Citizen-Centric and Multi-Curator Document Automation Platform: The Curator Perspective

Document automation is an approach that supports the creation of electronic documents in a flexible and efficient way. These systems allow the definition and management of (document) templates, which are extended versions of common documents with particular elements called fields, merge fields, form objects, etc. This paper introduces and discusses qDocs, a citizen-centric and multi-curator document automation platform for managing dynamic electronic documents (e.g. id cards, forms, certificates) accessible to any citizen in a easy and secure way. qDocs provides a single point of access for citizens to create, use and manage their own documents. These documents are produced from templates curated by public or private organizations (named as curators) that also participate in this qDocs ecosystem. This paper discusses particularly how curators may define, design and configure their templates and then make them available to citizens, allowing access to their respective documents in a secure and flexible way

12-week melatonin administration had no effect on diabetes risk markers and fat intake in overweight women night workers

IntroductionInteractions between circadian clocks and key mediators of chronic low-grade inflammation associated with fat consumption may be important in maintaining metabolic homeostasis and may pose a risk for the development of obesity-associated comorbidities, especially type 2 diabetes (T2DM).ObjectiveThe aims of the present study were to evaluate the effects of melatonin administration on diabetes risk markers according to dietary lipid profile (pro-inflammatory versus anti-inflammatory) in excessive weight night workers, and to determine the effect of administration on fat consumption profile.MethodsA randomized, controlled, double-blind, crossover clinical trial involving 27 nursing professionals working permanent night shifts under a 12×36-hour system. The melatonin group (12 weeks) used synthetic melatonin (3 mg) only on days off and between shifts, while the placebo group (12 weeks) was instructed to take a placebo, also on days off and between shifts. For inflammatory characteristics, participants were divided into pro-inflammatory (saturated fats, trans fats and cholesterol) and anti-inflammatory (monounsaturated, polyunsaturated fats and EPA + DHA) groups according to fatty acid determinations. At baseline and at the end of each phase, blood glucose, insulin, glycosylated hemoglobin plasma concentrations were collected, and HOMA-IR was calculated.ConclusionMelatonin administration for 12 weeks had no effect on T2DM risk markers according to dietary lipid profile (pro-inflammatory or anti-inflammatory potential) in excessive weight night workers. Among the limitations of the study include the fact that the low dose may have influenced the results expected in the hypothesis, and individual adaptations to night work were not evaluated. The insights discussed are important for future research investigating the influence of melatonin and fats considered anti- or pro-inflammatory on glucose and insulin homeostasis related to night work

Pertinência da História Antiga na Educação Básica: abordagens didáticas e elementos do cotidiano / Relevance of Old History in basic education: teaching approaches and elements of daily

A Antiguidade corresponde a um recorte histórico que abrange o estudo de civilizações distantes, no tempo e no espaço, da realidade dos alunos de Educação Básica das escolas brasileiras. Este contraste pode gerar dúvidas por parte dos alunos a respeito da necessidade de se aprender sobre os conteúdos de História Antiga. Tal sensação de indiferença ou negação pode atingir até mesmo os professores da disciplina, influenciando sua prática. Este artigo traz um breve estudo acerca dos objetivos da História como ciência humana e como disciplina do Ensino Básico, mostrando as funções a que se destinou ao longo dos processos de mudanças políticas e sociais no Brasil, evidenciando assim, a relevância que o conhecimento possui. Em seguida, aborda-se a necessidade de se redefinir os procedimentos didáticos adotados para trabalhar a História Antiga em sala de aula, pautando-se na possibilidade de conectar as preconcepções dos alunos, influenciadas pelo universo em que vivem, aos elementos característicos das civilizações que compõem a Antiguidade. Utilizou-se de uma pesquisa bibliográfica através de livros, artigos, dissertações e teses encontradas nos sites da CAPES e da Scielo. Além de fomentar a discussão teórica, o trabalho apresenta alguns exemplos de práticas para buscar responder às indagações dos alunos acerca da relevância da História Antiga para a compreensão de seu próprio cotidiano, e possibilitar a condução de um trabalho pedagógico onde os discentes identifiquem-se com a temática estudada. 

In situ drug release measuring in α-TCP cement by electrochemical impedance spectroscopy

The use of drug delivery systems is a good technique to leave the right quantity of medicine in the patient’s body in a suitable dose, because the drug application is delivered directly to the affected region. The current techniques such as HPLC and UV–Vis for the drug delivery calculation has some disadvantages, as the accuracy and the loss of the sample after characterization. With the aim of reducing the amount of material used during the characterization and have a nondestructive test with instantaneous results, the present paper shows the possibility of using electrochemical impedance spectroscopy (EIS) to have a drug delivery measurement during the release phenomena for a calcium phosphate cement (CFC) delivery system with gentamicin sulfate (GS) and lidocaine hydrochloride (LH), at a ratio of 1% and 2%, respectively. The equivalent circuit and the chemical mechanism involved during the measurements have been proposed as a tool to determine the drug delivery profile. The method has been compared with the UV–Vis technique. XRD was realized to verify conditions, before and after release. It was possible to verify the potential for using EIS as an instant technique to quantify drug delivery

Sucesso pessoal, profissional e intelectual a partir do diagnóstico e intervenção na discalculia nos anos iniciais do ensino fundamental / Personal, professional and intellectual success from diagnosis and intervention in dyscalculia years Starting elementary school

O presente artigo compreende um estudo bibliográfico realizado em artigos acadêmicos e sítios da internet relacionados ao campo da Psicopedagogia Clínica, objetivando abordar a discalculia em seus aspectos e manifestações no ensino fundamental I – fase da vida escolar dos alunos em que começa a se trabalhar com a quantificação e números propriamente ditos – bem como, relatar sobre orientações psicopedagógicas nesse contexto. O primeiro capítulo vem abordar conceitos em geral sobre a discalculia no ambiente escolar, tendo por fundamentação autores correlacionados e ambientes virtuais de comunicação, quais sejam: Silva (2008), Furlanetto (2012),  Westein (2013), Silva (2008), Bossa (2007), Coll, Marchesi Palácios (1995), Moura (2000), Andrade Silva (2009), Pinheiro (2009), dentre outros. Em seguida trago observações concernentes ao papel do docente no processo de diagnóstico e encaminhamento ao profissional da Psicopedagogia. Por fim, venho sugerir estratégias e materiais que possam ser utilizados pelos profissionais competentes no processo de tratamento da discalculia em alunos considerados anteriormente nos processos de avaliação e intervenção pedagógicas como discalcúlicos

Contribution for new genetic markers of rheumatoid arthritis activity and severity : sequencing of the tumor necrosis factor-alpha gene promoter

© 2007 Fonseca et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly citedThe objective of this study was to assess whether clinical measures of rheumatoid arthritis activity and severity were influenced by tumor necrosis factor-alpha (TNF-alpha) promoter genotype/haplotype markers. Each patient's disease activity was assessed by the disease activity score using 28 joint counts (DAS28) and functional capacity by the Health Assessment Questionnaire (HAQ) score. Systemic manifestations, radiological damage evaluated by the Sharp/van der Heijde (SvdH) score, disease-modifying anti-rheumatic drug use, joint surgeries, and work disability were also assessed. The promoter region of the TNF-alpha gene, between nucleotides -1,318 and +49, was sequenced using an automated platform. Five hundred fifty-four patients were evaluated and genotyped for 10 single-nucleotide polymorphism (SNP) markers, but 5 of these markers were excluded due to failure to fall within Hardy-Weinberg equilibrium or to monomorphism. Patients with more than 10 years of disease duration (DD) presented significant associations between the -857 SNP and systemic manifestations, as well as joint surgeries. Associations were also found between the -308 SNP and work disability in patients with more than 2 years of DD and radiological damage in patients with less than 10 years of DD. A borderline effect was found between the -238 SNP and HAQ score and radiological damage in patients with 2 to 10 years of DD. An association was also found between haplotypes and the SvdH score for those with more than 10 years of DD. An association was found between some TNF-alpha promoter SNPs and systemic manifestations, radiological progression, HAQ score, work disability, and joint surgeries, particularly in some classes of DD and between haplotypes and radiological progression for those with more than 10 years of DD.This work was supported by grant POCTI/SAU-ESP/59111/2004 from Fundação Ciência e Tecnologia.info:eu-repo/semantics/publishedVersio

Prototype of an affordable pressure-controlled emergency mechanical ventilator for COVID-19

We present a viable prototype of a simple mechanical ventilator intended as a last resort to ventilate COVID-19 patients. The prototype implements the pressure-controlled continuous mandatory ventilation mode (PC-CMV) with settable breathing rates, inspiration/expiration time ratios and FiO2 modulation. Although safe, the design aims to minimize the use of technical components and those used are common in industry, so its construction may be possible in times of logistical shortage or disruption or in areas with reduced access to technical materials and at a moderate cost, affordable to lower income countries. Most of the device can be manufactured by modest technical means and construction plans are provided.Comment: This version differs from version 2 in that it includes toxicological and bio-safety tests and updated electronic

Highlights of the Brazilian Thoracic Association guidelines for interstitial lung diseases

Interstitial lung diseases (ILDs) are heterogeneous disorders, involving a large number of conditions, the approach to which continues to pose an enormous challenge for pulmonologists. The 2012 Brazilian Thoracic Association ILD Guidelines were established in order to provide Brazilian pulmonologists with an instrument that can facilitate the management of patients with ILDs, standardizing the criteria used for the diagnosis of different conditions and offering guidance on the best treatment in various situations. The objective of this article was to briefly describe the highlights of those guidelines.As doenças pulmonares intersticiais (DPIs) são afecções heterogêneas, envolvendo um elevado número de condições, cuja abordagem ainda é um grande desafio para o pneumologista. As Diretrizes de DPIs da Sociedade Brasileira de Pneumologia e Tisiologia, publicadas em 2012, foram estabelecidas com o intuito de fornecer aos pneumologistas brasileiros um instrumento que possa facilitar a abordagem dos pacientes com DPIs, padronizando-se os critérios utilizados para a definição diagnóstica das diferentes condições, além de orientar sobre o melhor tratamento nas diferentes situações. Esse artigo teve como objetivo descrever resumidamente os principais destaques dessas diretrizes.Universidade de São Paulo Faculdade de Medicina Hospital das ClínicasUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Curso de Pós-Graduação de Doenças Pulmonares IntersticiaisUniversidade Federal de Ciências da Saúde de Porto AlegreSanta Casa de Porto Alegre Ambulatório de Doenças IntersticiaisSES Hospital Regional da Asa Norte Serviço de Doenças TorácicasFundação Jorge Duprat Figueiredo de Segurança e Medicina do Trabalho Serviço de MedicinaUniversidade Estadual de Campinas Faculdade de Ciências Médicas Departamento de Clínica MédicaUniversidade Federal do Estado do Rio de JaneiroUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de PatologiaHospital do Servidor Público Estadual de São Paulo Serviço de Anatomia PatológicaUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de MedicinaUniversidade de São Paulo Faculdade de Medicina de Ribeirão Preto Divisão de PneumologiaUniversidade Federal de Santa Catarina Departamento de Clínica MédicaUniversidade Federal de Santa Catarina Hospital UniversitárioHospital de Messejana Ambulatório de Doenças IntersticiaisHospital do Servidor Público Estadual de São Paulo Ambulatório de Doenças IntersticiaisUniversidade de São Paulo Faculdade de Medicina Instituto do CoraçãoUniversidade Federal FluminenseUniversidade de São Paulo Faculdade de MedicinaHospital Sírio Libanês Núcleo Avançado de TóraxUniversidade Federal da BahiaHospital do Servidor Público Estadual de São PauloHospital do Câncer Antônio Cândido CamargoUNIFESP, EPM, Curso de Pós-Graduação de Doenças Pulmonares IntersticiaisUNIFESP, EPM, Depto. de PatologiaUNIFESP, EPMSciEL