Adhesive Properties and Sensitivity to Antifungal Drugs of Candida Albicans, Which Are Released From Patients of Gastroenterological Profile with Candidiasis of the Mucosa of the Upper Part of the Digestive Tract

Candida albicans were released from 146 loci from 89 patients in order to perform the investigation. The fourth stage of contamination by Candida albicans in the scrape from the tongue and candidiasis of the esophagus or /and the stomach during microbiologic investigations of the biopsy materials were the main criterion for this research. HIV-infected patients and patients in whom antibacterial therapy was done less than in four weeks were excluded from the investigation. Microorganisms were taken from the next biopsy materials: oropharyngeal area included 81, esophagus contained 30, stomach included 24 in general (the body of the stomach contained 14 and antrum included 10, gastric juice included 11. Adhesion evaluation was done by microtechnique in U-shaped microplates with formalized erythrocytes 0(І), Rh +. According to the results of the investigation, the released fungi in 51,37 % of cases were characterized as nonadherent ones, in 28,77 % of cases it was defined as low level of adhesiveness and only in 17,12 % of cases it was determined as average and high level of the adhesiveness. Adhesiveness increase was not associated with the increase of the contamination of the oral cavity and with the severity of the damage of the mucosa of the esophagus or /and the stomach. In 97,8 % of cases, strains of Candida albicans were sensitive to fluconazole, in 75,6 % of cases, strains were sensitive to itraconasole and in 24,4 % of cases they were determined as moderately sensitive and resistant that initiates fluconazole as the drug of the choice for the treatment of the candidiasis of the mucosa of the upper part of the digestive tract. So, received data determines the necessity to detect factors of dysfunction of antifungal resistance of the mucosa that detects the development of its candidal damage

ADHESIVE PROPERTIES AND SENSITIVITY TO ANTIFUNGAL DRUGS OF CANDIDA ALBICANS, WHICH ARE RELEASED FROM PATIENTS OF GASTROENTEROLOGICAL PROFILE WITH CANDIDIASIS OF THE MUCOSA OF THE UPPER PART OF THE DIGESTIVE TRACT

Candida albicans were released from 146 loci from 89 patients in order to perform the investigation. The fourth stage of contamination by Candida albicans in the scrape from the tongue and candidiasis of the esophagus or /and the stomach during microbiologic investigations of the biopsy materials were the main criterion for this research. HIV-infected patients and patients in whom antibacterial therapy was done less than in four weeks were excluded from the investigation. Microorganisms were taken from the next biopsy materials: oropharyngeal area included 81, esophagus contained 30, stomach included 24 in general (the body of the stomach contained 14 and antrum included 10, gastric juice included 11. Adhesion evaluation was done by microtechnique in U-shaped microplates with formalized erythrocytes 0(І), Rh +. According to the results of the investigation, the released fungi in 51,37 % of cases were characterized as nonadherent ones, in 28,77 % of cases it was defined as low level of adhesiveness and only in 17,12 % of cases it was determined as average and high level of the adhesiveness. Adhesiveness increase was not associated with the increase of the contamination of the oral cavity and with the severity of the damage of the mucosa of the esophagus or /and the stomach. In 97,8 % of cases, strains of Candida albicans were sensitive to fluconazole, in 75,6 % of cases, strains were sensitive to itraconasole and in 24,4 % of cases they were determined as moderately sensitive and resistant that initiates fluconazole as the drug of the choice for the treatment of the candidiasis of the mucosa of the upper part of the digestive tract. So, received data determines the necessity to detect factors of dysfunction of antifungal resistance of the mucosa that detects the development of its candidal damage

IODINE DEFICIENCY AND PATHOLOGY OF THYROID GLAND AS A BACKGROUND STATE OF CANDIDIASIS OF MUCOSA OF THE UPPER PART OF DIGESTIVE TRACT

There were examined 119 patients of gastroenterological profile, who, according to the results of microbiological examination of scraping from tongue and biopsy material of digestive tract and stomach, were divided into three groups: 1 group – patients with oropharyngeal candidiasis and surface candidiasis of mucous tunic, 2 group – patients with invasion of Candida fungi in mucous tunic, 3 group – patients without oropharyngeal candidiasis and without growth of fungi in biopsy material. The status of iodine provision was studied in 78 persons. The results of research revealed that at structural changes of thyroid gland the dominating position in patients with candidiasis of mucous tunic occupies the nodular goiter– 29,31% and 36,36% for 1 and 2 group respectively, whereas in 3 group the frequency of nodular goiter was 11,76%, at that hyperplasia and nodular goiter in patients with fungi invasion in mucous tunic was revealed 2,6 times more often comparing with patients without candidiasis (χ2=4,01; р<0,05). In patients with oropharyngeal and surface candidiasis and invasive candidiasis of mucous tunic of the upper part of digestive tract the hard degree of iodine nutrition deficiency with thyroglobulin level higher than 40 ng/ml was revealed in more than half of cases. At that the frequency of hard iodine deficiency at fungi invasion in mucous tunic 4,2 times higher comparing with patients without candidiasis of mucous tunic (F=0,024; р<0,05). So, the concomitant comorbid state with pathology of thyroid gland and iodine deficiency is an aggravating factor in the course of candida infection that is necessary to be taken into account at clinical monitoring of patients with candidiasis of mucous tunic of the upper part of gastrointestinal tract.&nbsp

IODINE DEFICIENCY AND PATHOLOGY OF THYROID GLAND AS A BACKGROUND STATE OF CANDIDIASIS OF MUCOSA OF THE UPPER PART OF DIGESTIVE TRACT

There were examined 119 patients of gastroenterological profile, who, according to the results of microbiological examination of scraping from tongue and biopsy material of digestive tract and stomach, were divided into three groups: 1 group – patients with oropharyngeal candidiasis and surface candidiasis of mucous tunic, 2 group – patients with invasion of Candida fungi in mucous tunic, 3 group – patients without oropharyngeal candidiasis and without growth of fungi in biopsy material. The status of iodine provision was studied in 78 persons. The results of research revealed that at structural changes of thyroid gland the dominating position in patients with candidiasis of mucous tunic occupies the nodular goiter– 29,31% and 36,36% for 1 and 2 group respectively, whereas in 3 group the frequency of nodular goiter was 11,76%, at that hyperplasia and nodular goiter in patients with fungi invasion in mucous tunic was revealed 2,6 times more often comparing with patients without candidiasis (χ2=4,01; р<0,05). In patients with oropharyngeal and surface candidiasis and invasive candidiasis of mucous tunic of the upper part of digestive tract the hard degree of iodine nutrition deficiency with thyroglobulin level higher than 40 ng/ml was revealed in more than half of cases. At that the frequency of hard iodine deficiency at fungi invasion in mucous tunic 4,2 times higher comparing with patients without candidiasis of mucous tunic (F=0,024; р<0,05).So, the concomitant comorbid state with pathology of thyroid gland and iodine deficiency is an aggravating factor in the course of candida infection that is necessary to be taken into account at clinical monitoring of patients with candidiasis of mucous tunic of the upper part of gastrointestinal tract.

Details of 3D electronic structure of some Fe-based superconductors and their superconducting order parameters

In this thesis, the results of analyzing the electronic structure of two iron-based superconductors: FeSe and LiFeAs are presented. To access the electronic structure, angle-resolved photoemission spectroscopy was used. In our analysis, we focus on the structure of the superconducting gap and the influence of nematicity on the electronic structure. We have revealed changes in the electronic structure of FeSe caused by nematicity in all parts of the Brillouin zone. A scale of these changes is smaller than it was believed earlier. Also, we have observed an anomalous shift of the dispersions in opposite directions with temperature in this material. We have observed anisotropic superconducting gap on all sheets of the Fermi surfaces of both: FeSe and LiFeAs. We have shown that in LiFeAs, rotational symmetry is broken in the superconducting state, which manifests not only in the gap symmetry but also in the shapes of the Fermi surfaces sheets. This result indicates a realization of a novel phenomenon of superconductivity-induced nematicity:1 Iron-based superconductors 1.1 Introduction to iron-based superconductors 1.2 LiFeAs - special iron-based superconductor 1.3 FeSe - structurally simplest iron-based superconductor 2 Angle-Resolved Photoemission 3 Temperature evolution of the electronic structure of FeSe 3.1 Effects of nematicity from low-temperature measurements 3.2 Temperature dependent shift of the dispersions 3.3 Discussion and conclusions 4 Three-dimensional superconducting gap in FeSe 4.1 Superconducting gap on the electron-like pockets 4.2 Superconducting gap on the hole-like pocket 4.3 Discussion and conclusions 5 Superconductivity-induced nematicity in LiFeAs 5.1 Superconducting gap 5.2 Nematicity 5.3 Discussion and conclusions Summar

Bolshevik Discursive Practices: The Emergence of the Genre of Communist Biography (Based on the Materials of the Ural Periodicals Published During the Russian Civil War)

After the Bolsheviks took power, they were faced with one of the most important tasks: a communist project to create a New Man. One of the methods used for this purpose was the creation of biographical and autobiographical texts. This article describes the process by which the genre of communist biography emerged in the initial period of the Russian Civil War. The author compares this genre with the hagiographic literature, noting their similar structure. The study is based on Ural periodicals published during the Civil War. It demonstrates that, like hagiographical literature, communist biography depicts not an actual person, but an idealized image: a revolutionary striving for the communism as the higher truth.     Keywords: Bolshevik discourse, biography, Ural, Soviet subjectivity, revolutionaries, Russian Civil Wa