A social realist challenge to the structuring of professional practice knowledge for initial teacher education in England

Professional practice knowledge for beginning teachers involves grappling with the extent to which ‘theory’ and ‘practice’ should be evident during initial teacher education courses. The end point assessment tool for such programmes in England is that of the Teachers’ Standards (DfE, 2011). Successful achievement in relation to these, results in the award of Qualified Teacher Status (QTS). Of concern is the number of teachers who successfully secure QTS and subsequently leave the profession early. This thesis contributes an analysis of the particular way that the theory/practice relationship has been structured within the Teachers’ Standards and the impact that this form has had on professional agency.The prioritisation of the observable is contrasted with manifestations that recognise that within a moment of practice, invisible yet durable knowledge structuring mechanisms are also present. In order to accord these mechanisms due agency, the concept of diffraction (the physical phenomenon of wave interference), (Barad 2007) was drawn upon to enrich Bernstein’s (2000) social realist analysis of discourse. The data was gathered from a School Centered Initial Teacher Training (SCITT) provider in the West Midlands. The knowledge structuring dialogues from eight pairs of Teacher Educators and Beginning Teachers were analysed using Legitimation Code Theory (Maton, 2014) to reveal the extent to which practice was time and space bound.The findings suggest that when context-transcending forms of knowledge specialise observable practices relationally, there is increased potential for coherent professional knowledges to result. Structuring professional practice knowledge in this way, contrasts with forms of knowledge particularisation evident within the Teachers’ Standards and the knowledge dualisms that are often conspicuous in the literature. Therefore a challenge is offered to existing forms of professional practice knowledge structuring by drawing on quantum (entangling materials and minds) rather than Cartesian (separation of mind and matter) conceptions of time and space

Developing a national barometer of prejudice and discrimination in Britain

This is the first national survey of prejudice for over a decade. It measures prejudice and discrimination in Britain experienced by people with a wide range of protected characteristics: age, disability, race, sex, religion or belief, sexual orientation, pregnancy and maternity, and gender reassignment. Our report demonstrates the value of using a national survey of this type to measure prejudice and discrimination in Britain and to set out a benchmark for future surveys. The purpose of this research is to help establish a national ‘barometer’ for monitoring changes in the attitudes and experiences of the general population. We were commissioned by the Equality and Human Rights Commission to design and run a national survey of prejudice, using a consistent set of measures across a range of protected characteristics. We surveyed 2,853 adults in Britain using the NatCen Panel surveys and carried out an additional survey to target minority groups that may otherwise not be well represented in the survey. Our approach provides new insights into the form and prevalence of prejudice and discrimination in Britain. Measuring these issues in a consistent way across protected characteristics groups and across England, Scotland and Wales, gives us a uniquely recent and comparable overview. It enables us to look across a range of measures to paint a meaningful picture of the prejudice affecting a particular protected characteristic, rather than looking at individual measures on their own. Although it does not yet provide a picture of prejudice and discrimination for all protected characteristics – which would require a larger and further-developed survey – it sets out a workable model for a future national instrument for monitoring these issues in Britain. This report provides an overview of what we have found out about people’s experiences and expressions of prejudice in Britain

Developing a national barometer of prejudice and discrimination in Britain

This is the first national survey of prejudice in Britain for over a decade. It measures prejudice and discrimination experienced by people with a wide range of protected characteristics. The aim of this report is to demonstrate the value of using a national survey of this type to measure people’s experiences of prejudice in Britain, as well as people’s attitudes towards others. It also aims to set a benchmark for future surveys. The research was designed by Professor Dominic Abrams and Dr Hannah Swift from the Centre for the Study of Group Processes, University of Kent, and Professor Diane Houston from Birkbeck, University of London. It was conducted by the National Centre for Social Research

Sustaining professionalism: Teachers as co‐enquirers in curriculum design

In England, the development of teachers' curriculum design capabilities has been identified as a ‘challenge remaining’ (Department for Education [DfE]. (2022). Opportunity for all: Strong schools with great teachers for your child. https://www.gov.uk/government/publications/opportunity-for-all-strong-schools-with-great-teachers-for-your-child ). A recent White Paper (Department for Education [DfE]. (2022). Opportunity for all: Strong schools with great teachers for your child. https://www.gov.uk/government/publications/opportunity-for-all-strong-schools-with-great-teachers-for-your-child ) offered access to a publicly funded online platform as a solution. Drawing on Stenhouse's concepts of teachers as researchers and curriculum as an inquiry process, this article argues that such a policy initiative restricts both curriculum and professional development. An alternative approach to curriculum design, one based on Stenhouse's conception of the iterative development of teachers' professional and curriculum knowledge is profiled. In this article, we, as four teacher-researchers, analyse a project which featured the Curriculum Design Coherence (CDC) model. We share insights gained from our involvement, both in relation to our professional learning and the impact of our curriculum design work on our pupils. We argue that the ‘othering’ of teachers in research contributes towards the under valuing of practice-informed evidence in policy making. We draw on the work of Lawrence Stenhouse to inform a different means of generating educational research evidence, one that sustains teacher-researchers through engagement with principles and concepts so as to inform policy and curriculum development

Linking chondrocyte and synovial transcriptional profile to clinical phenotype in osteoarthritis.

OBJECTIVES: To determine how gene expression profiles in osteoarthritis joint tissues relate to patient phenotypes and whether molecular subtypes can be reproducibly captured by a molecular classification algorithm. METHODS: We analysed RNA sequencing data from cartilage and synovium in 113 osteoarthritis patients, applying unsupervised clustering and Multi-Omics Factor Analysis to characterise transcriptional profiles. We tested the association of the molecularly defined patient subgroups with clinical characteristics from electronic health records. RESULTS: We detected two patient subgroups in low-grade cartilage (showing no/minimal degeneration, cartilage normal/softening only), with differences associated with inflammation, extracellular matrix-related and cell adhesion pathways. The high-inflammation subgroup was associated with female sex (OR 4.12, p=0.0024) and prescription of proton pump inhibitors (OR 4.21, p=0.0040). We identified two independent patient subgroupings in osteoarthritis synovium: one related to inflammation and the other to extracellular matrix and cell adhesion processes. A seven-gene classifier including MMP13, APOD, MMP2, MMP1, CYTL1, IL6 and C15orf48 recapitulated the main axis of molecular heterogeneity in low-grade knee osteoarthritis cartilage (correlation ρ=-0.88, p<10-10) and was reproducible in an independent patient cohort (ρ=-0.85, p<10-10). CONCLUSIONS: These data support the reproducible stratification of osteoarthritis patients by molecular subtype and the exploration of new avenues for tailored treatments

The Berkeley Sample of Stripped-Envelope Supernovae

We present the complete sample of stripped-envelope supernova (SN) spectra observed by the Lick Observatory Supernova Search (LOSS) collaboration over the last three decades: 888 spectra of 302 SNe, 652 published here for the first time, with 384 spectra (of 92 SNe) having photometrically-determined phases. After correcting for redshift and Milky Way dust reddening and reevaluating the spectroscopic classifications for each SN, we construct mean spectra of the three major spectral subtypes (Types IIb, Ib, and Ic) binned by phase. We compare measures of line strengths and widths made from this sample to the results of previous efforts, confirming that O I {\lambda}7774 absorption is stronger and found at higher velocity in Type Ic SNe than in Types Ib or IIb SNe in the first 30 days after peak brightness, though the widths of nebular emission lines are consistent across subtypes. We also highlight newly available observations for a few rare subpopulations of interest.Comment: 13 pages; 14 figures; 3 tables. Accepted for publication in MNRA

Human Pancreatic Acinar Cells Do Not Respond to Cholecystokinin

Pancreatic secretion can be influenced by cholecystokinin (CCK) either directly via actions on acinar cells or indirectly via actions on nerves. The presence and functional roles of CCK receptors on human pancreatic acinar cells remains unclear. In the current study human pancreatic acini were isolated and then treated with CCK-8, gastrin and/or carbachol. Functional parameters were measured including intracellular [Ca2+] and amylase secretion. It was observed that human acini did not respond to CCK agonists but did respond to carbachol with robust increases in functional parameters. Adenoviral-mediated gene transfer of CCK1 or CCK2 receptors to the human cells resulted in cell responses to CCK agonists. In order to determine the reason for the lack of responsiveness of the human acini, expression of receptor mRNAs was determined using quantitative RT-PCR and localized by in situ hybridization. mRNA levels for CCK1 receptors were ∼30 times lower than those of CCK2 receptors, which were ∼10 times lower than those of m3 Ach receptors as measured by quantitative PCR. Neither CCK1 nor CCK2 receptors were localized in adult human pancreas by i n situ hybridization. These results indicate that human pancreatic acinar cells do not respond directly to CCK receptor activation and this is likely due to an insufficient level of receptor expression.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73903/1/j.1600-0773.2002.910610.x.pd

Improved Standardization of Type II-P Supernovae: Application to an Expanded Sample

In the epoch of precise and accurate cosmology, cross-confirmation using a variety of cosmographic methods is paramount to circumvent systematic uncertainties. Owing to progenitor histories and explosion physics differing from those of Type Ia SNe (SNe Ia), Type II-plateau supernovae (SNe II-P) are unlikely to be affected by evolution in the same way. Based on a new analysis of 17 SNe II-P, and on an improved methodology, we find that SNe II-P are good standardizable candles, almost comparable to SNe Ia. We derive a tight Hubble diagram with a dispersion of 10% in distance, using the simple correlation between luminosity and photospheric velocity introduced by Hamuy & Pinto 2002. We show that the descendent method of Nugent et al. 2006 can be further simplified and that the correction for dust extinction has low statistical impact. We find that our SN sample favors, on average, a very steep dust law with total to selective extinction R_V<2. Such an extinction law has been recently inferred for many SNe Ia. Our results indicate that a distance measurement can be obtained with a single spectrum of a SN II-P during the plateau phase combined with sparse photometric measurements.Comment: ApJ accepted version. Minor change