Comment le technicien en radiologie médicale (TRM) adapte-t-il sa prise en charge d'un jeune adulte en radiothérapie ?: travail de Bachelor

Notre travail de Bachelor porte sur l’adaptation du TRM lorsqu’il prend en charge un jeune adulte en radiothérapie. Nous voulions avoir l’avis du TRM sur ce sujet pour comprendre et analyser les moyens qu’il met en oeuvre pour prendre en charge ce type de patient. Cette population qui n’est pas très courante dans un service de radiothérapie a des caractéristiques particulières. Nous avons donc analysé le jeune adulte du point de vue du TRM, pour mieux comprendre la situation qu’il vit et ses enjeux

A reassessment of prebiotically relevant chemical agents for the activation of α-amino acids and peptides

International audienceFrom an origin-of-life perspective, processes able to provide energy to feed self-organizing systems are required for the formation of their own components but also to maintain a far from equilibrium state essential for the system to remain under kinetic control. α-Amino acid N-carboxyanhydrides (NCAs) and 5(4H)-oxazolones represent activated intermediates of the chemistry of peptides that may be involved in the self-organization of life and in the evolution of translation. An experimental survey of previously published activating agents has been carried out using the epimerization associated with the transient formation of 5(4H)-oxazolones as a tool to monitor their potential to promote strong activation. None of reagents investigated in this survey proved to be totally satisfactory demonstrating that the identification of activation processes remains a crucial goal in this field

Acrodermatitis enteropática: tratamiento con Zinc

Se presenta un nuevo caso de Acrodermatitis Enteropática en un lactante de 2,5 meses de vida, fruto de embarazo gemelar bivitelino pretérmino (36 S), de aparición gradual desde los 15 días de vida. Había seguido lactancia artificial exclusivamente desde su nacimiento, al igual que su hermano gemelo que no presentó la enfermedad. Entre los exámenes complementarios destacaba una importante hipozincemia, fosfatasas alcalinas descendidas, alteraciones en la inmunidad celular, rasgos de inmadurez cerebral en el EEG y discreta atrofia vellositaria en la muestra biópsica intestinal. El Tratamiento con sulfato de Zinc a la dosis de 10 mg/Kg/día hizo remitir el cuadro clínico y analítico en pocos días. A los 4 meses de edad abandonó el tratamiento, reapareciendo a los 22 días los síntomas digestivos y cutáneos; la zincemia en ese momento era elevada (175 mcg/dl). Esta falta de relación entre la zincemia y la clínica sugiere que en la Acrodermatitis Enteropática el defecto de transporte del Zn afecta no sólo al enterocito sino también a otras células del organismo y que el criterio para mantener el tratamiento y fijar la dosis debe ser clínico y no analítico

مواقف النحاة من القياس الذهنيّ

القياس الذهني من الأصول المعتمدة في تقين نظرية النحو والصرف، بوصفه مولداً للعديد من القوانين والأحكام النحوية والصرفية التي لا وجود لنص في السماع لشواهد عليها، أو وجوده في نصوص مختلف عليها، مثل : توليد تقدم الحال الجملة، أو كف الفعل عن الفاعل ونائبه، أو الجزم بالظروف، مثل: عندما ارتضاه النحاة أصلا من أصول النحو، وأساساً بنوا عليه العديد من المسائل والأحكام والتطبيقات؛ لهذا تسلّط الدراسة الضوء على مواقف النحاة القدامى والمحدثين من القياس الذهني، قصد إبراز دور القياس الذهني في بناء أنظار النحاة، والكشف عن أهم المعايير التي احتكم إليها النحاة في هذا النوع من القياس

Design and implementation of Traffic Flow based Street Light Control System with effective utilization of solar energy

Street Light Control System which operates automatically is not only easiest but also the intelligent system. This system can be set to operate in automatic mode, which regulates the streetlight according to detection of moving object. The main objective of this project is to save the power from street lighting in rural areas where there will be very less use of street lights after 11pm to morning 5am. So here, in this project we use automatic ON/OFF mechanism of street lighting by detecting the movement of object (vehicle/person). In this project, we use renewable source of energy i.e., solar power for street lighting. Apart from this, we replace normal bulbs in street lighting with LEDs due to which the power consumption in reduced by 3 times. And also, we use IR sensors to detect the movement of object to activate the lighting a few meters before the object is about to reach the lighting area. Here, the IR sensors are deactivated after a timing delay of 30seconds and similarly remaining sensors are activated and deactivated after 30seconds. We also place a battery backup for 2days in order to supply power continuously in the worst cases such as rainy time. We also connect this solar power region to the grid to supply excessive power to the grid to avoid saturation of battery and also vice-versa i.e., to receive power from grid in rainy seasons and winter seasons. So, this is a very effective way of saving a large amount of power

Nuclear egress of TDP-43 and FUS occurs independently of Exportin-1/CRM1

TDP-43 and FUS are nuclear proteins with multiple functions in mRNA processing. They play key roles in ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia), where they are partially lost from the nucleus and aggregate in the cytoplasm of neurons and glial cells. Defects in nucleocytoplasmic transport contribute to this pathology, hence nuclear import of both proteins has been studied in detail. However, their nuclear export routes remain poorly characterized and it is unclear whether aberrant nuclear export contributes to TDP-43 or FUS pathology. Here we show that predicted nuclear export signals in TDP-43 and FUS are non-functional and that both proteins are exported independently of the export receptor CRM1/Exportin-1. Silencing of Exportin-5 or the mRNA export factor Aly/REF, as well as mutations that abrogate RNA-binding do not impair export of TDP-43 and FUS. However, artificially enlarging TDP-43 or FUS impairs their nuclear egress, suggesting that they could leave the nucleus by passive diffusion. Finally, we found that inhibition of transcription causes accelerated nuclear egress of TDP-43, suggesting that newly synthesized RNA retains TDP-43 in the nucleus, limiting its egress into the cytoplasm. Our findings implicate reduced nuclear retention as a possible factor contributing to mislocalization of TDP-43 in ALS/FTD

Interaction modulation through arrays of clustered methyl-arginine protein modifications

Systematic analysis of human arginine methylation identifies two distinct signaling modes;either isolated modifications akin to canonical post-translational modification regulation, or clustered arrays within disordered protein sequence. Hundreds of proteins contain these methyl-arginine arrays and are more prone to accumulate mutations and more tightly expression-regulated than dispersed methylation targets. Arginines within an array in the highly methylated RNA-binding protein synaptotagmin binding cytoplasmic RNA interacting protein (SYNCRIP) were experimentally shown to function in concert, providing a tunable protein interaction interface. Quantitative immunoprecipitation assays defined two distinct cumulative binding mechanisms operating across 18 proximal arginine-glycine (RG) motifs in SYNCRIP. Functional binding to the methyltransferase PRMT1 was promoted by continual arginine stretches, whereas interaction with the methyl-binding protein SMN1 was arginine content-dependent irrespective of linear position within the unstructured region. This study highlights how highly repetitive modifiable amino acid arrays in low structural complexity regions can provide regulatory platforms, with SYNCRIP as an extreme example how arginine methylation leverages these disordered sequences to mediate cellular interactions

Cumulative regulatory potential of clustered methyl-arginine protein modifications

Systematic analysis of human arginine methylation events bifurcates its signaling mechanism, functioning either in isolation akin to canonical PTM regulation or clustered within disordered protein sequence. Hundreds of proteins contain methyl-arginine clusters and are more prone to mutation and more tightly expression-regulated than dispersed methylation targets. Arginine clusters in the highly methylated RNA binding protein SYNCRIP were experimentally shown to function in concert providing a tunable protein interaction interface. Quantitative immuno-precipitation assays defined two distinct cumulative regulatory mechanisms operating across 18 proximal arginine-glycine motifs in SYNCRIP. Functional binding to the methyl-transferase PRMT1 was promoted by continual arginine stretches while interaction with the methyl-binding protein SMN1 was arginine content dependent irrespective of linear position within the unstructured region. This study highlights how highly repetitive di-amino acid motifs in otherwise low structural complexity regions can provide regulatory potential, and with SYNCRIP as an extreme example how PTMs leverage these disordered sequences to drive cellular functions