10 research outputs found
Zfhx3-mediated genetic ablation of the SCN abolishes light entrainable circadian activity while sparing food anticipatory activity.
- Author
- Publication venue
- iScience
- Publication date
- 01/10/2021
- Field of study
Circadian rhythms persist in almost all organisms and are crucial for maintaining appropriate timing in physiology and behaviour. Here, we describe a mouse mutant where the central mammalian pacemaker, the suprachiasmatic nucleus (SCN), has been genetically ablated by conditional deletion of the transcription factor Zfhx3 in the developing hypothalamus. Mutants were arrhythmic over the light-dark cycle and in constant darkness. Moreover, rhythms of metabolic parameters were ablated in vivo although molecular oscillations in the liver maintained some rhythmicity. Despite disruptions to SCN cell identity and circuitry, mutants could still anticipate food availability, yet other zeitgebers - including social cues from cage-mates - were ineffective in restoring rhythmicity although activity levels in mutants were altered. This work highlights a critical role for Zfhx3 in the development of a functional SCN, while its genetic ablation further defines the contribution of SCN circuitry in orchestrating physiological and behavioral responses to environmental signals
Global disparities in surgeonsâ workloads, academic engagement and rest periods: the on-calL shIft fOr geNEral SurgeonS (LIONESS) study
- Author
- Abdelkhalek Mohamed
- AbellaÌn Antonio Melero
- AbelloÌ David
- Abu-Arish Hamdoon
- Acevedo Ana Karen Radilla
- Adamina Michel
- Adamovich Dmitry Mikhailovich
- Addeo Pietro
- Adewunmi Olayinka Lukman
- Aeschbacher Pauline
- Afolabi Akinwale Ibrahim
- Agastra Ervis
- Agresta Ferdinando
- Aguilar Juan Carlos Cardozo
- Ahmed Bensaad
- Ahmed Nauman
- Aimal Aimal Khan
- Aiolfi Alberto
- Akay Omer
- al-Najami Issam
- Al-Shehari Mohammed
- Alconchel Felipe
- Alesina Pier Francesco
- Alhazmi Ahmad
- Ali Mahmoud Ibrahim
- Aliyev Vusal
- Alonso Patricia
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- Sotiropoulou Maria
- Sotiropoulu Maria
- Souadka Amine
- Sousa Xavier
- Souza Hamilton Petry
- Spampinato Marcello Giuseppe
- Sparavigna Marco
- Spartalis Eleftherios
- Spartalis Michael
- Sperotto Beatrice
- Spiezio Giovanni
- Spoletini Gabriele
- Stecca Tommaso
- Stijns Jasper
- Stocco Alberto
- Stringfield Sarah Beth
- Stubbs Benjamin M.
- Subramaniam Ravichandran
- Supit Tommy
- Syed Syed Muhammad Ali
- Syn Nicholas L.
- Synekidou Eirini
- Tadesse Robel
- Taeme Mulugeta
- Taffese Abebe
- Takkenberg Marijn
- Tallon-Aguilar Luis
- Tamini NicoloÌ
- Tampaki Ekaterini Christina
- Tampakis Athanasios
- Tan Jessica J.
- Tan Jih Huei
- Tandoi Francesco
- Tantravahi Umasankar
- Tarallo Mariarita
- Tartaglia Nicola
- Tasselli Francesco Menegon
- Tasselli Francesco Menegon
- Tatar Cihad
- Tayeh Salim
- Taylor John Vincent
- Ted Tedla Gebretsadik
- Teddy Tewodros Abule Bilata
- Tegegn Ayenachew Getachew
- Tejedor Patricia
- Tekin Oguzhan
- Tellez Clara
- Tenconi Silvia Maria
- Tense Tadesse H.
- Tepelenis Kostas
- Teran Alfonso Ivan Sanchez
- TereÌs Lara Blanco
- Terwes Natasha Loria
- Tesfay Goytom Knfe
- Thambi Prem
- Tita AgustiÌn
- Tolla Ashenafi Negash
- Tolonen Matti
- Tomada Elisa Paoluzzi
- Tomasicchio Giovanni
- Toscano Marta JimeÌnez
- Toti Johannes M. A.
- Travers Lawrence Albert Salter
- Tropeano Francesca Paola
- Tryliskyy Yegor
- Tsouknidas Ioannis
- Tufo Andrea
- Tur-Martinez Jaume
- Tur-Martinez Jaume
- Tura Marina Vila
- Turrado-Rodriguez Victor
- Turri Giulia
- Tutino Roberta
- Uccelli Matteo
- Uggeri Fabio
- Uzunoglu Mustafa Yener
- Uzzau Alessandro
- Uzzau Alessandro
- Vailas Michail
- Vailas Michail
- Valadez Michel Hernandez
- Valdivieso Xavier HGarciÌa
- Valinoti AgustiÌn
- Van Doorn Berend
- van Ramshorst Gabrielle
- Vanerio Patricio
- Vannelli Alberto
- Vanni Gianluca
- Vanni Gianluca
- Varela Cristopher
- Varela Cristopher L.
- Vargas Luis Felipe Cabrera
- Vellei Samantha
- Verdi Daunia
- Veroux Massimiliano
- Veroux Massimiliano
- Vescio Francesca
- Vigorita Vincenzo
- Vilallonga Ramon
- Vincenzi Paolo
- Vinci Danilo
- Vinci Danilo
- Violante Tommaso
- Visag-Castillo Victor
- Voon Kelvin
- WaleÌšdziak Maciej
- Wani Ajaz
- Wani Ishfaq Ahmad
- Wani Rauf
- Wassie Chekol
- Wilkins Alex
- Wyroslak-Najs Justyna
- Yallew Gebeyaw Mengist
- Yang Wah
- Yildirim Ali Cihat
- Yildiz Ishak
- Yiu Andrew
- Yiu Andrew
- Younis Muhammad Umar
- Yusoff Ahmad Ramzi
- Zacharis Georgios
- Zafra David Ambrona
- Zaghloul Tarek M.
- Zambon Martina
- Zanus Giacomo
- Zarnescu Narcis Octavian
- Zeb Muhammad
- Zena Alemayehu Shanko
- Zerbo Domenico
- Zuchini AndreÌs Mendoza
- Zullo Alessia
- Publication venue
- Publication date
- 29/04/2024
- Field of study
: The workload of general surgeons is multifaceted, encompassing not only surgical procedures but also a myriad of other responsibilities. From April to May 2023, we conducted a CHERRIES-compliant internet-based survey analyzing clinical practice, academic engagement, and post-on-call rest. The questionnaire featured six sections with 35 questions. Statistical analysis used Chi-square tests, ANOVA, and logistic regression (SPSSŸ v. 28). The survey received a total of 1.046 responses (65.4%). Over 78.0% of responders came from Europe, 65.1% came from a general surgery unit; 92.8% of European and 87.5% of North American respondents were involved in research, compared to 71.7% in Africa. Europe led in publishing research studies (6.6 ± 8.6 yearly). Teaching involvement was high in North America (100%) and Africa (91.7%). Surgeons reported an average of 6.7 ± 4.9 on-call shifts per month, with European and North American surgeons experiencing 6.5 ± 4.9 and 7.8 ± 4.1 on-calls monthly, respectively. African surgeons had the highest on-call frequency (8.7 ± 6.1). Post-on-call, only 35.1% of respondents received a day off. Europeans were most likely (40%) to have a day off, while African surgeons were least likely (6.7%). On the adjusted multivariable analysis HDI (Human Development Index) (aOR 1.993) hospital capacity > 400 beds (aOR 2.423), working in a specialty surgery unit (aOR 2.087), and making the on-call in-house (aOR 5.446), significantly predicted the likelihood of having a day off after an on-call shift. Our study revealed critical insights into the disparities in workload, access to research, and professional opportunities for surgeons across different continents, underscored by the HDI
Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial
- Author
- Abani Obbina
- Abbas Ali
- Abbas Fatima
- Abbas Mustafa
- Abbasi Sadia
- Abbass Hakam
- Abbott Alfie
- Abdallah Nabeel
- Abdelaziz Ashraf
- Abdelfattah Mohamed
- Abdelqader Bushra
- Abdo David
- Abdul Rasheed Althaf
- Abdul Basir
- Abdul-Kadir Rezan
- Abdul-Raheem Rasheed
- Abdulakeem Ajibode
- Abdulle Amina
- Abdulmumeen Abdulfatahi
- Abdulshukkoor Niyaz
- Abdusamad Kula
- Abed El Khaleq Yazeed
- Abedalla Mai
- Abeer Ul Amna Abeer Ul Amna
- Abernethy Katrina
- Abo-Leyah Hani
- Aboaba Adebanke
- Abou-Haggar Ahmed
- Abouibrahim Mahmoud
- Abraham Miriam
- Abraham Tizzy
- Abraheem Abraheem
- Abrams Judith
- Abu Hyacinth-John
- Abu-Arafeh Ahmed
- Abubacker Syed M
- Abung Akata
- Aceampong Yaa
- Achara Amaka
- Acharya Devikumar
- Acheampong Sarah
- Acheson Janet
- Acosta Andres
- Acton Catherine
- Adabie-Ankrah Jacqueline
- Adair Sara
- Adam Fiona
- Adam Matthew
- Adamali Huzaifa
- Adams Carol
- Adams Charlotte
- Adams Kate
- Adams Lisa
- Adams Richard
- Adams Tim
- Adcock Kirsty
- Addai Jemaimah
- Adebiyi Ade
- Adegoke Ken
- Adell Vicki
- Ademokun Debo
- Adenwalla Sherna
- Adesemoye Oluwasegun A
- Adewunmi Emmanuel O
- Adeyemi Joyce
- Adhikary Rina
- Adkins Gabrielle
- Adnan Adnan
- Aeron-Thomas John
- Affleck Debbie
- Affron Dominic
- Afnan Carmel
- Afridi Muhammad
- Aftab Zainab A
- Agarwal Meenakshi
- Agbeko Rachel
- Agbo Chris
- Agent Penny
- Aggarwal Sunil
- Aghababaie Arameh
- Ahamed Sadiq Shafana
- Ahammed Nazeer Mohamed H
- Ahmad Humayun
- Ahmad Mohammad
- Ahmad Syed
- Ahmed Ali Roa
- Ahmed Asim
- Ahmed Bilal
- Ahmed Forizuddin
- Ahmed Hamze
- Ahmed Iram
- Ahmed Irshad
- Ahmed Khaled
- Ahmed Liban
- Ahmed Mahin
- Ahmed Maria C
- Ahmed Muhammad S
- Ahmed Naseer
- Ahmed Nausheen
- Ahmed Osama
- Ahmed Rajia A
- Ahmed Rizwan
- Ahmed Saif
- Ahmed Sammiya
- Ahmed Sana
- Ahmed Sara
- Ahmed Sophia
- Ahmed Syed
- Ahmed Syed Haris
- Ahmer Sana
- Ail Dhiraj
- Ainsworth Mark
- Airoldi Giulia
- Aissa Myriam
- Aitken Lindianne
- Ajay Bini
- Ajeneye Francis
- Ajibode Abdulakeem
- Ajmi Ayesha
- Akbar Tahir
- Akhtar Naim
- Akhtar Nasim
- Akhtar Nauman
- Akili Suha
- Akindolie Oludoyinsola
- Akinfenwa Yinka
- Akinkugbe Olugbenga
- Akinpelu Ibrahim
- Akinwumiju Olajide
- Aktinade Olugbenro
- Al Aaraj Ahmad
- Al Balushi Asma
- Al Dakhola Majd
- Al Swaifi Aladdin
- Al-Abadi Eslam
- Al-Asadi Abbas
- Al-Asadi Karina
- Al-Bayati Manaf
- Al-Fori Julyan
- Al-Hakim Bahij
- Al-Hity Shams
- Al-Jibury Maithem
- Al-Juboori Saba
- Al-Khalil Majid
- Al-Moasseb Hassan
- Al-Obaidi Magda
- Al-Rabahi Akram
- Al-Ramadhani Bahar
- Al-Saadi Zayneb
- Al-Shahi Salman Rustam
- Al-Shamkhani Warkaq
- Al-Sheklly Bashar
- Aladangady Narendra
- Alam Ayaz
- Alam Sajid
- Alatzoglou Kyriaki
- Albert Paul
- Albon Lorraine
- Alcorn Gemma
- Alcorn Stephen
- Aldana Aggie
- Alderdice David
- Aldouri Rayan
- Aldridge Jonathan
- Aldridge Nicolas
- Alegria Ana
- Alexander Alison
- Alexander John
- Alexander Peter D G
- Alford Charlotte
- Alghazawi Laith
- Ali Ali
- Ali Asad
- Ali Fawzia R
- Ali Hoodo
- Ali Jawad
- Ali Mariam
- Ali Mohammad
- Ali Nayab
- Ali Oudai
- Ali Sabira
- Ali Sakina
- Ali Syed
- Alina Abid
- Aliyuda Fine
- Alizadeh Katrin
- Alkhusheh Moutaz
- Allameddine Allameddine
- Allan Fiona
- Allan Rachel
- Allanson Alison
- Allcock Robert
- Allen Beverley
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- Allison Kathryn
- Allman Bethan
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- Alomari Lina
- Alshaer Inji
- Altaf Sara
- Alvarez Mary
- Alyas Balaal
- Alzetani Maysaa
- Amamou Susan
- Amar Noor
- Ambalavanan Sakkarai
- Ambler Sarah-Jayne
- Ambrogetti Robert
- Ambrose Chris
- Ameen Amir
- Amenyah Kenneth
- Amezaga Maria R
- Amin Allison
- Amin Amina
- Amin Kanish
- Amin Syed
- Amin Tara
- Amjad Amjad
- Amjad Neelma
- Ammoun Mariam
- Amosun Victoria
- Amsha Khaled
- Amy Pugh
- Anand Atul
- Anand Rekha
- Anandappa Samantha
- Anderson Julie
- Anderson Kevin
- Anderson Laura
- Anderson Michelle
- Anderson Nicola
- Anderson Rachel
- Anderson Rory
- Anderson Wendy
- Andreou Prematie
- Andrews Angela
- Andrews Antonette
- Andrews Jill
- Andrews Susan
- Andrikopoulos Gregory
- Aneke Kanayochukwu
- Ang Andrew
- Ang Wan Wei
- Angel Tammy
- Angela Aramburo
- Angelini Paola
- Anguvaa Lazarus
- Anichtchik Oleg
- Anim-Somuah Millicent
- Aniruddhan Krishnan
- Annett Jessica
- Anstey Patrick J
- Anstey Rebekah
- Anthony Alpha
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- Antill Philip
- Antonina Zhelyazkova
- Anu Varghese
- Anwar Muhammad
- Apostolides George
- Apostolopoulos Aristeidis
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- Appleyard Diane
- Aquino Maia Far
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- Araujo Mariana
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- Arimoto Ryoki
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- Armstrong-Fisher Sylvia
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- Arnold David
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- Arora Dhawal
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- Arroyo Andrea
- Arter Arslam
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- Arya Rita
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- Ashby Glen
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- Ashcroft Samuel
- Asher Deborah
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- Ashford Ben
- Ashgar Suhail
- Ashish Abdul
- Ashman-Flavell Sally
- Ashok Sundar
- Ashour Abd-El-Aziz
- Ashraf Muhammad Z
- Ashraf Saima
- Ashraq Mohammad B
- Ashton Deborah
- Ashton Susan
- Ashworth Andrew
- Ashworth Rebecca
- Aslam Arshia
- Asogan Harshini
- Asquith Abigail
- Asrar Atif
- Assaf Omar
- Astin-Chamberlain Raine
- Athay-Hunt Richard
- Athorne Deborah
- Atkins Billie
- Atkins Christopher
- Atkins Stacey
- Atkinson John
- Atkinson Vicki
- Atraskiewicz Brygitta
- Atterbury Claire
- Attia Abdul Ahmad
- Atugonza Rita
- Aubrey Paula
- Aujayeb Avinash
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- Aung Ni
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- Austin Emily
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- Awadzi Gabriel
- Awan Atia
- Aya Aszad
- Ayaz Eman
- Ayers Amanda
- Azam Jawwad
- Azharuddin Mohammed
- Aziz Ghazala
- Aziz N
- Azkoul Ali
- Azman Shah Ashaari
- Azzopardi Giada
- Azzoug Hocine
- Babatunde Fiyinfoluwa
- Babi Melvin
- Babiker Babiker
- Babington Gayna
- Babirecki Matthew
- Babores Marta
- Babs-Osibodu Adetona O
- Bacciarelli Sammy
- Bachar Roudi
- Bacon Gina
- Bacon Jenny
- Badal Bibi
- Badhan Gurpreet R
- Badhrinarayanan Shreya
- Bae Joseph P
- Bafekr Mishamandani Sibel
- Baggaley Alice
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- Bagley Graham
- Bagmane Dinesh
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- Bailey Katie
- Bailey Lindsey
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- Baillie Hamish
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- Bain Jennifer
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- Baird David
- Baird Susan
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- Bakerly Nawar
- Bakhtiar Nauman
- Bakoulas Panos
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- Balkee Sonya
- Ball Ceri
- Ballard Kasia
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- Balmforth Craig
- Balogh Emese
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- Bancroft Hollie
- Bancroft Tanya
- Banda Joyce
- Bandaru Krishna
- Bandi Srini
- Bandla Nageswar
- Bandyopadhyam Somaditya
- Banerjee Amit
- Banerjee Millie
- Banerjee Ritwik
- Banks Harrison
- Banks Lauren
- Banks Luke
- Banks Paul
- Bannister Oliver
- Bansal Bharat
- Banthorpe Robert
- Banton Laura
- Baptist Mariamma
- Baqai Tanya
- Baral Ananya Mouli
- Baramova Desislava
- Barber Alex
- Barber Russel
- Barbon Emma
- Barbosa Miriam
- Barbosa Monica
- Barbour Jamie
- Barclay Alexander
- Barclay Claire
- Bardsley George
- Bareford Stephanie
- Bari Shahedal
- Barker Amy
- Barker Debbie
- Barker Helen
- Barker Joseph
- Barker Leon
- Barker Oliver
- Barker-Williams Kerry
- Barkha Sinha
- Barla Juliana
- Barlow Gavin
- Barlow Richard
- Barlow Valerie
- Barnacle James
- Barnard Alex
- Barnes Debi
- Barnes Nicky
- Barnes Theresa
- Barnetson Calum
- Barnett Amy
- Barnett Matthew
- Barnett-Vanes Ashton
- Barnsley William
- Barr Andrew
- Barr David
- Barratt Shaney
- Barrera Manuella
- Barrett Amy
- Barrett Fiona
- Barrett Jessica
- Barry Joe
- Bartholomew Jazz
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- Bartlett Georgina
- Barton Greg
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- Barton Rachael
- Baruah Rosaleen
- Baryschpolec Sonia
- Bashyal Archana
- Basker Betsy
- Basoglu Ayten
- Bass Gilda
- Bassett G
- Bassett John
- Bassford Chris
- Bassi Pavinder
- Bassis Betsy
- Bassoy Bengisu
- Bastion Victoria
- Basumatary Anupam
- Bate Tristan
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- Bateman Ian
- Bateman Kathryn
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- Batham Sally
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- Batty Harry
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- Bautista Carina
- Bawa Fareha
- Bawani Fatima S
- Bax Simon
- Baxter Lydia
- Baxter Matt
- Baxter Nicola
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- Bayes Hannah
- Baylem Charlotte
- Bayliss Lee
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- Bell Dina
- Bell Gareth
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- Bell Joshua
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- Biswas Nibedan
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- Blackler Joanne
- Blackley Samantha
- Blackman Helen
- Blackmore Stuart
- Blackstock Caroline
- Blackwood Loraine
- Blakemore Francesca
- Blamey Helen
- Bland Alison
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- Blankley Simon
- Blanton Mary
- Blaxill Parry
- Blaxland Jenny
- Blaylock Katie
- Blazeby Jane
- Blears Carol
- Blencowe Natalie
- Blofield Donna
- Bloom Ben
- Bloomfield Jack
- Bloss Angela
- Bloxham Hannah
- Blundell Louise
- Blunsum Andrew
- Blunt Mark
- Blyth Ian
- Blyth Kevin
- Blythe Andrew
- Blythe Karen
- Boampoaa Marilyn
- Bobie Boniface
- Bobruk Karen
- Bodalia Pritesh
- Bodasing Neena
- Bodenham Tanya
- Bodh Sherin
- Boehmer Gabriele
- Boffito Marta
- Bohmova Kristyna
- Bokhandi Sumit
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- Bokhari Saba
- Bokhari Sakina
- Bokhari Syed Owais
- Boles Ambrose
- Bollington Sarah
- Bolton Sam
- Bomken Charlotte
- Bond Charlotte
- Bond Hayley
- Bond Helena
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- Bond Thomas
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- Bonney Lizzy
- Boorman Leigh
- Booth Catherine
- Borbone Joanne
- Borhani Cameron
- Borman Naomi
- Borrell Rachel
- Boshir Mamu
- Bottrill Fiona
- Bough Laura
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- Boult Zoe
- Bourke Miriam
- Bourke Stephen
- Bourne Michelle
- Bousfield Rachel
- Boustred Lucy
- Bowen Darren
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- Bowes Amy
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- Bowman Louise
- Bowman Simon
- Bowmer Rachel
- Bowring Angie
- Bowyer Geoff
- Bowyer Helen
- Boyd Carmel
- Boyd Jenny
- Boyd Laura
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- Boyle Rosalind
- Boyles Louise
- Bozdag Osman
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- Brackstone Charlotte
- Bradburn Rob
- Bradder Jodie
- Bradley Barry
- Bradley Clare Jane
- Bradley Pamela
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- Bradshaw Lynne
- Bradshaw Sarah
- Bradshaw Zena
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- Brady Shirin
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- Brassington Louise
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- Brearey Stephen
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- Briggs Mark
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- Brown Niall
- Brown Pauline
- Brown Rachel
- Brown Richard
- Brown Robert
- Brown Steven
- Brown Tom
- Brown Wayne
- Browne Bria
- Browne Charlotte
- Browne Duncan
- Browne Mitchell
- Brownlee Stephen
- Brraka Alba
- Bruce David
- Bruce Johanna
- Bruce Michelle
- Brudlo Wojciech
- Brunskill Nigel
- Brunton Alan
- Brunton Margaret
- Bryan Mandy
- Bryant Meera
- Buazon April
- Buch Maya
- Buchan Julie
- Buchan Ruaridh
- Buchanan Alexis
- Buchanan Ruaridh
- Buche Danielle
- Buck Amanda
- Buckland Matthew
- Buckley Laura
- Buckley Philip
- Buckley Sarah
- Buckman Carol
- Buckmire Kathleen
- Bugg George
- Bujazia Ramadan
- Bukhari Marwan
- Bukhari Shanze
- Bulbulia Richard
- Bull Alex
- Bull Damian
- Bull Rhian
- Bull Thomas
- Bulteel Naomi
- Bumunarachchi Kasun
- Bungue-Tuble Roneleeh
- Burchett Caroline
- Burda Dorota
- Burden Christy
- Burden Thomas G
- Burgess Mika
- Burgess Paula
- Burgess Richard
- Burgess Sophia
- Burgett Paula
- Burman Adrian
- Burnard Sara
- Burnett Caroline
- Burnett John
- Burns Amanda
- Burns Amy
- Burns Collette
- Burns James
- Burns Karen
- Burns Samuel
- Burns Sarah
- Burrage Daniel
- Burrage Sadie
- Burrows Kate
- Burston Claire
- Burton Ben
- Burton Fiona
- Burton Matthew
- Busby Angela
- Butcher Deborah
- Butler Aaron
- Butler Jessica
- Butler Joanne
- Butler Joshua
- Butler Lesley
- Butler Peter
- Butler Susan
- Butt Al-Tahoor
- Butt Mohammad M
- Butt Sophia
- Butterworth Caryl
- Butterworth-Cowin Nicola
- Buttery Robert
- Buttle Tom
- Button Heather
- Buttress Daniel
- Publication venue
- 'Elsevier BV'
- Publication date
- 13/02/2021
- Field of study
SummaryBackground Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatoryactions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19.Methods In this randomised, controlled, open-label, adaptive platform trial (Randomised Evaluation of COVID-19Therapy [RECOVERY]), several possible treatments were compared with usual care in patients admitted to hospitalwith COVID-19 in the UK. The trial is underway at 176 hospitals in the UK. Eligible and consenting patients wererandomly allocated to either usual standard of care alone or usual standard of care plus azithromycin 500 mg once perday by mouth or intravenously for 10 days or until discharge (or allocation to one of the other RECOVERY treatmentgroups). Patients were assigned via web-based simple (unstratified) randomisation with allocation concealment andwere twice as likely to be randomly assigned to usual care than to any of the active treatment groups. Participants andlocal study staff were not masked to the allocated treatment, but all others involved in the trial were masked to theoutcome data during the trial. The primary outcome was 28-day all-cause mortality, assessed in the intention-to-treatpopulation. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936.Findings Between April 7 and Nov 27, 2020, of 16 442 patients enrolled in the RECOVERY trial, 9433 (57%) wereeligible and 7763 were included in the assessment of azithromycin. The mean age of these study participants was65·3 years (SD 15·7) and approximately a third were women (2944 [38%] of 7763). 2582 patients were randomlyallocated to receive azithromycin and 5181 patients were randomly allocated to usual care alone. Overall,561 (22%) patients allocated to azithromycin and 1162 (22%) patients allocated to usual care died within 28 days(rate ratio 0·97, 95% CI 0·87â1·07; p=0·50). No significant difference was seen in duration of hospital stay (median10 days [IQR 5 to >28] vs 11 days [5 to >28]) or the proportion of patients discharged from hospital alive within 28 days(rate ratio 1·04, 95% CI 0·98â1·10; p=0·19). Among those not on invasive mechanical ventilation at baseline, nosignificant difference was seen in the proportion meeting the composite endpoint of invasive mechanical ventilationor death (risk ratio 0·95, 95% CI 0·87â1·03; p=0·24).Interpretation In patients admitted to hospital with COVID-19, azithromycin did not improve survival or otherprespecified clinical outcomes. Azithromycin use in patients admitted to hospital with COVID-19 should be restrictedto patients in whom there is a clear antimicrobial indication
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
- Author
- Abad-Motos Ane
- Abbas Ahmed M.
- Abbas Mostafa
- Abbasi Mujeeb
- Abbott Tom
- Abd Karim Muhammad Fairuz Shah
- Abdalaal Ibrahim
- Abdel-Galil Khalid
- Abdelemam Rania
- Abdelgawad Abdalrahman
- Abdelkarim Maryam
- Abdelkhalek Mohamed
- Abdelmageed Abdelfatah
- Abdelmawgoud Sherif
- Abdelmohsen Sarah
- Abdelrahman Ahmed Saber
- Abdelrahman Mostafa
- Abdelwahab Khaled
- Abdou Hossam
- Abdulai Darling Ramatu
- Abdulkhaleq Marwa
- Abdullah Bahiyah
- Abdulsalam Khalifa
- Abdulsalam Shuaib
- Abdur-Rahman Lukman
- Abdus-Salam Rukiyat
- Abdussalam Hameedat Opeyemi
- Abebrese John Tabiri
- Abeldaño Ariel
- Abou-Khalil Jad
- Abou-Taleb Hisham
- Abozid Anwaar
- Abozied Hesham
- Abrate Alberto
- Abu-Zaid Ahmed
- Abubakar Mohammed Kabir
- Abud Burçin
- Abuzaid Mohammed
- Adam Albushra Altayeb
- Adamina Michel
- Adamou Harissou
- Adamu Auwal
- Adamu Kabir Musa
- Adanu Kekeli
- Adebara Idowu
- Adebola Oluwaseyi
- Ademuyiwa Adesoji
- Adeniran Abiodun
- Adepiti Akinfolarin
- Aderogba Adeleke Akeem
- Adesunkanmi Abdulhafiz
- Adeyeye Ademola
- Adisa Adewale
- Adjeso Theophilus Justus Kofi
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adu-Aryee Nii Armah
- Adumah Collins
- Afzal Irrum
- Agapov Mikhail
- Agarwal Gaurav
- Agarwal Ravi
- Agbeko Anita Eseenam
- Agbeno Evans Kofi
- Agbonrofo Peter
- Agboola Oluseyi
- Aggarwal Gaurav
- Aghadi Ifeanyi
- Aghtarafi Natasha
- Agrawal Amit
- Agresta Ferdinando
- Aguado HĂ©ctor J.
- Aguilera-Arevalo Maria-Lorena
- Aherne Thomas
- Ahmad Aline
- Ahmad Maleeha
- Ahmad Misbahu
- Ahmad Sarwat
- Ahmad Shahzaib
- Ahmad Shoaib
- Ahmed Hayat Tarig Abdelhafiz
- Ahmed Khalid
- Ahmed Sharwany
- Ahmed Shima
- Ahmed Usama
- Aisuodionoe-Shadrach Oseremen
- Aitken Sarah
- Ajenifuja Kayode
- Ajiya Abdulrazak
- Akeel Nouf
- Akin Emrah
- Akinajo Opeyemi
- Akinyemi Tosin
- Akrida Ioanna
- Aktokmakyan Talar Vartanoglu
- Akwaisah Ayoub
- Al Bettar Osama
- Al-Badawi Ismail A.
- Al-Juaifari Maytham
- Al-Khyatt Waleed
- Al-Mallah Abdullah
- Al-Nusairi Ahmed
- Al-Saadi Nina
- Al-Sayaghi Khaled
- Al-Shaiji Tariq
- Al-Shehari Mohammed
- Al-Touny Aiman
- Al-Touny Shimaa A.
- Aladawi Omar
- Aladna Abdallah
- Alali Mahmoud
- Alam Mahmood
- Alam Mohammed Shadrul
- Alarabi Rehab
- Alawneh Yazan
- Alayande Barnabas
- Albanese Erminia
- Albayadi Eslam
- Albdour Maram
- Alconchel Felipe
- Alderazi Amer
- Alegbeleye Bamidele
- Alekberli Tural
- Alemu Misganaw Alemu Adimass
- Alexander Philip
- Alfieri Alex
- Algahtany Khaled
- Algarni Kamal
- Alhamad Ameen
- Alhamid Mohammad
- Alharmi Rawan A. Rahman
- Alharthi Mohammed
- Alhazmi Barrag
- Ali Mohamed Shafi Mahboob
- Ali Stephen
- Alibrahim Hidar
- Aljaaly Hattan
- Aljaiuossi Anas
- Aljanadi Firas
- Aljiffry Murad
- Aljirdabi Noof
- Alkahlan Mohammed
- Alkhalifa Elmustafa
- Alkhatib Sondos
- Alkhatieb Maram
- Allan Anna
- Almarshad Felwa
- Almgla Naser
- Almhimid Ali
- Almiqlash Bushray
- Almoshantaf Mohammad Badr
- Almutairi Abdulmjeed
- Alnsour Abed Alfattah Mahmoud
- Alobied Majd
- Alomar Osama
- Alonso JesĂșs AarĂłn MartĂnez
- Alonso Manuel Diez
- Alonso Nestor Fabian Pedraza
- Alonso Veronica
- Alqallaf Abdullah
- Alqaseer Asma
- Alrayes Bourhan
- Alsefri Maryam
- Alser Osaid
- Alsharif Mohammed
- Alsori Mohamed
- Altaf Abdulmalik
- Altinel Yuksel
- Altiner Saygin
- Altouny Ahmad
- Altun Demet
- Alvarez Natalia
- Alvarez-Lozada Luis Adrian
- Alvi Abdul
- Alwael Athari
- Alwash Mohammed
- Alyami Ziyad
- Alyousef Mohammed
- Alzahrani Saud
- Alzerwi Nasser
- Amin Shivang
- Amir Mohammed
- Ammar Ahmed Siddique
- Ammendola Michele
- Amores Remedios Revilla
- Amrayev Sultan
- Anastasiadou Sofia
- Ancans Guntis
- Anderson Caroline
- Andreani Lorenzo
- Andreotti Dario
- Andreuccetti Jacopo
- Andrianakis Alexandros
- Andro Christophe
- Anesi Alexandre
- Angamuthu Stephen
- Angeles Martina Aida
- Angelico Roberta
- Angelis Fragkiskos
- Angelou Dimitrios
- Angelou Kyveli
- Angulo Victor Pinto
- Anjum Arfa
- Anjum Muhammad Ayyub
- Annicchiarico Alfredo
- Anoldo Pietro
- Ansaloni Luca
- Anthoulakis Christos
- Antonelli Amedeo
- Anwar Mohamed
- Anwar Sumadi Lukman
- Anwer Mariyah
- Anyanwu Lofty-John
- Apostolou Christos
- Apostolou Konstantinos
- Appiah-Kubi Adu
- Aprea Giovanni
- Arbab Hana
- Archer James
- Ardura Francisco
- Aremu Muyiwa
- Arif Tahera
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- Armatura Giulia
- Armijos Daniel
- Arnaout Ali
- Arnaoutoglou Eleni
- Arnaud Alexis P.
- Arneja Jugpal
- Arrangoiz Rodrigo
- Arshad Muhammad
- Arthur Joshua
- Ashcroft James
- Ashford Bruce
- Ashraf Fariha
- Asiimwe Daniel
- Asirifi Samuel Amoako
- Asla Amir
- Aslam Ramisha
- Aspide Raffaele
- Ataya Karim
- Ateca Ibabe Villalabeitia
- Atici Semra Demirli
- Atis Gokhan
- Atkins William
- Atkinson Kate
- Attwood Joseph
- Auerkari Aino
- Augestad Knut Magne
- Augustin Goran
- Aujayeb Avinash
- Avella Pasquale
- Awad Ahmed K.
- Awad Hadeel
- Awad Rabih
- Awad Selmy
- Ayad Kusay
- Ayana Birhanu
- Aydin Yener
- Ayeni Funbi
- Aytac Erman
- Azab Ahmed
- Azami Rizwan
- Azize Diallo Abdoul
- Azzam Ahmed Y.
- Azzis Olivier
- Baba Yabasin Iddrisu
- Babis George
- Bacalbasa Nicolae
- Badiani Sarit
- Badran Saif
- Baduell Albert
- Baeesa Saleh
- Baertschiger Reto
- Bafaquh Mohammed
- Bahassan Omar Mohammed
- Bahrami-Hessari Michael
- Baia Marco
- Baidoo Ebikela Ivie
- Bailey Karen
- Baili Efstratia
- Bains Lovenish
- Baiocchi Gian Luca
- Baiocchi Glauco
- Baiyewu Lateef Ayodele
- Bajaj Ankur
- Bajunaid Khalid
- Balagobi Balasingam
- Balasubramanian Ishwarya
- Balduzzi Alberto
- Baldwin Alexander
- Balla Andrea
- Balogh Zsolt J.
- Balogun James A.
- Balogun Simon
- Baloyiannis Ioannis
- Ban Vin Shen
- Bandyopadhyay Samik Kumar
- Bandyopadhyay Soham
- Banerjee Sumit
- Banipal Gurpreet Singh
- Banky Balazs
- Bannone Elisa
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- Bareka Metaxia
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- Barlow Ciaran
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- Barranquero Alberto G.
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- Basendowah Mohammed
- Bashir Mahmod
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- Bateman Antony
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- Bayhan HĂŒseyin
- Bayo Heura Llaquet
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- Beamish Andrew
- Beasley Nigel
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- Becerra Angel
- Bedada Alemayehu Ginbo
- Bedzhanyan Arkady
- Begum Farzana
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- Bergkvist David JuliĂ
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- Bloemers Frank
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- Bonavina Luigi
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- Bondurri Andrea
- Bonilla Antonio Ramos
- Bonsaana Gilbert Batieka
- Booth L.
- Borg Elaine
- Borges Miguel FrĂłis
- Borges Nuno
- Bork Ulrich
- Borselle Dominika
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- Botelho Pedro
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- Bouliaris Konstantinos
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- Bozbiyik Osman
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- Branagan Graham
- Branzan Daniela
- Brasset Camille
- Bratus Dejan
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- Bright Tim
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- Brodkin Edgar
- Broglia Alessandro
- Brolese Alberto
- Browning Rebecca
- Bruzzaniti Placido
- BrzeszczyĆski Filip
- Bsisu Isam
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- Budd Gabrielle
- Bukhari Syed Imran
- Bulian Dirk Rolf
- Bumbasirevic Uros
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- Burlov Nikita
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- Capobianco Mattia
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- Christodoulou Prokopis
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- Cunningham Brian
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- Cutmore Carina
- Czako Ladislav
- CĂĄceres Freud
- D'Acapito Fabrizio
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- D'Archi Sabatino
- D'Oria Mario
- D'Sa Prashanth
- Daddi Niccolo'
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- Dawson Jonathon
- Dbouk Samer
- De AlarcĂłn Jaime RodrĂguez
- De Andrés-Asenjo Beatriz
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- De Haro Joaquin
- De Jesus Labrador Hernandez Gregorio
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- De La Medina Antonio Ramos
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- De Nardi Paola
- De Oliveira Gabriel Paiva
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- Degarege Dawit
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- Demetriades Andreas K
- Demetriou Charis
- Demir Sebahattin
- Dennis Rory
- Deputy Mohammed
- Derilo Habtamu
- Des DĂ©serts Marc Danguy
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- Ebrahim Abdulla
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- Edwards John
- Efetov Sergey
- Efremov Sergey
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- Ekwen Gerald
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- El Assaad Hadi
- El Boghdady Michael
- El Tayeb Essam Eldien Abuobaida Banaga Hag
- El-Boghdadly Kariem
- El-Hussuna Alaa
- El-Kassas Mohamed
- Elagili Ahmed
- Elahi Zain
- Elbadawy Merihan A.
- Elbahnasawy Mohamed
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- Elghadban Hosam
- Elhadi Muhammed
- Elhassan Wael Atif Fadl
- Elkazaz Ahmed
- Ellafi Amera Ali Dakheel
- Elliot R.
- Elnour Moheyaldien Ahmed Elamin
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- Elsahli Saifaleslam
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- Elshahawy Mahmoud Abdelaziz Mohamed
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- Eskinazi Diego
- Esposito Sofia
- Eugene Muneza
- Ezanno Anne-Cecile
- Ezeanochie Michael
- Ezeme Constantine
- Ezenwa Ekene
- Ezomike Uchechukwu
- Fadalla Tarig
- Fadel Zahir T
- Fahim Margo Medhat Fouad
- Fahmy Ali
- Faiz Javaria
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- Podda Mauro
- Poillucci Gaetano
- Pollok Joerg Matthias
- Pontecorvi Emanuele
- Porcu Alberto
- Potamianos Spyridon
- Potten Stephanie
- Pournaras Dimitri
- Power Nicholas
- Prada Carlos
- Pradhan Akhilesh
- Pramesh C.S.
- Prats Milagros Carrasco
- Prieto Mikel
- PrijoviÄ NebojĆĄa
- Prodromidou Anastasia
- Proud David
- Prucher Gian Marco
- Prusty Lydia
- Pu Jingya Jane
- Pucher Philip
- Punjabi Prakash P
- Puri Ajay
- Purich Kieran
- PĂ©rez Beatriz GĂłmez
- PĂ©rez-BertĂłlez Sonia
- Qader Kawthar
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- Quadri Oladeji
- Quaresima Silvia
- Querney Jill
- Quintana-Villamandos Begoña
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- Rabie Mohamed
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- RadivojeviÄ Renata Curic
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- SekuliÄ Aleksandar
- Semple Abigail
- Sen Comert
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- Senni Carlotta
- Sensi Bruno
- Seraj Shaikh Sanjid
- Serban Andreea-Madalina
- Serenari Matteo
- Serra Margherita
- Serra Marta Lopes
- Seshadri Ramakrishnan Ayloor
- Sethi Aman
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- SeÄan Tomislav
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- Shelat Vishal
- Shelmerdine Lauren
- Sherif Ahmed Elshawadfy
- Shiban Ehab
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- Shmukler Daniel
- Shokor Muntaser Abu
- Sholadoye Tunde T.
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- Shrestha Rashmit
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- Sica Giuseppe
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- Siragusa Leandro
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- Sodhai Vivek
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- Suer Muhammed Salih
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- Sundarraju Shalini
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- Szakmany Tamas
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- Yigit Banu
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- Yotsov Tsanko
- Younis Muhammad Umar
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- Yusefi Hossein
- Zabaleta Jon
- Zabkiewicz Catheriner
- Zaccaria Giulia
- Zacharia Bincy
- Zafar Syed Nabeel
- Zago Mauro
- Zaheen Zakia
- Zahid Zahra
- Zaimis Tilemachos
- Zakaria Andee Dzulkarnaen
- Zambon Martina
- Zamora Lindsey
- Zampogna Biagio
- Zancana Giuseppa
- Zani Augusto
- Zanin Luca
- Zanini Nicola
- Zapardiel Ignacio
- Zapata Carlos Shiraishi
- Zarif Pierre
- ZarĂĄnd Attila
- Zehnder Philipp
- Zenger Serkan
- Zenha HorĂĄcio
- Zhu Michael Z. L.
- Ziemann Sebastian
- Zimak Danijela Mrazovac
- Zimak Zoran
- Zivkovic Dragana
- Zizzo Maurizio
- Zucker Benjamin
- Zwain Yasir
- Zyskowski Michael
- Ăvila Clara Castro
- ĂlgĂ„ Andreas
- Ăakici Mehmet Ăaǧlar
- Ăelik Enes
- Ăelik Meryem Nur
- Ăzçay Necdet
- Ćevik HĂŒsnĂŒ
- Ć antak Goran
- Ć imko KristiĂĄn
- ĆœateckĂœ Jan
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2023
- Field of study
Abstract
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and lowâmiddle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of âsingle-useâ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for lowâmiddle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both highâ and lowâmiddleâincome countries
Forward genetics identifies a novel sleep mutant with sleep state inertia and REM sleep deficits
- Author
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 01/08/2020
- Field of study
Switches between global sleep and wakefulness states are believed to be dictated by top-down influences arising from subcortical nuclei. Using forward genetics and in vivo electrophysiology, we identified a recessive mouse mutant line characterized by a substantially reduced propensity to transition between wake and sleep states with an especially pronounced deficit in initiating rapid eye movement (REM) sleep episodes. The causative mutation, an lle102Asn substitution in the synaptic vesicular protein, VAMP2, was associated with morphological synaptic changes and specific behavioral deficits, while in vitro electrophysiological investigations with fluorescence imaging revealed a markedly diminished probability of vesicular release in mutants. Our data show that global shifts in the synaptic efficiency across brain-wide networks leads to an altered probability of vigilance state transitions, possibly as a result of an altered excitability balance within local circuits controlling sleep-wake architecture.ISSN:2375-254
Novel infectious agents causing uveitis
- Author
- A Adan
- A Al-Hazmi
- A Bronner
- A Mendivil
- A Mittal
- A Mittal
- A Mohan
- A Rohani
- AC Kennedy
- AC Wielanek
- AL Siam
- B Chanana
- B Granel
- B Mundel
- B Pastorino
- BL Ligon
- C Haritoglou
- C Haritoglou
- CJ Peters
- CK Chan
- D Nash
- DHW Su
- DS Ellis
- ED Fourie
- EL Raab
- F Abroug
- F Hasebe
- F Simon
- G Borgherini
- G Pialoux
- GD Presley
- H Esgin
- HK Kapoor
- HL Hudson
- HS Bains
- I Jordan
- I Schuffenecker
- J Alio
- J Castanet
- J Gea-Banacloche
- JK Sarkar
- JM Meegan
- JP Myers
- JR Lukas
- K Bacsal
- KH Wen
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- L Paufique
- LL Garcia
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- LW Laughlin
- M Chhabra
- M Khairallah
- M Khairallah
- M Khairallah
- M Khairallah
- M Khairallah
- M Khairallah
- M Pfeffer
- MA Samuel
- Moncef Khairallah
- MS Elwan
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- OD Olaleye
- P Lalitha
- PK Kaiser
- R Daubney
- R Gilad
- R Mazaud
- RA Adelman
- RB Eidsness
- RC Siqueira
- RJ Duffey
- RJ Pollack
- RK Seth
- RM Myers
- RW Kuchtey
- S Garg
- S Mehta
- S Nimmannitya
- S Shaikh
- S Vandenbelt
- S Verdot
- SB Halstead
- SG Alpert
- Sivakumar R. Rathinam
- SN Chatterjee
- Sonia Attia
- Soon Phaik Chee
- SP Kalantri
- TM Lu
- TW Smith
- V Cruz-Villegas
- V Ravi
- V Vaispapir
- VA Arankalle
- Venu Nadella
- VS Hershberger
- W Anninger
- WK Lim
- WV Anninger
- Y Nagaki
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2009
- Field of study
10.1007/s10792-009-9319-6International Ophthalmology1-1
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- 'UCLA American Indian Studies Center'
- Publication date
- Field of study
Effects of pre-operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study
- Author
- Ababneh Hazim
- Abad Gurumeta Alfredo
- Abad-Motos Ane
- Abbo Olivier
- Abbott Tom
- Abd Elwahab Sami
- Abdelkabir Mohammed
- Abdelkhalek Mohamed
- Abdur-Rahman Lukman
- Abebe Metasebia
- Aboazamazem Hajir
- Abou Chaar Mohamad K.
- Abou Chaar Mohamad K.
- Abouelnagah Galal
- Abozied Hesham
- Abu Salhiyeh Ala'a
- Abu-Ismail Luai
- Abu-Mehsen Marah
- Abukhalaf Sadi A.
- Abuleil Amro
- Achalandabaso Boira Mar
- Ackermann Travis
- Acquah Daniel Kwesi
- Adam Mohammed Elmujtba Adam Essa
- Adamina Michel
- Ademuyiwa Adesoji
- Adesanya Opeoluwa
- Adisa Adewale
- Afolabi Akinwale
- Agarwal Arnav
- Agarwal Gaurav
- Agastra Ervis
- Agbadebo Mouhamed
- Agbonrofo Peter
- Aguiar Junior Samuel
- Aguilera-Arevalo Maria-Lorena
- Ahmad Amer
- Ahmad Siddique
- Ahmed Waheed-Ul-Rahman
- Aigner Felix
- Akhavizadegan Hamed
- Akhbari Melika
- Akililu Yemisirach Bizuneh
- Akinmade Akinola
- Al Ameer Ahmed
- Al Amri Abdulrahman
- Al Balushi Zainab
- Al Maadany Faraj
- Al-Manaseer Balqees Mahmoud
- Al-Naggar Hamza
- Aladawi Omar
- Alajalen Amer
- Alalawi Yousef
- Alameer Ehab
- Alansari Arowa Hassan Abdulrahman
- Alawami Mohammed
- Alawneh Yazan
- Alayan Mohammed
- Alberdi San Roman Igor
- Albertsmeier Markus
- Alcaraz Fuentes Marta
- Alderazi Amer
- Aldressi Wafa
- Alexander Philip
- AlFakhri Abdullah
- Alharthi Mohammed
- Alhefdhi Amal
- Alkadeeki Ghadah
- Alkaseek Akram
- Alkhatib Ahmad
- Almabayev Ydyrys
- Almeida-Reis Rui
- Almiqlash Bushray
- Almoguera Jorge
- Almugaddami Ayman
- Almulhim Abddulrahman Saleh
- Alonso Mendoza Veronica
- Alqudah Majdi Ali
- Alrayes Bourhan
- Alsaadi Hayder
- Alser Osaid
- Alshaar Muhammad
- Alshahrani Mushabab
- Alshareef Khayriyah
- Alshehri Ameen
- Alshryda Sattar
- Alsibai Sareyah
- Alsunna Zaid
- Altaf Humera Naz
- Althumairi Azah
- Althumairi Azah
- Alyami Mohammad
- Alzahrani Abdulrahman
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- Alzerwi Nasser
- Amisi Nicolas
- Amnaina Mohamed
- Andre Benoit
- Andres Calvache Jose
- Angeles Martina Aida
- Anwer Mariyah
- Anyanwu Lofty-John
- Aqeelah Ahmed
- Aqil Sabra
- Arevalo Sandoval Danilo Alfonso
- Argus Leah
- Arias Claudia
- Arnalsteen Laurent
- Arnaud Alexis P.
- Asif Muhammad
- Assefa Melatework
- Ataide Gomes Gustavo Mendonca
- Atnafu Bahru
- Aviles Jimenez Pablo Mijahil
- Awad Selmy
- Ayasra Faris
- Ayoub Abdu
- Ayub Bushra
- Azevedo Jose
- Azevedo Jose
- Azevedo Pedro
- Aziz Aliya
- Azzam Ahmed Y.
- Bacalbasa Nicolae
- Badareesh L.
- Badenes Rafael
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- Baia Catarina
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- Baliarsing Lipika
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- Ballouhey Quentin
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- Batista Sylvia
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- Bekele Kebebe
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- Bele Uros
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- Bezabih Yoseph Solomon
- Bhanderi Shivam
- Bhangu Aneel
- Bhat Dhananjaya
- Bhatti Abu Bakar Hafeez
- Bhende Vishal
- Biccard Bruce
- Blanco-Colino Ruth
- Boccalatte Luis
- Boisson Matthieu
- Bolatbekova Raikhan
- Bolger Jarlath
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- Bonci Eduard-Alexandru
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- Borowski David W.
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- Bywater Edward P.
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- do Amaral Campos Heloisa Galvao
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- Enjuto Diego
- Escudero Mario I.
- Eskander Antoine
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- Espinosa-Bravo Martin
- Estaire Gomez Mercedes
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- Fahmy Mohamed
- Fakhradiyev Ildar
- Falcon Pacheco Glenda Marina
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- Farooq Umer
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- Fernandez Coimbra Felipe Jose
- Fernandez Martin Maria Teresa
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- Girard Edouard
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- Glasbey James C.
- Glasbey James C.
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- Gohar Muhammad
- Gomez Fernandez Laura
- Gomez Perez Beatriz
- Gomez-Fernandez Hugo
- Gomez-Rosado Juan-Carlos
- Gonzalez-Suarez Susana
- Gourlay Ralph
- Gousias Konstantinos
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- Grama Florin
- Griffiths Ewen
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- Gulla Aiste
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- Gupta Rahul
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- Hailu Samuel
- Hakami Ibrahim
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- Hamdun Intisar Hisham Said
- Hameed B. M. Zeeshan
- Haran Cheyaanthan
- Harper Luke
- Harrison Ewen M.
- Hashimoto Daisuke
- Hassan Ramy A.
- Hecker Andreas
- Heredia Fernando
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- Hervieux Erik
- Herzberg Jonas
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- Hodgson Russell
- Hoehn Philipp
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- Horch Raymund E.
- Horisberger Karoline
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- Huang Abel
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- Kamphues Carsten
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- Kavalaka Alfie
- Keatley James M.
- Kembuan Gabriele
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- Keppler Lena
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- Kroon Hidde M.
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- Litvin Andrey
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- Loeffler Markus W.
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- Maria Trujillo Lina
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- Marta Modolo Maria
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- Pramesh C. S.
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- Rajanbabu Anupama
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- Ramos-Luengo Adolfo
- Ranganath N.
- Rasoaherinomenjanahary Fanjandrainy
- Rassweiler-Seyfried Marie-Claire
- Raut Monish
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- Regalo Guillermo
- Reim Daniel
- Reinhard Tobias
- Ren Dong-Lin
- Rennie Sarah
- Rennie Sarah
- Rey Valcarcel Cristina
- Riba Martinez Mireia
- Rice Henry E.
- Rida Ahmed Hossam Eldin Fouad
- Rio Javier
- Rios Chiuyari Jose
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- Rissmann Anke
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- Rivera Carlos J-Perez
- Roberts Keith
- Rodas Alejandra
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- Russell Crispin
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- Sarwar Muhammad Zeeshan
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- Schlager Daniel
- Schmedding Andrea
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- Schoneveld Martijn
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- Sekar Arunkumar
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- Shanthanna Harsha
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- Simoes Joana F. F.
- Simoes Joana F. F.
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- Soni Rajesh
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- Spelsberg Fritz
- St-germain Pascal
- Stadler Josef
- Stavridis Sotir
- Stavrou Gregor A.
- Steinkamp Pieter
- Stephens Matthew
- Stevens Sean
- Stewart Grant D.
- Stijns Jasper
- Stoleriu Mircea Gabriel
- Subbian Anbukkani
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- Zabaleta Jon
- Zahid Imdad Ahmad
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- Zapata Carlos Shiraishi
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- Zarour Ahmad
- Zarour Ahmad
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- Zequi Stenio C.
- Zhou Xuanyu
- Zhussupov Baurzhan
- Zimmelman Natalie
- Zmora Oded
- Zmora Oded
- Publication venue
- Publication date
- 01/01/2021
- Field of study
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Effects of pre-operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study an international prospective cohort study
- Author
- Ababneh  Hazim
- Abad-Motos  Ane
- Abbas  Ferial Mohamed Ali
- Abbo  Olivier
- Abbott  Tom
- Abbott  Tom
- Abdelkabir  Mohammed
- Abdelkhalek  Mohamed
- Abdoun  Meriem
- Abdur-Rahman  Lukman
- Abdur-Rahman  Lukman
- Abebe  Metasebia
- Aboazamazem  Hajir
- Abou Chaar  Mohamad K.
- Abou Chaar  Mohamad K.
- Abouelnagah  Galal
- Abozied  Hesham
- Abu Salhiyeh  Ala A.
- Abu-Ismail  Luai
- Abu-Mehsen  Marah
- Abuawad  Carla
- Abukhalaf  Sadi A.
- Abuleil  Amro
- Ackermann  Travis
- Acquah  Daniel Kwesi
- Adam  Mohammed Elmujtba Adam Essa
- Adamina  Michel
- Adamina  Michel
- Ademuyiwa  Adesoji
- Adesanya  Opeoluwa
- Adisa  Adewale
- Adisa  Adewale
- Afolabi  Akinwale
- Agarwal  Arnav
- Agarwal  Gaurav
- Agarwal  Ketan
- Agastra  Ervis
- Agastra  Ervis
- Agbadebo  Mouhamed
- Agbonrofo  Peter
- Aguilera-Arevalo  Maria-Lorena
- Aguilera-Arevalo  Maria-Lorena
- Ahmad  Amer
- Ahmad  Siddique
- Ahmadi  Navid
- Ahmed  Waheed-Ul-Rahman
- Aigner  Felix
- Aiken  Taylor
- Akhavizadegan  Hamed
- Akhbari  Melika
- Akililu  Yemisirach Bizuneh
- Akinmade  Akinola
- Al Ameer  Ahmed
- Al Ameer  Ahmed
- Al Amri  Abdulrahman
- Al Balushi  Zainab
- Al Islam Ben Jouira  Rayet
- Al Maadany  Faraj
- Al-Manaseer  Balqees Mahmoud
- Al-Naggar  Hamza
- Al-Naggar  Hamza
- Al-Raimi  Ibrahim
- Al-Sabbagh  Yusra
- Al-Shehari  Mohammed
- Aladawi  Omar
- Alajalen  Amer
- Alalawi  Yousef
- AlAmeer  Ehab
- Alameer  Ehab
- Alansari  Arowa Hassan Abdulrahman
- Alawami  Mohammed
- Alawneh  Yazan
- Alayan  Mohammed
- Albared  Sara Maa
- Albertsmeier  Markus
- Albertsmeier  Markus
- Alderazi  Amer
- Aldlyami  Ehab
- Aldressi  Wafa
- Alecci  Anna
- Alexander  Philip
- AlFakhri  Abdullah
- Alharthi  Mohammed
- Alhassoun  Turki
- Alhefdhi  Amal
- Alkadeeki  Ghadah
- Alkaseek  Akram
- Alkhatib  Ahmad
- Allemand  Carola
- Almabayev  Ydyrys
- Almeida-Reis  Rui
- Almiqlash  Bushray
- Almoguera  Jorge
- Almugaddami  Ayman
- Almulhim  Abddulrahman Saleh
- Alnachoukati  Omar
- Alnahr  Hareth
- Alonso  JesĂșs AarĂłn MartĂnez
- Alonso  Manuel Diez
- Alonso  Nestor Fabian Pedraza
- Alqudah  Majdi Ali
- Alrayes  Bourhan
- Alsaadi  Hayder
- Alsaadi  Hayder
- Alser  Osaid
- Alshaar  Muhammad
- Alshahrani  Mushabab
- Alshareef  Khayriyah
- Alshehri  Ameen
- Alshryda  Sattar
- Alshryda  Sattar
- Alsibai  Sareyah
- Alsunna  Zaid
- Altaf  Humera Naz
- Althumairi  Azah
- Althumairi  Azah
- Althumairi  Azah
- Alvarado  Carlos Eduardo Otiniano
- Alyami  Mohammad
- Alzahrani  Abdulrahman
- Alzaidi  Turki M.
- Alzate  Juan Pablo
- Alzerwi  Nasser
- Amisi  Nicolas
- Amnaina  Mohamed
- Amor  MarĂa Sol Crespi
- André  Benoßt
- Angeles  Martina Aida
- Anwer  Mariyah
- Anyanwu  Lofty-John
- Aouabed  Nesrine
- Aqeelah  Ahmed
- Aqil  Sabra
- Arancibia  José Alfredo Calderón
- Arango  Maria Clara Mendoza
- Arbane  Gill
- Argus  Leah
- Arias  Claudia
- Arnalsteen  Laurent
- Arnaud  Alexis P.
- Arnaud  Alexis P.
- Asif  Muhammad
- Assefa  Melatework
- Atnafu  Bahru
- Aulerio  Giuliana D.
- Aurora Â
- Awad  Selmy
- Ayasra  Faris
- Ayasra  Faris
- Ayoub  Abdu
- Ayub  Bushra
- Ayub  Khurram
- Azevedo  José
- Azevedo  José
- Azevedo  Pedro
- Aziz  Aliya
- Azzam  Ahmed Y.
- Bacalbasa  Nicolae
- Badareesh  L.
- Badenes  Rafael
- Badiani  Sarit
- Baig  Mariam
- Bains  Lovenish
- Baiocchi  Glauco
- Baiocchi  Glauco
- Baiocchi  Glauco
- Bajaj  Ankur
- Balanta-Melo  Juliån
- Balasubramanya  Supriya
- Bali  Oussama
- Baliarsing  Lipika
- Ball  Alasdair
- Ballouhey  Quentin
- Ban  Vin Shen
- Bankhead-Kendall  Brittany
- Bankhead-Kendall  Brittany
- Barillas  Sabrina
- Barker  John
- Barros  Aldo Vieira
- Basnayake  Oshan
- Bastet  Joaquin
- Basu  Somprakas
- Bateman  Antony
- Bath  Michael
- Batista  Sylvia
- Bauset  Juan Carlos Catalå
- Bayo  Heura Llaquet
- BaĂa  Catarina
- Behzadi  Abdollah
- Bekele  Kebebe
- Bele  Uros
- Bele  Uros
- Bellver  Pedro Palazon
- Ben Amer  Anass
- Benallel  Nassim
- Benson  Ruth
- Berber  Norberto
- Bergeat  Damien
- Bergkvist  David JuliĂ
- Bernal-Sprekelsen  Juan Carlos
- Berndtson  Allison
- Bertrand  Marta
- Bescós  Coro
- Bezabih  Yoseph Solomon
- Bhanderi  Shivam
- Bhangu  Aneel
- Bhangu  Aneel
- Bhat  Dhananjaya
- Bhatti  Abu Bakar Hafeez
- Bhende  Vishal
- Bhutiani  Neal
- Bianco  AgustĂn
- Biccard  Bruce
- Blanco-Colino  Ruth
- Blanco-Colino  Ruth
- Blanco-Colino  Ruth
- Blasco  Laura Sånchez
- Boccalatte  Luis
- Boccalatte  Luis
- Boccalatte  Luis
- Boira  Mar Achalandabaso
- Boisson  Matthieu
- Bolatbekova  Raikhan
- Bolger  Jarlath
- Bollano  Enton
- Bonci  Eduard-Alexandru
- Bonci  Eduard-Alexandru
- Borda-Luque  Giuliano
- Boretto  Jorge G.
- Borges  Filipe Castro
- Bork  Ulrich
- Borowski  David W.
- Botero  Marcela Velez
- Bouaoud  Souad
- Bouche  Pierre-Alban
- Bouchenak  Kamel
- Boucher  Sophie
- Boudou  Rocio
- Bouhuwaish  Ahmad
- Brandariz  Rodrigo
- Branquinho  Rita
- Brar  Amanpreet
- Brar  Amanpreet
- Bravo  Ana Maria Minaya
- Bravo  Ana Maria Minaya
- Breen  Kerry
- Brennan  Caitlin
- Brien  Stephen O.
- Bright  Tim
- Brown  Wendy
- Brunaud  Laurent
- Brunner  Stefan M.
- Buarque  Igor Lima
- Bucyibaruta  Georges
- Bukhari  Syed Imran
- Buljubasich  Martin
- Burchakchi  Arturo
- Burgan  Dania
- Busnelli  Virginia Cano
- Buttaro  Martin
- Butyrskii  Aleksandr
- Bwala  Kefas
- Bywater  Edward P.
- C Â Ricci
- Caiado  André
- Caicedo  Lina
- Cal  Fernando Bonilla
- Callcut  Rachael
- Calvache  Albaro José Nieto
- Calvache  Jose Andres
- Calvache  Jose Andres
- Calvache  Jose Andres
- Calzaretta  Laura Gisela Alvarez
- Campana  Juan Pablo
- Campos  Heloisa Galvão do Amaral
- Capitaine  Daniel
- Cappeliez  Serge
- Cardoso  Paulo
- Carmichael  Heather
- Carminatti  Tomas
- Carrera  Jacqueline
- Carreras-Castañer  Anna
- Caruana  Edward
- Cereghini  Julian
- Cerovac  Anis
- Cerovac  Anis
- Chadi  Sami
- Chakrabortee  Sohini
- Chan  Matthew
- Chandrasinghe  Pramodh
- Chapatwala  Reema
- Charbonneau  Helene
- Charles  Shane
- Chaudhary  Muhammad Hamid
- Chaudhry  Daoud
- Chaudhry  Daoud
- Chaudhry  Navneet Kumar
- Chauhan  Govind Singh
- Chebaro  Alexandre
- Chew  Min Hoe
- Chin  Theresa
- Chinyowa  Simbarashe
- Chiuyari  Jose Rios
- Choong  Peter
- Chowdappa  Raghunandan Gorantlu
- Chowdhury  Sharfuddin
- Christensen  Peter
- Chuan  Alwin
- Chwat  Carina
- Chwat  Carina
- Clancy  Cillian
- Coimbra  Felipe José Fernandez
- Coleman  Julia
- Colmenares  Yahaira Tatiana Carpio
- Colås-Ruiz  Enrique
- Connelly  Tara
- Connor  Clare O.
- Coonar  Aman
- Corbett  Harriet
- Corella  Fernando
- Corripio-Sanchez  Ramon
- Costa  Luciana Cidade
- Costas-Chavarri  Ainhoa
- Costea  Radu
- Cotta  EstefanĂa
- Cox  Daniel
- Cox  Daniel
- Creavin  Ben
- Croattini  Roberto Sebastiån
- Croghan  Stefanie M.
- Crétolle  Célia
- Cukier  Moises
- Cukier  Moises
- Cullinane  Carolyn
- Cunha  Miguel F.
- Cunha  Miguel F.
- Dajti  Irida
- Dajti  Irida
- Dajti  Irida
- Daoud  Hassan
- Das  Rishi
- Davies-Jones  Gareth
- Davis  Niall
- Dawson  Amanda Caroline
- Dawson  Amanda Caroline
- Dawson  Brett E.
- Dbeis  Rachel
- De Andrés-Asenjo  Beatriz
- De Cortazar  Unai Garcia
- de Dieu  Haragirimana Jean
- de LeĂłn  Laura RomĂĄn GarcĂa
- De Simone  Belinda
- Dean  Benjamin
- Degefa  Eyueal
- Del Pilar Paucar Urbina  Arazzelly
- Delibegovic  Samir
- Delisau-Puig  Olga
- Dell  Angela
- Demetrashvili  Zaza
- Demetrashvili  Zaza
- Demetriades  Andreas K.
- Derilo  Habtamu
- Desai  Anant
- Deus  Ana Clåudia
- Dharap  Satish
- Dhondt  Bert
- Dhufera  Hailu
- Di Martino  Marcello
- Di Saverio  Salomone
- Di Vincenzo  Marcela
- Diaz-Couselo  Fernando
- Diehl  Thomas
- Dimofte  Mihail-Gabriel
- DiNome  Maggie
- Djahida  Bahraoui
- Doerner  Johannes
- Domenech  Julio
- Donlon  Noel
- Drake  Frederick
- Drake  Thomas
- Drasovean  Radu
- Duarte  Amalia Barrios
- Duarte  Carolina Lugo
- Dube  Surya Kumar
- Duchalais  Emilie
- Dudi-Venkata  Nagendra
- Duran  Irani
- Duric  Natalie
- Duro  Agustin
- Dwaga  Sumayya Essayah
- Dziakova  Jana
- Déserts  Marc Danguy des
- DĂaz-Feijoo  Berta
- Earley  Helen
- Eberbach  Helge
- Edwards  John
- Edwards  John
- Efetov  Sergey
- Efetov  Sergey
- Egoroff  Natasha
- Eiras  Miguel Angel Freiria
- Ekenze  Sebastian
- El Helw  Amin
- El Kafsi  JihÚne
- El-Boghdadly  Kariem
- El-Boghdadly  Kariem
- El-Hussuna  Alaa
- Elhadi  Muhammed
- Elhadi  Muhammed
- Elhajdawe  Fras
- Elliott  Brodie
- Ellojli  Ibrahim
- Elwahab  Sami Abd
- Emerson  Hannah
- Emile  Sameh
- Emile  Sameh
- Enjuto  Diego
- Escartin  Jorge
- Escudero  DamiĂĄn GarcĂa
- Escudero  Mario I.
- Eskander  Antoine
- Espin-Basany  Eloy
- Espino  Pablo Calvo
- Espinosa-Bravo  Martin
- Esquivel  Carlos
- Estruch  Nuria Montferrer
- Etchill  Eric
- Evans  Jonathan
- Evelyn  Nissi
- Ezanno  Anne-Cecile
- Fahadullah  Muhammad
- Fahmy  Mohamed
- Fakhradiyev  Ildar
- Fakhradiyev  Ildar
- Farfus  Anthony
- Farik  Shebani
- Farooq  Umer
- Faulkner  Gemma
- Faustin  Ntirenganya
- Fernandez  Juan Delgado
- Fernandez  Laura Gomez
- Fernandez  Maria Sol
- Fernåndez  Fåtima Sånchez
- Fernåndez-López  Antonio-José
- Ferrer  Antonio Perez
- Ferry  Jenny
- Figari  Marcelo
- Figueroa  Rodrigo
- Figueroa-Casanova  Rafael
- Filipce  Venko
- Filipescu  Daniela
- Fiore  Marco
- Fisseha  Tigist
- Flamey  Nicolas
- Fleming  Christina
- Flexman  Alana
- Fluegen  Georg
- Flumignan  Ronald
- Ford  Samuel
- Forero-Torres  Alexander
- Forneris  Agustin Albani
- Fotopoulou  Christina
- Fowler  Alexander
- Fraidenraij  Uriel
- Fredon  Fabien
- Fuentes  Marta Alcaraz
- Fuentes  Tyare
- Fujimoto  Yuki
- Futaba  Kaori
- Gagnier  Joel
- Gahwagi  Milad
- Gallegos  Diego
- Gallino  Esteban Sebastian
- Gallo  Gaetano
- Ganly  Ian
- Garcia  Manuel
- Garcia-Adamez  Jorge
- GarcĂa  Lucia Diego
- GarcĂa  Pablo MartĂn
- GarcĂa-Mansilla  AgustĂn Maria
- GarcĂa-Montoya  Oscar-JuliĂĄn
- Gaujoux  Sebastien
- Gauna  Guillermo Hernandez
- Gempt  Jens
- Georgiades  Fanourios
- Gerchunoff  José Ignacio
- Ghani  Muhammad Owais Abdul
- Ghazal  Ahmad
- Ghazwani  Salman
- Ghodke  Rahul
- Ghosh  Dhruva
- Ghosh  Dhruva
- Ghosh  Indranil
- Ghozy  Sherief
- Ghunaim  Mohammed
- Gialamas  Eleftherios
- Gialamas  Eleftherios
- Gigena  Cecilia
- Gil-Sala  Daniel
- Ginghina  Octav
- Giorgakis  Emmanouil
- Girard  Edouard
- Girard  Noémie
- Gishanthan  Shanthamoorthy
- Gjata  Arben
- Gjyli  Kostandin
- Glasbey  James C.
- Glasbey  James C.
- Glass  Nina
- Glowka  Tim R.
- Gohar  Muhammad
- Golet  Marta Roldón
- Gomes  Gustavo Mendonça AtaĂde
- Gomez  Jose Tomas Castell
- Gomez-Fernandez  Hugo
- Gomez-Rosado  Juan-Carlos
- Gonzalez  Diana Samantha
- Gonzalez  Marcos
- Gonzalez  Matias Ignacio
- Gonzalez  Santiago Valderrabano
- Gonzålez  Javier Serrano
- Gonzålez-Gimeno  Maria Jose
- Gonzålez-Suårez  Susana
- Goransky  Jeremias
- Gosain  Ankush
- Gourlay  Ralph
- Gousias  Konstantinos
- Gouvas  Nikolaos
- Gouvas  Nikolaos
- Grama  Florin
- Grassano  Bianca
- Greenhalgh  Michael
- Griffiths  Ewen
- Gronchi  Alessandro
- Groot  Gary
- Gross  Jefferson
- Guillen  Jose Ramon Oliver
- Gujjuri  Rohan R.
- Gujjuri  Rohan R.
- Gulla  Aiste
- Gunawansa  Nalaka
- Gupta  Anand
- Gupta  Rahul
- Gurumeta  Alfredo Abad
- Gut  Anna Eleonora
- Gómez  Mercedes Estaire
- Ha  Jeong
- Habumuremyi  Sosthene
- Hadzibegovic  Ana Danic
- Haidar  Hanan
- Haider  Fayza
- Haif  Assia
- Hailu  Samuel
- Hailu  Samuel
- Hakami  Ibrahim
- Hamad  Faten Reyad Bani
- Hamdun  Intisar Hisham Said
- Hameed  Zeeshan
- Hammed  Ali
- Hammond  John
- Haran  Cheyaanthan
- Hardie  John
- Harper  Luke
- Harrison  Ewen M.
- Harrison  Ewen M.
- Hashimoto  Daisuke
- Hassan  Ramy A.
- Hecker  Andreas
- Henein  Christin
- Heredia  Fernando
- Heriot  Alexander
- Hervieux  Erik
- Herzberg  Jonas
- Higuera  Felipe
- Hilmi  Ahmed
- Hirji  Sameer
- Hirschburger  Markus
- Hodgson  Russell
- Holc  Fernando
- Hollington  Paul
- Hollyman  Marianne
- Horch  Raymund E.
- Horisberger  Karoline
- Hossain  Kamral
- Huang  Abel
- Husain  Shatha
- Hutchinson  Peter
- Hyman  Gabriella Yael
- Höhn  Philipp
- Iascano  Fernando Martinez
- Ikele  Hilary
- Imanishimwe  Alphonsine
- Incorvia  Joseph
- Incorvia  Joseph
- Infante  Antonio Rodriguez
- Ingabire  Jc Allen
- Ionescu  Sebastian
- Isaac  Otolia
- Isik  Arda
- Isik  Arda
- Iskander  Othman
- Jain  Kavitha
- Jain  Ritu
- Jamal  Aiman
- Jamal  Mohammad
- James  Harelimana Grace
- Jauregui  Esteban Gabriel
- Javadpour  Mohsen
- Javed  Saad
- Javed  Saad
- Jaworska  Natalia
- Jayarajah  Umesh
- Jayarajah  Umesh
- Jeandel  Clement
- Jenkinson  Michael
- Jimaale  Elmi Ahmed Mohamed
- Jimenez  Raul
- Jimenez  Virginia
- Jiménez  Pablo Mijahil Avilés
- Jiménez  Pablo Mijahil Avilés
- Jin-Young  Jang
- Jira  Moa
- Jisry  Ghassan
- Jlassi  Haithem
- Johnson  David
- Jones  Conor S.
- Jonker  Pascal
- Jouffret  Lionel
- JĂșnior  Samuel Aguiar
- Kaafarani  Haytham
- Kaafarani  Haytham
- Kaafarani  Haytham
- Kabir  Syed Mohammad Umar
- Kabweru  Wilberforce M.
- Kache  Stephen
- Kacimi  Salah Eddine Oussama
- Kaidarova  Dilyara
- Kaiser  Julia Christina
- Kakeeto  Andrew
- Kaman  Lileswar
- Kamarajah  Sivesh K.
- Kamarajah  Sivesh K.
- Kamphues  Carsten
- Kandevani  Naser Yousefzadeh
- Kannan  Ravi
- Karout  Lina
- Karthigeyan  Madhivanan
- Kassir  Radwan
- Kauppila  Joonas H.
- Kauppila  Joonas H.
- Kaups-Fresno  Krista
- Kavalakat  Alfie
- Keatley  James M.
- Kembuan  Gabriele
- Keppler  Alexander M.
- Keppler  Lena
- Kerawala  Asad Ali
- Kerawala  Cyrus
- Kerpaci  Jola
- Khadidja  Kouidri
- Khalifa  Houda
- Khalil  Kareem S.
- Khamees  Almu'atasim
- Khan  Tabassum
- Khatri  Chetan
- Kherani  Safeena
- Khokhar  Muhammad Imran
- Khosravi  Mohammad
- Khosravi  Mohammad Hossein
- Kieser  David
- King  Jasmin
- Kirov  Mikhail
- Kiweewa  Ronald
- Klat  Jaroslav
- Knight  Stephen Richard
- Kochetkov  Viktor
- Koh  Cherry
- Koh  Frederick
- Koh  Frederick
- Kolias  Angelos
- Komen  Niels
- Konate  Ibrahima
- Konrads  Christian
- Kopetskyi  Slava
- Kopjar  Tomislav
- Kornblith  Lucy
- Kowalski  Luiz Paulo
- Koƥir  Jurij Aleƥ
- Koƥir  Jurij Aleƥ
- Kpangon  Cyrille
- Kronberger  Irmgard
- Kronberger  Irmgard Elisabeth
- Kroon  Hidde M.
- Kruijff  Schelto
- Kudsk-Iversen  SÞren
- Kulimbet  Mukhtar
- Kulkarni  Amruta
- Kumar  Aruna
- Kumar  Ashwani
- Kundra  Rakesh
- Kuroda  Naoto
- Kwan  Tsun Yu
- Königsrainer  Alfred
- la Medina  Antonio Ramos-De
- Laban  Simon
- Lakkis  Zaher
- Lakpriya  Sathya
- Lalmi  Ismahene
- LalĂn  Agustina Florencia Castro
- Lami  Mariam
- Landaluce-Olavarria  Aitor
- Larrañaga  Juan
- Latif  Haider
- Lau  Lorena Fuentes Rivera
- Laudani  Veronica
- Laudani  Veronica
- Laura  Saura GarcĂa
- Lavanya Kannaiyan  R.
- Lawal  Taiwo Akeem
- Lawani  Ismaïl
- Lawani  Ismaïl
- Lawday  Samuel
- Le Bian  Alban Zarzavadjian
- Lederhuber  Hans
- Lekuya  Hervé Monka
- Lekuya  Hervé Monka
- Lekuya  Hervé Monka
- Leung  Elaine
- LeventoÄlu  Sezai
- LeventoÄlu  Sezai
- Lewis-Lloyd  Christopher
- Lewis-Lloyd  Christopher
- Li  Elizabeth
- Li  Elizabeth
- Lidder  Surjit
- Lincango-Naranjo  Eddy
- Lincango-Naranjo  Eddy
- Lindert  Judith
- Linz  Valerie Catherine
- Litvin  Andrey
- Litvin  Andrey
- Liveris  Anna
- Liyo  Juan
- Llano  Lionel
- Lo  Terence
- Loaloa  Mohamed Reda
- Lobos  Pablo
- Lohsiriwat  Varut
- Losada  Manuel
- Lott  Natalie
- Lou  Wenhui
- Lowey  Megan
- Lozada  Jorge Centeno
- LoÌffler  Markus W.
- Lucchini  Sergio Martin
- Lucchini  Sergio Martin
- Lueckel  Stephanie
- Lugones  Ignacio
- Lule  Herman
- Lule  Herman
- Lule  Herman
- Luna  Joaquin
- Luzzi  Emilia
- López  Anna Sånchez
- López  Cristina Barrena
- Mabood  Waleed
- Macchiavello  Roberto
- MacKenzie  Shawn
- Madabhavi  Irappa
- Madkhali  Tariq
- Madrid  Constanza
- Mahakalkar  Chandrashekhar
- Maher  Mark
- Maimbo  Mayaba
- Maji  Suvendu
- Majid  Haroon Javaid
- Major  Piotr
- Major  Piotr
- Makdissi  Fabiana
- Makkai-Popa  Silviu Tiberiu
- Maldonado-Marcos  Eloy
- Maleki  Esmaeil Rezghi
- Malik  Muhammad Usman
- Mallén  Victoria Duque
- Manceau  Gilles
- Mann  Harvinder
- Mann  Harvinder
- Mansour  Ahmed
- Maricic  Maximiliano
- Mariño  Lucia Porteiro
- Marquez  Lucila
- Marson  Ella J.
- Martin  Janet
- Martin  Janet
- Martinez  Antonio Alberto
- Martinez  Eneida Diaz
- Martinez  Laura
- Martins  Paulo
- MartĂn  Maria Teresa FernĂĄndez
- MartĂn-LĂĄez  RubĂ©n
- MartĂnez  Daniel FernĂĄndez
- MartĂnez  MarĂa JosĂ©
- MartĂnez  Mireia Riba
- Marçal  André
- Mashbari  Hassan
- Mashhour  Mohamed
- Mashhour  Mohamed
- Mashhour  Mohamed
- Massoud  John George
- Mastroianni  Gustavo
- Mata-Suarez  Santiago Miguel
- Matai  Anil
- Mateo-Sierra  Olga
- Matovu  Paul
- Mayer  Horacio F.
- Mayol  Julio
- Mazingi  Dennis
- Mc Loughlin  Santiago
- McDonnell  Brendan
- McGuinness  Matthew James
- McIntosh  Nick
- McKay  Siobhan
- Mclean  Kenneth A.
- Mclean  Kenneth A.
- McNestry  Catherine
- Meara  John G.
- Meelad  Ayman
- Mege  Diane
- Megersa  Abebe
- Mehraj  Asif
- MejĂa  Dolores
- Melendez  Robinson Mas
- Melero  Alba Vazquez
- Melo  Miguel Rocha
- Mendes  Filipa
- Mendiola  Gian
- Mendoza  Efrain
- Mendoza  Veronica Alonso
- Mengesha  Mengistu G.
- Mengesha  Mengistu G.
- Mengesha  Mengistu Gebreyohanes
- Mentz  Ricardo Esteban
- Meola  Antonio
- Mercado  Pedro
- Mersich  Tamås
- Metallidis  Symeon
- MeÌvo Romaric Tobome  S.
- Michael  Antony Louis Rex
- Migliorelli  Federico
- Mihanovic  Jakov
- Mihanovic  Jakov
- Milan  Peiman Brouki
- Mills  Emily
- Mimica  Ximena
- Mironescu  Aurel
- Mishra  Tushar
- Misra  Sanjeev
- Misrai  Vincent
- Mittal  Rohin
- Mitul  Ashrarur Rahman
- Mlambo  Busisiwe
- Modabber  Ali
- Modolo  Maria Marta
- Modolo  Maria Marta
- Modolo  Maria Marta
- Modolo  Maria Marta
- Mohamed  Awadelkarim
- Mohammed  Alsnosy Abdullah Khalefa
- Mohammed  Diary
- Mohan  Helen
- Mohsen  Mustafa Abo
- Mohyieldin  Omar
- Moir  John
- Molitvin  Yegor
- Mondino  Jose
- Montal  Silvina
- Montenegro  Emileth
- Morales-Puebla  José Manuel
- Morris  Brian
- Morsy  Amr
- Mosley  Frances
- Moss  Jana-Lee
- Mostafa  Badr
- Motas  Natalia
- Moug  Susan
- Moya-Angeler  Joaquin
- Moyano  Pablo
- Mozafari  Masoud
- Mozel  Michelle
- Mozo  Ana Sånchez
- Msherghi  Ahmed
- Mubezi  Isaac
- Muheilan  Muheilan
- Munyaneza  Emmanuel
- Munyika  Akutu
- Muralidharan  Vijayaragavan
- Muriel  MarĂa Emilia
- Mushiwokufa  Willard
- Muthu  Sathish
- Naem  Antoine
- Nagar  Manoj
- Nakagawa  Suely
- Nappi  Francesco
- Naseem  Muhammad Yasir
- Nashidengo  Pueya Rashid
- Nashidengo  Pueya Rashid
- Naunheim  Matthew
- Nayen  Alejandra
- Ncogoza  Isaie
- Ndayishyigikiye  Marcel Didier
- Ndong  Abdourahmane
- Ndong  Abdourahmane
- Negoi  Ionut
- Negoi  Ionut
- Negussie  Abraham
- Nepogodiev  Dmitri
- Nepogodiev  Dmitri
- Nepogodiev  Dmitri
- Nessim  Carolyn
- Neto  Joao Pedreira Duprat
- Newman  Samuel
- Ng-Kamstra  Joshua
- Ngu  James
- Ngulube  Allan
- Niazi  Sami Ullah
- Nicholson  Kristina
- Nidaw  Melkamu
- Nikolaieva  Karine
- Niquen-Jimenez  Milagros
- Nitschke  Christine
- Nkembi  Armande Subayi
- Nogueiro  Jorge
- Noll  Florencia
- Noltes  Milou
- Noltes  Milou
- Norman  Lisa
- Norman  Lisa
- Nouh  Thamer
- Novysedlåk  René
- Novysedlåk  René
- Nowak  Kai
- Ntirenganya  Faustin
- Nunez  Jade
- Nurgozhin  Talgat
- Nuñez  Jorge
- Nuñez  Jorge
- Nwegbu  Chukwuemeka
- NĂșñez  Bernardo
- Odejinmi  Funlayo
- Odetto  Diego
- Ofori  Bernard
- Ojeda  Ximena Paola Vasquez
- Okereke  Chukwuma
- Okonkwo  Ijeoma
- Okunlola  Abiodun
- Olaogun  Julius
- Olaywah  Noor
- Oliva  Agustina Rene
- Oliveira  João
- Olivos  Maricarmen
- Olivos  Maricarmen
- Olori  Samson
- Olson  Kristofor A.
- Omar  Omar M.
- Omari  Rand Y.
- Oosterlinck  Wouter
- Ortiz  Maria Rosa
- Oscco  Regina Amparo Ugarte
- Osinaike  Babatunde
- Ots  Riinu
- Outani  Oumaima
- Outani  Oumaima
- Outani  Oumaima
- Pablo  Carmignani
- Pachajoa  Diana Alejandra Pantoja
- Pacheco  Glenda Marina Falcon
- Pacilli  Maurizio
- Padmore  Greg
- Palacios  Nelson Morales
- Pallardel  Jenner Betalleluz
- Panyko  Arpåd
- Paranjape  Charu
- Parmar  Chetan
- Passadore  Martin
- Pata  Francesco
- Patel  Akshay
- Patel  Rakesh
- Pawar  Pranay
- Peiper  Christian
- Pejkova  Sofija
- Pejkova  Sofija
- Pellino  Gianluca
- Perdomo  Valentina Gutiérrez
- Pereira  Rita Gonçalves
- Perez Rivera  Carlos J.
- Perez Rivera  Carlos J.
- Perez-Chrzanowska  Hanna
- Perinotti  Roberto
- Pfister  Karin
- Phadnis  Ashish
- Picciochi  Maria
- Picciochi  Maria
- Pigeolet  Manon
- Pilar Tormos PeÌrez  M.
- Pius  Riinu
- Plarre  Philipp
- Pockney  Peter
- Pockney  Peter
- Pockney  Peter
- Pockney  Peter
- Poggi  Catalina
- Police  Andrea
- Ponugoti  Nikhil
- Portilla  Ana LucĂa
- Portilla  Fabian Rojas
- Porumb  Vlad
- Powell  Simon
- Prada  Jorge
- Pramesh  C. S.
- Prat-Ortells  Jordi
- Prats  Milagros Carrasco
- Premoli  Eduardo Jorge
- Prieto  Mikel
- Puiggrós  Laura Cårdenas
- Putnis  Soni
- Pykhteev  Vadim
- Pérez  Beatriz Gómez
- Pérez-Bertólez  Sonia
- Qasem  Abdulrahman
- Qassem  Faisal
- Qassem  Mohamed
- Quante  Markus
- Quintana-Villamandos  Begoña
- Qureshi  Ahmad Uzair
- Qureshi  Ahmad Uzair
- R Â Casadei
- Ra'ed  Hazim
- Radenkovic  Dejan
- Raevskaya  Marianna
- Rahbari  Nuh
- Rahy-MartĂn  Aida Cristina
- Rai  Lajpat
- Rajan  Shiv
- Rajanbabu  Anupama
- Ramallo-SolĂs  Irene
- Rammohan  Ashwin
- Ramos  MarĂa Lourdes
- Ramos-Luengo  Adolfo
- Ranganath  N.
- Rasoaherinomenjanahary  Fanjandrainy
- Rassweiler-Seyfried  Marie-Claire
- Rattan  Rishi
- Rattanasirivilai  Pornjittra
- Raut  Monish
- Recinos  Gustavo
- Recinos  Gustavo
- Regalo  Guillermo
- Reim  Daniel
- Reinhard  Tobias
- Reinke  Caroline
- Reisenauer  Janani
- Ren  Dong-Lin
- Rennie  Sarah
- Rennie  Sarah
- Rice  Henry E.
- Rice  Henry E.
- Rida  Ahmed Hossam Eldin Fouad
- Rio  Javier
- Ripollés-Melchor  Javier
- Rissmann  Anke
- Roberts  Keith
- Rodas  Alejandra
- Rodriguez  Juliana
- Rodriguez-Abreu  Julia
- Rodriquez  Jennifer
- RodrĂguez-Tesouro  Ana
- Rogers  Luke
- Rokohl  Alexander Christopher
- Roman  Igor Alberdi San
- Romera  Susana Bella
- Ronellenfitsch  Ulrich
- Rosas  Patricio
- Roslani  April Camilla
- Roslani  April Camilla
- Roslani  April Camilla
- Rossi  Gustavo
- Rossi  Luciano
- Rosso  Andres
- Roth  Andreas
- Rubio-Palau  Josep
- Ruiz  Alitza Gutiérrez
- Ruiz-MarĂn  Miguel
- Russell  Crispin
- RutegÄrd  Martin
- Ruzgar  Nensi Melissa
- Ryan  Ăanna
- Saad  Mahmoud M.
- Saadi  Jose
- Sacdalan  Marie Dione
- Sacdalan  Marie Dione
- Sacras  Maria LuĂs
- Saenz  Dinimo Bolivar
- Safieddine  Najib
- Sagar  Jayesh
- Saier  Tim
- Salazar  Esteban Gonzalez
- Salazar  Ivana Ines Pedraza
- Sale  Danjuma
- Saleh  Ismail Ali
- Salem  Marwa
- Saliev  Timur
- Saliev  Timur
- Sallam  Asser
- Samadov  Elgun
- Samaka  Rehab
- Samison  Luc Hervé
- Sampaio-Alves  Mafalda
- Sancho-Muriel  Jorge
- Sandoval  Danilo Alfonso Arévalo
- Sandoval  Danilo Alfonso Arévalo
- Santos  IrÚne
- Santos  IrÚne
- Santos-Costa  Paulo
- Sanz-Gonzalez  Rosa
- Sarjanoja  Elise
- Sarwar  Muhammad Zeeshan
- Satoi  Sohei
- Satoi  Sohei
- Sauvain  Marc-Olivier
- Sayyed  Raza
- Scalabre  Aurélien
- Schache  Andrew
- Scher  Pablo
- Scherñuk  Jordån
- Schlager  Daniel
- Schmedding  Andrea
- Schnitzbauer  Andreas
- Schoneveld  Martijn
- Seegert  Sara
- Seeliger  Barbara
- Seguin-Givelet  Agathe
- Sekar  Arunkumar
- Serralheiro  Pedro
- Seyi-Olajide  Justina
- Seyi-Olajide  Justina
- Shah  Rakesh
- Shaikh  Shafaque
- Shanthanna  Harsha
- Sharma  Abhishek
- Sharma  Rahul Deo
- Sharma  Shilpa
- Shaw  Catherine
- Shaw  Catherine
- Shaw  Richard
- Shehata  Sameh
- Shehta  Ahmed
- Sherif  Ahmed Elshawadfy
- Shih  Emily
- Shrestha  Ashish Lal
- Shumbash  Kibruyisfaw
- Siamuchembu  Maphios
- Siddique  Haleema
- Sieira-Gil  Ramon
- Sigamoney  Kohila
- Sikakulya  Franck K.
- Silva  Camilo Ortiz
- Silva  Nelson
- Silva-Igua  Liliana
- Simoes  Joana Ff
- Simoes  Joana Ff
- Simoes  Joana Ff
- Sin  MÂȘPilar Canals
- Singh  Harvinder
- Singisetti  Kiran
- Sinnerton  Robert
- Sisay  Silamlak
- Slavchev  Mihail
- Slavchev  Mihail
- Slim  Karem
- Slullitel  Pablo
- Smart  Neil
- Soares  Ana
- Sodhai  Vivek
- Sole  Oriol Martin
- SolĂ©  MisericĂČrdia JordĂ
- Soni  Rajesh
- Sonksen  Julian
- Sooriyabandara  Charitha
- Soria  Vanesa Garcia
- Soto-Darias  Ivån
- Soualili  Zineddine
- Spelsberg  Fritz
- Squiers  John
- Srishankar  Selvaratnam
- St-Germain  Pascal
- Stadler  Josef
- Stang  MarĂa Verona
- Stavridis  Sotir
- Stavrou  Gregor A.
- Steinkamp  Pieter
- Steinkamp  Pieter
- Stephens  Matthew
- Stevens  Sean
- Stewart  Grant D.
- Stewart  Grant D.
- Stijns  Jasper
- Stoleriu  Mircea Gabriel
- Suarez  Marcelo Moreno
- Subbian  Anbukkani
- Suliaman  Taha
- Sultan  Rizwan
- Sultana  Asma
- Sumadi  Adnan
- Sund  Malin
- Surendran  Arthika
- Suroy  Atul
- Szakmany  Tamas
- Sånchez  Alberto Cabañero
- Sånchez  Iran Irani Durån
- SĂĄnchez-CabĂșs  Santiago
- Tabiri  Stephen
- Taboada  MarĂa Victoria
- Tachella  Sofia
- Tadesse  Anteneh
- Talat  Nabila
- Talib  Ahmar Iftikhar
- Talwar  Rishi
- Tamoos  Khalil
- Tampaki  Ekaterini Christina
- Tan  Lorwai
- Tariq  Aiman
- Tariq  Muhammad
- Tarrado  Xavier
- Taylor  Elliott H.
- Teague  Rebecca
- Teasdale  Ella
- Tefera  Teshome
- Tejero-Pintor  Francisco J.
- Tendeng  Jacques
- Teo  Nan Zun
- Teresa GavaldaÌ PelliceÌ Â M.
- Testelin  Sylvie
- Thakar  Sumit
- Thereska  Dariel
- Thereska  Dariel
- Thies  Cristina Ojeda
- Thyavihally  Yuvaraja
- Tirapegui  Sebastian
- Todorovic  Lazar
- Tojal  André
- Tolani  Musliu Adetola
- Toma  Elena Adelina
- Tornini  Alejandra
- Toro  Carlos Andres Marulanda
- Torres  Martha Luz
- Toscano  Marta Jimenez
- Totty  Joshua
- Townend  Philip
- Traeger  Luke
- Traverso  Rogelio
- Tripathi  Manjul
- Trout  Isobel M.
- Trujillo  Lina MarĂa
- Tsegaye  Bereket
- Tsoulfas  Georgios
- Tudela  Kiara
- Turinawe  Gaston
- Turner  Paul
- Turrado-Rodriguez  Victor
- Uffelmann  Constanza
- Ugarte-Sierra  Bakarne
- Usang  Usang
- Vaccaro  Carlos
- Vagni  Roberto
- Vaishnav  Dhaivat
- Valcarcel  Cristina Rey
- Valdez  Pedro
- Valerio  Ana Clara
- Vallam  Karthik Chandra
- Vallve-Bernal  Marc
- van Ramshorst  Gabrielle
- van Ramshorst  Gabrielle
- Vargas  Lara
- Varghese  Chris
- Varghese  Chris
- Varghese  Chris
- Varghese  Chris
- Vartanian  Jose Guilherme
- Vaughan-Shaw  Peter
- Vayoth  Sudheer Othiyil
- Vaysburg  Dennis
- Vaysse  Charlotte
- Velasco  Jorge Caño
- Velasquez  Enrique Jose Ruiz
- Venkatappa  Sunil Kumar
- Venn  Mary L.
- Verhaeghe  Romain
- Verhaeghe  Romain
- Vidal  Rafael Perez
- Vidya  Raghavan
- Vijayakumar Vijayakumar  M.
- Villanueva  Julio
- Vimalakanthan  Thanusan
- Vita  Diana Crego
- Vivancos  Patricia Caja
- Viveiros  Octavio
- Vives  Inmaculada
- Vives  Josep Maria Muñoz
- Vo  Uyen Giao
- von Pusch  Silke
- Vrapi  Enxhi
- Våzquez  Irene Ortega
- Wafi  Omar
- Wagner  Arthur
- Waissbluth  Sofia
- Waqar  Shahzad Hussain
- Watson  David
- Watson  Eleanor
- Watters  David
- Weeraddana  Prabuth Dulanjan
- Wells  Cameron
- Welter  Stefan
- Wettstein  Dåniel
- Wickramasinghe  Dakshitha
- Wickramasinghe  Dakshitha
- Wiegering  Armin
- Wijeysundera  Duminda
- Williams  Emmanuel
- Williams  Omolara
- Williams  Omolara
- Wilson  Michael
- Wolf  Sebastian
- Wolfer  Susanne
- Wong  Enoch
- Wright  Deborah
- Wright  Deborah
- Wright  Naomi
- Wuraola  Funmilola
- Wuraola  Funmilola
- Xaviour  Okedi Francis
- Xu  William
- Yadev  I.
- Yagoub  Ghozlan
- Yaqoob  Eesha
- Yaqoob  Hassan Nawaz
- Yasin  Seid Mohammed
- Yazbek  Guilherme
- Yebes  Alvaro
- Yeung  Justin
- Yip  Sebastian Shu
- Youssef  Mina
- Zabaleta  Jon
- Zahid  Imdad Ahmad
- Zanoni  Gerardo
- Zapardiel  Ignacio
- Zapata  Carlos Shiraishi
- Zarnescu  Narcis Octavian
- Zarour  Ahmad
- Zarour  Ahmad
- Zarour  Ahmad
- Zarratea  Celeste Soledad
- Zegarra  Sergio
- Zequi  Stenio C.
- Zezular  Damaris Idara Anabel
- Zhou  Xuanyu
- Zhussupov  Baurzhan
- Zijaj  Lorena
- Zimmelman  Natalie
- Zmora  Oded
- Zmora  Oded
- Zohra  Belabbes Fatima
- Publication venue
- HAL CCSD
- Publication date
- 01/11/2021
- Field of study
We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complications after elective surgery during the global SARS-CoV-2 pandemic. We performed an international prospective cohort study including patients undergoing elective surgery in October 2020. Isolation was defined as the period before surgery during which patients did not leave their house or receive visitors from outside their household. The primary outcome was postoperative pulmonary complications, adjusted in multivariable models for measured confounders. Pre-defined sub-group analyses were performed for the primary outcome. A total of 96,454 patients from 114 countries were included and overall, 26,948 (27.9%) patients isolated before surgery. Postoperative pulmonary complications were recorded in 1947 (2.0%) patients of which 227 (11.7%) were associated with SARS-CoV-2 infection. Patients who isolated pre-operatively were older, had more respiratory comorbidities and were more commonly from areas of high SARS-CoV-2 incidence and high-income countries. Although the overall rates of postoperative pulmonary complications were similar in those that isolated and those that did not (2.1% vs 2.0%, respectively), isolation was associated with higher rates of postoperative pulmonary complications after adjustment (adjusted OR 1.20, 95%CI 1.05â1.36, p = 0.005). Sensitivity analyses revealed no further differences when patients were categorised by: pre-operative testing; use of COVID-19-free pathways; or community SARS-CoV-2 prevalence. The rate of postoperative pulmonary complications increased with periods of isolation longer than 3 days, with an OR (95%CI) at 4â7 days or â„ 8 days of 1.25 (1.04â1.48), p = 0.015 and 1.31 (1.11â1.55), p = 0.001, respectively. Isolation before elective surgery might be associated with a small but clinically important increased risk of postoperative pulmonary complications. Longer periods of isolation showed no reduction in the risk of postoperative pulmonary complications. These findings have significant implications for global provision of elective surgical care. We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complications after elective surgery during the global SARS-CoV-2 pandemic. We performed an international prospective cohort study including patients undergoing elective surgery in October 2020. Isolation was defined as the period before surgery during which patients did not leave their house or receive visitors from outside their household. The primary outcome was postoperative pulmonary complications, adjusted in multivariable models for measured confounders. Pre-defined sub-group analyses were performed for the primary outcome. A total of 96,454 patients from 114 countries were included and overall, 26,948 (27.9%) patients isolated before surgery. Postoperative pulmonary complications were recorded in 1947 (2.0%) patients of which 227 (11.7%) were associated with SARS-CoV-2 infection. Patients who isolated pre-operatively were older, had more respiratory comorbidities and were more commonly from areas of high SARS-CoV-2 incidence and high-income countries. Although the overall rates of postoperative pulmonary complications were similar in those that isolated and those that did not (2.1% vs 2.0%, respectively), isolation was associated with higher rates of postoperative pulmonary complications after adjustment (adjusted OR 1.20, 95%CI 1.05â1.36, p = 0.005). Sensitivity analyses revealed no further differences when patients were categorised by: pre-operative testing; use of COVID-19-free pathways; or community SARS-CoV-2 prevalence. The rate of postoperative pulmonary complications increased with periods of isolation longer than 3 days, with an OR (95%CI) at 4â7 days or â„ 8 days of 1.25 (1.04â1.48), p = 0.015 and 1.31 (1.11â1.55), p = 0.001, respectively. Isolation before elective surgery might be associated with a small but clinically important increased risk of postoperative pulmonary complications. Longer periods of isolation showed no reduction in the risk of postoperative pulmonary complications. These findings have significant implications for global provision of elective surgical care
Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries
- Author
- Aarts Frits
- Ababneh Hazim
- Abad-Motos Ane
- Abaidalla Ahmed
- Abbakar Malaz
- Abd El Aal Ahmed
- Abd-Errazik Mohammad Ahmad
- Abdalradiy Abdalrahmman G
- Abdelkhalek Mohamed
- Abdelkhalek Mostafa
- Abdellatif Ahmed
- Abdellatif Mohamed
- Abdelsaid Kirolas
- Abdou Khaled
- Abdulfatah Mustapha
- Abdullah Mohammad Amer
- Abdullahi Mustapha Miko Mohammed
- AbellĂĄn Antonio Melero
- Abeysinghe Nayana
- Abiyere Henry
- Achimas-Cadariu Patriciu Andrei
- Adakaya Sıla
- Adam Nicolas
- Adams Benita
- Adams Ferdinand
- Adegboye Kazeem
- Adeyeye Ademola
- Adra Lama
- Adu-Poku Patricia
- Afuwape Oludolapo
- Afzal Ameer
- Afzal Muhammad Farooq
- Agapov Mihail
- Agara Daniel
- Aggarwal Manisha
- Agger Erika
- Aghadi Ifeanyi Kene
- Ahmed Amjed Yassir
- Ahmed Haleemasahdia
- Ahmed Khalil
- Ahmed Manar
- Ahmed Masood
- Ahmed Safia
- Ahn Hong Min
- Aibe Raquel
- Aigner Felix
- Aissat Abdenour
- Aitbaeva Arai
- Akay Omer
- Akbar Ali
- Akbas Ahmet
- Akere Abidemi
- Akesen Selcan
- Akgun Erhan
- Akhtar Naseem
- Akın Emrah
- Akova Elif
- Aktas Serhat
- Akçay Ăzlem
- Al Masri Mahmoud
- Al-Alnsi Ahmed
- Al-Hutheifi Roqia'A
- Al-Jarrah Amar
- Al-Naggar Hamza
- Al-Shehari Mohammed
- Alamin Nadeen
- Alawi Raneen
- Alawlaqi Dina
- Alawneh Fade
- Alberola Maria José
- Albers Michael
- Alcolea Natalia GonzĂĄlez
- Aleem Muhammad
- Alegre InĂȘs
- Alegre Javier Martinez
- Alexandre Flavia
- Alexandrescu Corina
- Alexnder Abelevich
- Alexopoulou Kalliopi
- Alfonso Beatriz AmorĂłs
- Ali Ahmed
- Ali Che Saniati Che
- Ali Danish
- Ali Madeeha
- Ali Mahmoud Abdelwahab
- Ali Manhal Hashim
- Ali Noura Al
- Alikhanli Jhale
- Aliyeva Zumrud
- Aliyu Mohammed
- Aljawder Hasan
- Allen Kate
- Almahmeed Ebrahim
- Alonso Alfredo
- Alonso Javier Etreros
- Alsamneh Muneer
- Alsayadi Ramzi
- Altinel Yuksel
- Altintoprak Fatih
- Altomare Donato F
- Alvarenga Isabella
- Alvarez Laura Jimenez
- Alvarez-Bautista Francisco Emmanuel
- Alvarez-DĂez Marcos
- Alves Brenda Chayanny
- Amadigwe Rita
- Amado Andreia
- Amado FabĂola
- Amador Cristina GarcĂa
- Amanullah Nazli
- Amaral HĂ©lida Aline Tomacheski
- Amaral Luis
- Amin-Tai Hizami
- Aminu Bashiru
- Amir Ahmad Suhaimi
- Ammar Ahmed Siddique
- Ammar Mona Ahmed
- Ammendola Michele
- Ammerata Giorgio
- Amorim Edgar
- Ancans Guntis
- Anderson Tom
- Andrade Diogo
- Andrejevic Predrag
- AndrĂ©s Beatriz DĂaz San
- Anestiadou Elissavet
- Ang Chin Wee
- Angelo Franceschi
- Anokhin Evgeny
- Anoldo Pietro
- Antakia Ramez
- Anton Majd
- Antonelli Serena
- Antropoli Carmine
- Anula Rocio
- Anwar Jamal
- Anyadike Florence
- Apostolakidou Magda
- Apostolidi Eirini
- Aprea Giovanni
- Arabadzhiev Angel
- Arakawa Satoshi
- Arauz Jazmin
- Aravindan U
- Aremu Abdurrahman
- Aremu Isiaka
- Argawy Osama
- Arican Can
- Arida Zahed Abu
- Armellin Claudia
- Arnaoutoglou Eleni
- Arreguy-Borges Kanthya
- Artigot Mariano
- Arturi Alessandro
- Arulappan Nirupama
- Arya Shobhit
- Arynov Ardak
- Asaad Peter
- Asano Yukio
- Ascari Francesca
- Asgarov Mohsum
- Ashmawy Soad
- Aslam Muhammad Imran
- Assimakopoulou Elena
- Assis Ana
- Astilleta Romina
- Atanasov Boyko
- Atendido Tiffany
- Athanasakis Elias
- Atici Semra Demirli
- Avellaneda Nicholas
- Avellaneda Nicolas
- Avseren Goksu
- Awead Marwa
- Ayandipo Omobolaji
- Aybar Engin
- Aydin Funda
- Aydin Gaye
- Ayoub Kusay
- Aytac Erman
- Aytaç Erman
- Azevedo Jose
- Azevedo Patricia
- Azhar Najia
- Aziz Gowhar
- Azman Zairul Azwan Mohd
- AĆkar Ahmet
- Babatunde Olanrewaju
- Badawi Marwa
- Baek Jeong-Heum
- Baez Noelia FernĂĄndez
- Baeza-Murcia Melody
- Bagnardi Francesco
- Baharom Salahudin
- Baik Seung Hyuk
- Baimakhanov Abylai
- Bains Lovenish
- Baker Aleksandra
- Bakmaz Bernarda
- Bala Abubakar Muhammad
- Balaban Vladimir
- Balalis Dimitrios
- Balasubramaniam Dinesh
- Balathayalan Yathev
- Baldi Claudio
- Balestri Riccardo
- Balfour James
- Ballah Abubakar
- Ballian Nikiforos
- Balooshi Iman Al
- Baloyiannis Ioannis
- Bamford Richard
- Bandar Mahdi Al
- Banham Gail
- Bannoud Mohammad Hassan
- Baptista Victor
- Baral Jörg
- Barbalace Nicolas
- Barbato Giuseppe
- Barbosa Anderson
- Bareka Metaxia
- Baris Baver
- Barradas Renato
- Barreda Sara Castillo
- Barrena-Blazquez Silvestra
- Barton Jess
- Bartosiak Katarzyna
- Bashilkina Olga
- Bashir Mohammed
- Basile Raffaele
- Basnyat Pradeep
- Batool Sana
- Bautista Wilson Manuel SĂĄnchez
- Bayhan ZĂŒlfĂŒ
- Bayo José Manuel Muros
- BayĂłn Raquel Ălvaro
- Baños Pedro Antonio Parra
- Beard David
- Bedzhanyan Arkady
- Behilil Chakib
- Bekele Kebebe
- Belarmino Armin
- Belay Million
- Belev Nikolay
- Bellato Vittoria
- BeltrĂĄn de Heredia Juan
- Belvedere Angela
- Benetti Emilio
- Benetti Sara
- Bengueddach Aicha
- Benjelloun El Bachir
- Benkabbou Amine
- Bennett James
- Bensafir Salim
- Bergamini Carlo
- Bernotaite Vlada
- Beron Reinaldo Isaacs
- Bethune Robert
- Bezede Cosmin
- Beznosenko Andriy
- Bhangu Aneel
- Bhargava Aman
- Bhat Rama Rani Krishna
- Bianchi Romina
- Bianco Francesco
- Bigoni Irene
- Binetti Margherita
- Bintintan Vasile
- Biondi Alberto
- Biondo Santino Antonio
- Bisgin Tayfun
- Bisheet George
- Bissett Ian
- Biswas Jyotirmoy
- Blackwell Sue
- Blanco Pablo
- Blanco Raquel RĂos
- Blanco-Colino Ruth
- Blasco Laura Fraile
- Blazquez-Martin Alma
- Bobadilla Billy Jimenez
- Bocancia Raluca
- Boccia Giuseppe
- Bogatikov Alexander
- Bolanle Olajide Edward
- Bomfa-Barbosa Alysson
- Bompou Effrosyni
- Bonardello Michela
- Bonci Eduard-Alexandru
- Bordom Daniel Osei
- Borges Filipe
- Borghi Felice
- Boschiero Matheus Negri
- Bose Bodhisattva
- Bouchagier Konstantinos
- Boudjenan-Serradj Nabil
- Boudoux Sabrina
- Bourazani Maria
- Boyce Stephen
- Bozbiyik Osman
- Bracale Umberto
- Brachini Gioia
- Bradulskis Saulius
- Brainsa Eneida
- Brandström Gustav
- Braumille Markus
- Bravo Ana Minaya
- Bravo Raquel
- Bredikhin Mikhail
- Brito Noelia
- Bruni Andrea
- Buccianti Piero
- Buchs Nicolas
- Buchwald Pamela
- Budnikova Ina
- BudrikienÄ Rima
- Buey Lourdes
- Buijs Louis
- Buleje Jorge Alejandro Benavides
- Burlov Nikita
- Butt Anam
- Byshetty Rajendar
- Bywater Edward
- Bzikha Ilham
- BĂĄnky BalĂĄzs
- BĂŠlum Jens Kristian
- Caballero-Delgado Javier
- Cabrera Claudia
- Cafranga EstĂbaliz GutiĂ©rrez
- Cagnazzo Federica
- Calabria Mariangela
- Calabro' Marcello
- Caliendo Domenico
- Calin Camelia
- Caliskan Cemil
- Callan Rory
- Callari Cosimo
- Caltea Mihaela
- Calvo Almudena Castro
- Camacho Amparo
- Cammarata Francesco
- Campanati Renato
- Campanelli Michela
- Campbell Marion
- Canals LucĂa Otazu
- Canda Aras Emre
- Cano-Matias Auxiliadora
- Cao Victor Hugo Bruno
- Capolupo Gabriella Teresa
- Cappiello Antonio
- Capuano Marianna
- Capusan Alina
- Carannante Filippo
- Carbone Ludovico
- Cardelli Stefano
- Carden Claire
- Cardoso Diogo
- Caricato Marco
- Carlin Patricia Saez
- Carlini Massimo
- Carlos Sandra
- Carneros Virginia Jimenez
- Carosso Fabio
- Caroço Teresa Vieira
- Carpelan Anu
- Carpenter Holly
- Carrascosa-Morales Irene
- Carrie Augusto
- Carrizo Claudia
- Carta Giuseppina
- Carvalho Alexandre
- Carvello Michele
- Casanova Daniel
- Cascais Raquel
- Cassia Gabriela
- Castaldi Antonio
- Castaño Renata
- Castiglioni Simone
- Castillo Enrique Roca
- Castro Marta Cuartero
- Catalano Pablo
- Cato Liam
- Caz Esra
- Cebolla Elena Sagarra
- Cecchini Ilaria
- CeldrĂĄn Rebeca GonzĂĄlez
- Celik Hale Kefeli
- Ceretti Andrea Pisani
- Ceron Silvia Ferrer
- Cervellera Maurizio
- Cervone Carmela
- Chacko Anil
- Chandrasinghe Pramodh
- Charakopoulou Alexandra
- Chardalias Leonidas
- Chaturvedi Arun
- Chatzikomnitsa Paraskevi
- Chaudhari Abhishek
- Chaudhry Sanjay
- Chawla Tabish
- Chee Corissa
- Chen Nevin
- Cheng Kuang I
- Chiarugi Massimo
- Chisthi Meer
- Chitnis Abhishek
- Chitul Andrei
- Chmielewski Gaspard
- Cholewa Hanna
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- Yew Chor Kuan
- Yılmaz GĂŒlseren
- Yilmazlar Tuncay
- YiÄit Direnç
- Yoldas Tayfun
- Yonekura Hiroshi
- Yorkmui Liu
- Yoshino Kenji
- Younes Lina
- Young Trudi
- Yule Michael
- Yusoff Zakiah Mohd
- Zaari Fatimazahraa
- Zabiyaka Mikhail
- ZadroĆŒna Monika
- Zafar Madiha
- Zagaynov Eugeny
- Zaidi Syed-Nadeem
- Zaimis Tilemachos
- Zain Wan Zainira Wan
- Zainy Rhendra Hardy Mohamad
- Zakaria Andee Dzulkarnaen
- Zakaria Maheen
- Zakaria Zaidi
- Zamudio-Bautista Jorge Luis
- Zanc Loredana
- Zanoni Andrea
- Zanus Giacomo
- Zapparoli Alessandro
- Zappone Anna
- Zarzava Eirini
- Zatari Dirar
- Zawadzki Marek
- Zayakov Georgi
- Zaycev Andrey
- Zazo Aya
- Zazo Rama
- Zdravkovic Maja
- Zengin Abdullah KaÄan
- Zeringa Georgia
- Zimmerman David D E
- Zuhdy Mohammad
- Zvirych Vitalii
- Zywicka Ewa
- Ălvarez-Llano Laura
- Ăngelo Miguel Duarte
- ĂSullivan Sara Nuñez
- Ăzçelik Mehmet Faik
- Äoza Ivo
- Ćanlı Ahmet Necati
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Background
Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks.
Methods
The internationally intended protocol, iteratively co-developed by a multistage Delphi process, comprised an online educational module introducing risk stratification, an intraoperative checklist, and harmonized surgical techniques. Clusters (hospital teams) were randomized to one of three arms with varied sequences of intervention/data collection by a derived stepped-wedge batch design (at least 18 hospital teams per batch). Patients were blinded to the study allocation. Low- and middle-income country enrolment was encouraged. The primary outcome (assessed by intention to treat) was anastomotic leak rate, and subgroup analyses by module completion (at least 80 per cent of surgeons, high engagement; less than 50 per cent, low engagement) were preplanned.
Results
A total 355 hospital teams registered, with 332 from 64 countries (39.2 per cent low and middle income) included in the final analysis. The online modules were completed by half of the surgeons (2143 of 4411). The primary analysis included 3039 of the 3268 patients recruited (206 patients had no anastomosis and 23 were lost to follow-up), with anastomotic leaks arising before and after the intervention in 10.1 and 9.6 per cent respectively (adjusted OR 0.87, 95 per cent c.i. 0.59 to 1.30; P = 0.498). The proportion of surgeons completing the educational modules was an influence: the leak rate decreased from 12.2 per cent (61 of 500) before intervention to 5.1 per cent (24 of 473) after intervention in high-engagement centres (adjusted OR 0.36, 0.20 to 0.64; P < 0.001), but this was not observed in low-engagement hospitals (8.3 per cent (59 of 714) and 13.8 per cent (61 of 443) respectively; adjusted OR 2.09, 1.31 to 3.31).
Conclusion
Completion of globally available digital training by engaged teams can alter anastomotic leak rates. Registration number: NCT04270721 (http://www.clinicaltrials.gov)