Clinical Presentation and Outcomes of Kawasaki Disease in Children from Latin America: A Multicenter Observational Study from the REKAMLATINA Network

Objetivos: Describir la presentación clínica, el manejo y los resultados de la enfermedad de Kawasaki (EK) en Latinoamérica y evaluar los indicadores pronósticos tempranos de aneurisma de la arteria coronaria (AAC). Diseño del estudio: Se realizó un estudio observacional basado en el registro de la EK en 64 centros pediátricos participantes de 19 países latinoamericanos de forma retrospectiva entre el 1 de enero de 2009 y el 31 de diciembre de 2013, y de forma prospectiva desde el 1 de junio de 2014 hasta el 31 de mayo de 2017. Se recopilaron datos demográficos, clínicos y de laboratorio iniciales. Se utilizó una regresión logística que incorporaba factores clínicos y la puntuación z máxima de la arteria coronaria en la presentación inicial (entre 10 días antes y 5 días después de la inmunoglobulina intravenosa [IGIV]) para desarrollar un modelo pronóstico de AAC durante el seguimiento (>5 días después de la IGIV). Resultados: De 1853 pacientes con EK, el ingreso tardío (>10 días tras el inicio de la fiebre) se produjo en el 16%, el 25% tuvo EK incompleta y el 11% fue resistente a la IGIV. Entre los 671 sujetos con puntuación z de la arteria coronaria notificada durante el seguimiento (mediana: 79 días; IQR: 36, 186), el 21% presentaba AAC, incluido un 4% con aneurismas gigantes. Un modelo pronóstico simple que utilizaba sólo una puntuación z de la arteria coronaria máxima ≥2,5 en la presentación inicial fue óptimo para predecir la AAC durante el seguimiento (área bajo la curva: 0,84; IC del 95%: 0,80, 0,88). Conclusiones: De nuestra población latinoamericana, la puntuación z de la arteria coronaria ≥2,5 en la presentación inicial fue el factor pronóstico más importante que precedió a la AAC durante el seguimiento. Estos resultados resaltan la importancia de la ecocardiografía temprana durante la presentación inicial de la EK. © 2023 Los autoresObjectives: To describe the clinical presentation, management, and outcomes of Kawasaki disease (KD) in Latin America and to evaluate early prognostic indicators of coronary artery aneurysm (CAA). Study design: An observational KD registry-based study was conducted in 64 participating pediatric centers across 19 Latin American countries retrospectively between January 1, 2009, and December 31, 2013, and prospectively from June 1, 2014, to May 31, 2017. Demographic and initial clinical and laboratory data were collected. Logistic regression incorporating clinical factors and maximum coronary artery z-score at initial presentation (between 10 days before and 5 days after intravenous immunoglobulin [IVIG]) was used to develop a prognostic model for CAA during follow-up (>5 days after IVIG). Results: Of 1853 patients with KD, delayed admission (>10 days after fever onset) occurred in 16%, 25% had incomplete KD, and 11% were resistant to IVIG. Among 671 subjects with reported coronary artery z-score during follow-up (median: 79 days; IQR: 36, 186), 21% had CAA, including 4% with giant aneurysms. A simple prognostic model utilizing only a maximum coronary artery z-score ≥2.5 at initial presentation was optimal to predict CAA during follow-up (area under the curve: 0.84; 95% CI: 0.80, 0.88). Conclusion: From our Latin American population, coronary artery z-score ≥2.5 at initial presentation was the most important prognostic factor preceding CAA during follow-up. These results highlight the importance of early echocardiography during the initial presentation of KD. © 2023 The Author(s

Peri-operative red blood cell transfusion in neonates and infants: NEonate and Children audiT of Anaesthesia pRactice IN Europe: A prospective European multicentre observational study

BACKGROUND: Little is known about current clinical practice concerning peri-operative red blood cell transfusion in neonates and small infants. Guidelines suggest transfusions based on haemoglobin thresholds ranging from 8.5 to 12 g dl-1, distinguishing between children from birth to day 7 (week 1), from day 8 to day 14 (week 2) or from day 15 (≥week 3) onwards. OBJECTIVE: To observe peri-operative red blood cell transfusion practice according to guidelines in relation to patient outcome. DESIGN: A multicentre observational study. SETTING: The NEonate-Children sTudy of Anaesthesia pRactice IN Europe (NECTARINE) trial recruited patients up to 60 weeks' postmenstrual age undergoing anaesthesia for surgical or diagnostic procedures from 165 centres in 31 European countries between March 2016 and January 2017. PATIENTS: The data included 5609 patients undergoing 6542 procedures. Inclusion criteria was a peri-operative red blood cell transfusion. MAIN OUTCOME MEASURES: The primary endpoint was the haemoglobin level triggering a transfusion for neonates in week 1, week 2 and week 3. Secondary endpoints were transfusion volumes, 'delta haemoglobin' (preprocedure - transfusion-triggering) and 30-day and 90-day morbidity and mortality. RESULTS: Peri-operative red blood cell transfusions were recorded during 447 procedures (6.9%). The median haemoglobin levels triggering a transfusion were 9.6 [IQR 8.7 to 10.9] g dl-1 for neonates in week 1, 9.6 [7.7 to 10.4] g dl-1 in week 2 and 8.0 [7.3 to 9.0] g dl-1 in week 3. The median transfusion volume was 17.1 [11.1 to 26.4] ml kg-1 with a median delta haemoglobin of 1.8 [0.0 to 3.6] g dl-1. Thirty-day morbidity was 47.8% with an overall mortality of 11.3%. CONCLUSIONS: Results indicate lower transfusion-triggering haemoglobin thresholds in clinical practice than suggested by current guidelines. The high morbidity and mortality of this NECTARINE sub-cohort calls for investigative action and evidence-based guidelines addressing peri-operative red blood cell transfusions strategies. TRIAL REGISTRATION: ClinicalTrials.gov, identifier: NCT02350348

Seafood consumption, omega-3 fatty acids intake, and life-time prevalence of depression in the PREDIMED-Plus trial

BACKGROUND: The aim of this analysis was to ascertain the type of relationship between fish and seafood consumption, omega-3 polyunsaturated fatty acids (ω-3 PUFA) intake, and depression prevalence. METHODS: Cross-sectional analyses of the PREDIMED-Plus trial. Fish and seafood consumption and ω-3 PUFA intake were assessed through a validated food-frequency questionnaire. Self-reported life-time medical diagnosis of depression or use of antidepressants was considered as outcome. Depressive symptoms were collected by the Beck Depression Inventory-II. Logistic regression models were used to estimate the association between seafood products and ω-3 PUFA consumption and depression. Multiple linear regression models were fitted to assess the association between fish and long-chain (LC) ω-3 PUFA intake and depressive symptoms. RESULTS: Out of 6587 participants, there were 1367 cases of depression. Total seafood consumption was not associated with depression. The odds ratios (ORs) (95% confidence intervals (CIs)) for the 2nd, 3rd, and 4th quintiles of consumption of fatty fish were 0.77 (0.63⁻0.94), 0.71 (0.58⁻0.87), and 0.78 (0.64⁻0.96), respectively, and p for trend = 0.759. Moderate intake of total LC ω-3 PUFA (approximately 0.5⁻1 g/day) was significantly associated with a lower prevalence of depression. CONCLUSION: In our study, moderate fish and LC ω-3 PUFA intake, but not high intake, was associated with lower odds of depression suggesting a U-shaped relationship.This research was funded by the Spanish Ministry of Health (Carlos III Health Institute) through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund (grant numbers and corresponding codes: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14-00696, PI14/01206, PI14/01919, PI14/00853), the European Research Council (Advanced Research Grant 2013–2018; 340918) grant to MAMG, the Recercaixa grant to J. S-S. and NB (2013ACUP00194), the grant from the Consejería de Salud de la Junta de Andalucía (PI0458/2013; PS0358/2016), the SEMERGEN grant, and FEDER funds (CB06/03)

Associations between dietary polyphenols and type 2 diabetes in a cross-sectional analysis of the PREDIMED-plus trial: Role of body mass index and sex

Overweight and obesity are important risk factors for type 2 diabetes (T2D). Moving towards healthier diets, namely, diets rich in bioactive compounds, could decrease the odds of suffering T2D. However, those individuals with high body mass index (BMI) may have altered absorption or metabolism of some nutrients and dietary components, including polyphenols. Therefore, we aimed to assess whether high intakes of some classes of polyphenols are associated with T2D in a population with metabolic syndrome and how these associations depend on BMI and sex. This baseline cross-sectional analysis includes 6633 participants from the PREDIMED-Plus trial. Polyphenol intakes were calculated from food frequency questionnaires (FFQ). Cox regression models with constant time at risk and robust variance estimators were used to estimate the prevalence ratios (PRs) for polyphenol intake and T2D prevalence using the lowest quartile as the reference group. Analyses were stratified by sex and BMI groups (overweight and obese) to evaluate potential effect modification. Catechins, proanthocyanidins, hydroxybenzoic acids, and lignans were inversely associated with T2D. Hydroxycinnamic acids were directly related in men. These associations were different depending on sex and BMI, that is, women and overweight obtained stronger inverse association

Associations between dietary polyphenols and type 2 diabetes in a cross-sectional analysis of the PREDIMED-plus trial: Role of body mass index and sex

Overweight and obesity are important risk factors for type 2 diabetes (T2D). Moving towards healthier diets, namely, diets rich in bioactive compounds, could decrease the odds of suffering T2D. However, those individuals with high body mass index (BMI) may have altered absorption or metabolism of some nutrients and dietary components, including polyphenols. Therefore, we aimed to assess whether high intakes of some classes of polyphenols are associated with T2D in a population with metabolic syndrome and how these associations depend on BMI and sex. This baseline cross-sectional analysis includes 6633 participants from the PREDIMED-Plus trial. Polyphenol intakes were calculated from food frequency questionnaires (FFQ). Cox regression models with constant time at risk and robust variance estimators were used to estimate the prevalence ratios (PRs) for polyphenol intake and T2D prevalence using the lowest quartile as the reference group. Analyses were stratified by sex and BMI groups (overweight and obese) to evaluate potential effect modification. Catechins, proanthocyanidins, hydroxybenzoic acids, and lignans were inversely associated with T2D. Hydroxycinnamic acids were directly related in men. These associations were different depending on sex and BMI, that is, women and overweight obtained stronger inverse association

Associations between dietary polyphenols and type 2 diabetes in a cross-sectional analysis of the PREDIMED-Plus Trial: role of body mass index and sex

Overweight and obesity are important risk factors for type 2 diabetes (T2D). Moving towards healthier diets, namely, diets rich in bioactive compounds, could decrease the odds of suffering T2D. However, those individuals with high body mass index (BMI) may have altered absorption or metabolism of some nutrients and dietary components, including polyphenols. Therefore, we aimed to assess whether high intakes of some classes of polyphenols are associated with T2D in a population with metabolic syndrome and how these associations depend on BMI and sex. This baseline cross-sectional analysis includes 6633 participants from the PREDIMED-Plus trial. Polyphenol intakes were calculated from food frequency questionnaires (FFQ). Cox regression models with constant time at risk and robust variance estimators were used to estimate the prevalence ratios (PRs) for polyphenol intake and T2D prevalence using the lowest quartile as the reference group. Analyses were stratified by sex and BMI groups (overweight and obese) to evaluate potential effect modification. Catechins, proanthocyanidins, hydroxybenzoic acids, and lignans were inversely associated with T2D. Hydroxycinnamic acids were directly related in men. These associations were different depending on sex and BMI, that is, women and overweight obtained stronger inverse associations.The PREDIMED-Plus trial was supported by the official Spanish Institutions for funding scientific biomedical research, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn) and Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund (four coordinated Fondo de Investigaciones Sanitarias projects leaded by J.S.-S. and J.V., including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, and PI17/00926), the Especial Action Project entitled Implementación y evaluación de una intervención intensiva sobre la actividad física Cohorte PREDIMED-Plus grant to J.S.-S., European Research Council (Advanced Research Grant 2014–2019, 340918) to M.Á.M.-G., the Recercaixa grant to J.S.-S. (2013ACUP00194), grants from the Consejería de Salud de la Junta de Andalucía (PI0458/2013, PS0358/2016, and PI0137/2018), a grant from the Generalitat Valenciana (PROMETEO/2017/017), a SEMERGEN grant, a CICYT grant provided by the Ministerio de Ciencia, Innovación y Universidades (AGL2016-75329-R), and funds from the European Regional Development Fund (CB06/03). Food companies Hojiblanca (Lucena, Spain) and Patrimonio Comunal Olivarero (Madrid, Spain) donated extra virgin olive oil, and the Almond Board of California (Modesto, CA, USA), American Pistachio Growers (Fresno, CA, USA), and Paramount Farms (Wonderful Company, LLC, Los Angeles, CA, USA) donated nuts. J.K. was supported by the “FOLIUM” program within the FUTURMed project entitled Talent for the medicine within the future from the Fundació Institut d’Investigació Sanitària Illes Balears. This call was co-financed at 50% with charge to the Operational Program FSE 2014-2020 of the Balearic Islands

Competencia mediática: investigación sobre el grado de competencia de la ciudadanía en España

Producción CientíficaLa educación mediática no ha tenido un papel importante en los currículos escolares, en los planes de estudios universitarios, en los medios de comunicación y en la propia sociedad, a pesar de la fuerte presencia de la comunicación mediática en todos los ámbitos de nuestra vida personal y social. Este abandono de la educación mediática implica una ausencia de definiciones y de evaluaciones sobre el grado de competencia mediática de las personas. Un primer paso para la definición del concepto de competencia mediática se dio mediante el diseño del documento «Competencias en Comunicación Audiovisual», auspiciado por el CAC) y consensuado por un grupo de expertos españoles. El documento define los ámbitos de incidencia de esta competencia y las dimensiones que debe cumplir: el lenguaje, la tecnología, los procesos de producción y programación, la ideología y los valores, la recepción y las audiencias, y la dimensión estética.Departamento de Historia Moderna, Contemporánea y de América, Periodismo y Comunicación Audiovisual y Publicidad

Medicina de Urgencias Tomo 1

Public health represents one of the greatest challenges in society, which is why it is essential to strengthen the links of scientific cooperation between the academy and the community under a common premise: guarantee the health of the population. In Ecuador, public health faces a historical challenge framed by two edges: the health crisis due to the Covid-19 pandemic and the shortcomings of the social system. This leads to thinking about both the importance of the problem and its possible solutions. Despite this, it is undeniable to affirm that all health personnel share a common ideology and the same commitment, guaranteeing the health of the population.Obviously it is not an easy task due to social uncertainty and the possible appearance of new diseases; however, it is based on a common denominator: basing decisions on the available scientific evidence or what is known as evidence-based medicine. The generation of new knowledge and the use of the best available scientific evidence is the only hope for solving the health problems that afflict the population. In this way, Emergency Medicine seeks to be a timely and practical clinical-therapeutic reference point for emerging regional circumstances, using updated international management guidelines as references and emphasizing evidence-based medicine. We are sure that it will be an invaluable contribution for health professionals.Emergency Medicine, in its two volumes, is a work carried out by teachers, students and medical and related specialists, from the Medicine and Nursing career of the Catholic University of Cuenca, Azogues Campus. In addition, it has the contribution of other medical specialists with extensive professional experience and contributes with 52 chapters that address clinical, surgical, pediatric, and gynecological-obstetric pathologies that require timely management in the emergency room. At the same time, this work addresses topics of current interest such as medicolegal aspects of emergency care, urgent complications in HIV infections, use of antimicrobials in emergencies, dose adjustment in patients with kidney failure; and, a special chapter on SARS-CoV-2: diagnostic-therapeutic management.La salud pública representa uno de los retos más grandes en la sociedad, razón por lo cual es fundamental que se robustezcan los vínculos de cooperación científica entre la academia y la colectividad bajo una premisa común: garantizar la salud de la población. En Ecuador, la salud pública afronta un reto histórico enmarcado en dos aristas: la crisis sanitaria debido a la pandemia por Covid-19 y las carencias del sistema social. Esto conduce a pensar tanto en la trascendencia del problema como en sus posibles soluciones. A pesar de aquello, resulta innegable afirmar que todo el personal sanitario comparte una ideología en común y el mismo compromiso, garantizar la salud de la población. Evidentemente no constituye una tarea fácil debido a la incertidumbre social y a la posible aparición de nuevas enfermedades; sin embargo, se basa en un denominador común: asentar las decisiones en la evidencia científica disponible o lo que se conoce como medicina basada en la evidencia. La generación de nuevo conocimiento y la utilización de la mejor evidencia científica disponible constituye la única esperanza para resolver los problemas de salud que aquejan a la población. De esta forma, Medicina de Urgencias busca ser un referente clínico- terapéutico, oportuno y práctico, de las circunstancias emergentes regionales, tomando como referencias guías de manejo internacionales actualizadas y haciendo hincapié en la medicina basada en la evidencia. Estamos seguros que será un aporte de carácter invaluable para los profesionales de la salud. Medicina de urgencias, en sus dos volúmenes, es una obra realizada por docentes, estudiantes y especialistas médicos y afines, de la carrera de Medicina y Enfermería de la Universidad Católica de Cuenca, Sede Azogues. Además, cuenta con el aporte de otros médicos especialistas con amplia trayectoria profesional y aporta con 52 capítulos que abordan patologías clínicas, quirúrgicas, pediátricas, y gíneco-obstétricas, que requieren manejo oportuno en la sala de emergencias.  Al mismo tiempo, la presente obra aborda temáticas de interés actual como aspectos médico legales de la atención en urgencias, complicaciones urgentes en las infecciones por VIH, uso de antimicrobianos en emergencias, ajuste de dosis en pacientes con insuficiencia renal; y, un capítulo especial sobre el SARS-CoV-2: manejo diagnóstico-terapéutico

Medicina de Urgencias Tomo 1

Public health represents one of the greatest challenges in society, which is why it is essential to strengthen the links of scientific cooperation between the academy and the community under a common premise: guarantee the health of the population. In Ecuador, public health faces a historical challenge framed by two edges: the health crisis due to the Covid-19 pandemic and the shortcomings of the social system. This leads to thinking about both the importance of the problem and its possible solutions. Despite this, it is undeniable to affirm that all health personnel share a common ideology and the same commitment, guaranteeing the health of the population.Obviously it is not an easy task due to social uncertainty and the possible appearance of new diseases; however, it is based on a common denominator: basing decisions on the available scientific evidence or what is known as evidence-based medicine. The generation of new knowledge and the use of the best available scientific evidence is the only hope for solving the health problems that afflict the population. In this way, Emergency Medicine seeks to be a timely and practical clinical-therapeutic reference point for emerging regional circumstances, using updated international management guidelines as references and emphasizing evidence-based medicine. We are sure that it will be an invaluable contribution for health professionals.Emergency Medicine, in its two volumes, is a work carried out by teachers, students and medical and related specialists, from the Medicine and Nursing career of the Catholic University of Cuenca, Azogues Campus. In addition, it has the contribution of other medical specialists with extensive professional experience and contributes with 52 chapters that address clinical, surgical, pediatric, and gynecological-obstetric pathologies that require timely management in the emergency room. At the same time, this work addresses topics of current interest such as medicolegal aspects of emergency care, urgent complications in HIV infections, use of antimicrobials in emergencies, dose adjustment in patients with kidney failure; and, a special chapter on SARS-CoV-2: diagnostic-therapeutic management.La salud pública representa uno de los retos más grandes en la sociedad, razón por lo cual es fundamental que se robustezcan los vínculos de cooperación científica entre la academia y la colectividad bajo una premisa común: garantizar la salud de la población. En Ecuador, la salud pública afronta un reto histórico enmarcado en dos aristas: la crisis sanitaria debido a la pandemia por Covid-19 y las carencias del sistema social. Esto conduce a pensar tanto en la trascendencia del problema como en sus posibles soluciones. A pesar de aquello, resulta innegable afirmar que todo el personal sanitario comparte una ideología en común y el mismo compromiso, garantizar la salud de la población. Evidentemente no constituye una tarea fácil debido a la incertidumbre social y a la posible aparición de nuevas enfermedades; sin embargo, se basa en un denominador común: asentar las decisiones en la evidencia científica disponible o lo que se conoce como medicina basada en la evidencia. La generación de nuevo conocimiento y la utilización de la mejor evidencia científica disponible constituye la única esperanza para resolver los problemas de salud que aquejan a la población. De esta forma, Medicina de Urgencias busca ser un referente clínico- terapéutico, oportuno y práctico, de las circunstancias emergentes regionales, tomando como referencias guías de manejo internacionales actualizadas y haciendo hincapié en la medicina basada en la evidencia. Estamos seguros que será un aporte de carácter invaluable para los profesionales de la salud. Medicina de urgencias, en sus dos volúmenes, es una obra realizada por docentes, estudiantes y especialistas médicos y afines, de la carrera de Medicina y Enfermería de la Universidad Católica de Cuenca, Sede Azogues. Además, cuenta con el aporte de otros médicos especialistas con amplia trayectoria profesional y aporta con 52 capítulos que abordan patologías clínicas, quirúrgicas, pediátricas, y gíneco-obstétricas, que requieren manejo oportuno en la sala de emergencias.  Al mismo tiempo, la presente obra aborda temáticas de interés actual como aspectos médico legales de la atención en urgencias, complicaciones urgentes en las infecciones por VIH, uso de antimicrobianos en emergencias, ajuste de dosis en pacientes con insuficiencia renal; y, un capítulo especial sobre el SARS-CoV-2: manejo diagnóstico-terapéutico

Medicina de Urgencias Tomo 1

Public health represents one of the greatest challenges in society, which is why it is essential to strengthen the links of scientific cooperation between the academy and the community under a common premise: guarantee the health of the population. In Ecuador, public health faces a historical challenge framed by two edges: the health crisis due to the Covid-19 pandemic and the shortcomings of the social system. This leads to thinking about both the importance of the problem and its possible solutions. Despite this, it is undeniable to affirm that all health personnel share a common ideology and the same commitment, guaranteeing the health of the population.Obviously it is not an easy task due to social uncertainty and the possible appearance of new diseases; however, it is based on a common denominator: basing decisions on the available scientific evidence or what is known as evidence-based medicine. The generation of new knowledge and the use of the best available scientific evidence is the only hope for solving the health problems that afflict the population. In this way, Emergency Medicine seeks to be a timely and practical clinical-therapeutic reference point for emerging regional circumstances, using updated international management guidelines as references and emphasizing evidence-based medicine. We are sure that it will be an invaluable contribution for health professionals.Emergency Medicine, in its two volumes, is a work carried out by teachers, students and medical and related specialists, from the Medicine and Nursing career of the Catholic University of Cuenca, Azogues Campus. In addition, it has the contribution of other medical specialists with extensive professional experience and contributes with 52 chapters that address clinical, surgical, pediatric, and gynecological-obstetric pathologies that require timely management in the emergency room. At the same time, this work addresses topics of current interest such as medicolegal aspects of emergency care, urgent complications in HIV infections, use of antimicrobials in emergencies, dose adjustment in patients with kidney failure; and, a special chapter on SARS-CoV-2: diagnostic-therapeutic management.La salud pública representa uno de los retos más grandes en la sociedad, razón por lo cual es fundamental que se robustezcan los vínculos de cooperación científica entre la academia y la colectividad bajo una premisa común: garantizar la salud de la población. En Ecuador, la salud pública afronta un reto histórico enmarcado en dos aristas: la crisis sanitaria debido a la pandemia por Covid-19 y las carencias del sistema social. Esto conduce a pensar tanto en la trascendencia del problema como en sus posibles soluciones. A pesar de aquello, resulta innegable afirmar que todo el personal sanitario comparte una ideología en común y el mismo compromiso, garantizar la salud de la población. Evidentemente no constituye una tarea fácil debido a la incertidumbre social y a la posible aparición de nuevas enfermedades; sin embargo, se basa en un denominador común: asentar las decisiones en la evidencia científica disponible o lo que se conoce como medicina basada en la evidencia. La generación de nuevo conocimiento y la utilización de la mejor evidencia científica disponible constituye la única esperanza para resolver los problemas de salud que aquejan a la población. De esta forma, Medicina de Urgencias busca ser un referente clínico- terapéutico, oportuno y práctico, de las circunstancias emergentes regionales, tomando como referencias guías de manejo internacionales actualizadas y haciendo hincapié en la medicina basada en la evidencia. Estamos seguros que será un aporte de carácter invaluable para los profesionales de la salud. Medicina de urgencias, en sus dos volúmenes, es una obra realizada por docentes, estudiantes y especialistas médicos y afines, de la carrera de Medicina y Enfermería de la Universidad Católica de Cuenca, Sede Azogues. Además, cuenta con el aporte de otros médicos especialistas con amplia trayectoria profesional y aporta con 52 capítulos que abordan patologías clínicas, quirúrgicas, pediátricas, y gíneco-obstétricas, que requieren manejo oportuno en la sala de emergencias.  Al mismo tiempo, la presente obra aborda temáticas de interés actual como aspectos médico legales de la atención en urgencias, complicaciones urgentes en las infecciones por VIH, uso de antimicrobianos en emergencias, ajuste de dosis en pacientes con insuficiencia renal; y, un capítulo especial sobre el SARS-CoV-2: manejo diagnóstico-terapéutico