The Essence of Private Property in Labour Law

The author makes an attempt to consider the conceptual issues of private property in labour law. On the basis of legal rules analysis the author distinguishes the actual problems of legal adjustment concerning labour relations and other ones connected with them

The Problems of the RF Labor Law Code Implementation and State Federal Supervision Enforcement in the Sphere of Labor Relations

The article deals with the problems of the RF Labor Law Code implementation. The authors study the theoretical and practical aspects of the state federal supervision enforcement in the sphere of labor legislation

Complex support of technological development of environmentally friendly toilet systems in passenger trains

Ensuring environmental-oriented turnover of fecal waste in passenger transport is necessary for the preservation of ecosystems, public health and sustainable development of transport complexes. The history of Russian railway toilet complexes begins with the launch of the first railway “Petersburg – Tsarskoe Selo” in 1837. In the USSR since 1985 The Ministry of Railways of the USSR thought about the need for experimental design work on the creation of closed systems for collecting sewage for passenger rolling stock. A set of scientific works on the creation of systems and equipment that protect the environment from chemical and  biological pollution was presented in the Railway transport program for 1990-2000.The article considers the negative impact of fecal waste on the environment and public health, as well as problems related to the maintenance of environmentally friendly toilet complexes of passenger cars. The main results of technological development of toilet complexes of transport systems have been outlined. The authors note the importance of timely comprehensive support (infrastructure, technical, organizational and economic, regulatory and methodological, personnel, and other) for the technological development of toilet complexes in the transport industry. In particular, the article reviewes some of the current problems of infrastructure, regulatory and methodological, organizational and economic support for the operation and maintenance of environmentally friendly toilet complexes. For the effective functioning of the environmentally friendly toilet complexes system of transport systems, the authors propose to use organizational and methodological tools that will allow you to systematically determine the actual level of technological development of the fecal waste disposal system of the environmentally friendly toilet complexes of passenger trains, to develop directions and measures to improve its  environmental and economic efficiency

Specific features of the substitution of Fe3+ impurity ions for Zr4+ in NaZr2(PO4)3 single crystals

The EPR spectra of Fe3+ impurity ions in NaZr 2(PO4)3 single crystals at 300 K are investigated, and the spin Hamiltonian of these ions is determined. A comparative analysis of the spin-Hamiltonian and crystal-field tensors is performed using the maximum invariant component method. It is demonstrated that Fe3+ impurity ions substitute for Zr4+ ions with local compensator ions located in cavities of the B type. It is revealed that the invariant of the spin-Hamiltonian tensor B4 and the crystal-field tensor V44 4 depend substantially on the mutual arrangement of ions in the first and second coordination spheres. The corresponding dependences are analyzed. © 2005 Pleiades Publishing, Inc

Synchronization of clocks

Peer reviewedPostprin

Comparative Study of Mycophenolate Mofetil and Methotrexate in Graft-Versus-Host Disease Prophylaxis in Adult Recipients of Related and Unrelated Allo-HSCT

Background. Although the use of methotrexate (MTX) and mycophenolate mofetil (MMF) for prophylaxis of graft-versus-host disease (GVHD) in allogeneic hematopoietic stem cell transplantation (allo-HSCT) was compared in a large number of studies, the published results are contradictory. This fact provides ground for the present retrospective single-center trial comparing these two approaches in GVHD prophylaxis. Materials & Methods. The present study included 294 allo-HSC recipients with MTX prophylaxis and 172 allo-HSC recipients with MMF prophylaxis. 36 % of patients underwent matched related donor transplantation, and 64 % of patients received matched unrelated donor transplantation. Results. Univariate and multivariate analyses showed that probability of acute grade 2–4 GVHD is 36 % vs. 39 % (hazard ratio [HR] 1.297; 95% confidence interval [95% CI] 0.931–1.795; p = 0.122), grade 3–4 GVHD was 21 % vs. 25 % (HR 1.472; 95% CI 0.951–2.256; p = 0.05), and probability of chronic GVHD was 52 % vs. 55 % (HR 0.978; 95% CI 0.951–1.406; p = 0.91). In the MTX and MMF groups there were no significant differences in transplantation mortality (HR 1.173; 95% CI 0.797–1.708; p = 0.43), relapse incidence (HR 1.034; 95% CI 0.743–1.428; p = 0.84), overall survival (HR 1.087; 95% CI 0.825–1.433; p = 0.55), event-free survival (HR 1.108; 95% CI 0.854–1.437; p = 0.43), disease and GVHD free survival (HR 1.065; 95% CI 0.845–1.343; p = 0.59). Engraftment occurred earlier when MMF was used (p = 0.035). Administration of MMF instead of MTX was associated with lower probability of toxic grade 3–4 hepatitis (7 % vs. 31 %; p < 0.0001) and grade 3–4 mucositis (23 % vs. 45 %; p = 0.0002). Conclusion. The efficacy of GVHD prophylaxis using MMF is comparable with that of MTX, but MMF is associated with a better safety profile due to reduced incidence of severe liver toxicity and mucositis

A comparative study of the effectiveness of magnesium orotate tautomers to com-pensate magnesium deficiency. Part I. The influence of magnesium orotate tautomers on laboratory animals and humans isolated cells

The objects of the research were erythrocytes and lymphocytes of humans and rats and human buccal epitheliocites. The hemolysis of erythrocytes and microelectrophoresic cell mobility in solutions of saline with the orotate magnesium tautomers was studied. The mobility of erythrocytes in the solution with the dihydroxy-form showed negative dynamics (the number of active erythrocytes decreased in 2 times), the activity of cells increased in hydroxy-forms solutions: the amplitude of vibrations of the erythrocyte membrane increased more than in 2 times. Moreover, in solutions with hydroxy- and dihydroxy-forms the active forms of lymphocytes appeared. In oxo-form solution this effect was not observed. Buccal epithelium cells react in a similar way. The amplitude cytolemma and the nuclear membrane vibrations is higher in solution with hydroxy-form magnesium orotate. Activation of nucleated buccal cells in solutions of hydroxy-form are more pronounced than activation of red blood cells. The stability of the erythrocyte membrane of animals with experimental magnesium deficiency to the action of a hypotonic solution is restored on the 10th day after taking tautomers and is more pronounced when taking the hydroxyl-form of magnesium orotate.Magnesium orotate tautomers have different mechanisms of absorption and have different properties in relation to participation in biochemical processes.Объектами исследования являлись эритроциты и лимфоциты крыс и эпителиоциты буккального эпителия человека. Исследовались гемолиз эритроцитов и микроэлектрофоретическая подвижность клеток в физрастворе с таутомерами оротата магния. Подвижность эритроцитов в растворе с дигидрокси-формой показала отрицательную динамику (количество активных эритроцитов снижалось в 2 раза), активность клеток увеличивалась в растворе с гидрокси-формой: амплитуда колебаний эритроцитарной мембраны повышается более, чем в 2 раза. кроме того, в растворах с гидрокси- и дигидрокси-формами появились активные формы лимфоцитов. В растворе с оксо-формой их нет. аналогично реагируют клетки буккального эпителия. амплитуда колебаний цитолеммы и ядерной мембраны выше в растворе с гидрокси-формой оротата магния. активизация ядросодержащих клеток буккального эпителия в растворах гидрокси-формы оротата магния выражена в большей степени, чем эритроцитов. Устойчивость эритроцитарной мембраны животных с экспериментальным дефицитом магния к действию гипотонического раствора восстанавливается на 10-й день после приема таутомеров и более выражена при приеме гидрокси-формы оротата магния. таутомеры оротата магния имеют различные механизмы всасывания и участия в биохимических процессах

Анализ факторов риска и эффективности Дефибротида для лечения синдрома обструкции синусоидов/веноокклюзионной болезни печени после аллогенной трансплантации гемопоэтических стволовых клеток у детей и взрослых

Introduction. Sinusoidal obstructive syndrome (SOS)/veno-occlusive liver disease (VOD) is one of the most dangerous complication of allogeneic hematopoietic stem cell transplantation (alloHSCT).The objective of our study was to analyze risk factors associated with SOS/VOD in children and adults after alloHSCT.Methods and materials. The study included 76 patients who were diagnosed with the development of SOS/VOD after alloHSCT performed in Raisa Gorbacheva Memorial Research Institute for Pediatric Oncology, Hematology and Transplantation between 2001 and 2019. 25 patients (32.9 %) were younger than 18 years, 51 patients (68.1 %) — 18 years and older. Among them, 17 patients were treated with defibrotide at a dose of 25 mg/kg per day, median therapy duration — 21 day.Results. One-year overall survival (OS) was significantly higher when partial and complete response to the therapy was achieved — 45 %, than when there was no response — 0 % in the general group (p = 0.001). According to the results of multivariate analysis of unrelated alloHSCT HR 2.040 (95 %CI 1.112-3.744, р = 0.021), acute GVHD HR 0.496 (95 % CI 0.272-0.903, р = 0.022), moderate/severe SOS/VOD HR 2.423 (95 % CI 1.298-4.524, p = 0.005) statistically significantly influenced the 1-year OS. Defibrotide and accompanying therapy did not significantly influence the 1-year OS in children and adults (n=76) - 53 % and 54 % (p=0.86), respectively. In a multivariate analysis. unrelated alloHSCT HR 8.172 (95 %CI 2.176-30.696, р=0.002) and moderate and severe SOS/VOD HR 9.077 (95 % CI 2.425-33.978, р=0.001) significantly influenced the 1-year OS in the pediatric group.Conclusion. The understanding of risk factors of adverse prognosis in patients SOS/VOD facilitates selection of patients who will benefit the most from therapy with defibrotide. Early administration of defibrotide in the course of VOD/SOS is crucial to achieve response.Введение. Синдром обструкции синусоидов (СОС)/веноокклюзионная болезнь печени (ВОБ) — одно из фатальных осложнений аллогенной трансплантации гемопоэтических стволовых клеток (аллоТГСК).Целью исследования является оценка факторов риска и эффективности применения Дефибротида при СОС/ ВОБ у детей и взрослых после аллоТГСК.Методы и материалы. В исследование включены 76 пациентов НИИДОГИТ им. Р. М. Горбачёвой после аллоТГСК, у которых в период с 2001 по 2019 г. было выявлено развитие СОС/ВОБ печени. В возрасте до 18 лет наблюдали 25 (32,9 %) пациентов, 51 (68,1 %) пациент — 18 лет и старше. Из них 17 пациентов получили Дефибротид в дозе 25 мг/кг в сутки, медиана длительности терапии составила 21 день.Результаты. Однолетняя общая выживаемость (ОВ) была значимо выше при достижении частичного и полного ответа на терапию — 45 %, чем при отсутствии ответа — 0 % в общей группе (р = 0,001). По результатам многофакторного анализа аллоТГСК от неродственного донора ОР 2,040 (95 % ДИ 1,112 — 3,744, р = 0,021), наличие острой реакции «трансплантат против хозяина» (оРТПХ) ОР 0,496 (95 % ДИ 0,272 — 0,903, р = 0,022), степень СОС/ВОБ ОР 2,423 (95 % ДИ 1,298 — 4,524, р = 0,005) статистически значимо влияли на 1-летнюю ОВ. При применении Дефибротида и сопроводительной терапии 1-летняя ОВ не различалась в группе взрослых и детей (n=76) и составила 53 и 54 % соответственно (Р = 0,86). В многофакторном анализе аллоТГСК от неродственного донора — ОР 8,172 (95 % ДИ 2,176 — 30,696, р = 0,002) и СОС/ВОБ 2 — 3-й степени — ОР 9,077 (95 % ДИ 2,425 — 33,978, р = 0,001) — статистически значимо влияли на 1-летнюю ОВ в педиатрической группе.Заключение. Обнаружение неблагоприятных факторов риска позволит сделать диагностику СОС/ВОБ более своевременной и безотлагательно начать терапию, что имеет ключевое значение для эффективного лечения данного осложнения аллоТГСК