电针中极穴对膀胱逼尿肌功能的调节作用

目的从尿动力学角度阐明电针中极穴对膀胱逼尿肌功能亢进和减弱2种异常状态的调节作用。方法雄性新西兰兔100只,以新斯的明制作膀胱逼尿肌功能亢进模型,以东莨菪碱制作膀胱逼尿肌功能减弱模型,在2种模型上电针中极穴,刺激频率为2 Hz和100 Hz,观察电针干预下尿动力学指标的动态变化,检测记录电针期间膀胱内压波型分型及电针结束即刻的尿液排出速度。结果电针2 Hz组可显著减慢膀胱逼尿肌功能亢进模型增快的排尿速度,电针2 Hz、100 Hz均可显著加快膀胱逼尿肌功能减弱模型减慢的排尿速度。结论电针中极穴可调节膀胱排尿期逼尿肌功能异常,电针作用存在频率差异性,电针2 Hz组比100 Hz组作用大

电针不同频率和取穴对膀胱逼尿肌功能减弱的调节效应差异研究

目的:探讨电针不同频率和取穴调节膀胱逼尿肌功能减弱的效应差异,为电针治疗排尿障碍症穴位及电针参数的选择提供依据。方法:100只新西兰兔随机分为对照组、模型组、电针组(据穴位及电针频率分为中极2Hz和100Hz、三阴交2Hz和100Hz、曲池2Hz和100Hz6个亚组)。静脉输注0.05%山莨菪碱建立逼尿肌功能减弱模型,检测指标为各组充盈期膀胱内压波形及排尿期分时排尿速度。结果:1)中极2Hz、三阴交2Hz、曲池2Hz、三阴交100Hz组的排尿初速度显著大于模型组(P曲池。结论:1)电针可显著加快逼尿肌功能减弱模型排尿期的排尿速度;2)2Hz电针加快排尿速度的效应优于100Hz电针,且效应存在穴位差异性,三阴交和中极穴优于曲池穴

2种逼尿肌功能障碍模型的建立

目的建立满足针刺疗效机理研究的逼尿肌功能障碍模型。方法将新西兰兔随机分为对照组、模型A组、模型B组,3组经尿道插管行膀胱持续以20 mL/h匀速定量灌注并动态测定膀胱内压,模型A组注射0.005%新斯的明10 mL,模型B组注射0.05%山莨菪碱10 mL,对照组注射10 mL生理盐水,记录该期间膀胱内压波动及给药结束即时的尿液排出速度。结果模型A组膀胱内压不稳定波型的例数显著高于对照组,排尿速度显著大于对照组;模型B组稳定型膀胱内压波型的例数显著多于对照组,排尿速度显著小于对照组。结论经静脉匀速注射新斯的明可建立膀胱逼尿肌过度活跃模型,经静脉匀速注射山莨菪碱可建立膀胱逼尿肌过度抑制模型,2种模型均为无创性,为在整体功能完整条件下,对排尿功能障碍性疾病的针刺疗效机理研究提供了动物模型基础

JUNO Sensitivity on Proton Decay p→νˉK+p\to \bar\nu K^+ Searches

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this paper, the potential on searching for proton decay in $p\to \bar\nu K^+$ mode with JUNO is investigated.The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits to suppress the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar\nu K^+$ is 36.9% with a background level of 0.2 events after 10 years of data taking. The estimated sensitivity based on 200 kton-years exposure is $9.6 \times 10^{33}$ years, competitive with the current best limits on the proton lifetime in this channel

JUNO sensitivity on proton decay p → ν K + searches*

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this study, the potential of searching for proton decay in the $p\to \bar{\nu} K^+$ mode with JUNO is investigated. The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar{\nu} K^+$ is 36.9% ± 4.9% with a background level of $0.2\pm 0.05({\rm syst})\pm$$0.2({\rm stat})$ events after 10 years of data collection. The estimated sensitivity based on 200 kton-years of exposure is $9.6 \times 10^{33}$ years, which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies