Experiencia en Cáritas Asturias en torno a la sensibilización en aspectos relacionados con la Economía Solidaria

Treball Final de Màster Universitari en Cooperació al Desenvolupament. Codi: SRP531. Curs acadèmic: 2016/201

El internacionalismo médico cubano en la memoria: un contenido de enseñanza/The Cuban medical internationalism in the memory: a content for the teaching

La introducción de la historia del internacionalismo médico cubano como contenido contextual en el proceso de formación de las nuevas generaciones de médicos, constituye una necesidad para enfrentar la desinformación con la que enemigos de Cuba atentan contra su identidad y es una alternativa eficaz desde la didáctica, para la formación del médico. Este ensayo se propone argumentar desde la didáctica la importancia del internacionalismo como contenido contextual, para la formación del médico, en el proceso de enseñanza aprendizaje de la disciplina Preparación para la Defensa, lo que permite el establecimiento de nexos con elementos propios de la cultura de la profesión, conducentes a un proceso contextualizado y desarrollador como el que demanda la sociedad cubana

Effects of Cannabidiol, Hypothermia, and Their Combination in Newborn Rats with Hypoxic-Ischemic Encephalopathy

Therapeutic hypothermia is well established as a standard treatment for infants with hypoxic-ischemic (HI) encephalopathy but it is only partially effective. The potential for combination treatments to augment hypothermic neuroprotection has major relevance. Our aim was to assess the effects of treating newborn rats following HI injury with cannabidiol (CBD) at 0.1 or 1 mg/kg, i.p., in normothermic (37.5°C) and hypothermic (32.0°C) conditions, from 7 d of age (neonatal phase) to 37 d of age (juvenile phase). Placebo or CBD was administered at 0.5, 24, and 48 h after HI injury. Two sensorimotor (rotarod and cylinder rearing) and two cognitive (novel object recognition and T-maze) tests were conducted 30 d after HI. The extent of brain damage was determined by magnetic resonance imaging, histologic evaluation, magnetic resonance spectroscopy, amplitude-integrated electroencephalography, and Western blotting. At 37 d, the HI insult produced impairments in all neurobehavioral scores (cognitive and sensorimotor tests), brain activity (electroencephalography), neuropathological score (temporoparietal cortexes and CA1 layer of hippocampus), lesion volume, magnetic resonance biomarkers of brain injury (metabolic dysfunction, excitotoxicity, neural damage, and mitochondrial impairment), oxidative stress, and inflammation (TNFα). We observed that CBD or hypothermia (to a lesser extent than CBD) alone improved cognitive and motor functions, as well as brain activity. When used together, CBD and hypothermia ameliorated brain excitotoxicity, oxidative stress, and inflammation, reduced brain infarct volume, lessened the extent of histologic damage, and demonstrated additivity in some parameters. Thus, coadministration of CBD and hypothermia could complement each other in their specific mechanisms to provide neuroprotection.F.J.A. has a research agreement with GW Research Ltd, which is now a part of Jazz Pharmaceuticals, from which he receives financial support. W.H. is an employee Jazz Pharmaceuticals. The authors declare no other competing financial interests. The present study was supported by Grant GWCRI1547 (GW Research Ltd., now part of Jazz Pharmaceuticals); Grant PI12/0852 (ISCIII-General SubDirectorate for Research Assessment and Promotion and the European Regional Development Funds/European Social Fund: “A way to build Europe”); and Grant UPV GIU 17/18 (University of the Basque Country)

El retropropulsor y estimulador de Buño: su uso en los prognatismos mandibulares, cambios cefalométricos

Introduction: a prospective study was conducted with the use of the retropropulsor and stimulator of Professor Indalecio Buño in 24 patients with mandibular prognathism in mixed dentition. Objective: to know the cephalometric changes during the use of the retropupulsor and stimulator. Material and methods: patients underwent lateral radiographs before and twelve months after, comparing cephalometric changes obtained as a result of skeletal and dentoalveolar changes achieved, taking into account sex too. Results: statistically increase of SNA angle and very significant reduction in SNB angle were found, which represented a significant change of the ANB angle. Conclusions: regarding sex, there were significant changes in the SNA angle in males and in females in SNB angle, in addition to a significant variation in females of 1 SNB angle. These changes helped in improving the profile, concave, and to uncross previous bites that characterize patients with class III mandibular prognathism syndrome.Introducción: el problema de los prognatismos mandibulares es motivo de interés permanente para genetistas, antropólogos, ortopedistas, ortodoncistas, pediatras, cirujanos y psiquiatras. Se realizó un estudio prospectivo con el uso del retropropulsor y timulador del profesor Indalecio Buño en 24 pacientes con prognatismos mandibulares en dentición mixta. Objetivo: conocer los cambios cefalométricos durante el uso del retropropulsor y estimulador. Material y método: se les realizaron telerradiografías de perfil, antes y doce meses después, comparando los cambios cefalométricos obtenidos como resultado de cambios esqueletales y dentoalveolares logrados, teniendo en cuenta el sexo también. Resultados: estadísticamente se encontró aumento del ángulo SNA y reducción del ángulo SNB muy significativos, lo que representó un cambio muy significativo del ángulo ANB. Conclusiones: en relación con el sexo, hubo cambios muy significativos en el ángulo SNA en los varones y en el ángulo SNB en las hembras, además de una variación muy significativa en las hembras, del ángulo 1 SNB. Estos cambios ayudaron en la mejoría del perfil, cóncavo, así como a descruzar las mordidas anteriores que caracterizan a los pacientes con prognatismos mandibulares en el síndrome de clase III

Genomic Insights into the Mobilome and Resistome of Sentinel Microorganisms Originating from Farms of Two Different Swine Production Systems

[EN] Antimicrobial resistance (AMR) is a threat to public health due to long-term antimicrobial use (AMU), which promotes the bacterial acquisition of antimicrobial resistance determinants (ARDs). Within food-producing animals, organic and extensive Iberian swine production is based on sustainable and eco-friendly management systems, providing an excellent opportunity to evaluate how sustained differences in AMU impact the development and spread of AMR. Here, through a whole-genome sequencing approach, we provide an in-depth characterization of the resistome and mobilome and their interaction in 466 sentinel bacteria, namely, Escherichia coli, Enterococcus spp., Campylobacter coli, and Staphylococcus spp., recovered from 37 intensive and organic-extensive pig farms. Both ARDs and mobile genetic elements (MGEs) were primarily taxon-associated, with higher similarities among bacteria which were closely phylogenetically related. E. coli exhibited the most diverse resistome and mobilome, with 85.4% mobilizable ARDs, 50.3% of which were plasmid-associated. Staphylococcus spp. exhibited a broad repertoire of ARDs and MGEs, with 52.3% of its resistome being mobilizable. Although Enterococcus spp. carried the highest number of ARDs per isolate and its plasmidome was similar in size to that of E. coli, 43.7% of its resistome was mobilizable. A narrow spectrum of ARDs constituted the C. coli resistome, with point mutations as its main AMR driver. A constrained AMU, as observed in organic-extensive herds, determined a reduction in the quantitative composition of the resistome and the complexity of the resistome-mobilome interaction. These results demonstrate taxon-associated AMR-MGE interactions and evidence that responsible AMU can contribute to reducing AMR pressure in the food chainSIWe acknowledge the excellent technical assistance provided by Diana Molina, Lucía Pérez, and Clara Vega, the help with data management provided by Laura Uelze, and the help by Katharina Thomas and Beatrice Baumann in sequencing library preparation. We also thank the veterinary practitioners and farmers for their willingness to collaborate and, in particular, Álvaro Fernández-Blanco for his support in contacting the farms. O.M.-A. received a grant from the Spanish Government (Ministerio de Universidades), no. EST 19/00806, for a short stay at the German Federal Institute for Risk Assessment. O.M.-A. also holds a grant from the Spanish Government (Ministerio de Educación y Formación Profesional), no. FPU 16/03485. H.A. is financially supported by the “Beatriz Galindo” Program from the Spanish Government (Ministerio de Educación y Formación Profesional), no. BEAGAL-18-106. Study design was performed by A.C., H.A. and A.A.-O. Samples were prepared by O.M.-A. M.B. performed the whole-genome sequencing. C.D. performed the computational analyses, with contribution from J.F.C.-D. Statistical analyses were performed by O.M.-A. with contributions from C.D. and J.F.C.-D. B.M., H.A. and A.A.-O. provided technical and scientific support on the analysis. O.M.-A., H.A., A.C., A.A.-O., B.M., M.B. and C.D. participated in writing the manuscript or contributed to its revision. All authors revised the manuscript and approved the final versio

Quasifree (p, 2p) Reactions on Oxygen Isotopes: Observation of Isospin Independence of the Reduced Single-Particle Strength

Quasifree one-proton knockout reactions have been employed in inverse kinematics for a systematic study of the structure of stable and exotic oxygen isotopes at the R3B=LAND setup with incident beam energies in the range of 300–450 MeV=u. The oxygen isotopic chain offers a large variation of separation energies that allows for a quantitative understanding of single-particle strength with changing isospin asymmetry. Quasifree knockout reactions provide a complementary approach to intermediate-energy onenucleon removal reactions. Inclusive cross sections for quasifree knockout reactions of the type AOðp; 2pÞA−1 N have been determined and compared to calculations based on the eikonal reaction theory. The reduction factors for the single-particle strength with respect to the independent-particle model were obtained and compared to state-of-the-art ab initio predictions. The results do not show any significant dependence on proton-neutron asymmetryThis work was supported by the German Federal Ministry for Education and Research (BMBF project 05P15RDFN1), and through the GSI-TU Darmstadt cooperation agreement. The work of C. B., W. C., and G. W. was supported by the United Kingdom Science and Technology Facilities Council (STFC) under Grants No. ST/L005743/1 and No. ST/P005314/1. SCGF calculations were performed at the DiRAC Complexity system of the University of Leicester (BIS National E-1023 infrastructure capital Grant No. ST/K000373/1 and STFC 1024 Grant No. ST/K0003259/1). C. A. B. acknowledges support by the U.S. DOE Grant No. DE-FG02- 08ER41533 and the U.S. NSF Grant No. 1415656. L. M. F. acknowledges funding from MINECO FPA2015-65035-P project.S

Deep learning for MRI-based CT synthesis: a comparison of MRI sequences and neural network architectures

[Otros] Synthetic computed tomography (CT) images derived from magnetic resonance images (MRI) are of interest for radiotherapy planning and positron emission tomography (PET) attenuation correction. In recent years, deep learning implementations have demonstrated improvement over atlasbased and segmentation-based methods. Nevertheless, several open questions remain to be addressed, such as which is the best of MRI sequences and neural network architectures. In this work, we compared the performance of different combinations of two common MRI sequences (T1- and T2-weighted), and three state-of-the-art neural networks designed for medical image processing (Vnet, HighRes3dNet and ScaleNet). The experiments were conducted on brain datasets from a public database. Our results suggest that T1 images perform better than T2, but the results further improve when combining both sequences. The lowest mean average error over the entire head (MAE = 101.76 ± 10.4 HU) was achieved combining T1 and T2 scans with HighRes3dNet. All tested deep learning models achieved significantly lower MAE (p < 0.01) than a well-known atlas-based method.This work was supported by the Spanish Government grants TEC2016-79884-C2 and RTC-2016-5186-1, and by the European Union through the European Regional Development Fund (ERDF)Larroza, A.; Moliner, L.; Álvarez-Gómez, JM.; Oliver-Gil, S.; Espinós-Morató, H.; Vergara-Díaz, M.; Rodríguez-Álvarez, MJ. (2019). Deep learning for MRI-based CT synthesis: a comparison of MRI sequences and neural network architectures. IEEE. 1-4. https://doi.org/10.1109/NSS/MIC42101.2019.9060051S1

Antimicrobial use and production system shape the fecal, environmental, and slurry resistomes of pig farms

P. 1-17Background: The global threat of antimicrobial resistance (AMR) is a One Health problem impacted by antimicrobial use (AMU) for human and livestock applications. Extensive Iberian swine production is based on a more sustainable and eco-friendly management system, providing an excellent opportunity to evaluate how sustained differences in AMU impact the resistome, not only in the animals but also on the farm environment. Here, we evaluate the resistome footprint of an extensive pig farming system, maintained for decades, as compared to that of industrialized intensive pig farming by analyzing 105 fecal, environmental and slurry metagenomes from 38 farms. Results: Our results evidence a significantly higher abundance of antimicrobial resistance genes (ARGs) on intensive farms and a link between AMU and AMR to certain antimicrobial classes. We observed differences in the resistome across sample types, with a higher richness and dispersion of ARGs within environmental samples than on those from feces or slurry. Indeed, a deeper analysis revealed that differences among the three sample types were defined by taxa-ARGs associations. Interestingly, mobilome analyses revealed that the observed AMR differences between intensive and extensive farms could be linked to differences in the abundance of mobile genetic elements (MGEs). Thus, while there were no differences in the abundance of chromosomal-associated ARGs between intensive and extensive herds, a significantly higher abundance of integrons in the environment and plasmids, regardless of the sample type, was detected on intensive farms. Conclusions: Overall, this study shows how AMU, production system, and sample type influence, mainly through MGEs, the profile and dispersion of ARGs in pig production.S

Quasi-free neutron and proton knockout reactions from light nuclei in a wide neutron-to-proton asymmetry range

The quasi-free scattering reactions 11C and 10,11,12C have been studied in inverse kinematics at beam energies of 300–400 MeV/u at the R3B-LAND setup. The outgoing proton-proton and proton-neutron pairs were detected in coincidence with the reaction fragments in kinematically complete measurements. The efficiency to detect these pairs has been obtained from GEANT4 simulations which were tested using the 12C() and 12C( ) reactions. Experimental cross sections and momentum distributions have been obtained and compared to DWIA calculations based on eikonal theory. The new results reported here are combined with previously published cross sections for quasi-free scattering from oxygen and nitrogen isotopes and together they enable a systematic study of the reduction of single-particle strength compared to predictions of the shell model over a wide neutron-to-proton asymmetry range. The combined reduction factors show a weak or no dependence on isospin asymmetry, in contrast to the strong dependency reported in nucleon-removal reactions induced by nuclear targets at lower energies. However, the reduction factors for are found to be 'significantly smaller than for reactions for all investigated nuclei.This work was supported by the German Federal Ministry of Education and Research (BMBF projects 05P2015RDFN1 and 05P15WOFNA), through the GSI-TU Darmstadt cooperation agreement, by the State of Hesse through the LOEWE center HIC for FAIR, and the Helmholtz-Gemeinschaft through the graduate school HGS-HIRe. This work was supported by the European Union by means of the European Commission within its Seventh Framework Program (FP7) via ENSAR (Contract No. 262010), and the Spanish CICYT research grants FPA2012-32443, FPA2015-64969-07387, and FPA2015-69640-C2-1-P. This work has supported by the Swedish Research Council under contract number 621-2011-5324. C.A.B. acknowledges support from the U.S. NSF grant No. 1415656 and the U.S. DOE grant No. DE-FG02-08ER41533. Supported by the Portuguese FCT under the project PTDC/FIS/103902/2008.S

Instrumented splint for the diagnosis of bruxism

Bruxism is a health problem consisting in grinding or tightly clenching the upper and lower teeth. Both the grinding and sliding lead to wear of the teeth and produce a noise during the night that is sufficiently loud to disturb the sleep of anyone sharing the bedroom. The tension produced causes problems in the muscles, tissues and other structures surrounding the jaw, ear pain, headaches, lesions to the teeth and disorders in the jaw joints. For an early, rapid, effective and economical diagnosis of bruxism, we propose the use of instrumented splints to detect and record the intensity and duration of inter dental pressure episodes. This paper sets out the design, manufacture and testing of an instrumented splint for diagnosing the signs of bruxism. The system stands out for its use of piezoelectric polymeric sensors which, because of their reduced thickness, do not cause any alteration to the patient’s bite. It lets a quantitative assessment of intraoral pressure be made and bruxism behavior be diagnosed at an early stage, so as to being able to programme corrective actions before irreversible dental wear appears. The first “in vitro” simulations and “in vivo “trials performed served to demonstrate the feasibility of the system in accordance with the initial objectives