The beginnings of local radio in Catalonia

The beginnings of local radio in Cataloni

Els inicis de la Ràdio Local a Catalunya

Els inicis de la Ràdio Local a Cataluny

Flavodoxins as novel therapeutic targets against helicobacter pylori and other gastric pathogens

Flavodoxins are small soluble electron transfer proteins widely present in bacteria and absent in vertebrates. Flavodoxins participate in different metabolic pathways and, in some bacteria, they have been shown to be essential proteins representing promising therapeutic targets to fight bacterial infections. Using purified flavodoxin and chemical libraries, leads can be identified that block flavodoxin function and act as bactericidal molecules, as it has been demonstrated for Helicobacter pylori (Hp), the most prevalent human gastric pathogen. Increasing antimicrobial resistance by this bacterium has led current therapies to lose effectiveness, so alternative treatments are urgently required. Here, we summarize, with a focus on flavodoxin, opportunities for pharmacological intervention offered by the potential protein targets described for this bacterium and provide information on other gastrointestinal pathogens and also on bacteria from the gut microbiota that contain flavodoxin. The process of discovery and development of novel antimicrobials specific for Hp flavodoxin that is being carried out in our group is explained, as it can be extrapolated to the discovery of inhibitors specific for other gastric pathogens. The high specificity for Hp of the antimicrobials developed may be of help to reduce damage to the gut microbiota and to slow down the development of resistant Hp mutants

El delincuente español : el lenguaje : (estudio filológico, psicológico y sociológico), con dos vocabularios jergales

"Obras citadas in este libro": p. [339]-40"Autores citados in este libro": p. [337]-8.Mode of access: Internet

Numbers, space and motion, convergent data about their interaction. Behavioral, electrophysiological and TMS evidence

2006/2007In this thesis five studies on the relationship between numbers and space and between numbers and motion are presented. The introduction of the thesis contains a description of works dealing with the link between numbers and spatial attention. This includes some behavioral data exploring shifts of spatial attention induced by numbers, data from hemispatial neglect and neuroimaging data. We further explore space-number relationship across modalities (vision and audition) and discuss how the semantics of numbers are dependent or independent form the used modality. This includes an study on blind population using the auditory modality. In a second part, the possible relationship between numbers and motion is introduced and discussed. Two papers that bring convergent data about it are provided. In the first one, an interference of the perception of motion into a number comparison process is presented. In the second paper, a neural substrate in the intraparietal sulcus is proposed as a focus of intersection between number and motion processes. Finally, a study with neglect patients explore possible compensatory mechanism of motion in their altered spatial representation of numbers. Amounting evidence exists on the relationship between numbers and space (see introduction). Numbers´ semantics would have the form of a mental number line with spatial characteristics. Fischer and collaborators (2003) showed that a lateralized target presented on the left visual field (LVF) is detected faster after low numbers than after high numbers and a target presented on the right visual field (RVF) is detected faster following a high number than after low numbers. The studies presented here explore these shifts of attention induced by numbers in electrophysiological terms. Event related potentials (ERPs) allow to explore the process underlying this effect: we describe it as a conjunction of attentional sensory and cognitive, more controlled, mechanisms. We test the possibility that the effect extends to the auditory modality both in sighted and in blind individuals. And we show interesting differences between the two populations in the way they manipulate a similar left-to-right number representation. Regarding the link between motion and number processes, we show how rightward motion facilitates a process thought to call the core presentation of numbers: number comparison. We also explore the vertical dimension, in which upward motion has the same facilitatory effects in number comparison. We show how selective attention to motion has effects on the number comparison process and that his effect may be independent of space-location effects. Furthermore, using transcranial magnetic stimulation (TMS), we present evidence of possible common neural networks processing numbers and motion. One area of intersection, we show, is the ventral intraparietal sulcus (VIPS). VIPS has been proposed previously as an area processing motion in humans. We show that besides motion it is implied in number comparison processes. Finally, we use the behavioral paradigm from the third paper to explore possible effects of motion perception in number processing in hemispatial neglect. While several papers show their difficulty in the representation of the “left side” of the mental number line or in its access, we show that this difficulty or misrepresentation can be compensated by the external presentation of leftward coherent motion. Therefore, common attentional processes seem to be acting over external and internal representational space. In summary, the present thesis provides evidence of the space number relationship and describe how they interact through electrophysiological methods. Some tentative conclusions about the modality dependencies of the number-space link can be drawn from the comparison between modalities. Besides, when there is no access to the visual modality, in congenital blindness, we show how a left to right mental number line stands, but its manipulation varies. We propose motion as another process operating over number representation and provide direct evidence of this new link. Finally, we show how motion acts as a compensatory mechanism in neglect.XX Cicl

¿Todo lo que nos rodea es materia?: enseñanza de las propiedades de la materia y los materiales en un aula inclusiva de educación primaria utilizando una metodología de indagación

El presente Trabajo de Fin de Grado en Maestro de Educación Primaria que se refleja a continuación, ha sido desarrollado para comprobar si es viable trabajar por el método de indagación en un aula inclusiva. Para ello, se ha revisado bibliografía, diseñado y planificado una intervención de enseñanza por indagación que aborda la temática materia y materiales para un aula de 5º de Educación Primaria. Los resultados de la implementación de este aprendizaje cooperativo donde el alumno parte de sus propias ideas, han sido muy satisfactorios. Se puede afirmar que esta forma de trabajo es productiva y fomenta un alto grado de motivación y rendimiento, así como un aprendizaje óptimo para los Alumnos con Necesidades Específicas de Apoyo Educativo.This final project of the Elementary School Degree has been developed to confirm if it's viable to work with an inquiry method on an inclusive classroom. In order to achieve that, I have revised the bibliography and designed an intervention of inquiry teaching. This type of teaching address the subject of matter and materials on a 5th grade classroom. The result on the implementation of this learning method where the student has his own ideas has been very successful. We can confirm that this method of learning is productive and encourages a high level of motivation and performance as well as a satisfactory learning for the student with Special Need of Educative Support

Balancing the 2 Hemispheres in Simple Calculation: Evidence From Direct Cortical Electrostimulation

Published: 24 September 2016How do the parietal lobes contribute to simple calculation? Clinical and neuroimaging methods, which are based mainly on correlational evidence, have provided contrasting results so far. Here we used direct cortical electrostimulation during brain surgery to causally infer the role of the left and right parietal lobes in simple calculation. Stimulation provoked errors for addition and multiplication in different parietal areas on both hemispheres. Crucially, an innovative qualitative error analysis unveiled the functional contrast of the 2 parietal lobes. Right or left stimulation led to different types of substitution errors in multiplication, unveiling the function of the more active hemisphere. While inhibition of the left hemisphere led mainly to approximation errors, right hemisphere inhibition enhanced retrieval within a stored repertory. These results highlight the respective roles of each hemisphere in the network: rote retrieval of possible solutions by the left parietal areas and approximation to the correct solution by the right hemisphere. The bilateral orchestration between these functions guarantees precise calculation.This work was supported by the Italian Ministry of Health (grant RF-2009-1530973); by the University of Padua (Grant Progetto d’Ateneo CPDA131328 and Progetto strategico NEURAT) to C.S., and by the Spanish Ministry of Science and Innovation (grant PSI2014-53351) to E.S. and by financial assistance as a Severo Ochoa Center of Excellence SEV-2015-0490 to the BCBL (E.S.)

La actividad emprendedora: Análisis transversal en la Comunidad Foral de Navarra

Resumen En este trabajo se realiza un estudio del emprendimiento dentro de la Comunidad Foral de Navarra. Para ello utiliza los datos de la base de datos Global Entrepreneur Monitor con el objetivo de realizar un análisis de los diferentes factores que afectan en el emprendimiento, y, si hay diferencias entre género o entre emprendedores por necesidad, por oportunidad o nuevos emprendedores. Los resultados establecen la gran importancia de la autopercepción de las habilidades para emprender y de las oportunidades futuras de negocio. Abstract This paper studies entrepreneurship in Navarra, Spain. For this aim, this work uses the data of the Global Entrepreneur Monitor to analyses different factors that affect entrepreneurship, and, if there are differences between gender or between necessity, opportunity or nascent entrepreneurs. Results establish the great importance of self-perception of skills to entrepreneur and future business opportunities

El uso de las TIC en la enseñanza de las Matemáticas en Educación Primaria: aplicación a las fracciones

En este trabajo se muestra la gran importancia e influencia de las TIC en el contexto educativo. En el primer apartado se realiza un análisis sobre el impacto que ha tenido la utilización de las TIC en el ámbito educativo. En la segunda parte se analiza el currículo educativo de Castilla y León en el área de Matemáticas desde la perspectiva de las TIC, tanto a nivel general como a nivel. En tercer lugar, se estudian los aspectos positivos y negativos de la utilización de las TIC en las Matemáticas. Seguidamente, se establece una clasificación de los recursos tecnológicos que se disponen en la Red y que pueden ser de utilidad en dicha área, así como también se procede al estudio de algunos de los mismos. Finalmente, se termina con la descripción de una unidad didáctica en la cual se hace uso de las TIC, concretamente se trata de una gamificación donde se aplican varias Apps como GenMagic o Proyecto Gauss.Grado en Educación Primari