Voices in Crisis: An Exploration of Masculine Identity in Modernist Narratives

The period following World War I can be characterized in literature by the trauma and changes that promoted crises of masculinity. These crises, however, are not discussed between the men that suffer similar feelings of insecurity and anxiety; not approached as a tension in need of resolution. Exploring the narrative voices of Nick, Jake, Darl and Anse in The Great Gatsby, The Sun Also Rises, and As I Lay Dying, this thesis addresses the ways in which this unspoken phenomenon is essential to the modernist male narrative. I propose that, despite the widespread nature of this phenomenon, it is the voice of the individual – the preoccupations of his consciousness – that is the most appropriate point through which to examine these crises of masculinity

A Call for Minds: The Unknown Extent of Societal Influence on the Legal Rights of Involuntarily and Voluntarily Committed Mental Health Patients

This article begins and ends with a call for more empirical research to understand the connection between societal views of mental illness and the legal system. The author asserts that changing social perceptions of mental illness certainly affect legal outcomes and commitment levels, but the degree remains unknown. This article explores the above two topics through the framework of the Circuit Court \u27split\u27 regarding the Constitutional rights of persons committed to state mental health institutions. A main facet of the \u27split\u27 is centered on the Circuits\u27 disagreement about whether or not all mentally ill patients committed to institutions deserve the same Constitutional protections

Evaporative cooling systems to improve internal comfort in industrial buildings

Several studies were carried out to determine how hot or cold environments can affect task performance and can influence productivity. Usually, HVAC plants are exactly designed in order to guarantee comfortable internal conditions inside built environments, but not all kind of buildings are equipped with a heating or cooling plant, like for example, some industrial buildings. These buildings are often characterized by high internal thermal loads. For those buildings the ability of different plant configurations to improve indoor thermal conditions was considered taking into account the influence of several parameters, like weather conditions, internal gains, thermal transmittance, ventilation air flow rate, etc. Simulation results are compared in terms of energy savings and thermal comfort. \ua9 2017 The Author(s)

SERS-based nanobiosensing for ultrasensitive detection of the p53 tumor suppressor

Background: One of the main challenges in biomedicine is improvement of detection sensitivity to achieve tumor marker recognition at a very low concentration when the disease is not significantly advanced. A pivotal role in cancer defense is played by the p53 tumor suppressor, therefore its detection with high sensitivity may contribute considerably to early diagnosis of cancer. In this work, we present a new analytical method based on surface-enhanced Raman spectroscopy which could significantly increase the sensitivity of traditional bioaffinity techniques. p53 molecules were anchored to gold nanoparticles by means of the bifunctional linker 4-aminothiophenol (4-ATP). The characteristic vibrational bands of the p53-4-ATP nanoparticle system were then used to identify the p53 molecules when they were captured by a recognition substrate comprising a monolayer of azurin in molecules possessing significant affinity for this tumor suppressor. The Raman signal enhancement achieved by 4-ATP-mediated crosslinking of p53 to 50 nm gold nanoparticles enabled detect of this protein at a concentration down to 5 x 10(-13) M

Biomolecule recognition using piezoresistive nanomechanical force probes

Highly sensitive sensors are one of the enabling technologies for the biomarker detection in early stage diagnosis of pathologies. We have developed a self-sensing nanomechanical force probe able for detecting the unbinding of single couples of biomolecular partners in nearly physiological conditions. The embedding of a piezoresistive transducer into a nanomechanical cantilever enabled high force measurement capability with sub 10-pN resolution. Here, we present the design, microfabrication, optimization, and complete characterization of the sensor. The exceptional electromechanical performance obtained allowed us to detect biorecognition specific events underlying the biotin-avidin complex formation, by integrating the sensor in a commercial atomic force microscope.This work has been supported by the Spanish Ministry of Science and Innovation through projects NANOSELECT-CSD2007-00041(Consolider-Ingenio 2010) and TEC2011-23600, by the European Union through the COST ACTION TD1002 and partly supported by the PRIN-MIUR Project No. 2009 WPZM4S and by AIRC (Grant IG10412.)Peer reviewe

Complete breakdown of the Debye model of rotational relaxation near the isotropic-nematic phase boundary: Effects of intermolecular correlations in orientational dynamics

The Debye-Stokes-Einstein (DSE) model of rotational diffusion predicts that the rotational correlation times $\tau_{l}$ vary as $[l(l+1)]^{-1}$, where $l$ is the rank of the orientational correlation function (given in terms of the Legendre polynomial of rank $l$). One often finds significant deviation from this prediction, in either direction. In supercooled molecular liquids where the ratio $\tau_{1}/\tau_{2}$ falls considerably below three (the Debye limit), one usually invokes a jump diffusion model to explain the approach of the ratio $\tau_{1}/\tau_{2}$ to unity. Here we show in a computer simulation study of a standard model system for thermotropic liquid crystals that this ratio becomes much less than unity as the isotropic-nematic phase boundary is approached from the isotropic side. Simultaneously, the ratio $\tau_2/\eta$ (where $\eta$ is the shear viscosity of the liquid) becomes {\it much larger} than hydrodynamic value near the I-N transition. We have also analyzed the break down of the Debye model of rotational diffusion in ratios of higher order rotational correlation times. We show that the break down of the DSE model is due to the growth of orientational pair correlation and provide a mode coupling theory analysis to explain the results.Comment: Submitted to Physical Review

Experimental performance of a dual-source heat pump coupled with shallow horizontal ground heat exchangers

The present paper analyses the preliminary results about the performance of a dual-source heat pump (DSHP), able to switch between air and ground according to operating rules for the air-conditioning system. The prototype is composed by a common air-to-air heat pump whose refrigerant circuit has been modified for coupling through a plate heat exchanger with a geothermal closed loop, laid horizontally and edgeways into a shallow trench. As ground heat exchanger (GHE), the Flat-Panel solution has been chosen due to its higher performance in comparison with similar GHEs, that makes this solution suitable for the issue. To over/underload the GHE system according the air conditioning energy load, the closed loop can be reduced by means of valves. The switching between air and ground is then automatized with a control unit which controls valves according to rules based on air and ground temperature, air humidity, and frosting conditions at the evaporator. The prototype is fully monitored in terms of temperatures, pressures, flow rate and electricity supply, both at the refrigerant circuit and the closed loop. Moreover, a dedicated monitoring system collects data about weather conditions, ground temperature at several depths and distances from the Flat-Panels, and finally their heat flux. The heating performance of the DSHP is taken in comparison with the standard air-source solution, with evidence of the better behaviour, even for a closed loop drastically partialized.peer-reviewe

Optimized 3D Segmentation Algorithm for Shelly Sand Images

There is much to be gained from analysing and studying calcareous sediment, with applications ranging from the study of climate change, rock dating, and even building offshore oil rigs and wind farms. One way of performing this analysis is to obtain a µCT scan of the sediment, allowing scientists and engineers to automate much of their analysis using software. Many existing and prospective analysis techniques require handling individual grains. Thus, fast and effective segmentation is an essential first step for any such analysis. Segmentation is non-trivial; these scans hold a lot of information, exhibit ambiguous boundaries between objects, and many objects are hollow, making it even more difficult to apply traditional watershed segmentation. Addressing these issues, in this paper we propose an optimized 3D segmentation (O3DS) algorithm based on watersheds. We make use of branch recursion, partition the image by height prior to segmentation, artificially reducing the size of the largest connected objects. These and additional changes are extremely effective in optimizing performance; O3DS reduces the time to segment a 659x925x932 scan of sediment by 95.4% and produces better or comparable results when compared to similar implementation by our co-author

Serial analysis of mutation spectra (SAMS): a new approach for the determination of mutation spectra of site-specific DNA damage and their sequence dependence

Many mutations occur as a result of DNA synthesis past the site of DNA damage by DNA damage bypass polymerases. The frequency and types of mutations not only depend on the nature of the damage, but also on the sequence context, as revealed from analysis of mutation spectra of DNA exposed to mutagens. Herein we report a new method for the rapid determination of the effect of sequence context on mutagenesis called SAMS for serial analysis of mutation spectra. This technique makes use of the methodology that underlies serial analysis of gene expression (SAGE) to analyze mutations that result from DNA synthesis past a DNA lesion site-specifically embedded in a library of DNA sequences. To illustrate our technique we determined the effect of sequence context on mutations generated by DNA synthesis past a tetrahydrofuran abasic site model by the DNA damage bypass polymerase yeast polymerase η