811 research outputs found
The Three-Nucleon System at Next-To-Next-To-Leading Order
We calculate higher order corrections for the three-nucleon system up to
next-to-next-to-leading within an effective field theory with contact
interactions alone. We employ a subtraction formalism previously developed and
for which it has been shown that no new three-body force counterterm is needed
for complete renormalization up to this order. We give results for the
neutron-deuteron phaseshifts and the triton binding energy. Our results are in
very good agreement with experimental results and calculations using realistic
nucleon-nucleon potentials.Comment: 4 pages, 2 eps figures, revised version to appear in PR
Dispersion -box correction to the weak charge of the proton
We consider elastic scattering of electrons off a proton target. The parity
violating (PV) asymmetry arises at leading order in due to
interference of and exchange. The radiative corrections to this
leading mechanism were calculated in the literature and included in
experimental analyses, except for box and cross-box contributions.
We present here a dispersion calculation of these corrections in forward
kinematics. We demonstrate that at the GeV energies of current PV experiments,
such corrections are not suppressed by the small vector weak charge of the
electron, as occurs in the atomic PV. Our results suggest that the current
theoretical uncertainty in the analysis of the QWEAK experiment might be
substantially underestimated, and more accurate account of the dispersion
corrections are needed in order to interprete the PV data.Comment: 4 pages, 3 figures, revtex
Reconstructing a Z' Lagrangian using the LHC and low-energy data
We study the potential of the LHC and future low-energy experiments to
precisely measure the underlying model parameters of a new Z' boson. We
emphasize the complimentary information obtained from both on- and off-peak LHC
dilepton data, from the future Q-weak measurement of the weak charge of the
proton, and from a proposed measurement of parity violation in low-energy
Moller scattering. We demonstrate the importance of off-peak LHC data and
Q-weak for removing sign degeneracies between Z' couplings that occur if only
on-peak LHC data is studied. A future precision measurement of low-energy
Moller scattering can resolve a scaling degeneracy between quark and lepton
couplings that remains after analyzing LHC dilepton data, permitting an
extraction of the individual Z' couplings rather than combinations of them. We
study how precisely Z' properties can be extracted for LHC integrated
luminosities ranging from a few inverse femtobarns to super-LHC values of an
inverse attobarn. For the several example cases studied with M_Z'=1.5 TeV, we
find that coupling combinations can be determined with relative uncertainties
reaching 30% with 30 fb^-1 of integrated luminosity, while 50% is possible with
10 fb^-1. With SLHC luminosities of 1 ab^-1, we find that products of quark and
lepton couplings can be probed to 10%.Comment: 36 pages, 17 figure
The ATPase activity of MLH1 is required to orchestrate DNA double-strand breaks and end processing during class switch recombination.
PublishedJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tAntibody diversification through somatic hypermutation (SHM) and class switch recombination (CSR) are similarly initiated in B cells with the generation of U:G mismatches by activation-induced cytidine deaminase but differ in their subsequent mutagenic consequences. Although SHM relies on the generation of nondeleterious point mutations, CSR depends on the production of DNA double-strand breaks (DSBs) and their adequate recombination through nonhomologous end joining (NHEJ). MLH1, an ATPase member of the mismatch repair (MMR) machinery, is emerging as a likely regulator of whether a U:G mismatch progresses toward mutation or DSB formation. We conducted experiments on cancer modeled ATPase-deficient MLH1G67R knockin mice to determine the function that the ATPase domain of MLH1 mediates in SHM and CSR. Mlh1(GR/GR) mice displayed a significant decrease in CSR, mainly attributed to a reduction in the generation of DSBs and diminished accumulation of 53BP1 at the immunoglobulin switch regions. However, SHM was normal in these mice, which distinguishes MLH1 from upstream members of the MMR pathway and suggests a very specific role of its ATPase-dependent functions during CSR. In addition, we show that the residual switching events still taking place in Mlh1(GR/GR) mice display unique features, suggesting a role for the ATPase activity of MLH1 beyond the activation of the endonuclease functions of its MMR partner PMS2. A preference for switch junctions with longer microhomologies in Mlh1(GR/GR) mice suggests that through its ATPase activity, MLH1 also has an impact in DNA end processing, favoring canonical NHEJ downstream of the DSB. Collectively, our study shows that the ATPase domain of MLH1 is important to transmit the CSR signaling cascade both upstream and downstream of the generation of DSBs.Spanish Ministry of Education and ScienceNIHNational Women’s Division of the Albert Einstein College of Medicin
Reorganizing and integrating public health, health care, social care and wider public services:A theory-based framework for collaborative adaptive health networks to achieve the triple aim
Forty-one studies were included. Eight components were identified: social forces, resources, finance, relations, regulations, market, leadership, and accountability. Each component consists of three or more subcomponents, providing insight into (1) the (sub)component-specific strategies that accelerate PHM development, (2) the necessary contextual factors and mechanisms for these strategies to be successful and (3) the extracted theories that underlie the (sub)component-specific SCMO configurations. These theories originate from a wide variety of scientific disciplines. We bring these (sub)components together into what we call the Collabroative Adaptive Health Network (CAHN) framework
A Systematic Investigation on the Hemalog
Peer Reviewe
Low Energy Expansion in the Three Body System to All Orders and the Triton Channel
We extend and systematise the power counting for the three-body system, in
the context of the ``pion-less'' Effective Field Theory approach, to all orders
in the low-energy expansion. We show that a sub-leading part of the three-body
force appears at the third order and delineate how the expansion proceeds at
higher orders. After discussing the renormalisation issues in a simple bosonic
model, we compute the phase shifts for neutron-deuteron scattering in the
doublet S wave (triton) channel and compare our results with phase shift
analysis and potential model calculations.Comment: 22 pages revtex4, 7 figures in 8 .eps files. Figures cosmetically
changed, minor corrections. Version accepted for publication in Nucl Phys
Stability of and change in substance use risk personality:Gender differences and smoking cigarettes among early adolescents
OBJECTIVE: Adolescents show a steadily increasing inclination toward health risk behaviors, including smoking cigarettes. There is ample evidence that personality traits are related to smoking behavior. However, less is known about the stability of and change in these personality traits during early adolescence and whether smoking behavior affects the developmental trajectories. Moreover, less is known about the influence of gender on the course of personality. METHOD: Longitudinal data of three waves were used from 1121 early adolescents. To measure personality, the Substance Use Risk Profile Scale was used. Individual growth curve models were conducted to measure the stability, mean-level change and individual differences in change for personality. RESULTS: Stability of personality was moderate for boys and ranged from moderate to high for girls. On average early adolescents became more impulsive and more sensation seeking over a period of 18 months. Furthermore, hopelessness for girls increased and the increase in sensation seeking was higher for girls than for boys. Third, smoking behavior was related to all personality traits, indicating that smoking adolescents are more anxious, hopeless, impulsive and sensation seeking than non-smoking adolescents. CONCLUSIONS: Our results are in line with the disruption hypothesis, i.e., during early adolescence there is a dip in personality maturity. There are clear differences between girls and boys in stability of and change in personality traits. Besides, although smoking behavior is related to personality, the change in personality is probably related to other variables
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