383 research outputs found

    Los mayores y las nuevas tecnologías de la comunicación

    Get PDF
    [Resumen] Fundamentos: En una sociedad envejecida es necesario establecer nuevas alternativas que de alguna manera traten de satisfacer las necesidades de las personas mayores, a la vez que incrementen su calidad de vida percibida. En este sentido, las nuevas tecnologías, como la informática, se han convertido en una herramienta básica de nuestra sociedad, de la que los mayores, sin ninguna duda, podrán beneficiarse. El objetivo del presente trabajo es conocer la opinión de los mayores acerca de temas relacionados con la informática e Internet, así como su capacidad de acceso a las nuevas tecnologías y los conocimientos con los que cuentan. Métodos: Se realiza una entrevista estandarizada, de diseño propio, a una muestra de 105 personas mayores con una edad media de 73 años, residentes en la ciudad de A Coruña. Resultados: De los resultados obtenidos se constata que aunque la mayoría de las personas mayores no cuenta con ordenador personal ni ha trabajado con aplicaciones informáticas, les gustaría aprender más sobre este campo. Además, cuando se conectan a Internet lo hacen desde centros sociales y/o educativos, no encontrando excesivos problemas en su manejo y navegación. Conclusiones: Es necesario fomentar el uso de la informática por parte de los mayores, ya que en un futuro puede constituir una herramienta imprescindible en la intervención sobre problemas inherentes al envejecimiento como son el aislamiento o la soledad entre otros.[Abstract] new alternatives, that somehow try to satisfy the needs of elderly people and that at the same time increase their quality of life. On this sense, the new technologies, such as computer science, have become a basic tool of our society, and the elderly, without no doubt will be able to benefit from it. The objective of the present work is to know what the elderly think about themes related to computer science and internet, as well as their capacity of accessing to new technologies, and the knowledge that they have about them. Methods: A standarized interview has been made, it´s self designed, to a sample of 105 elderly people living in the city of A Coruña. Results: Although most elderly people don´t have a personal computer neither have worked with a computer application, would like to learn more about this field. When they are connected to internet they do it from social and/or educative centres, not having great problems neither in its handling or navigation. Conclusions: It´s necessary to promote the use of computer science on the elderly people, since in a future it can constitute an essential tool in the intervention on inherent problems to aging such as isolation or loneliness among others

    Transactive Response DNA-Binding Protein (TARDBP/TDP-43) Regulates Cell Permissivity to HIV-1 Infection by Acting on HDAC6

    Get PDF
    The transactive response DNA-binding protein (TARDBP/TDP-43) influences the processing of diverse transcripts, including that of histone deacetylase 6 (HDAC6). Here, we assessed TDP-43 activity in terms of regulating CD4+ T-cell permissivity to HIV-1 infection. We observed that overexpression of wt-TDP-43 increased both mRNA and protein levels of HDAC6, resulting in impaired HIV-1 infection independently of the viral envelope glycoprotein complex (Env) tropism. Consistently, using an HIV-1 Env-mediated cell-to-cell fusion model, the overexpression of TDP-43 levels negatively affected viral Env fusion capacity. Silencing of endogenous TDP-43 significantly decreased HDAC6 levels and increased the fusogenic and infection activities of the HIV-1 Env. Using pseudovirus bearing primary viral Envs from HIV-1 individuals, overexpression of wt-TDP-43 strongly reduced the infection activity of Envs from viremic non-progressors (VNP) and rapid progressors (RP) patients down to the levels of the inefficient HIV-1 Envs observed in long-term non-progressor elite controllers (LTNP-EC). On the contrary, silencing endogenous TDP-43 significantly favored the infectivity of primary Envs from VNP and RP individuals, and notably increased the infection of those from LTNP-EC. Taken together, our results indicate that TDP-43 shapes cell permissivity to HIV-1 infection, affecting viral Env fusion and infection capacities by altering the HDAC6 levels and associated tubulin-deacetylase anti-HIV-1 activity.This work is supported by the Spanish AIDS network “Red Temática Cooperativa de Investigación en SIDA” RD12/0017/0002, RD12/0017/0028, RD12/0017/0034, RD16/0025/0011, RDCIII16/0002/0005 and RD16/0025/0041 as part of the Plan Nacional R + D+I and co-funded by the Spanish “Instituto de Salud Carlos III (ISCIII)-Subdirección General de Evaluación y el Fondo Europeo de Desarrollo Regional (FEDER)”. J.B. is a researcher from “Fundació Institut de Recerca en Ciències de la Salut Germans Trias i Pujol” supported by the Health Department of the Catalonian Government/Generalitat de Catalunya and ISCIII grant numbers PI17/01318 and PI20/00093 (to J.B.). Work in CC Lab was supported by grants SAF (2010-17226) and (2016-77894-R) from MINECO (Spain), FIS (PI 13/02269, ISCIII) and PI20/00093. Work in CF Lab was supported by the Cabildo Insular de Tenerife (grants CGIEU0000219140 and “Apuestas científicas del ITER para colaborar en la lucha contra la COVID-19”); the agreement with the Instituto Tecnológico y de Energías Renovables (ITER) to strengthen scientific and technological education, training research, development and innovation in Genomics, Personalized Medicine and Biotechnology (grant number OA17/008). A.V.-F.’s Lab is supported by the European Regional Development Fund (ERDF), RTI2018-093747-B-100 (“Ministerio de Ciencia e Innovación”, Spain), “Ministerio de Ciencia, Innovación y Universidades” (Spain), ProID2020010093 (“Agencia Canaria de Investigación, Innovación y Sociedad de la Información” and European Social Fund), UNLL10-3E-783 (ERDF and “Fundación CajaCanarias”) and “SEGAI-ULL”. S.P-Y is funded by “Fundación Doctor Manuel Morales” (La Palma, Spain) and “Contrato Predoctoral Ministerio-ULL Formación de Doctores” (2019 Program) (“Ministerio de Ciencia, Innovación y Universidades”, Spain). R.C.-R. is funded by RD16/0025/0011 and ProID2020010093 (“Agencia Canaria de Investigación, Innovación y Sociedad de la Información” and European Social Fund). J.G.-L. is funded by the “Juan de la Cierva de Incorporación” Spanish Program (IJC2019-038902-I) (“Ayudas Juan de la Cierva de incorporación; Agencia Estatal de Investigación. Ministerio de Ciencia e Innovación”).S

    Measurement of the J/ψ pair production cross-section in pp collisions at √s=13 TeV

    Get PDF
    The production cross-section of J/ψ pairs is measured using a data sample of pp collisions collected by the LHCb experiment at a centre-of-mass energy of √s=13 TeV, corresponding to an integrated luminosity of 279 ±11 pb−1. The measurement is performed for J/ψ mesons with a transverse momentum of less than 10 GeV/c in the rapidity range 2.0 < y < 4.5. The production cross-section is measured to be 15.2 ± 1.0 ± 0.9 nb. The first uncertainty is statistical, and the second is systematic. The differential cross-sections as functions of several kinematic variables of the J/ψ pair are measured and compared to theoretical predictions.S

    Measurement of the B0s→J/ψη lifetime

    Get PDF
    Using a data set corresponding to an integrated luminosity of 3fb−1, collected by the LHCb experiment in ppcollisions at centre-of-mass energies of 7 and 8TeV, the effective lifetime in the B0s→J/ψηdecay mode, τeff, is measured to be τeff = 1.479±0.034 (stat)±0.011 (syst)ps. Assuming CPconservation, τeffcorresponds to the lifetime of the light B0smass eigenstate. This is the first measurement of the effective lifetime in this decay mode.S

    First study of the CP-violating phase and decay-width difference in B0s→ψ(2S)φ decays

    Get PDF
    A time-dependent angular analysis of B0s→ψ(2S)φdecays is performed using data recorded by the LHCb experiment. The data set corresponds to an integrated luminosity of 3.0 fb−1collected during Run1 of the LHC. The CP-violating phase and decay-width difference of the B0ssystem are measured to be φs=0.23+0.29−0.28±0.02 radand s=0.066+0.041−0.044±0.007 ps−1, respectively, where the first uncertainty is statistical and the second systematic. This is the first time that φsand shave been measured in a decay containing the ψ(2S)resonance.S

    Differential branching fraction and angular moments analysis of the decay B 0 → K +π− μ + μ − in the K∗0,2(1430)0 region

    Get PDF
    Measurements of the differential branching fraction and angular moments of the decay B 0 → K +π− μ + μ − in the K +π− invariant mass range 1330 < m(K +π−) < 1530 MeV/c 2 are presented. Proton-proton collision data are used, corresponding to an integrated luminosity of 3 fb−1 collected by the LHCb experiment. Differential branching fraction measurements are reported in five bins of the invariant mass squared of the dimuon system, q 2, between 0.1 and 8.0 GeV2 /c 4. For the first time, an angular analysis sensitive to the S-, P- and D-wave contributions of this rare decay is performed. The set of 40 normalised angular moments describing the decay is presented for the q 2 range 1.1-6.0 GeV2 /c 4.S

    Spatiotemporal Characteristics of the Largest HIV-1 CRF02_AG Outbreak in Spain: Evidence for Onward Transmissions

    Get PDF
    Background and Aim: The circulating recombinant form 02_AG (CRF02_AG) is the predominant clade among the human immunodeficiency virus type-1 (HIV-1) non-Bs with a prevalence of 5.97% (95% Confidence Interval-CI: 5.41–6.57%) across Spain. Our aim was to estimate the levels of regional clustering for CRF02_AG and the spatiotemporal characteristics of the largest CRF02_AG subepidemic in Spain.Methods: We studied 396 CRF02_AG sequences obtained from HIV-1 diagnosed patients during 2000–2014 from 10 autonomous communities of Spain. Phylogenetic analysis was performed on the 391 CRF02_AG sequences along with all globally sampled CRF02_AG sequences (N = 3,302) as references. Phylodynamic and phylogeographic analysis was performed to the largest CRF02_AG monophyletic cluster by a Bayesian method in BEAST v1.8.0 and by reconstructing ancestral states using the criterion of parsimony in Mesquite v3.4, respectively.Results: The HIV-1 CRF02_AG prevalence differed across Spanish autonomous communities we sampled from (p &lt; 0.001). Phylogenetic analysis revealed that 52.7% of the CRF02_AG sequences formed 56 monophyletic clusters, with a range of 2–79 sequences. The CRF02_AG regional dispersal differed across Spain (p = 0.003), as suggested by monophyletic clustering. For the largest monophyletic cluster (subepidemic) (N = 79), 49.4% of the clustered sequences originated from Madrid, while most sequences (51.9%) had been obtained from men having sex with men (MSM). Molecular clock analysis suggested that the origin (tMRCA) of the CRF02_AG subepidemic was in 2002 (median estimate; 95% Highest Posterior Density-HPD interval: 1999–2004). Additionally, we found significant clustering within the CRF02_AG subepidemic according to the ethnic origin.Conclusion: CRF02_AG has been introduced as a result of multiple introductions in Spain, following regional dispersal in several cases. We showed that CRF02_AG transmissions were mostly due to regional dispersal in Spain. The hot-spot for the largest CRF02_AG regional subepidemic in Spain was in Madrid associated with MSM transmission risk group. The existence of subepidemics suggest that several spillovers occurred from Madrid to other areas. CRF02_AG sequences from Hispanics were clustered in a separate subclade suggesting no linkage between the local and Hispanic subepidemics
    • …
    corecore