Síndrome do coração Pós-feriado: pacientes acometidos por arritmia cardíaca em detrimento do consumo exagerado de álcool: Post Holiday coração Syndrome: patients suffered by cardiac arrhythmia to the detriment of exaggerated alcohol consumption

INTRODUÇÃO: O álcool é conhecido por beneficiar o sistema cardiovascular com a ativação do sistema fibrinolítico, redução da agregação de plaquetas e aperfeiçoamento do perfil lipídico, entre outros mecanismos, quando consumido em doses moderadas. Todavia, seu uso de maneira abusiva culmina em patologias graves que podem evoluir para a morte, como a hipertensão arterial, a cardiomiopatia alcoólica, a arritmia cardíaca e até a “Síndrome do Coração Pós Feriado” ou do inglês, “Holiday Heart Syndrome”. OBJETIVOS: O presente estudo tem como objetivo delinear sobre a Síndrome do Coração Pós Feriado, transpassando por suas características clínicas, repercussões eletrofisiológicas, diagnóstico e manejo terapêutico. MATERIAIS E MÉTODOS: Dessa forma, o presente trabalho realizou uma revisão sistemática qualitativa, realizado no período entre julho e agosto de 2022, através de artigos das bases de dados Biblioteca Virtual em Saúde (BVS) e United States National Library of Medicine (PubMed). RESULTADOS E DISCUSSÃO: A interação do álcool no organismo está diretamente relacionada com o sistema nervoso autônomo do indivíduo, gerando um estado de desequilíbrio autonômico, assim há alterações elétricas, como acréscimo da frequência cardíaca, gerando um estado de taquicardia. A principal patologia encontrada em questão foi a taquicardia sinusal, sendo um tipo de arritmia e por conseguinte, notou-se a presença da fibrilação atrial, sendo o excesso no consumo de etanol é causador de aproximadamente 67% dos casos de emergências desta última enfermidade. CONCLUSÃO: Portanto, com base na literatura analisada, observou-se que a ingestão alcoólica aguda age retardando o sistema de condução cardíaco, atua no encurtamento do período refratário e o aumento da atividade simpática, além de aumentar os níveis de catecolaminas circulantes. Por fim, também se evidenciou uma associação entre álcool e fatores de risco, principalmente hipertensão e obesidade e essas patologias aumentam os episódios de fibrilação atrial

Caso para diagnóstico Case for Diagnosis

Relata-se o caso de paciente do sexo feminino, de 9 anos de idade, com história de lesões bolhosas exclusivamente no dimídio direito, que acomete vários familiares de forma simétrica e cuja histologia evidencia acantólise tipo muro dilapidado, correspondendo, assim, a uma apresentação rara de mosaicismo na doença de Hailey-Hailey.The case of a 9-year-old girl with a history of blistering lesions restricted to the right side of her body is described. Several family members are also affected in a symmetrical fashion. Histological examination showed acantholysis similar to a "dilapidated brick wall", corresponding to a rare presentation of mosaicism in Hailey-Hailey disease

Synthesis of new amphiphilic chlorin derivatives from protoporphyrin-IX dimethyl ester

a b s t r a c t A simple synthesis of new amphiphilic chlorin derivatives from protoporphyrin-IX dimethyl ester is reported. The preparation of such compounds is based in a straightforward methodology, which involves the Diels-Alder reaction of protoporphyrin-IX dimethyl ester with maleic anhydride followed by addition of nucleophilic species to the initially formed cycloadducts, a transformation, which is highly regioselective. Preliminary photophysical studies with the new compounds show that they meet adequate features for PDT applications

Antimicrobial Photodynamic Therapy against Endodontic Enterococcus faecalis and Candida albicans Mono and Mixed Biofilms in the Presence of Photosensitizers: A Comparative Study with Classical Endodontic Irrigants

Endodontic biofilms eradication from the infected root canal system remains as the primary focus in endodontic field. In this study, it was assessed the efficacy of antimicrobial Photodynamic Therapy (aPDT) with the Zn(II)chlorin e6 methyl ester (Zn(II)e6Me) activated by red light against monospecies and mixed biofilms of Enterococcus faecalis and Candida albicans. The results were compared with the ones obtained with Rose Bengal (RB), Toluidine Blue-O (TBO), the synthetic tetracationic porphyrin (TMPyP) as well as classical endodontic irrigants (3% NaOCl, 17% EDTA and 2% CHX). The antimicrobial efficacy of aPDT toward monospecies and mixed biofilms was quantified resorting to safranin red method. The changes of biofilm organization and of cellular ultrastructure were evaluated through several microscopy techniques (light, laser confocal and transmission electron microscopy). Zn(II)e6Me once activated with light for 60 or 90 s was able to remove around 60% of the biofilm's biomass. It was more efficient than TBO and RB and showed similar efficiency to TMPyP and classical irrigants, CHX and EDTA. As desirable in a PS, Zn(II)e6Me in the dark showed smaller activity than TMPyP. Only NaOCl revealed higher efficiency, with 70-90% of the biofilm's biomass removal. The organization of biofilms and the normal microbial cell ultrastructure were extensively damaged by the presence of Zn(II)e6Me. aPDT with Zn(II)e6Me showed to be an efficient antimicrobial strategy deserving further studies leading to a future clinical usage in endodontic disinfection

Synthesis of new amphiphilic chlorin derivatives from protoporphyrin-IX dimethyl ester

A simple synthesis of new amphiphilic chlorin derivatives from protoporphyrin-IX dimethyl ester is reported.The preparation Of Such compounds is based in a straightforward methodology, which involves the Diels-Alder reaction of protoporphyrin-IX dimethyl ester with maleic anhydride followed by addition of nucleophilic species to the initially formed cycloadducts, a transformation, which is highly regioselective. Preliminary photophysical studies with the new compounds show that they meet adequate features for PDT applications. (c) 2008 Elsevier Ltd. All rights reserved.CNPq[200414/2006-2

Transplante de melanócitos no piebaldismo: relato de caso Melanocyte transplant in piebaldism: case report

O piebaldismo é uma genodermatose rara onde as lesões acrômicas não respondem aos tratamentos tópico e fototerápico. Este artigo tem como objetivo demonstrar a importância do transplante de melanócitos, usando a técnica de minigrafting no tratamento do piebaldismo.<br>Piebaldism is a rare genodermatosis in which depigmented skin areas are unresponsive to topical or light treatment. This article describes the importance of transplant techniques using noncultured melanocytes (minigrafting) in the treatment of piebaldism

Zika virus in the Americas: Early epidemiological and genetic findings

Submitted by sandra infurna ([email protected]) on 2016-06-21T16:53:42Z No. of bitstreams: 1 gonzalo2_bello_etal_IOC_2016.pdf: 1066180 bytes, checksum: d43c1cf1b828de79e634ed276cc62178 (MD5)Approved for entry into archive by sandra infurna ([email protected]) on 2016-06-21T17:27:43Z (GMT) No. of bitstreams: 1 gonzalo2_bello_etal_IOC_2016.pdf: 1066180 bytes, checksum: d43c1cf1b828de79e634ed276cc62178 (MD5)Made available in DSpace on 2016-06-21T17:27:43Z (GMT). No. of bitstreams: 1 gonzalo2_bello_etal_IOC_2016.pdf: 1066180 bytes, checksum: d43c1cf1b828de79e634ed276cc62178 (MD5) Previous issue date: 2016Submitted by Angelo Silva ([email protected]) on 2016-07-07T11:16:45Z No. of bitstreams: 3 gonzalo2_bello_etal_IOC_2016.pdf.txt: 51037 bytes, checksum: bebf604bcb5623ddff92fec2bebc02a5 (MD5) gonzalo2_bello_etal_IOC_2016.pdf: 1066180 bytes, checksum: d43c1cf1b828de79e634ed276cc62178 (MD5) license.txt: 2991 bytes, checksum: 5a560609d32a3863062d77ff32785d58 (MD5)Approved for entry into archive by sandra infurna ([email protected]) on 2016-07-07T11:43:23Z (GMT) No. of bitstreams: 3 license.txt: 2991 bytes, checksum: 5a560609d32a3863062d77ff32785d58 (MD5) gonzalo2_bello_etal_IOC_2016.pdf: 1066180 bytes, checksum: d43c1cf1b828de79e634ed276cc62178 (MD5) gonzalo2_bello_etal_IOC_2016.pdf.txt: 51037 bytes, checksum: bebf604bcb5623ddff92fec2bebc02a5 (MD5)Made available in DSpace on 2016-07-07T11:43:23Z (GMT). No. of bitstreams: 3 license.txt: 2991 bytes, checksum: 5a560609d32a3863062d77ff32785d58 (MD5) gonzalo2_bello_etal_IOC_2016.pdf: 1066180 bytes, checksum: d43c1cf1b828de79e634ed276cc62178 (MD5) gonzalo2_bello_etal_IOC_2016.pdf.txt: 51037 bytes, checksum: bebf604bcb5623ddff92fec2bebc02a5 (MD5) Previous issue date: 2016Ministério da Saúde. Instituto Evandro Chagas, Centro de Inovação tecnológica. Ananindeua, PA, Brasil / University of Oxford. Department of Zoology. Oxford, UK.Ministério da Saúde. Instituto Evandro Chagas. Departamento de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brasil.University of Oxford. Department of Zoology. Oxford, UK.Universidade de São Paulo. Instituto Adolfo Lutz. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto Adolfo Lutz. São Paulo, SP, Brasil.University of Oxford. Department of Zoology. Oxford, UK.University of Oxford. Department of Zoology. Oxford, UK.University of Oxford. Department of Zoology. Oxford, UK.University of Oxford. Wellcome Trust Centre for Human Genetics. Oxford, UK.University of Oxford. Wellcome Trust Centre for Human Genetics. Oxford, UK.Universidade de São Paulo. Instituto Adolfo Lutz. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto Adolfo Lutz. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto Adolfo Lutz. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto Adolfo Lutz. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto Adolfo Lutz. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto Adolfo Lutz. São Paulo, SP, Brasil.Ministério da Saúde. Instituto Evandro Chagas. Departamento de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brasil.Ministério da Saúde. Instituto Evandro Chagas. Departamento de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brasil.Ministério da Saúde. Instituto Evandro Chagas. Departamento de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brasil.Ministério da Saúde. Instituto Evandro Chagas. Departamento de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brasil.Ministério da Saúde. Instituto Evandro Chagas. Departamento de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brasil.Ministério da Saúde. Instituto Evandro Chagas. Departamento de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brasil.Ministério da Saúde. Instituto Evandro Chagas. Departamento de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brasil.Ministério da Saúde. Instituto Evandro Chagas. Departamento de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brasil.Ministério da Saúde. Instituto Evandro Chagas. Departamento de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brasil.Ministério da Saúde. Instituto Evandro Chagas. Departamento de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brasil.Ministério da Saúde. Instituto Evandro Chagas. Departamento de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brasil.Ministério da Saúde. Instituto Evandro Chagas. Departamento de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brasil.Ministério da Saúde. Instituto Evandro Chagas. Departamento de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brasil.Ministério da Saúde. Instituto Evandro Chagas. Departamento de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brasil.University of Oxford. Department of Zoology. Oxford, UK / Metabiota. San Francisco, CA 94104, USA.University of Oxford. Department of Zoology. Oxford, UK.University of Oxford. Department of Zoology. Oxford, UK.Fundação Oswaldo Cruz. Salvador, BA, Brasil.Universidade Estadual de Feira de Santana, Feira de Santana. Departamento de Saúde. Centro de Pós-Graduação em Saúde Coletiva. Feira de Santana, BA, Brasil.Fundação Oswaldo Cruz. Salvador, BA, Brasil.University of Washington. Institute for Health Metrics and Evaluation,. Seattle, WA, USA / University of Oxford. Wellcome Trust Centre for Human Genetics. Oxford, UK.Ministério da Saúde. Instituto Evandro Chagas, Centro de Inovação tecnológica. Ananindeua, PA, Brasil.Ministério da Saúde. Instituto Evandro Chagas, Centro de Inovação tecnológica. Ananindeua, PA, BrasilMinistério da Saúde. Instituto Evandro Chagas, Centro de Inovação tecnológica. Ananindeua, PA, BrasilMinistério da Saúde. Instituto Evandro Chagas, Centro de Inovação tecnológica. Ananindeua, PA, BrasilMinistério da Saúde. Instituto Evandro Chagas, Centro de Inovação tecnológica. Ananindeua, PA, BrasilMinistério da Saúde. Instituto Evandro Chagas, Centro de Inovação tecnológica. Ananindeua, PA, BrasilMinistério da Saúde. Instituto Evandro Chagas, Centro de Inovação tecnológica. Ananindeua, PA, BrasilMinistério da Saúde. Instituto Evandro Chagas, Centro de Inovação tecnológica. Ananindeua, PA, BrasilMinistério da Saúde. Instituto Evandro Chagas, Centro de Inovação tecnológica. Ananindeua, PA, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Li Ka Shing Knowledge Institute. St. Michael’s Hospital. Toronto, Canada / University of Toronto. Department of Medicine. Division of Infectious Diseases. Toronto, Canada.University of Toronto.Dalla Lana School of Public Health. Toronto, Canada;Brasil. Ministério da Saúde. Brasília, DF, Brasil.Brasil. Ministério da Saúde. Brasília, DF, Brasil.University of Texas Medical Branch. Department of Pathology. Galveston, TX, USA.University of Oxford. Department of Zoology. Oxford, UK / Metabiota. San Francisco, CA 94104, USA.Ministério da Saúde. Instituto Evandro Chagas, Centro de Inovação tecnológica. Ananindeua, PA, Brasil / University of Texas Medical Branch. Department of Pathology. Galveston, TX, USA.Ministério da Saúde. Instituto Evandro Chagas. Departamento de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brasil.Brazil has experienced an unprecedented epidemic of Zika virus (ZIKV), with ~30,000 cases reported to date. ZIKV was first detected in Brazil in May 2015 and cases of microcephaly potentially associated with ZIKV infection were identified in November 2015. Using next generation sequencing we generated seven Brazilian ZIKV genomes, sampled from four self-limited cases, one blood donor, one fatal adult case, and one newborn with microcephaly and congenital malformations. Phylogenetic and molecular clock analyses show a single introduction of ZIKV into the Americas, estimated to have occurred between May-Dec 2013, more than 12 months prior to the detection of ZIKV in Brazil. The estimated date of origin coincides with an increase in air passengers to Brazil from ZIKV endemic areas, and with reported outbreaks in Pacific Islands. ZIKV genomes from Brazil are phylogenetically interspersed with those from other South American and Caribbean countries. Mapping mutations onto existing structural models revealed the context of viral amino acid changes present in the outbreak lineage; however no shared amino acid changes were found among the three currently available virus genomes from microcephaly cases. Municipality-level incidence data indicate that reports of suspected microcephaly in Brazil best correlate with ZIKV incidence around week 17 of pregnancy, although this does not demonstrate causation. Our genetic description and analysis of ZIKV isolates in Brazil provide a baseline for future studies of the evolution and molecular epidemiology in the Americas of this emerging virus

Data from: Zika virus in the Americas: early epidemiological and genetic findings

Brazil has experienced an unprecedented epidemic of Zika virus (ZIKV), with ~30,000 cases reported to date. ZIKV was first detected in Brazil in May 2015 and cases of microcephaly potentially associated with ZIKV infection were identified in November 2015. Using next generation sequencing we generated seven Brazilian ZIKV genomes, sampled from four self-limited cases, one blood donor, one fatal adult case, and one newborn with microcephaly and congenital malformations. Phylogenetic and molecular clock analyses show a single introduction of ZIKV into the Americas, estimated to have occurred between May-Dec 2013, more than 12 months prior to the detection of ZIKV in Brazil. The estimated date of origin coincides with an increase in air passengers to Brazil from ZIKV endemic areas, and with reported outbreaks in Pacific Islands. ZIKV genomes from Brazil are phylogenetically interspersed with those from other South American and Caribbean countries. Mapping mutations onto existing structural models revealed the context of viral amino acid changes present in the outbreak lineage; however no shared amino acid changes were found among the three currently available virus genomes from microcephaly cases. Municipality-level incidence data indicate that reports of suspected microcephaly in Brazil best correlate with ZIKV incidence around week 17 of pregnancy, although this does not demonstrate causation. Our genetic description and analysis of ZIKV isolates in Brazil provide a baseline for future studies of the evolution and molecular epidemiology in the Americas of this emerging virus

Epidemiological Data: Numbers of suspected ZIKV cases and suspected microcephaly cases per state and per epidemiological week.

Contains 1) CSV file with number suspected ZIKV cases from January 2015 to the end of December 2015; 2) CSV file with number of suspected microcephaly cases from January 2015 to the first week of January 2016. Numbers correspond to suspected microcephaly cases at week 20 of pregnancy; 3) CSV file with codes of state of residence and municipality of residence in Brazil; and 4) R scripts for correlation analysis described in SI Section 1.5