Comparison between use of combination of mifepristone and misoprostol versus misoprostol alone in the management of intrauterine fetal death

Background: Intrauterine fetal death (IUFD) is estimated to occur in 1% of all pregnancies. The advent of prostaglandins has revolutionized the management of IUFD. There are limited studies using a combined regimen of mifepristone and misoprost for induction of labor in IUFD. Hence this study was undertaken to assess the efficacy and safety of combined regimen with misoprostol alone, in the management of IUFD.Methods: This hospital based prospective study included 60 pregnant women with IUFD admitted at Mediciti Institute of Medical Sciences, during the period January 2015 to July 2016. An ultrasound scan was performed to confirm IUFD and localize the placenta. Women were divided alternatively into 2 groups with 30 in each group (group 1- women received 200 mg mifepristone orally followed by misoprostol after 24 hours & in group 2, 100 µg misoprostol  every 6 hourly for a maximum of 4 doses between gestational age  24-26 weeks, 25-50 µg 4 hourly for a maximum of 6 doses beyond 26 weeks).Results: The mean induction to delivery interval was 10 hours in group 1 and 16.3 hours in group 2 (p value 0.007). Mean dose of misoprostol required in group 1 was 1.87 and 2.67 in group 2 (p value 0.008). With respect to side effects, the two groups did not differ significantly.Conclusions: The combined regimen was more effective than misoprostol for the induction of labour in IUFD, in terms of higher rate of successful delivery and shorter induction to delivery interval.

Incidence of neutropenic fever and sepsis in patients receiving induction chemotherapy in acute leukemia

Background: Acute leukemias are treated with intensive chemotherapy protocols which are associated with increased risk of infections. The objective of this study was to determine the incidence of febrile neutropenia and sepsis in acute leukemia patients during induction chemotherapy.Methods: In this prospective study we analysed the data of febrile neutropenia of forty-four patients of acute leukemia treated with intensive chemotherapy protocols. Study was conducted in hemato-oncology unit of Government Medical College, Kozhikode from January 2018 to December 2018. Events of the first month of induction were assessed, data entered in Microsoft excel and analysed with SPSS software.Results: Febrile neutropenia developed in all patients with AML induction therapy and 21.4% patients with ALL induction therapy. Causative organism was identified in 41.6% of febrile neutropenia episodes. Major focus of infection was lower respiratory tract followed by gastrointestinal tract. Fungal infection was identified in 6.8% cases. Mortality in AML induction was 31% and that of ALL induction was 3.57%. Infection was the most common cause of mortality. No clinical or laboratory parameters were found significant to predict outcome during induction chemotherapy in acute leukemia.Conclusions: Neutropenic fever and sepsis are the major cause of mortality in acute leukemia during induction chemotherapy. Early initiation of appropriate antibiotics will help to improve outcome in the treatment of leukemia

A network-aware framework for energy-efficient data acquisition in wireless sensor networks

Wireless sensor networks enable users to monitor the physical world at an extremely high fidelity. In order to collect the data generated by these tiny-scale devices, the data management community has proposed the utilization of declarative data-acquisition frameworks. While these frameworks have facilitated the energy-efficient retrieval of data from the physical environment, they were agnostic of the underlying network topology and also did not support advanced query processing semantics. In this paper we present KSpot+, a distributed network-aware framework that optimizes network efficiency by combining three components: (i) the tree balancing module, which balances the workload of each sensor node by constructing efficient network topologies; (ii) the workload balancing module, which minimizes data reception inefficiencies by synchronizing the sensor network activity intervals; and (iii) the query processing module, which supports advanced query processing semantics. In order to validate the efficiency of our approach, we have developed a prototype implementation of KSpot+ in nesC and JAVA. In our experimental evaluation, we thoroughly assess the performance of KSpot+ using real datasets and show that KSpot+ provides significant energy reductions under a variety of conditions, thus significantly prolonging the longevity of a WSN

POLA KEMITRAAN PEMBANGUNAN PERUMAHAN BAGI PEKERJA INDUSTRI PT. APAC INTI CORPORA DI DESA LEMAHIRENG

Rumah merupakan salah satu kebutuhan mendasar yang harus dimiliki oleh setiap manusia disamping sandang dan pangan. Seiring dengan bertambahnya jumlah penduduk tiap tahunnya serta kebutuhan akan rumah semakin bertambah. Dalam penyediaan perumahan kita tidak bisa lepas dari permasalahan-permasalahan yang ada terkait dengan penyediaan perumahan yang salah satu permasalahannya yaitu dalam penyediaan perumahan bagi masyarakat berpenghasilan rendah atau MBR

KCNQ2 R144 variants cause neurodevelopmental disability with language impairment and autistic features without neonatal seizures through a gain-of-function mechanism

Prior studies have revealed remarkable phenotypic heterogeneity in KCNQ2-related disorders, correlated with effects on biophysical features of heterologously expressed channels. Here, we assessed phenotypes and functional properties associated with KCNQ2 missense variants R144W, R144Q, and R144G. We also explored in vitro blockade of channels carrying R144Q mutant subunits by amitriptyline

Cynology as leisure activity

This thesis aims to create a coherent set of actions that can be operated with a dog in their free time. The theoretical part is devoted to leisure activities. These activities are described and divided into recreational and performance. Further in work I recommend for whom are which activities appropriate. The practical part describes public awareness about cynological leisure activities. I contacted the individual clubs and tried to obtain data on the number and representation of men, women and youth

Nonlinear forces on a vertical truncated cylinder in Stokes 5th order waves-model test and validation of prediction model

Due to the character of the original source materials and the nature of batch digitization, quality control issues may be present in this document. Please report any quality issues you encounter to [email protected], referencing the URI of the item.Includes bibliographical references (leaves 84-85).Issued also on microfiche from Lange Micrographics.A series of experiments of forces on a fixed vertical truncated column due to Stokes 5th order like waves were done in a wave tank. An effort was made to generate the waves as close as possible to theoretical Stokes 5th order waves. A systematic analysis, which centers on the wave height and wave steepness, was done for the wave and wave effects on the forces. Wave elevation time series was measured in the absence of the model, at the site of the model. Horizontal and vertical forces on the model were measured using a dynamometer. Horizontal particle velocity was measured under a typical wave to find the difference between the theory and experiment. Forces on the model were calculated also using Universal Linear System Model by Kim and Wang (1999a & 199b). The measured forces (Fx, Fz) increased almost linearly with the wave steepness and with the wave period (wave height) at the given steepness. The horizontal and vertical force transfer functions Fx/(H/2) and Fz/(H/2) due to a 2.0 s period wave at H/L = 0.049 amount to 1.35 and 1.05 times the corresponding theoretical linear transfer function (LTF). The theoretical LTF was compared with the measured LTF. The theoretical LTF underestimates the measured horizontal force LTF, while it overestimates the measured vertical force LTF. The theoretical vertical linear force consistently over-predicts the nonlinear measured vertical force, whereas the theoretical linear horizontal force consistently under-predicts the nonlinear measured horizontal force. The theoretical prediction due to ULSM/L+Q (Universal Linear System Model/Linear + Quadratic) was compared with the measured horizontal and vertical forces for two typical wave forces due to low and high waves. The five harmonics of the measured and theoretical wave were the inputs. The use of the measured wave gave a more favorable comparison than the theoretical wave. However, the difference was small. Breaking of the waves at the cylinder was observed using photographs for some high waves. This trend worsened with the increasing wave height. The corresponding force time series behaves differently from the force time series due to waves that were not breaking at the cylinder