Evaluation of serum prolactin le-vels in children with febrile and afebrile convulsions

Bu çalışmada, konvülziyon geçiren çocuklarda serum prolaktin düzeyine bakarak epileptik durumları nonepileptik durumlardan ayırt etmede bu ölçütü kullanıp kullanamayacağımızı değerlendirmek istedik. Gereç ve yöntem: Haydarpaşa Numune Eğitim ve Araştırma Hastanesi Çocuk Sağlığı ve Hastalıkları Kliniği’ne febril ve afebril konvülziyon geçirerek getirilen 2 yıllık süreçteki toplam 51 olgu analiz edildi. Febril konvülziyon geçiren 8 erkek, 9 kız yaşları 32,8+- 22,9 ay olan toplam 17 çocuk grup 1’i oluşturdu. Grup 2 de ise ortalama yaş 76,4+- 48,4 ay olan 20 erkek, 14 kız toplam 34 çocuktan oluştu. Grup 3 ise 24 erkek, 26 kız poliklini ğimize konvülziyon dışı yakınmayla başvuran toplam 50 çocuktan oluşan kontrol grubuydu. Olgularda konvülziyon sonrası 1. saatte, 2. saatte ve 24. saatte venöz kan alınarak serum prolaktin düzeyi bakıldı. Bulgular: Serum prolaktin birinci saat değerleri afebril grupta (grup 2), febril gruba (grup 1) göre anlamlı yüksek bulundu. Serum prolaktininin postkonvulzif 24. saat değeri açısından 3 grup karşılaştırıldığında istatistiksel açıdan anlamlı farklılık tespit edilmedi. Sonuç: Çalışmamız afebril konvülziyonda birinci saatte bakılan prolaktin düzeyinin anlamlı yüksekliği bize epileptik nöbetlerin nonepileptik durumlardan ayrımında, EEG monitorizasyonu zor ula- şılabilir bir yöntem olduğu için, bu yöntemi kullanabileceğimizi göstermektedir.In this study, we wanted to evaluate if we can use the serum prolactin levels as a marker in differential diagnosis epileptic syndromes and non epileptic ones. Materials and methods We analyzed totally 51 children during two years who were admitted to our clinic by having experienced febrile or afebrile convulsions. Group 1 included 8 male and 9 female totally 17 children whose mean ages were 32.8+/- 22.9 months and had febrile convulsions. Group 2 had 20 males and 14 females 76.4 +/- 48.4 months aged totally 34 children who had experienced afebrile convulsions. Group 3 included 24 males 26 females who had no neurologic symptoms or convulsions but taken to our clinic by other symptomatologies. Blood samples of cases were evaluated in the first hour, in the second and 24.hour of post convulsive follow-up. Results: We found that serum prolactin levels were significantly higher in the afebril convulsive group (group 2) than in the febrile convulsive group (group1). Serum prolactin levels of post convulsive 24.hour determination revealed no statistically difference between the three groups. Conclusion: In this study, we concluded that, we can use serum prolactin levels in the first hour of post convulsive follow-up for differential diagnosis of epileptic syndromes and non epileptic ones, since EEG monitorization is a hardly performed evaluation

Evaluation of the Seroprevalence of Hepatit A and Vaccination Status in Children Aged Two and Sixteen Years

Objective: In this study; the aim was to evaluate the seroprevalence of hepatitis A virus (HAV) in 2-16 year age group, and the rate of hepatitis A vaccination.\ud Materials and Methods: This study was conducted on 400 children aged between 2 and 16 years with no chronic diseases who attended the pediatrics outpatient clinic in Health Sciences University, Haydarpaşa Numune Training and Research Hospital. After obtaining informed consent from the parents, blood samples were taken for investigating serological markers for hepatitis A in the microbiology laboratory using the ELISA method. The parents were asked whether or not their children had been vaccinated against hepatitis A. \ud Results: In this study 44.3% of the participants included were girls and 55.8% were boys. The mean age of the children was 10.8±4.18 years. 27.3% of patients were anti-HAV IgG-positive, and 11% had been vaccinated against hepatitis A. When we compared preschool and school age patients, anti-HAV IgG positivity was detected in all children who were vaccinated in the preschool group; while 5.9% of unvaccinated children were anti-HAV IgG-positive and 94.1% were negative. It was found that school age children were unvaccinated, and anti-HAV IgG was positive in 19.6% of the children and negative in 80.4% of the children.\ud Conclusion: In our study, although the prevalence of hepatitis A was found to be low compared to the eastern and southeastern cities of our country, it is still higher than in the developed countries. In order to prevent hepatitis A infection, it is necessary to improve the socio-economic conditions of the country, to create better sanitary conditions and hygienic practices, and raise awareness of the infection

Immunomodulator effect of topical zinc oxide application in tuberculin skin test

WOS: 000433094100008PubMed ID: 29607430OBJECTIVE: We aimed to evaluate the sensitivity of tuberculin skintest (purified protein derivative-PPD) by topical zinc application on test site to improve diagnostic reliability. METHODS: We performed this study in 100 children aged 6-14 years, and plasma zinc levels were analyzed after 10-12 hours fasting. After PPD, we applied 40% zinc oxide cream on one forearm and placebo on the other forearm. PPD indurations were measured 72 hours later. RESULTS: In this study, 26% of the children showed increases in PPD induration following local zinc applications. There was no correlation between indurations size and serum zinc levels. CONCLUSION: We concluded that topical zinc cream application can enhance sensitivity of tuberculin reactivityin the diagnosis of tuberculosis

The effects of antiepileptic therapies on se-rum lipid levels in childhood

Amaç: Biz bu çalışmayı, epileptik çocukların uzun süreli izleminde uygulanan antiepileptik tedavinin, lipid profiline etkisini araştırmak için yaptık. Materyal Metod: Bu çalışma, yaşları 2.5 ile 14 yaş arası değişen 56 çocuğu kapsamaktadır. Bunların ,ortalama yaş aralığı 8.71±3.3 yaştır. Çocukların 24’ü kız, 32’si erkektir. Çalışmaya alınan 19 çocuk generalize epilepsi, 37’si parsiyel epilepsi geçirmişti. Karbamazepin kullanan 16 çocuk grup I’i, okskarbazepin kullanan 21 çocuk grup II’yi, sodyum valproat kullanan 19 çocuk grup III’ü oluşturdu. Tedavinin başlangıcında, 3., 6. ve 12. aylarında, venöz kan alınarak serum kolesterol, VLDL, LDL, HDL, trigliserit seviyeleri bakıldı. Bulgular: Gruplar arasında başlangıç, 3., 6. ve 12. serum total kolesterol, VLDL, LDL, HDLve trigliserit seviyeleri açısından anlamlı farklılık bulunmadı. Sonuç: Oniki ay boyunca uygulanan antiepileptik tedavi, gruplar arasında lipid seviyeleri ( kolesterol, HDL, LDL, VLDL, trigliserit )üzerine anlamlı değişiklik göstermedi. Bir yıllık,izlemde serum lipid seviyelerinin etkilenmediği sonucuna vardık.Objective: We performed this study, in order to investigate the effects of antiepileptic therapies on serum lipid levels during long term follow- up of epileptic children. Material and Method: This study included 56 children, whose ages were 8.71±3.3 years. Twentyfour of children were female and 32 of whom were male. When 19 children had generalize epilpsies, 37 had parsiyel ones. Carbamazepin has been experienced on 16 ( grup I ), Okskarbazepin on 21 ( grup II ) and sodium valproat has been experienced on 19 children .At beginning and during, the third, sixth and twelfth months of antiepileptic therapies, serum lipid levels were evaluated. Results: There was no statiscially difference for serum total colesterol levels among the groups during the 3., 6., 12. months controls. Serum trigliserit LDL, HDL, VLDLcholesterol levels revealed no significant difference as well, among the groups during monthly (3., 6., 12. month) controls. Conclusion : The groups who were followed by different antiepileptic therapies revealed no significant difference for serum lipid levels during 12 months.We concluded that, antiepileptic therapies did not affect serum lipid levels during one year follow-up

Evaluation of Children who are Followed and Treated with the Diagnosis of Brucellosis

Brusellozis temelde bir hayvan hastalığı olup, insanlara genelde enfekte hayvanların etleri, sütleri ve süt ürünleri ile bulaşır, çok farklı klinik tablolarla seyredebilir. Bu çalışmamızda kliniğimizde brucella tanısıyla takip ve tedavi ettiğimiz 16 hastamızı geriye dönük olarak inceledik. Olgularda %75'le en sık saptanan şikâyet eklem ağrısı idi. Diğer sık saptanan şikâyetler %63 ile ateş, %56 ile halsizlik, %38 ile eklemde şişlik, %32 ile karın ağrısı, terleme, kusma, vücut ağrısı idi. Olgularda en sık saptanan fizik muayene bulgusu %63 ile ateşti. Olgulardan%50'sinde hepatomegali ve/ veya splenomegali, %13 ünde lenfadenomegali saptanmıştır. Olguların hepsi en az ikili tedavi almış olup, %13 (n=2) hasta üçlü tedavi almıştır. Tedaviye başlandıktan üç gün sonra bütün hastaların şikâyetleri gerilemiştir. Bütün hastaların tedavileri altı haftaya tamamlanmıştır. Olgulardan ikisinde relaps görülmüştür (%13). Bu hastalardan biri daha önce başka bir şehirde bir yıl tedavi görmüş olan hastadır. Diğer hasta ikili tedavi almıştırBrucellosis is primarily an animal disease, is transmitted to humans by meats, milk and milk products of infected animals, can be seen in very different clinical presentations. In this study, 16 patients who were followed up and treated with the diagnosis of Brucellosis in our clinic were evaluated retrospectively. The most frequent complaint of the cases was joint pain by 75%. Other frequent complaints were fever by 63%, weakness by 56%, joint swelling by 38%, abdominal pain, sweating, vomiting, body pain by 32%. The most frequent physical examination finding of the cases was fever by 63%. Hepatomegaly and/or splenomegaly were determined in 50% of the cases and lymphadenopathy was seen in 13% of them. All patients received treatment with two types of antibiotics, 13% of them (n=2) received three types of antibiotics. Three days after the initiation of treatment, the complaints of all patients were decreased. The treatments of all patients have been completed in six weeks. In two cases (13%), relapse was observed. One of these patients had been treated previously for a year in a different city. Other patient received dual therapy

Evaluation of demographic features, clinical and laboratory findings of probable cases with Crimean-Congo hemorrhagic fever

Amaç: Biz, 2007-2009 yılları arasında Kırım Kongo Kanamalı Ateş Hastalığı riski taşıyan, kene tarafından ısırılarak kliniğimize getirilen çocukları semptomlar, demografik özellikler ve laboratuvar bulguları açısından değerlendirmeyi amaçladık. Materyal ve metod: Bu çalışmaya, kene tarafından ısırılmış yaşları 0-14 yaş arası olan 32 erkek ve 31 kız çocuğu alınmıştır. Kız çocuklar için ortalama yaş aralığı 3,92 ± 2.75, erkek çocuklar için ise 4,42 ± 2.77 yaş idi. Başvuru semptomları, hematolojik bulgular (hemogram, AST, ALT, INR, PT ) ve hastalığın sonucu değerlendirildi. Bulgular: Kliniğimize yatırılarak, takip ve tedavi edilen çocuklarda 3-10 günlük inkübasyon dönemini takiben akut başlangıçlı ateş en sık görülen semptomdu. Ateşi baş ağrısı, myalji, artralji, iştahsı zlık, güçsüzlük gibi nonspesifik semptomlar takip etti. Laboratuvar bulgularında lökositoz, düşük hemoglobin ve hematokrit değerleri, yüksek AST, uzamış PT ve trombositopeni görüldü. Tüm çocuklarda tam iyileşme sağlandı. Sonuç: 2007-2009 salgınlarında, Kırım Kongo Kanamalı Ateşi etkeni olan Hyalomma cinsi kenenin İstanbul daki olgulardan sorumlu olmadığını gözledik. Kırım Kongo Kanamalı Ateşi epidemiyolojisi ve yayılımını; iklim, çevresel etmenler ve kişilerin alışkanlıkları gibi faktörler etkilediğinden, halkın bilinçlendirilmesini içeren kene kontrol ve korunma stratejilerinin farkında olmalıyız.Objective: We aimed to evaluate the symptoms, demographic features and laboratory findings of children who were bited by ticks and taken to our clinic with risk assessment of Crimean- Congo Hemorrhagic Fever (CCHF) between 2007- 2009 years. Materials and methods: This study included 32 male and 31 female children aged between 0 and 14 years old who were bited by ticks. The mean ages were 3.92 ± 2.75 years for girls and 4.42 ± 2,77 years for boys. Presenting symptoms, haematological manifestations (hemogram, AST, ALT, INR, PT ) and outcome of the disease were evaluated. Results: Following an incubation period of 3-10 days, acute- onset fever was the most commonly seen symptom among our hospitalized children. Nonspesific symptoms such as headache, myalgia, arthalgia, nausea, weakness followed the fever. Laboratory findings revealed leucocytosis, decreased hemoglobin and haematocrit levels, elevated AST, prolonged prothrombin time and thrombocytopenia. Full recovery was obtained in all children without any fatal outcome. Conclusion: We experienced that, the vector for CCHF, the Hyalomma tick was not present in ‹stanbul between 2007-2009 outbreaks. Since climate, environmental factors and human behaviour influence CCHF epidemiology and spread, whe should be aware of tick-control and prevention strategies including public education

Demir eksikliği anemisine etki eden faktörlerin ve labaratuar parametrelerinin incelenmesi

Çocukluk dönemindeki demir eksikliği anemisi mental ve motor gelişmede fonksiyon bozukluğuna sebep olabildiğinden, bu aneminin önlenmesi için özen gösterilmelidir. Bu çalış­ manın amacı, anne sütü alım süresi, ilk iki yaşta inek sütü alımı ve düzenli demir kullanımının kan parametreleri üzerine etkilerini araştırmaktır. Materyal ve Method: Bu çalışmaya 2006- 2008 yılları arasında HNH(Haydarpaşa Numune Hastanesi) Pediatri kliniğinde yatan ve demir eksikliği anemisi saptanan 6 ay-14 yaş arası 181 çocuk alındı. Tüm çocuklar aneminin ağırlığına göre hafif, orta ve ağır olmak üzere üç gruba ayrıldı. Doğum ağırlığı, inek sütü alımı, anne sütü kullanım süresi ve düzenli demir alımının aneminin ağırlı­ ğıyla ilişkisi ve hematolojik parametre/ere etkisi incelendi. Bulgular: Ağır anemi grubunun yaş ortalamaları hafif ve orta anemi gruplarından istatistiksel olarak anlamlı derecede yüksek bulunmuştur (p=0,0001). Hafif ve orta anemi grupları arasında anne sütü kullanım süresi açısından istatistiksel olarak anlamlı farklılık gözlenmiştir (p=O,OOOJ). Anne sütü kullanım süresi 12 ayın altında olanlarda hafif ve orta şiddette anemi görülme sıklığı daha fazla bulunmuştur. Tartışma ve Sonuç: Biz bu çalışmada, demir eksikliği anemisinden korunmak için, anne/erin bebeklerini anne sütüyle besleme, demirden zenginleştirilmiş beslenme ve 4. aydan itibaren demir desteğinin önemi konusunda bilgilendirilmesi gerektiği sonucuna vardık.introduction and Aim: Since iron deficiency anemia in child can lead to dysfunction in mental and motor development, optimal care should be attended to prevention of this anemia. The goal of this study is, to investigate the duration of maternal breast-feeding , feeding w ith cow' s milk during the first two years and the effects of iron supplementation in hematalogic parameters. Material and Methods: This study involved 181 children who were 6 months-14 years old, hospitalized in HNH pediatric clinic with the diagnosis of iron deficiency anemia between 2006- 2008 years. All children were divided into three groups as: mi/d, moderate and severe. Birth weight, nutrition with cow' s mi/k, duration of breast-feeding, adequate iron intake related with the varying degrees ir on deficiency anemia and the effects of it in hematological parameters were evaluated. Results: The me an age value was significantly higher in the severe anemia group than the mild and moderate one s. The duration of breast-feeding was statistically significantly different between the mi/d and moderate anemia groups. Mi/d and moderate iron deficiency anemia were commonly seen in the infants who were breast-fed under 12 months old. Conclusion: W e concluded that, mothers should be educated about the importance of breast-feeding, nutrition fortified with iron and iron supplementation after six months, in order to prevent iron deficiency anemia

The GABA(A) receptor gamma y2 subunit (R43Q) mutation in febrile seizures

WOS: 000333866200016PubMed ID: 24630281BACKGROUND: Febrile seizure is the most common form of childhood seizure. Although its exact cause is unclear, many researchers emphasize the importance of its genetic predisposition. Recent genetic studies revealed the importance of the mutations of the gamma-aminobutyric acid A receptor as the etiology of the febrile seizures. R43Q mutation affecting the gamma 2-subunit N-terminal domain has been related to childhood absence epilepsy and febrile seizure. METHODS: We investigated R43Q mutations of the GABRG2 gene, located on the long arm of chromosome 5 encoding the gamma 2-subunit of the gamma-aminobutyric acid A receptor. We studied 44 patients with febrile seizure and 49 children without any febrile seizure who were admitted to our clinic. RESULTS: We found that 36% of our patient group, the children who experienced febrile convulsions, had heterozygous R43Q mutation. Statistical studies revealed that heterozygous R43Q mutation of gamma-aminobutyric acid A receptor gamma 2 subunit was higher in the study group than in the control group (P < 0.01). CONCLUSIONS: Heterozygous gamma-aminobutyric acid A receptor gamma 2 subunit (R43Q) mutation may have an effect in the development of febrile seizures