A Liquid Assay for Screening Fungal Virulence Factors

It is difficult to develop drugs against fungal infections due to the fact that both fungi and their hosts are eukaryotic. Using a model host-pathogen system, factors involved in the infection can be identified and studied. By using these two genetic model organisms and this assay in high-throughput screens of genetic knockouts, fungal virulence factors can be identified. We are developing a liquid culture assay for studying the effects of co-culturing Caenorhabditis elegans with Saccharomyces cerevisiae mutants. From the results of all the experiments, we concluded that there are other factors that can cause the death of the C. elegans in liquid assay which are not S. cerevisiae related

Forcing anomalous scaling on demographic fluctuations

We discuss the conditions under which a population of anomalously diffusing individuals can be characterized by demographic fluctuations that are anomalously scaling themselves. Two examples are provided in the case of individuals migrating by Gaussian diffusion, and by a sequence of L\'evy flights.Comment: 5 pages 2 figure

Particle Dispersion on Rapidly Folding Random Hetero-Polymers

We investigate the dynamics of a particle moving randomly along a disordered hetero-polymer subjected to rapid conformational changes which induce superdiffusive motion in chemical coordinates. We study the antagonistic interplay between the enhanced diffusion and the quenched disorder. The dispersion speed exhibits universal behavior independent of the folding statistics. On the other hand it is strongly affected by the structure of the disordered potential. The results may serve as a reference point for a number of translocation phenomena observed in biological cells, such as protein dynamics on DNA strands.Comment: 4 pages, 4 figure

Levy Flights in Inhomogeneous Media

We investigate the impact of external periodic potentials on superdiffusive random walks known as Levy flights and show that even strongly superdiffusive transport is substantially affected by the external field. Unlike ordinary random walks, Levy flights are surprisingly sensitive to the shape of the potential while their asymptotic behavior ceases to depend on the Levy index $\mu$. Our analysis is based on a novel generalization of the Fokker-Planck equation suitable for systems in thermal equilibrium. Thus, the results presented are applicable to the large class of situations in which superdiffusion is caused by topological complexity, such as diffusion on folded polymers and scale-free networks.Comment: 4 pages, 4 figure

Spatial clustering of interacting bugs: Levy flights versus Gaussian jumps

A biological competition model where the individuals of the same species perform a two-dimensional Markovian continuous-time random walk and undergo reproduction and death is studied. The competition is introduced through the assumption that the reproduction rate depends on the crowding in the neighborhood. The spatial dynamics corresponds either to normal diffusion characterized by Gaussian jumps or to superdiffusion characterized by L\'evy flights. It is observed that in both cases periodic patterns occur for appropriate parameters of the model, indicating that the general macroscopic collective behavior of the system is more strongly influenced by the competition for the resources than by the type of spatial dynamics. However, some differences arise that are discussed.Comment: This version incorporates in the text the correction published as an Erratum in Europhysics Letters (EPL) 95, 69902 (2011) [doi: 10.1209/0295-5075/95/69902

The fractional Keller-Segel model

The Keller-Segel model is a system of partial differential equations modelling chemotactic aggregation in cellular systems. This model has blowing up solutions for large enough initial conditions in dimensions d >= 2, but all the solutions are regular in one dimension; a mathematical fact that crucially affects the patterns that can form in the biological system. One of the strongest assumptions of the Keller-Segel model is the diffusive character of the cellular motion, known to be false in many situations. We extend this model to such situations in which the cellular dispersal is better modelled by a fractional operator. We analyze this fractional Keller-Segel model and find that all solutions are again globally bounded in time in one dimension. This fact shows the robustness of the main biological conclusions obtained from the Keller-Segel model

Enhancing Rip Current/ Beach Safety Awareness Among Teenagers

Rip current awareness is a serious issue considering the average 100 fatalities annually and 23,000 lifeguard rescues. This report prepared for the National Oceanic and Atmospheric Administration\u27s Rip Current Task Force, recommends powerful and cost-effective ways to promote rip current awareness to teenagers. Top recommendations include: creating an internet chat bot which provides weather forecasts, implementing classroom enhancement including programs and partnerships, and placing public service announcements. These recommendations can educate teenagers about rip currents and help save lives

Fractional Diffusion Equation for a Power-Law-Truncated Levy Process

Truncated Levy flights are stochastic processes which display a crossover from a heavy-tailed Levy behavior to a faster decaying probability distribution function (pdf). Putting less weight on long flights overcomes the divergence of the Levy distribution second moment. We introduce a fractional generalization of the diffusion equation, whose solution defines a process in which a Levy flight of exponent alpha is truncated by a power-law of exponent 5 - alpha. A closed form for the characteristic function of the process is derived. The pdf of the displacement slowly converges to a Gaussian in its central part showing however a power law far tail. Possible applications are discussed

Sheared bioconvection in a horizontal tube

The recent interest in using microorganisms for biofuels is motivation enough to study bioconvection and cell dispersion in tubes subject to imposed flow. To optimize light and nutrient uptake, many microorganisms swim in directions biased by environmental cues (e.g. phototaxis in algae and chemotaxis in bacteria). Such taxes inevitably lead to accumulations of cells, which, as many microorganisms have a density different to the fluid, can induce hydrodynamic instabilites. The large-scale fluid flow and spectacular patterns that arise are termed bioconvection. However, the extent to which bioconvection is affected or suppressed by an imposed fluid flow, and how bioconvection influences the mean flow profile and cell transport are open questions. This experimental study is the first to address these issues by quantifying the patterns due to suspensions of the gravitactic and gyrotactic green biflagellate alga Chlamydomonas in horizontal tubes subject to an imposed flow. With no flow, the dependence of the dominant pattern wavelength at pattern onset on cell concentration is established for three different tube diameters. For small imposed flows, the vertical plumes of cells are observed merely to bow in the direction of flow. For sufficiently high flow rates, the plumes progressively fragment into piecewise linear diagonal plumes, unexpectedly inclined at constant angles and translating at fixed speeds. The pattern wavelength generally grows with flow rate, with transitions at critical rates that depend on concentration. Even at high imposed flow rates, bioconvection is not wholly suppressed and perturbs the flow field.Comment: 19 pages, 9 figures, published version available at http://iopscience.iop.org/1478-3975/7/4/04600

Modeling the Searching Behavior of Social Monkeys

We discuss various features of the trajectories of spider monkeys looking for food in a tropical forest, as observed recently in an extensive {\it in situ} study. Some of the features observed can be interpreted as the result of social interactions. In addition, a simple model of deterministic walk in a random environment reproduces the observed angular correlations between successive steps, and in some cases, the emergence of L\'evy distributions for the length of the steps.Comment: 7 pages, 3 figure