121 research outputs found

    Variables para cálculo automatizado de niveles de percepción en encuesta de peligro, vulnerabilidad y riesgo. (Original)

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    The study was carried out at the municipalities of the province Guantánamo, for the sake of diagnosing the perception of danger, vulnerability and risk for environmental events, to make easy the overtaking the Defense Council in these territories The computerized parcel was used for the introduction of the data SPSS Data Entry version 4,0 and for processing, the parcel SPSS 25,0 for Windows. The introduction of a set of new variables and making good use of the SPSS's functionalities danger, vulnerability and environmental risk of the respondents in each of the questions of the opinion poll, eliminating the possible human error in calculations that way calculated of automated way the perceptual levels themselves.El estudio se realizó en los municipios de la provincia Guantánamo con el objetivo de diagnosticar la percepción de peligro, vulnerabilidad y riesgo por eventos ambientales, para facilitar la toma de decisiones del Consejo de Defensa en estos territorios. Para la introducción de los datos fue utilizado el paquete computarizado SPSS Data Entry, versión 4.0, y para el procesamiento, el paquete SPSS 25.0 para Windows. Con la introducción de un conjunto de variables nuevas y aprovechando las funcionalidades del SPSS, se calcularon, de manera automatizada, los niveles de percepción peligro, vulnerabilidad y riesgo ambiental de los encuestados en cada una de las preguntas, eliminando así el posible error humano en los cálculos

    Analysis of Physical and Mechanical Properties of Mud Brick Enhanced with Asphalt Recycling

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    Introduction: In this work we have carried out a physical and mechanical analysis of the improvement of the material of mud brick (in Colombia it is known as "Adobe") with recycled asphalt. Objective: Evaluate in the laboratory, the behavior of the material of mud brick with the addition of recycled asphalt. Method: In order to meet the objective, quantitative research was conducted to characterize the physical evidence by analysis of particle size and density. The same tests characterize the mechanical strength in mud brick blocks, built with zero, two, four and eight percent recycled asphalt doses. It is based on laboratory testing Results:  According to the results obtained in the tests, mechanical properties, such as resistance to compression and bending were improve, adding recycled asphalt to Mud brick and in comparison with samples without content of asphalt. Conclusions: The mud bricks stabilized with two percent of recycled asphalt have the best performance in compressive and flexural strength according to laboratory testing.Introduction: In this work we have carried out a physical and mechanical analysis of the improvement of the material of mud brick (in Colombia it is known as "Adobe") with recycled asphalt. Objective: Evaluate in the laboratory, the behavior of the material of mud brick with the addition of recycled asphalt. Method: In order to meet the objective, quantitative research was conducted to characterize the physical evidence by analysis of particle size and density. The same tests characterize the mechanical strength in mud brick blocks, built with zero, two, four and eight percent recycled asphalt doses. It is based on laboratory testing Results:  According to the results obtained in the tests, mechanical properties, such as resistance to compression and bending were improve, adding recycled asphalt to Mud brick and in comparison with samples without content of asphalt. Conclusions: The mud bricks stabilized with two percent of recycled asphalt have the best performance in compressive and flexural strength according to laboratory testing

    Analysis of Physical and Mechanical Properties of Mud Brick Enhanced with Asphalt Recycling

    Get PDF
    Introduction: In this work we have carried out a physical and mechanical analysis of the improvement of the material of mud brick (in Colombia it is known as "Adobe") with recycled asphalt. Objective: Evaluate in the laboratory, the behavior of the material of mud brick with the addition of recycled asphalt. Method: In order to meet the objective, quantitative research was conducted to characterize the physical evidence by analysis of particle size and density. The same tests characterize the mechanical strength in mud brick blocks, built with zero, two, four and eight percent recycled asphalt doses. It is based on laboratory testing Results:  According to the results obtained in the tests, mechanical properties, such as resistance to compression and bending were improve, adding recycled asphalt to Mud brick and in comparison with samples without content of asphalt. Conclusions: The mud bricks stabilized with two percent of recycled asphalt have the best performance in compressive and flexural strength according to laboratory testing.Introduction: In this work we have carried out a physical and mechanical analysis of the improvement of the material of mud brick (in Colombia it is known as "Adobe") with recycled asphalt. Objective: Evaluate in the laboratory, the behavior of the material of mud brick with the addition of recycled asphalt. Method: In order to meet the objective, quantitative research was conducted to characterize the physical evidence by analysis of particle size and density. The same tests characterize the mechanical strength in mud brick blocks, built with zero, two, four and eight percent recycled asphalt doses. It is based on laboratory testing Results:  According to the results obtained in the tests, mechanical properties, such as resistance to compression and bending were improve, adding recycled asphalt to Mud brick and in comparison with samples without content of asphalt. Conclusions: The mud bricks stabilized with two percent of recycled asphalt have the best performance in compressive and flexural strength according to laboratory testing

    Guided Weekly Reflection Papers

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    The experience gained by our team of educational innovation with the implementation of the “Weekly Reflection Papers” has led us to diversify and make more flexible the employed methodology. The modified tool, applied during the academic year 2010-2011, was called “Guided Weekly Reflection Papers”. The aim of this modification has been the development of certain abilities and skills of the students, with particular emphasis on their ability to integrate, review and apply knowledge in a critical and reflective way. The professors guide the student´s work through a series of questions on which the students must apply the most significant concepts studied each week, to prove the acquisition of such aptitudes and skills

    Guided Weekly Reflection Papers

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    The experience gained by our team of educational innovation with the implementation of the “Weekly Reflection Papers” has led us to diversify and make more flexible the employed methodology. The modified tool, applied during the academic year 2010-2011, was called “Guided Weekly Reflection Papers”. The aim of this modification has been the development of certain abilities and skills of the students, with particular emphasis on their ability to integrate, review and apply knowledge in a critical and reflective way. The professors guide the student´s work through a series of questions on which the students must apply the most significant concepts studied each week, to prove the acquisition of such aptitudes and skills

    Left atrial geometry and outcome of atrial fibrillation ablation: results from the multicentre LAGO-AF study

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    Aims: Left atrial (LA) remodelling is a key determinant of atrial fibrillation (AF) ablation outcome. Optimal methods to assess this process are scarce. LA sphericity is a shape-based parameter shown to be independently associated to procedural success. In a multicentre study, we aimed to test the feasibility of assessing LA sphericity and evaluate its capability to predict procedural outcomes. Methods and results: This study included consecutive patients undergoing first AF ablation during 2013. A 3D model of the LA chamber, excluding pulmonary veins and LA appendage, was used to quantify LA volume (LAV) and LA sphericity (≥82.1% was considered spherical LA). In total, 243 patients were included across 9 centres (71% men, aged 56 ± 10 years, 44% with hypertension and 76% CHA2DS2-VASc ≤ 1). Most patients had paroxysmal AF (66%) and underwent radiofrequency ablation (60%). Mean LA diameter (LAD), LAV, and LA sphericity were 42 ± 6 mm, 100 ± 33 mL, and 82.6 ± 3.5%, respectively. Adjusted Cox models identified paroxysmal AF [hazard ratio (HR 0.54, P = 0.032)] and LA sphericity (HR 1.87, P = 0.035) as independent predictors for AF recurrence. A combined clinical-imaging score [Left Atrial Geometry and Outcome (LAGO)] including five items (AF phenotype, structural heart disease, CHA2DS2-VASc ≤ 1, LAD, and LA sphericity) classified patients at low (≤2 points) and high risk (≥3 points) of procedural failure (35% vs. 82% recurrence at 3-year follow-up, respectively; HR 3.10, P < 0.001). Conclusion: In this multicentre, real-life cohort, LA sphericity and AF phenotype were the strongest predictors of AF ablation outcome after adjustment for covariates. The LAGO score was easy to implement, identified high risk of procedural failure, and could help select optimal candidates. Clinical Trial Registration Information: NCT02373982 (http://clinicaltrials.gov/ct2/show/NCT02373982)

    Utility of CYP2D6 copy number variants as prognostic biomarker in localized anal squamous cell carcinoma

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    Background: Anal squamous cell carcinoma (ASCC) is an infrequent tumor whose treatment has not changed since the 1970s. The aim of this study is the identification of biomarkers allowing personalized treatments and improvement of therapeutic outcomes. Methods: Forty-six paraffin tumor samples from ASCC patients were analyzed by whole-exome sequencing. Copy number variants (CNVs) were identified and their relation to disease-free survival (DFS) was studied and validated in an independent retrospective cohort of 101 ASCC patients from the Multidisciplinary Spanish Digestive Cancer Group (GEMCAD). GEMCAD cohort proteomics allowed assessing the biological features of these tumors. Results: On the discovery cohort, the median age was 61 years old, 50% were males, stages I/II/III: 3 (7%)/16 (35%)/27 (58%), respectively, median DFS was 33 months, and overall survival was 45 months. Twenty-nine genes whose duplication was related to DFS were identified. The most representative was duplications of the CYP2D locus, including CYP2D6, CYP2D7P, and CYP2D8P genes. Patients with CYP2D6 CNV had worse DFS at 5 years than those with two CYP2D6 copies (21% vs. 84%; p <.0002, hazard ratio [HR], 5.8; 95% confidence interval [CI], 2.7–24.9). In the GEMCAD validation cohort, patients with CYP2D6 CNV also had worse DFS at 5 years (56% vs. 87%; p =.02, HR = 3.6; 95% CI, 1.1–5.7). Mitochondria and mitochondrial cell-cycle proteins were overexpressed in patients with CYP2D6 CNV. Conclusions: Tumor CYP2D6 CNV identified patients with a significantly worse DFS at 5 years among localized ASCC patients treated with 5-fluorouracil, mitomycin C, and radiotherapy. Proteomics pointed out mitochondria and mitochondrial cell-cycle genes as possible therapeutic targets for these high-risk patients. Plain Language Summary: Anal squamous cell carcinoma is an infrequent tumor whose treatment has not been changed since the 1970s. However, disease-free survival in late staged tumors is between 40% and 70%. The presence of an alteration in the number of copies of CYP2D6 gene is a biomarker of worse disease-free survival. The analysis of the proteins in these high-risk patients pointed out mitochondria and mitochondrial cell-cycle genes as possible therapeutic targets. Therefore, the determination of the number of copies of CYP2D6 allows the identification of anal squamous carcinoma patients with a high-risk of relapse that could be redirected to a clinical trial. Additionally, this study may be useful to suggest new treatment strategies to increase current therapy efficacyIdiPAZ, Grant/Award Number: Jesús Antolín Garciarena Fellowship; European Proteomics Infrastructure Consortium, Grant/Award Number: 823839, Horizon 2020 Programm

    Options. Journal of the UNAB Financial Engineering Program. Volume 2 No. 3 January 2008

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    Empezando este nuevo siglo inicia labores la extensión del programa en San Gil, hoy ya se cuenta con cuatro cohortes graduadas. El 8 de mayo del 2001, se promulga el decreto 792 y posteriormente, el 29 de junio, el Decreto 1279 por medio de los cuales se establecieron los estándares de calidad para la creación, oferta y funcionamiento de programas académicos de pregrado en Ingeniería. Desde ese momento la Universidad organizó un equipo de trabajo con la finalidad de elaborar un documento en el que se muestre lo que la UNAB entiende como Ingeniería y cómo atiende a la formación de profesionales en este campo.¿Qué ha pasado en el nuevo siglo ? . - 4} Una nota sobre el cálculo del valor con endeudamiento constante . - 6 El mercado accionario en Colombia: Pruebas de eficiencia y aplicación de modelos en la estructuración de portafolios de inversión 14 “La competencia siempre produce perdedores..." 24 ¿En qué consiste analizar la incertidumbre en el cálculo de la reserva petrolera? 30 Instrumento novedoso de predicción en finanzas 34 Medición del riesgo en el mercado accionario colombiano explicado por variables exógenas 38 Cálculo yAnálisis de Betas para el Modelo CAPM 43 La toma de decisiones en las operaciones de exploración petrolera. 50 La brecha del desarrollo y la medida de la pobreza. 54Starting this new century, the extension of the program in San Gil begins work, today there are four graduate cohorts. On May 8, 2001, Decree 792 was enacted and later, on June 29, Decree 1279 by by means of which the quality standards for the creation, offer and operation of undergraduate academic programs in Engineering were established. From that moment on, the University organized a work team in order to prepare a document that shows what UNAB understands as Engineering and how it attends to the training of professionals in this field

    Metabolomic profile of cancer stem cell-derived exosomes from patients with malignant melanoma

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    Malignant melanoma (MM) is the most aggressive and life-threatening form of skin cancer. It is characterized by an extraordinary metastasis capacity and chemotherapy resistance, mainly due to melanoma cancer stem cells (CSCs). To date, there are no suitable clinical diagnostic, prognostic or predictive biomarkers for this neoplasia. Therefore, there is an urgent need for new MM biomarkers that enable early diagnosis and effective disease monitoring. Exosomes represent a novel source of biomarkers since they can be easily isolated from different body fluids. In this work, a primary patient-derived MM cell line enriched in CSCs was characterized by assessing the expression of specific markers and their stem-like properties. Exosomes derived from CSCs and serums from patients with MM were characterized, and their metabolomic profile was analysed by highresolution mass spectrometry (HRMS) following an untargeted approach and applying univariate and multivariate statistical analyses. The aim of this study was to search potential biomarkers for the diagnosis of this disease. Our results showed significant metabolomic differences in exosomes derived from MM CSCs compared with those from differentiated tumour cells and also in serum-derived exosomes from patients with MM compared to those from healthy controls. Interestingly, we identified similarities between structural lipids differentially expressed in CSC-derived exosomes and those derived from patients with MM such as the glycerophosphocholine PC 16:0/0:0. To our knowledge, this is the first metabolomic-based study aimed at characterizing exosomes derived from melanoma CSCs and patients’ serum in order to identify potential biomarkers for MM diagnosis. We conclude that metabolomic characterization of CSC-derived exosomes sets an open door to the discovery of clinically useful biomarkers in this neoplasia.MICIU FPU15/03682 FPU15/02350Ministerio de Ciencia, Innovación y Universidades (MICIU) MAT2015-62644.C2.2.R RTI2018-101309-BC2Instituto de Salud Carlos III PIE16-00045Junta de Andalucía SOMM17/6109/UGR (UCE-PP2017-3)European Union (EU) SOMM17/6109/UGR (UCE-PP2017-3)Chair 'Doctors Galera-Requena in cancer stem cell research' CMC-CTS963Fundación MEDIN
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