after implantation revealed 100% fusion rates in all treatment groups. The three treatment groups showed a significant decrease in lateral bending at the fusion levels at 12 weeks (P < 0.05) and 26 weeks (P < 0.001) compared to the 6 week time-point. Flexion-extension and axial rotation were also reduced over time, but statistical significance was only reached in flexion-extension for AG and BCPputty between the 6 and 26 week time-points (P < 0.05). No significant differences in ROM were observed between the treatment groups at any of the time-points investigated. Histological assessment at 12 weeks showed fusion rates of 75%, 92%, and 83% for AG, BCPgranules and BCPputty, respectively. The fusion rates were further increased 26 weeks postimplantation. Similar trends of bone growth were observed by histomorphometry. The fusion mass consisted of at least 55% bone for all treatment groups 26 weeks after implantation. These results suggest that this BCP with submicron surface topography, in granules or putty form, is a promising alternative to autograft for spinal fusion

Studies of Methods for Synthesizing X-Alkoxyfurans.

Aucubin, a compound isolated from the leaves of Aucuba japonica and other plants, has been assigned the structure by Karrer and Schmid. It is of interest as the first x-furanol derivative reported as a natural product. [...

Arab culture and architecture of the Umayyad Period : a comparative study with special reference to the results of the excavations of Hisham's palace

EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Motor Conduction Alterations In Spinal Stenosis Patients Immediately After Physical Stress And Following Decompressive Surgery

Neurogenic claudication is often seen in patients with lumbar spinal stenosis. The pathogenesis of neurogenic claudication is thought to be due to relative ischemia of cauda equina roots during exercise. We studied the effect of transient ischemia brought on by exercise on motor conduction in patients suffering from lumbar spinal stenosis. We found that there is a statistically significant difference in the motor evoked potential latency time and in the peripheral motor conduction time measured before and after exercise in the patients with signs of neurological deficit (Hest p<O.0001). This difference was not found to be statistically significant in patients without neurological deficits (ttest p>O.05). We also evaluated the sensitivity of motor evoked potentials in detecting motor conduction abnormalities before and after the onset of neurogenic claudication. We found that 65% of the patients with lumbar spinal stenosis had abnormal evoked potentials. This value increased to 76% after the onset of claudication.La claudication neurogène est souvent observée chez les patients souffrant de sténose lombaire. La pathogenèse de cette claudication est due à l’ischémie relative présente au niveau des racines lombaires durant I'exercice. Nous avons étudié "effet de cette ischémie transitoire sur 'a conduction nerveuse. Nous avons démontré I'existence d'une différence significative entre Ie temps de latence du potentiel évoqué moteur (TLPEM) et Ie temps de latence de la conduction nerveuse périphérique avant et après I'exercice chez les patients ayant des signes de déficit neurologique. Cette différence n'a pas été démontrée chez les patients sans signes de souffrance neurologique. Nous avons également évalué la sensibilité des potentiels évoqués à détecer des anomalies de conduction avant et après la claudication. Nous avons trouvé que 65 % des patients avec sténose lombaire avaient des potentiels évoqués anormaux. Cette valeur est montée a 76 % après claudication