Optimal control of thermal damage to targetted regions in a biological material

Paper No. HT-FED2004-56426, pp. 733-736; 4 pagesASME 2004 Heat Transfer/Fluids Engineering Summer ConferenceVolume 4Conference Sponsors: Heat Transfer Division and Fluids Engineering DivisionISBN: 0-7918-4693-8 | eISBN: 0-7918-3740-8International audienceA numerical technique with potential applications in hyperthermia treatment planning is presented. The treatment is simulated using a 2D transient computational model of the Pennes bioheat equation within an optimization algorithm. The algorithm recovers the heating protocol which will lead to a desired damage field. The relationship between temperature, time and thermal damage is expressed as a first order rate process using the Arrhenius equation. The objective function of the control problem is based on this thermal damage model. The adjoint method in conjunction with the conjugate gradient algorithm is used to minimize the objective function. The results from a numerical simulation show good agreement between the optimal damage field and the damage field recovered by the algorithm. A comparison between the recovered damage field and the commonly used thermal dose is also made

In Vivo 3D Analysis of Thoracic Kinematics : Changes in Size and Shape During Breathing and Their Implications for Respiratory Function in Recent Humans and Fossil Hominins

The human ribcage expands and contracts during respiration as a result of the interaction between the morphology of the ribs, the costo-vertebral articulations and respiratory muscles. Variations in these factors are said to produce differences in the kinematics of the upper thorax and the lower thorax, but the extent and nature of any such differences and their functional implications have not yet been quantified. Applying geometric morphometrics we measured 402 three-dimensional (3D) landmarks and semilandmarks of 3D models built from computed tomographic scans of thoraces of 20 healthy adult subjects in maximal forced inspiration (FI) and expiration (FE). We addressed the hypothesis that upper and lower parts of the ribcage differ in kinematics and compared different models of functional compartmentalization. During inspiration the thorax superior to the level of the sixth ribs undergoes antero-posterior expansion that differs significantly from the medio-lateral expansion characteristic of the thorax below this level. This supports previous suggestions for dividing the thorax into a pulmonary and diaphragmatic part. While both compartments differed significantly in mean size and shape during FE and FI the size changes in the lower compartment were significantly larger. Additionally, for the same degree of kinematic shape change, the pulmonary thorax changes less in size than the diaphragmatic thorax. Therefore, variations in the form and function of the diaphragmatic thorax will have a strong impact on respiratory function. This has important implications for interpreting differences in thorax shape in terms of respiratory functional differences within and among recent humans and fossil hominins. Anat Rec, 300:255–264, 2017

Computed Tomography Measurement of Rib Cage Morphometry in Emphysema

Background: Factors determining the shape of the human rib cage are not completely understood. We aimed to quantify the contribution of anthropometric and COPD-related changes to rib cage variability in adult cigarette smokers. Methods: Rib cage diameters and areas (calculated from the inner surface of the rib cage) in 816 smokers with or without COPD, were evaluated at three anatomical levels using computed tomography (CT). CTs were analyzed with software, which allows quantification of total emphysema (emphysema%). The relationship between rib cage measurements and anthropometric factors, lung function indices, and %emphysema were tested using linear regression models. Results: A model that included gender, age, BMI, emphysema%, forced expiratory volume in one second (FEV1)%, and forced vital capacity (FVC)% fit best with the rib cage measurements (R2  = 64% for the rib cage area variation at the lower anatomical level). Gender had the biggest impact on rib cage diameter and area (105.3 cm2; 95% CI: 111.7 to 98.8 for male lower area). Emphysema% was responsible for an increase in size of upper and middle CT areas (up to 5.4 cm2; 95% CI: 3.0 to 7.8 for an emphysema increase of 5%). Lower rib cage areas decreased as FVC% decreased (5.1 cm2; 95% CI: 2.5 to 7.6 for 10 percentage points of FVC variation). Conclusions: This study demonstrates that simple CT measurements can predict rib cage morphometric variability and also highlight relationships between rib cage morphometry and emphysema

Accidental Injury Analysis and Protection for Automated Vehicles

This chapter summarizes our recent research on accidental injury analysis and new passive restraint concepts for automated vehicle occupant protection. Recent trends to develop highly automated driving systems (ADS) may enable occupants to sit in non-conventional ways with various seating positions. Such seating position may subject occupants to 360 degree of principal direction of force (PDOF). Current government regulatory crash tests and evaluation standards known as New Car Assessment Programs (NCAP) and other motor safety regulations have been implemented in the automotive industry mainly for the protection of forward-facing seated occupants in frontal, side, and rollover vehicle crashes. Automated vehicles will pose challenges and opportunities for occupant protection. In addition, automation may lead to an increase in occupants from more diverse populations in crash conditions and seating arrangements. More studies are required to better understand the kinematics, injuries, and protection for the ADS occupants on other new seating positions and postures from various crashes. Our latest research focused on occupant injury risk analysis and new restraint concepts for the ADS occupants at different seating positions, especially at the side-facing seat. This chapter summarizes our major findings from the research, including occupant injury risk assessment methods, estimated injury patterns and severities at different PDOF and seating arrangements, as well as new restraint concepts for mitigation of the ADS occupant injures

OPTIMAL CONTROL OF THERMAL DAMAGE TO TARGETTED REGIONS IN A BIOLOGICAL MATERIAL

ABSTRACT A numerical technique with potential applications in hyperthermia treatment planning is presented. The treatment is simulated using a 2D transient computational model of the Pennes bioheat equation within an optimization algorithm. The algorithm recovers the heating protocol which will lead to a desired damage field. The relationship between temperature, time and thermal damage is expressed as a first order rate process using the Arrhenius equation. The objective function of the control problem is based on this thermal damage model. The adjoint method in conjunction with the conjugate gradient algorithm is used to minimize the objective function. The results from a numerical simulation show good agreement between the optimal damage field and the damage field recovered by the algorithm. A comparison between the recovered damage field and the commonly used thermal dose is also made

Experimental Validation of an Inverse Heat Transfer Algorithm forOptimizing a Hyperthermia Treatment

International audienc

Experimental Validation of an Inverse Heat Transfer Algorithm forOptimizing a Hyperthermia Treatment

International audienc

A preliminary study of human model head and neck response to frontal loading in nontraditional occupant seating configurations

<p><b>Objective</b>: Computational human body models (HBMs) are nominally omnidirectional surrogates given their structural basis in human anatomy. As a result, such models are well suited for studies related to occupant safety in anticipated highly automated vehicles (HAVs). We utilize a well-validated HBM to study the head and neck kinematics in simulations of nontraditional occupant seating configurations.</p> <p><b>Methods</b>: The GHBMC M50-O v. 4.4 HBM was gravity settled into a generic seat buck and situated in a seated posture. The model was simulated in angular increments of 15 degrees clockwise from forward facing to rear facing. A pulse of 17.0 kph (NASS median) was used in each to simulate a frontal impact for each of the 13 seating configurations. Belt anchor points were rotated with the seat; the airbag was appropriately powered based on delta-V, and was not used in rear-facing orientations. Neck forces and moments were calculated.</p> <p><b>Results</b>: The 30-degree oblique case was found to result in the maximum neck load and sagittal moment, and thus Neck Injury Criteria (NIJ). Neck loads were minimized in the rear facing condition. The moments and loads, however, were greatest in the lateral seating configuration for these frontal crash simulations.</p> <p><b>Conclusions</b>: In a recent policy statement on HAVs, the NHTSA indicated that vehicle manufacturers will be expected to provide countermeasures that will fully protect occupants given any planned seating or interior configurations. Furthermore, the agency indicated that virtual tests using human models could be used to demonstrate such efficacy. While the results presented are only appropriate for comparison within this study, they do indicate that human models provide reasonable biomechanical data for nontraditional occupant seating arrangements.</p