5,404 research outputs found
Modeling eating disorders of cognitive impaired people
Millions of people all around the world suffer from eating
disorders, known as anorexia nervosa, bulimia nervosa, pica, and others. When eating disorders coexist with other mental health disorders, eating disorders often go undiagnosed and untreated; a low number of sufferers
obtain treatment for the eating disorder. Unfortunately, eating disorders have also the highest mortality rate of any mental illness, upwards of 20%.
This paper focuses on monitoring eating disorders of cognitive impaired people as patients with the Alzheimer’s disease. The proposed approach relies on the application of Ambient Intelligence (AmI) technologies and a new method for the detection of abnormal human behaviors in a controlled environment
Barrier Paradox in the Klein Zone
We study the solutions for a one-dimensional electrostatic potential in the
Dirac equation when the incoming wave packet exhibits the Klein paradox (pair
production). With a barrier potential we demonstrate the existence of multiple
reflections (and transmissions). The antiparticle solutions which are
necessarily localized within the barrier region create new pairs with each
reflection at the potential walls. Consequently we encounter a new paradox for
the barrier because successive outgoing wave amplitudes grow geometrically.Comment: 10 page
Clustering of vertically constrained passive particles in homogeneous, isotropic turbulence
We analyze the dynamics of small particles vertically confined, by means of a
linear restoring force, to move within a horizontal fluid slab in a
three-dimensional (3D) homogeneous isotropic turbulent velocity field. The
model that we introduce and study is possibly the simplest description for the
dynamics of small aquatic organisms that, due to swimming, active regulation of
their buoyancy, or any other mechanism, maintain themselves in a shallow
horizontal layer below the free surface of oceans or lakes. By varying the
strength of the restoring force, we are able to control the thickness of the
fluid slab in which the particles can move. This allows us to analyze the
statistical features of the system over a wide range of conditions going from a
fully 3D incompressible flow (corresponding to the case of no confinement) to
the extremely confined case corresponding to a two-dimensional slice. The
background 3D turbulent velocity field is evolved by means of fully resolved
direct numerical simulations. Whenever some level of vertical confinement is
present, the particle trajectories deviate from that of fluid tracers and the
particles experience an effectively compressible velocity field. Here, we have
quantified the compressibility, the preferential concentration of the
particles, and the correlation dimension by changing the strength of the
restoring force. The main result is that there exists a particular value of the
force constant, corresponding to a mean slab depth approximately equal to a few
times the Kolmogorov length scale, that maximizes the clustering of the
particles
The heuristic strategies for assessing wireless sensor network: an event-based formal approach
Wireless Sensor Networks (WSNs) are increasingly being adopted in critical applications. In these networks undesired events may undermine the reliability level; thus their effects need to be properly assessed from the early stages of the development process onwards to minimize the chances of unexpected problems during use. In this paper we propose two heuristic strategies: what-if analysis and robustness checking. They allow to drive designers towards optimal WSN deployment solutions, from the point of view of the connection and data delivery resiliency, exploiting a formal approach based on the event calculus formal language. The heuristics are backed up by a support tool aimed to simplify their adoption by system designers. The tool allows to specify the target WSN in a user-friendly way and it is able to elaborate the two heuristic strategies by means of the event calculus specifications automatically generated. The WSN reliability is assessed computing a set of specific metrics. The effectiveness of the strategies is shown in the context of three case studies
Willems' Fundamental Lemma for State-Space Systems and Its Extension to Multiple Datasets
Willems et al.'s fundamental lemma asserts that all trajectories of a linear system can be obtained from a single given one, assuming that a persistency of excitation and a controllability condition hold. This result has profound implications for system identification and data-driven control, and has seen a revival over the last few years. The purpose of this letter is to extend Willems' lemma to the situation where multiple (possibly short) system trajectories are given instead of a single long one. To this end, we introduce a notion of collective persistency of excitation. We will show that all trajectories of a linear system can be obtained from a given finite number of trajectories, as long as these are collectively persistently exciting. We will demonstrate that this result enables the identification of linear systems from data sets with missing samples. Additionally, we show that the result is of practical significance in data-driven control of unstable systems
A spatial model of autocatalytic reactions
Biological cells with all of their surface structure and complex interior
stripped away are essentially vesicles - membranes composed of lipid bilayers
which form closed sacs. Vesicles are thought to be relevant as models of
primitive protocells, and they could have provided the ideal environment for
pre-biotic reactions to occur. In this paper, we investigate the stochastic
dynamics of a set of autocatalytic reactions, within a spatially bounded
domain, so as to mimic a primordial cell. The discreteness of the constituents
of the autocatalytic reactions gives rise to large sustained oscillations, even
when the number of constituents is quite large. These oscillations are
spatio-temporal in nature, unlike those found in previous studies, which
consisted only of temporal oscillations. We speculate that these oscillations
may have a role in seeding membrane instabilities which lead to vesicle
division. In this way synchronization could be achieved between protocell
growth and the reproduction rate of the constituents (the protogenetic
material) in simple protocells.Comment: Submitted to Phys. Rev.
Fibronectin-binding protein B (FnBPB) from Staphylococcus aureus protects against the antimicrobial activity of histones
Staphylococcus aureus is a Gram-positive bacterium that can cause both superficial and deep-seated infections. Histones released by neutrophils kill bacteria by binding to the bacterial cell surface and causing membrane damage. We postulated that cell wall–anchored proteins protect S. aureus from the bactericidal effects of histones by binding to and sequestering histones away from the cell envelope. Here, we focused on S. aureus strain LAC and by using an array of biochemical assays, including surface plasmon resonance and ELISA, discovered that fibronectin-binding protein B (FnBPB) is the main histone receptor. FnBPB bound all types of histones, but histone H3 displayed the highest affinity and bactericidal activity and was therefore investigated further. H3 bound specifically to the A domain of recombinant FnBPB with a K D of 86 nM, 20-fold lower than that for fibrinogen. Binding apparently occurred by the same mechanism by which FnBPB binds to fibrinogen, because FnBPB variants defective in fibrinogen binding also did not bind H3. An FnBPB-deletion mutant of S. aureus LAC bound less H3 and was more susceptible to its bactericidal activity and to neutrophil extracellular traps, whereas an FnBPB-overexpressing mutant bound more H3 and was more resistant than the WT. FnBPB bound simultaneously to H3 and plasminogen, which after activation by tissue plasminogen activator cleaved the bound histone. We conclude that FnBPB provides a dual immune-evasion function that captures histones and prevents them from reaching the bacterial membrane and simultaneously binds plasminogen, thereby promoting its conversion to plasmin to destroy the bound histone
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