The American People and the New Deal

Analysis of the Popular Front created by Franklin Roosevelt during the New Deal in which he was able to appeal to a broad spectrum of society across class, socioeconomic, religious, and political lines

Modeling gene regulation in liver hepatocellular carcinoma with random forests

Liver hepatocellular carcinoma (HCC) remains a leading cause of cancer-related death. Poor understanding of the mechanisms underlying HCC prevents early detection and leads to high mortality. We developed a random forest model that incorporates copy-number variation, DNA methylation, transcription factor, and microRNA binding information as features to predict gene expression in HCC. Our model achieved a highly significant correlation between predicted and measured expression of held-out genes. Furthermore, we identified potential regulators of gene expression in HCC. Many of these regulators have been previously found to be associated with cancer and are differentially expressed in HCC. We also evaluated our predicted target sets for these regulators by making comparison with experimental results. Lastly, we found that the transcription factor E2F6, one of the candidate regulators inferred by our model, is predictive of survival rate in HCC. Results of this study will provide directions for future prospective studies in HCC.No sponso

Differentially Private Nonparametric Hypothesis Testing

Hypothesis tests are a crucial statistical tool for data mining and are the workhorse of scientific research in many fields. Here we study differentially private tests of independence between a categorical and a continuous variable. We take as our starting point traditional nonparametric tests, which require no distributional assumption (e.g., normality) about the data distribution. We present private analogues of the Kruskal-Wallis, Mann-Whitney, and Wilcoxon signed-rank tests, as well as the parametric one-sample t-test. These tests use novel test statistics developed specifically for the private setting. We compare our tests to prior work, both on parametric and nonparametric tests. We find that in all cases our new nonparametric tests achieve large improvements in statistical power, even when the assumptions of parametric tests are met

The Impact of Relationship Separation on Suicidality and Mental Health

Introduction: Relationship separation is common and can be a significant risk factor for suicidal thoughts and behaviours. However, there exists a paucity of research that explores the relationship between suicidality and separation, and even less focusing on accessible interventions for separated individuals. Methods: A systematic review was conducted to establish the impact of intimate partner relationships on suicidality, specifically how relationship separation contributes to suicidal thoughts and behaviours. An online cross-sectional survey was developed to explore potential predictors of suicidality and to identify challenges, benefits and help-seeking strategies following a relationship separation. A final systematic review was conducted to assess the impact of existing separation interventions on mental health, specifically focusing on suicidal thoughts and behaviours. The results from these studies guided the development of MindCast, a six-session, online podcast program based on Brief Interpersonal Psychotherapy (IPT-B), designed for people who have separated from a relationship. The effectiveness of this intervention was evaluated through a randomised controlled trial of 124 Australian participants who had separated in the last six months. Results: The results of the systematic reviews highlighted that relationship separation and poor quality relationships are likely to be important risk factors for suicidal thoughts and behaviours and are a frequent trigger for a suicide attempt. However, there exists a paucity of trials that adequately assess the effects of non-marital relationship separation interventions on mental health outcomes and none that consider suicidal thoughts and/or behaviours. The cross-sectional study identified greater symptoms of antagonism and disinhibition and less active coping, decreased positive family support, less negative friends and lower self-esteem as being significantly associated with increased odds of suicidal ideation. Qualitative analyses revealed that males were significantly more likely to report “no benefit” to the separation, compared with females who were significantly more likely to report “leaving an abusive and/or negative relationship” and “moving on” as benefits to the relationship break-up. Although the MindCast intervention did not have a significant effect on depression or suicidal ideation, across time, between group effects sizes (post, d = 0.50 and follow-up, d = 0.10) indicated that the MindCast intervention may have the potential to decrease depressive symptoms in people who have separated from a relationship, compared to a control condition. Low post-intervention (n = 30) and follow-up (n = 20) response rates were a primary limitation. Conclusion: The MindCast podcast represents the first self-directed, online podcast developed for people who have separated from an intimate partner relationship. It was also the first study of its kind to adapt IPT, of any form, to a podcast format and to explore the influence of such an intervention on suicidal ideation and broader psychosocial targets. Although the results did not indicate that the intervention was effective in terms of targeting primary mental health outcomes, qualitative feedback suggests that participants were keen to engage in the content. Further, the small to moderate between group effect sizes were encouraging and suggest that significant effects may be observed in an adequately powered trial. Research focusing on suicide prevention and early intervention is needed to continue to identify risk factors and key intervention areas

INOVASI DAN SENI PADA VALUE ENGINEERING UNTUK PENGELOLAAN KONSTRUKSI

The success of a project is often evaluated on the basis of the cost amount the project has spent and the punctuality of completing the project. In effect, such aspect as how the project executor is able to interpret the asset user's interest to do his/her business activities successfully in the project is frequently unobserved. This project executor's interpretation ability can be seen from the project design he/she creates to meet his/her customer's satisfaction, for example comfotable atmosphere and function fulfilment of the project. Therefore, to enable an architecture meets the customer up-to-date needs, the enhancement of the Value engineering and innovation to find the lowest cost, easy to implement, and fast method is needed. Monte Carlo Simulation has been used for explaining the method

Hybrid Single Shot Manufacturing of Multi-Materials Structure for Automotive Applications

Multi-material design is one of the most attractive methods for automakers to reduce production cost while achieving lightweighting to meet stringent regulations and fuel efficiency concerns. Lightweighting, parts consolidation, reduction in assembly time and cost, and diverse functionalities are some advantages to the use of multi-material design in the automotive industry. However, the current technology of multi-material manufacturing faces some drawbacks, such as high cycle time, the necessity of various tooling and machinery systems, tight tolerance requirements, and extended planning effort on the production line. In this study, a technique named the Hybrid Single Shot (HSS), which is similar to Polymer Injection Forming (PIF), is used to manufacture CF/Epoxy-Thermoplastic components in a single operation. Unlike the PIF method, a carbon fiber /epoxy prepreg sheet is used as an insert material instead of sheet metal. In this technique, an injected polymer melt behaves like a forming medium to form the inserted thermoset sheet, in a single operation. Molten polymer not only forms but also bonds with the thermoset sheet using the high temperature of the polymer, in one process. CF/Epoxy sheet with injected thermoplastic is a hybrid structure that combines high mechanical properties of thermoset composite with the toughness and complex geometries of injected thermoplastic into a single component. A feasibility study was conducted for developing an integrated technology for the manufacturing of thermoset CF/Epoxy prepreg sheet with an injection of polypropylene to overcome the high cycle time and production cost associated with the manufacturing of such hybrids. Several sample parts were manufactured to demonstrate the effect of the process parameters on the process performance and the appearance of the final hybrid component. Although the results were promising, it showed some practical challenges such as excessive penetration, inadequate deformation, and warpage. Various process and design parameters are applied to the hybrid single shot process to circumvent these challenges. For example, a lower injection speed rate and the injection temperature are applied to increase the viscosity to prevent the penetration of polymeric melt through the thermoset sheet. Also, to evaluate the impact of polymer injection on the degree of cure of the prepreg sheet, Differential Scanning Calorimetry (DSC) analysis is conducted at a different pre-heat time before and after injection. The results showed that an increase in pre-heating time and injection temperature significantly enhanced the curing of the prepreg sheet after injection. Further, the mechanical properties of the hybrid part will be examined to identify the effect of individual properties of CF/ Epoxy and PP on the final component. Another contribution of this study is that it avoids many difficulties that conventional TS/TP joining techniques face. Specifically, these traditional joining methods, namely mechanical fastening, adhesive bonding, and welding, are time-consuming and labor-intensive. Also, mechanical fastening causes delamination and possible galvanic corrosion while adhesive bonding requires extensive surface preparation. Despite the time and weight advantages, welding techniques tend to create local delamination due to high local temperature. The hybrid single shot method is a promising alternative to overcome all the challenges that conventional methods face. A lap shear test is conducted to address the bonding conditions between polypropylene and CF/Epoxy prepreg. The experimental results presented in the previous chapters have revealed that the final geometry of the hybrid part is highly dependent on the preheating conditions and pressure field applied on the prepreg sheet during the injection phase. The pressure distribution is then a function of selected polymer, process settings, and most importantly of the geometry of the flow channel. To model the forming of the prepreg sheet due to this non-uniform pressure field, it is essential to couple all the physical events occurring inside the cavity. Therefore, the last contribution of this study is to have a better understanding on the effect of interaction injection, forming and curing on the final geometry of prepreg sheet, a quick yet accurate simulation of the HSS process. This simulation includes the consideration of the non-uniform pressure distribution of the melt flow and the prepreg sheet deformation behavior based on a new experimentally calibrated numerical approach

Linear motor for multi-car elevators, design and position measurement

Multi-car elevator is an emerging technology consisting of two or more elevator cars moving independently in an elevator hoistway, which has become more appealing as building heights increase. In this paper, the design and drive methodologies for a linear motor driven multi-car elevator system with independently moving cars is introduced together with experimental results. Additionally, a safety method developed for the linear motor elevator and the conditions necessary for its proper operation are discussed. The new results introduced in this paper are in the areas of the design method of the linear motor for multi-car elevator system, and the preliminary results for the position measurement system

MODELING AND DEVELOPMENT OF THE DYNAMIC ENVIRONMENTAL SIMULATION CHAMBER (DESC) FOR CALIBRATION OF AIR QUALITY MONITORING SENSORS

The thesis describes the development steps for the dynamic environmental simulation chamber (DESC) and carbon dioxide sensor calibration by using DESC. The sensors are Figaro, COZIR and K30 CO2 sensor

A Bibliyographic Study on the Ph. D. and M.A Theses Done Between 1987-1999 on Turkish Language and Literature I

In this article a thesis bibliography has been formed on Turkis Language and literature through collecting several articles defining thesis works and information sources of the institutions gathering necessary knowledge on this subject. The work has been divided in four parts. Folk Literature, New Turkish Literature, Turkish Language and Old Turkish Literature. In this article fırst two topics which are Folk and New Turkish Literature have been published. The rest will be published in coming issues