Adhesive Properties and Sensitivity to Antifungal Drugs of Candida Albicans, Which Are Released From Patients of Gastroenterological Profile with Candidiasis of the Mucosa of the Upper Part of the Digestive Tract

Abstract

Candida albicans were released from 146 loci from 89 patients in order to perform the investigation. The fourth stage of contamination by Candida albicans in the scrape from the tongue and candidiasis of the esophagus or /and the stomach during microbiologic investigations of the biopsy materials were the main criterion for this research. HIV-infected patients and patients in whom antibacterial therapy was done less than in four weeks were excluded from the investigation. Microorganisms were taken from the next biopsy materials: oropharyngeal area included 81, esophagus contained 30, stomach included 24 in general (the body of the stomach contained 14 and antrum included 10, gastric juice included 11. Adhesion evaluation was done by microtechnique in U-shaped microplates with formalized erythrocytes 0(І), Rh +. According to the results of the investigation, the released fungi in 51,37 % of cases were characterized as nonadherent ones, in 28,77 % of cases it was defined as low level of adhesiveness and only in 17,12 % of cases it was determined as average and high level of the adhesiveness. Adhesiveness increase was not associated with the increase of the contamination of the oral cavity and with the severity of the damage of the mucosa of the esophagus or /and the stomach. In 97,8 % of cases, strains of Candida albicans were sensitive to fluconazole, in 75,6 % of cases, strains were sensitive to itraconasole and in 24,4 % of cases they were determined as moderately sensitive and resistant that initiates fluconazole as the drug of the choice for the treatment of the candidiasis of the mucosa of the upper part of the digestive tract. So, received data determines the necessity to detect factors of dysfunction of antifungal resistance of the mucosa that detects the development of its candidal damage