Gpr158 mediates osteocalcin's regulation of cognition

That osteocalcin (OCN) is necessary for hippocampal-dependent memory and to prevent anxiety-like behaviors raises novel questions. One question is to determine whether OCN is also sufficient to improve these behaviors in wild-type mice, when circulating levels of OCN decline as they do with age. Here we show that the presence of OCN is necessary for the beneficial influence of plasma from young mice when injected into older mice on memory and that peripheral delivery of OCN is sufficient to improve memory and decrease anxiety-like behaviors in 16-mo-old mice. A second question is to identify a receptor transducing OCN signal in neurons. Genetic, electrophysiological, molecular, and behavioral assays identify Gpr158, an orphan G protein-coupled receptor expressed in neurons of the CA3 region of the hippocampus, as transducing OCN's regulation of hippocampal-dependent memory in part through inositol 1,4,5-trisphosphate and brain-derived neurotrophic factor. These results indicate that exogenous OCN can improve hippocampal-dependent memory in mice and identify molecular tools to harness this pathway for therapeutic purposes

A collaboratively derived environmental research agenda for Galapagos

Galápagos is one of the most pristine archipelagos in the world and its conservation relies upon research and sensible management. In recent decades both the interest in, and the needs of, the islands have increased, yet the funds and capacity for necessary research have remained limited. It has become, therefore, increasingly important to identify areas of priority research to assist decision-making in Galápagos conservation. This study identified 50 questions considered priorities for future research and management. The exercise involved the collaboration of policy makers, practitioners and researchers from more than 30 different organisations. Initially, 360 people were consulted to generate 781 questions. An established process of preworkshop voting and three rounds to reduce and reword the questions, followed by a two-day workshop, was used to produce the final 50 questions. The most common issues raised by this list of questions were human population growth, climate change and the impact of invasive alien species. These results have already been used by a range of organisations and politicians and are expected to provide the basis for future research on the islands so that its sustainability may be enhanced. </jats:p

Analysis of PTH and PTHrp influence in regulating the control of energy balance by the central nervous system

Résumé confidentielConfidential abstrac

Traité des matieres criminelles suivant l'ordonnance du mois d'Août 1670 & les edits, declarations du roi, arrâts & réglemens intervenus jusqu'à présent ...

Sign.: a[macron]-e[macron]\p4\s, A-Z\p4\s, 2A-2Z\p4\s, 3A-3Z\p4\s, 4A-4O\p4\s, 4P\p2\sTexto con apostillas marginale

Traité des matières criminelles

- Obra disponibilizada originalmente na Gallica (Biblioteca Nacional da França)

Recueil de jurisprudence civile du pays de droit écrit et coutumier , par ordre alphabétique. Quatrième édition, considérablement augmentée, par Me Guy Du Rousseaud de La Combe,...

Avec mode text

Identification of biological targets for argon

CERVOXYNational audienc

Identification of biological targets for argon

CERVOXYNational audienc

Identification of biological targets for argon

CERVOXYInternational audienc