Endobronchial solitary fibrous tumor

Solitary fibrous tumor (SFT) is a mesenchymal neoplasm that appears primarily in the pleura and rarely in intrapulmonary or endobronchial topography. The authors report the case of a 47-year-old woman who presented obstructive respiratory symptoms for 4 years. The chest computed tomography and bronchoscopy showed an obstructive polypoid lesion located between the trachea and the left main bronchus associated with distal atelectasis of the left lung. A resection of the lesion was performed and, macroscopically, the mass was oval, encapsulated, and firm, measuring 2.3 × 1.7 × 1.5 cm. Histology revealed low-grade mesenchymal spindle cell neoplasm, with alternating cellularity, myxoid areas, and mature adipose tissue outbreaks, as well as blood vessels with irregular walls. The immunohistochemical study was positive for CD34, CD99, and BCL2. The diagnosis was SFT in an unusual topography. The patient’s symptoms remitted after tumor excision, and no systemic problems were evident. SFTs primarily affect adults and often follow a benign course; however, their behavior is unpredictable. The presence of necrosis and mitotic activity may portend a poor prognosis. Endobronchial SFTs are rare but should be evaluated and monitored similar to SFTs at other sites, with a long-term follow-u

Endobronchial solitary fibrous tumor

Solitary fibrous tumor (SFT) is a mesenchymal neoplasm that appears primarily in the pleura and rarely in intrapulmonary or endobronchial topography. The authors report the case of a 47-year-old woman who presented obstructive respiratory symptoms for 4 years. The chest computed tomography and bronchoscopy showed an obstructive polypoid lesion located between the trachea and the left main bronchus associated with distal atelectasis of the left lung. A resection of the lesion was performed and, macroscopically, the mass was oval, encapsulated, and firm, measuring 2.3 × 1.7 × 1.5 cm. Histology revealed low-grade mesenchymal spindle cell neoplasm, with alternating cellularity, myxoid areas, and mature adipose tissue outbreaks, as well as blood vessels with irregular walls. The immunohistochemical study was positive for CD34, CD99, and BCL2. The diagnosis was SFT in an unusual topography. The patient’s symptoms remitted after tumor excision, and no systemic problems were evident. SFTs primarily affect adults and often follow a benign course; however, their behavior is unpredictable. The presence of necrosis and mitotic activity may portend a poor prognosis. Endobronchial SFTs are rare but should be evaluated and monitored similar to SFTs at other sites, with a long-term follow-u

Sedentarismo e sua relação com a demência

O sedentarismo é um fator de risco modificável significativo para a demência. Existe uma base sólida de evidências que indica que adultos cognitivamente saudáveis que se engajam em níveis mais elevados de exercício e atividade física geral apresentam um menor risco para o desenvolvimento de demência. Além disso, embora as evidências sejam mais limitadas, existem indícios de que a prática regular de exercícios pode, possivelmente, retardar o declínio cognitivo após o estabelecimento do comprometimento cognitivo leve e da demência. Trata-se de uma revisão de literatura, a qual a base de dados foi retirada das plataformas SciELO (Scientific Electronic Library Online) e PubMed. A pesquisa foi realizada em outubro de 2023, atendendo aos critérios de inclusão que foram artigos dos anos 2000 a 2023, na língua portuguesa e inglesa, textos online e em textos completos, teses, dissertações de mestrado, capítulos de livros, monografias, literaturas em revistas além de periódicos científicos foram incluídos na realização da revisão bibliográfica.  Embora o formato e a quantidade ideais de atividade física não seja bem estabelecido na literatura para esta população específica, a recomendação da Organização Mundial da Saúde de 150 minutos de atividade física aeróbica de intensidade moderada por semana é um guia útil para as pessoas idosas.

Uso de álcool durante tratamento medicamentoso

Introdução: Este trabalho aborda a combinação delicada de álcool e medicamentos, destacando os efeitos prejudiciais do álcool no sistema nervoso central e nos órgãos do corpo. O álcool passa por um complexo processo metabólico após a ingestão, afetando a absorção, distribuição, metabolismo e excreção de medicamentos. Essas interações podem comprometer a eficácia do tratamento e aumentar os riscos à saúde, enfatizando a necessidade de conscientização entre profissionais de saúde e pacientes. Evitar o álcool durante o uso de medicamentos é uma escolha sensata e protetora. Metodologia: Este trabalho é uma revisão de literatura com base em artigos de 2019 a 2023, em português, espanhol e inglês, obtidos das plataformas SciELO e PubMed. Foram incluídos textos completos, teses, dissertações, capítulos de livros, monografias e artigos em revistas e periódicos científicos. Foram utilizados descritores em saúde (DeCS) como "Álcool", "Tratamento" e "Medicamento" para avaliação dos textos. Resultados: O álcool tem efeitos prejudiciais no sistema nervoso central e nos órgãos, variando entre indivíduos. Sua absorção ocorre no intestino delgado e no estômago. O álcool afeta diversos órgãos, contribuindo para doenças ou interferindo nos efeitos dos medicamentos. No cérebro, estimula a liberação de serotonina, afetando o humor. No estômago, altera a mucosa e aumenta a produção de ácido gástrico. O álcool também pode inibir a ação do hormônio antidiurético (ADH), aumentando o volume urinário. As interações entre álcool e medicamentos podem ser farmacocinéticas, absortivas, biotransformativas, excretoras ou hipoglicemiantes. Elas impactam a absorção, distribuição, metabolismo e excreção de medicamentos, podendo resultar em efeitos indesejados. Conclusão: O uso combinado de álcool e medicamentos representa um sério risco à saúde e à vida. O álcool tem efeitos prejudiciais e interage de várias maneiras com medicamentos. Profissionais de saúde e pacientes precisam estar cientes desses perigos. Consultas médicas e uso responsável de medicamentos são fundamentais para a eficácia do tratamento e a proteção dos pacientes. Evitar o álcool durante o tratamento é a decisão mais segura e prudente para preservar a vida e o bem-estar

Educomunicação e suas áreas de intervenção: Novos paradigmas para o diálogo intercultural

oai:omp.abpeducom.org.br:publicationFormat/1O material aqui divulgado representa, em essência, a contribuição do VII Encontro Brasileiro de Educomunicação ao V Global MIL Week, da UNESCO, ocorrido na ECA/USP, entre 3 e 5 de novembro de 2016. Estamos diante de um conjunto de 104 papers executivos, com uma média de entre 7 e 10 páginas, cada um. Com este rico e abundante material, chegamos ao sétimo e-book publicado pela ABPEducom, em seus seis primeiros anos de existência. A especificidade desta obra é a de trazer as “Áreas de Intervenção” do campo da Educomunicação, colocando-as a serviço de uma meta essencial ao agir educomunicativo: o diálogo intercultural, trabalhado na linha do tema geral do evento internacional: Media and Information Literacy: New Paradigms for Intercultural Dialogue

Novel insights into the genomic basis of citrus canker based on the genome sequences of two strains of Xanthomonas fuscans subsp. aurantifolii

Background: Citrus canker is a disease that has severe economic impact on the citrus industry worldwide. There are three types of canker, called A, B, and C. The three types have different phenotypes and affect different citrus species. The causative agent for type A is Xanthomonas citri subsp. citri, whose genome sequence was made available in 2002. Xanthomonas fuscans subsp. aurantifolii strain B causes canker B and Xanthomonas fuscans subsp. aurantifolii strain C causes canker C. Results: We have sequenced the genomes of strains B and C to draft status. We have compared their genomic content to X. citri subsp. citri and to other Xanthomonas genomes, with special emphasis on type III secreted effector repertoires. In addition to pthA, already known to be present in all three citrus canker strains, two additional effector genes, xopE3 and xopAI, are also present in all three strains and are both located on the same putative genomic island. These two effector genes, along with one other effector-like gene in the same region, are thus good candidates for being pathogenicity factors on citrus. Numerous gene content differences also exist between the three cankers strains, which can be correlated with their different virulence and host range. Particular attention was placed on the analysis of genes involved in biofilm formation and quorum sensing, type IV secretion, flagellum synthesis and motility, lipopolysacharide synthesis, and on the gene xacPNP, which codes for a natriuretic protein. Conclusion: We have uncovered numerous commonalities and differences in gene content between the genomes of the pathogenic agents causing citrus canker A, B, and C and other Xanthomonas genomes. Molecular genetics can now be employed to determine the role of these genes in plant-microbe interactions. The gained knowledge will be instrumental for improving citrus canker control.Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)Conselho Nacional de Desenvolvimento CientIfico e Tecnologico (CNPq)Coordenacao para Aperfeicoamento de Pessoal de Ensino Superior (CAPES)Fundo de Defesa da Citricultura (FUNDECITRUS

Optimasi Portofolio Resiko Menggunakan Model Markowitz MVO Dikaitkan dengan Keterbatasan Manusia dalam Memprediksi Masa Depan dalam Perspektif Al-Qur`an

Risk portfolio on modern finance has become increasingly technical, requiring the use of sophisticated mathematical tools in both research and practice. Since companies cannot insure themselves completely against risk, as human incompetence in predicting the future precisely that written in Al-Quran surah Luqman verse 34, they have to manage it to yield an optimal portfolio. The objective here is to minimize the variance among all portfolios, or alternatively, to maximize expected return among all portfolios that has at least a certain expected return. Furthermore, this study focuses on optimizing risk portfolio so called Markowitz MVO (Mean-Variance Optimization). Some theoretical frameworks for analysis are arithmetic mean, geometric mean, variance, covariance, linear programming, and quadratic programming. Moreover, finding a minimum variance portfolio produces a convex quadratic programming, that is minimizing the objective function ðð¥with constraintsð ð 𥠥 ðandð´ð¥ = ð. The outcome of this research is the solution of optimal risk portofolio in some investments that could be finished smoothly using MATLAB R2007b software together with its graphic analysis

Differential cross section measurements for the production of a W boson in association with jets in proton–proton collisions at √s = 7 TeV

Measurements are reported of differential cross sections for the production of a W boson, which decays into a muon and a neutrino, in association with jets, as a function of several variables, including the transverse momenta (pT) and pseudorapidities of the four leading jets, the scalar sum of jet transverse momenta (HT), and the difference in azimuthal angle between the directions of each jet and the muon. The data sample of pp collisions at a centre-of-mass energy of 7 TeV was collected with the CMS detector at the LHC and corresponds to an integrated luminosity of 5.0 fb[superscript −1]. The measured cross sections are compared to predictions from Monte Carlo generators, MadGraph + pythia and sherpa, and to next-to-leading-order calculations from BlackHat + sherpa. The differential cross sections are found to be in agreement with the predictions, apart from the pT distributions of the leading jets at high pT values, the distributions of the HT at high-HT and low jet multiplicity, and the distribution of the difference in azimuthal angle between the leading jet and the muon at low values.United States. Dept. of EnergyNational Science Foundation (U.S.)Alfred P. Sloan Foundatio