284 research outputs found

    Representations of swine flu: Perspectives from a Malaysian pig farm

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    © The Author(s), 2010. This is the author's accepted manuscript. The final published article is available from the link below.Novel influenza viruses are seen, internationally, as posing considerable health challenges, but public responses to such viruses are often rooted in cultural representations of disease and risk. However, little research has been conducted in locations associated with the origin of a pandemic. We examined representations and risk perceptions associated with swine flu amongst 120 Malaysian pig farmers. Thirty-seven per cent of respondents felt at particular risk of infection, two-thirds were somewhat or very concerned about being infected. Those respondents who were the most anxious believed particular societal “out-groups” (homosexuals, the homeless and prostitutes) to be at higher infection risk. Although few (4%) reported direct discrimination, 46% claimed friends had avoided them since the swine flu outbreak. Findings are discussed in the context of evolutionary, social representations and terror management theories of response to pandemic threat

    First order sigma-delta modulator of an oversampling ADC design in CMOS using floating gate MOSFETS

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    We report a new architecture for a sigma-delta oversampling analog-to-digital converter (ADC) in which the first order modulator is realized using the floating gate MOSFETs at the input stage of an integrator and the comparator. The first order modulator is designed using an 8 MHz sampling clock frequency and implemented in a standard 1.5µm n-well CMOS process. The decimator is an off-chip sinc-filter and is programmed using the VERILOG and tested with Altera Flex EPF10K70RC240 FPGA board. The ADC gives an 8-bit resolution with a 65 kHz bandwidth

    Analisis Supposed Capable Fault sebagai Data Dukung Rencana Tapak PLTN Bojonegara, Propinsi Banten

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    ANALISIS SUPPOSED CAPABLE FAULT SEBAGAI DATA DUKUNG RENCANA TAPAK PLTN BOJONEGARA, PROPINSI BANTEN. Lokasi sesar dan daerah beradius 150 km dari garis sesar atau zona sesar merupakan daerah yang tertolak atau dihindari dalam pemilihan daerah tapak interes PLTN. Tujuan penelitian adalah untuk mengidentifikasi keberadaan sesar permukaan atau sesar kapabel di lokasi tapak PLTN. Metodologi penelitian meliputi interpretasistruktur sesar, analisis seismik refleksi di darat dan laut, analisis seismotektonik, dan menentukan daerah terbebas bahaya pensesaran permukaan. Wilayah studi regional, yaitu radius 150 km dari daerah interes, mencakup Propinsi Banten, DKI Jakarta, Jawa Barat, dan Sumatera Selatan (sebagian Lampung). Hasil interpretasi citra landsat, struktur sesar memperlihatkan pola yang berarah timur laut - barat daya yang diwakili oleh Sesar Cimandiri, barat laut – tenggara yang diwakili oleh Sesar Citandui, Sesar Baribis, Sesar Tangkuban Perahu. Pola sesar yang berarah timur laut – barat daya diperkirakan merupakan pola struktur mendatar sinistral (left lateral faults), dan pola sesar yang berarah barat laut – tenggara merupakan sesar mendatar dekstral (right lateral faults). Berdasarkan data seismik di darat, sesar yang menembus sampai Formasi Cisubuh dikategorikan sebagai Supposed Capable Fault. Analisis sekuen stratigrafi seismik laut dikorelasikan dengan satuan umur pengendapan pada Zaman Plistosen, dimana terbagi dalam QT (Batas Tersier dan Plistosen Awal), Q1 (Batas Plistosen Awal dan Plistosen Tengah), dan Q2 (Batas Plistosen Tengah dan Plistosen Akhir), suppose capable fault menembus sekuen Plistosen awal hingga akhir. Hasil analisis seismotektonik terdapat sesar kapabel diperkirakan (supposed capable fault)

    Validated High Performance Liquid Chromatography Method for Analysis of Cefadroxil Monohydrate in Human Plasma

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    Purpose: To develop a simple, rapid and sensitive high performance liquid chromatography (HPLC) method for the determination of cefadroxil monohydrate in human plasma.Methods: Schimadzu HPLC with LC solution software was used with Waters Spherisorb, C18 (5 μm, 150mm × 4.5mm) column. The mobile phase was sodium dihydrogen phosphate buffer pH 4.0 and methanol in a ratio of 96:4. Flow rate was 1.5 ml/min and injection volume was 100 μl. Peak response was detected at 260 nm.Results: System suitability results revealed that the coefficient of variation (CV) for retention time, peak response, tailing factor and resolution of six replicate injections was < 3 %. The method was selective to determine cefadroxil in plasma because there was no peak interference of plasma with cefadroxil at its retention time (7.792 min). Linearity was in the range of 0.5 - 30 μg/ml with slope and intercept of 41694.53 and 22614.87, respectively (R2 = 0.9953). Limit of detection (LOD) and lower limit of quantification (LLOQ) of the method were 0.03 and 0.06 μg/ml, respectively. Absolute recovery of cefadroxil from plasma was in the range 71 - 90.4 %, while inter-day and intra-day analysis showed satisfactory precision and accuracy; thus, the method was reproducible with the range of CV, i.e., 0.35 - 4.01 and 1.88 - 7.9 % for interday and intraday precision, respectively.Conclusion: The developed method being simple, rapid, reproducible can be suitably employed in pharmacokinetic and bioequivalence studies of cefadroxil monohydrate.Keywords: Validation, Cefadroxil monohydrate, Human plasma, Pharmacokinetics Bioequivalenc

    Assessing the effectiveness of business support services in England: evidence from a theory based evaluation

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    In England, publicly supported advisory services for small firms are organised primarily through the Business Link (BL) network. Based on the programme theory underlying this business support services we develop four propositions and test these empirically using data from a new survey of over 3,000 English small firms. Our empirical results provide a broad validation of the programme theory underlying BL assistance for small firms in England during 2003, and more limited support for its effectiveness. More specifically, we find strong support for the value of BL operators maintaining a high profile as a way of boosting take-up. We also find some support for the approach to market segmentation adopted by BL allowing more intensive assistance to be targeted on younger firms and those with limited liability status. In terms of the outcomes of BL support, and allowing for issues of sample selection, we find no significant effects on growth from ‘other’ assistance but do find positive and significant employment growth effects from intensive assistance. This provides partial support for the programme theory assertion that BL support will lead to improvements in business growth performance and stronger support for the proposition that there would be differential outcomes from intensive and other assistance. The positive employment growth outcomes identified here from intensive assistance, even allowing for sample selection, suggest something of an improvement in the effectiveness of the BL network since the late 1990s

    Response of the Human Circadian System to Millisecond Flashes of Light

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    Ocular light sensitivity is the primary mechanism by which the central circadian clock, located in the suprachiasmatic nucleus (SCN), remains synchronized with the external geophysical day. This process is dependent on both the intensity and timing of the light exposure. Little is known about the impact of the duration of light exposure on the synchronization process in humans. In vitro and behavioral data, however, indicate the circadian clock in rodents can respond to sequences of millisecond light flashes. In a cross-over design, we tested the capacity of humans (n = 7) to respond to a sequence of 60 2-msec pulses of moderately bright light (473 lux) given over an hour during the night. Compared to a control dark exposure, after which there was a 3.5±7.3 min circadian phase delay, the millisecond light flashes delayed the circadian clock by 45±13 min (p<0.01). These light flashes also concomitantly increased subjective and objective alertness while suppressing delta and sigma activity (p<0.05) in the electroencephalogram (EEG). Our data indicate that phase shifting of the human circadian clock and immediate alerting effects can be observed in response to brief flashes of light. These data are consistent with the hypothesis that the circadian system can temporally integrate extraordinarily brief light exposures
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