Valoración clínico-radiológica de la articulación femoropatelar en prótesis que conservan los ligamentos cruzados

Se realizó un estudio retrospectivo en 104 pacientes con 116 prótesis tricompartimentales de rodilla que conservan los dos ligamentos cruzados. Se analizó la situación radiológica de la rótula, su relación con el implante protésico y los efectos de estos factores sobre la movilidad de la rodilla. Se realizaron proyecciones radiográficas AP, lateral y axial a 30° y se obtuvieron las siguientes variables: espesor residual rotuliano, posición del componente metálico respecto a la rótula, ángulo de Laurin, y grado de subluxación rotuliana. Se comparó la relación existente entre las diferentes variables, y éstas con respecto a los grados de flexión. Un 52,2% de las patelas presentaban una alineación central. Se obtuvo una relación significativa entre el ángulo de inclinación y el grado de subluxación patelar, sin embargo las variables a estudio no han presentado influencia en el grado de movilidad protésica, dentro de los rangos expuestos.A retrospective study was performed in 104 patients with 116 tricompartimental non-constrained knee prostheses. The radiological possition of the patella, its relationwith the prosthetic implant and the effect of these factors in the final range of movement of the knee were analyzed. AP, lateral and 30° axial radiological views were taken and the following variables were studied: residual patellar thickness, position of the metallic component with respect to the patella, Laurin''s angle and subluxation of the patella.The relation between these findings and also respect to postoperative maximum flexion were investigated. Overall, 52% of the patella tracked centrally. A statystical significant relation between the inclination angle and the patellar subluxation degree was obtained. However, within the exposed ranges, the studied variables have not demonstrated influence in the prosthetic range of movement

Pairwise dichotomous cohesiveness measures

Producción CientíficaAbstract In a framework where experts or agents express their opinions in a dichotomous way, we analyze the cohesiveness of their opinions on axed set of issues in a population. A parametric family of related measures are introduced and axiomatically characterized. They are ordinally equivalent when the population isxed, and some further properties are proved. In order to argue that this restricted dichotomous situation is nevertheless versatile, the paper ends with several empirical illustrations based on real forecasts (for the 2012 American presidential election) and elections (with real data from referenda in two countries and from elections in several scientic societies).Ministerio de Economía, Industria y Competitividad (Project ECO2012-31933)Ministerio de Economía, Industria y Competitividad (Project ECO2012-32178)Ministerio de Economía, Industria y Competitividad (Proyect CGL2008-06003-C03-03/CLI)Ministerio de Economía, Industria y Competitividad (Project CGL2011-29396-C03-02)

FT-Raman and infrared spectroscopic study of aragonite-strontianite (CaxSr1-xC03) solid solution

Synthetic aragonite-strontianite solid-solution samples have been studied using dispersive IR and FT-Raman spectroscopy. In addition to the end-members, nine samples over a range of composition from Ca0,9Sr0,1CO3 to Ca0,1Sr0,9CO3 were analysed. Carbonate anion internal modes are examined in detail by means of band-shape analysis and component fitting procedures. Positional disorder induced by the random cationic substitution results in strong increase of the halfwidth in several vibrational bands. Results obtained for the doubly degenerate modes (antisymmetric stretching and bending, v3 and v4) reveal the presence of three components both in the IR antisymmetric stretching band as well as in the Raman antisymmetric bending band. These observations are interpreted in terms of an overtone 2v4 in possible Fermi resonance with the corresponding vg fundamental in the IR spectra, and the presence of Davidov (factor group) splitting in the FT-Raman v4 band. Lattice modes in the FT-Raman spectra demonstrate weaker cohesion between the cation/carbonate/cation layers in aragonite (synth) than in strontianite (synth)

Disorder induced phase segregation in La2/3Ca1/3MnO3 manganites

Neutron powder diffraction experiments on La2/3Ca1/3MnO3 over a broad temperature range above and below the metal-insulator transition have been analyzed beyond the Rietveld average approach by use of Reverse Monte Carlo modelling. This approach allows the calculation of atomic pair distribution functions and spin correlation functions constrained to describe the observed Bragg and diffuse nuclear and magnetic scattering. The results evidence phase separation within a paramagnetic matrix into ferro and antiferromagnetic domains correlated to anistropic lattice distortions in the vicinity of the metal-insulator transition.Comment: 3 pages, 4 figures. Submitted to Phys. Rev. Lett. Figure 1 replace

Abundant bacteria in the proximal and distal intestine of healthy Siberian sturgeons (Acipenser baerii)

The gut microbiota plays a key role in animal health, including immune and metabolic homeostasis. Despite the economic relevance of the sturgeon, studies addressing the gut microbiome of this species are scarce and have focused only on the hindgut. The objective of this work was to use Illumina metabarcoding technology to compare the bacterial microbiomes of two different intestinal locations, the proximal intestine (small intestine) and the distal intestine (hindgut containing the spiral valve), of healthy Siberian sturgeons (Acipenser baerii) reared on two different farms in Spain. Although a high degree of interindividual variability was observed, certain differences between the anatomical parts and between the geographical locations were clear. The results show that the sequences corresponding to the most abundant taxa were the basis for clustering according to anatomical region (proximal and distal intestine), whereas the less abundant taxa were the basis for clustering according to the geographical location of the fish farms. Finally, the results also indicate the existence of certain bacteria that are present in the intestinal tracts of all the fish analyzed in this study; this information may be useful in future studies aiming to establish differences based upon fish health or disease

Análisis de la solución sólida aragonito-estroncianita mediante espectroscopia vibracional (Infrarrojo y FT-Raman)

Depto. de Mineralogía y PetrologíaFac. de Ciencias GeológicasTRUEpu

A comparison and methodological proposal for hybrid approaches to quantify environmental impacts: A case study for renewable energies

The transition towards a more sustainable and decarbonised energy system is mandatory for achieving global climate objectives, and counting on proper tools to evaluate sustainability is essential. Among sustainability assessment methodologies, hybrid approaches integrating Input-Output analysis (IOA) and Life Cycle Assessment (LCA) are often proposed to overcome limitations and take advantage of strengths of both methodologies. In this paper we propose a new hybrid tiered approach, named Identification and Subtraction Method (ISM). Through a case study of Concentrated Solar Power (CSP) technology, we test the proposed method assessing seven environmental indicators and compare the results obtained by different methodological approaches: Environmental Extended Multiregional Input-Output (EMRIO), LCA and two hybrid approaches. Results showed that, in general, LCA and EMRIO provide the lowest and uppest impact values, respectively. The ISM method expands the LCA boundaries by including indirect impacts, avoiding double-counting and retaining the technological detail and representativeness of the LCA. The main advantage is the ability to establish with high accuracy the impact coming from the LCA system boundaries. Furthermore, ISM is easy to undertake for LCA practitioners, is a low time-consuming hybrid approach once the LCA and EMRIO models are run, and it does not require the alteration of the IO matrix as other hybrid methods. However, the need to perform the EMRIO and LCA analysis could imply high detailed data needs. An additional limitation of the model is that it is not be able to include partial contributions from EMRIO sectors. The highest differences between results obtained by the different methods are found in the assessment of local impacts and the resources depletion, while the methods tend to agree more on global and regional impacts quantification. However, there are limitations to the implementation of the impact characterization methods that should be borne in mind when comparing the results of the different methods

Hybrid Approaches to Quantify the Environmental Impacts of Renewable Energy Technologies: A Comparison and Methodological Proposal

The transition towards a more sustainable and decarbonised energy system is mandatory for achieving global climate objectives, and renewable energies are essential to this purpose. There are different methodologies to assess the sustainability, each with its strengths and limitations. Thus, hybrid approaches integrating Input-Output analysis and Life Cycle Assessment (LCA) are often proposed to overcome limitations and take advantage of strengths of renewable technologies. Through a case study of Concentrated Solar Power (CSP) technology, a potentially significant technology in the European context, this study provides an environmental assessment of seven environmental indicators by applying and comparing methodological approaches: Environmental Extended Multiregional Input-Output (EMRIO), Life Cycle Assessment and two hybrid approaches used in literature. Among those, we propose a new hybrid tieredapproach, named Identification and Subtraction Method (ISM), that expands the boundaries of the LCA method, identifying in MRIO results the impacts from sectors not included in the LCA. The results indicated that the LCA and EMRIO approaches provide impact values in the lower and upper ranges, respectively, although there are some exceptions. The proposed ISM method achieves to expand the LCA boundaries by including indirect impacts, avoiding any double-counting and retaining the technological detail and representativeness of the process-based LCA.The highest differences between methods are found in the assessment of local impacts and the depletion of the resources for either fuels or minerals and metals, while the methods tend to agree more on the quantification of global and regional impacts. However, there are limitations to the implementation of the impact characterization methods and the quantification of the potential impacts that should be borne in mind when comparing the results of the different methods

Higher incidence of adverse events in isolated patients compared with non-isolated patients: A cohort study

Objective To determine whether isolated patients admitted to hospital have a higher incidence of adverse events (AEs), to identify their nature, impact and preventability. Design Prospective cohort study with isolated and non-isolated patients. Setting One public university hospital in the Valencian Community (southeast Spain). Participants We consecutively collected 400 patients, 200 isolated and 200 non-isolated, age =18 years old, to match according to date of entry, admission department, sex, age (±5 years) and disease severity from April 2017 to October 2018. Exclusion criteria: patients age <18 years old and/or reverse isolation patients. Primary and secondary outcome measures The primary outcome as the AE, defined according to the National Study of Adverse Effects linked to Hospitalisation (Estudio Nacional Sobre los Efectos Adversos) criteria. Cumulative incidence rates and AE incidence density rates were calculated. Results The incidence of isolated patients with AEs 16.5% (95% CI 11.4% to 21.6%) compared with 9.5% (95% CI 5.4% to 13.6%) in non-isolated (p<0.03). The incidence density of patients with AEs among isolated patients was 11.8 per 1000?days/patient (95%?CI 7.8 to 15.9) compared with 4.3 per 1000?days/patient (95%?CI 2.4 to 6.3) among non-isolated patients (p<0.001). The incidence of AEs among isolated patients was 18.5% compared with 11% for non-isolated patients (p<0.09). Among the 37 AEs detected in 33 isolated patients, and the 22 AEs detected in 19 non-isolated patients, most corresponded to healthcare-associated infections (HAIs) for both isolated and non-isolated patients (48.6% vs 45.4%). There were significant differences with respect to the preventability of AEs, (67.6% among isolated patients compared with 52.6% among non-isolated patients). Conclusions AEs were significantly higher in isolated patients compared with non-isolated patients, more than half being preventable and with HAIs as the primary cause. It is essential to improve training and the safety culture of healthcare professionals relating to the care provided to this type of patient

The impact of genetic adaptation on chimpanzee subspecies differentiation

Published: November 25, 2019Chimpanzees, humans' closest relatives, are in danger of extinction. Aside from direct human impacts such as hunting and habitat destruction, a key threat is transmissible disease. As humans continue to encroach upon their habitats, which shrink in size and grow in density, the risk of inter-population and cross-species viral transmission increases, a point dramatically made in the reverse with the global HIV/AIDS pandemic. Inhabiting central Africa, the four subspecies of chimpanzees differ in demographic history and geographical range, and are likely differentially adapted to their particular local environments. To quantitatively explore s genetic adaptation, we investigated the genic enrichment for SNPs highly differentiated between chimpanzee subspecies. Previous analyses of such patterns in human populations exhibited limited evidence of adaptation. In contrast, chimpanzees show evidence of recent positive selection, with differences among subspecies. Specifically, we observe strong evidence of recent selection in eastern chimpanzees, with highly differentiated SNPs being uniquely enriched in genic sites in a way that is expected under recent adaptation but not under neutral evolution or background selection. These sites are enriched for genes involved in immune responses to pathogens, and for genes inferred to differentiate the immune response to infection by simian immunodeficiency virus (SIV) in natural vs. non-natural host species. Conversely, central chimpanzees exhibit an enrichment of signatures of positive selection only at cytokine receptors, due to selective sweeps in CCR3, CCR9 and CXCR6 -paralogs of CCR5 and CXCR4, the two major receptors utilized by HIV to enter human cells. Thus, our results suggest that positive selection has contributed to the genetic and phenotypic differentiation of chimpanzee subspecies, and that viruses likely play a predominate role in this differentiation, with SIV being a likely selective agent. Interestingly, our results suggest that SIV has elicited distinctive adaptive responses in these two chimpanzee subspecies.Joshua M. Schmidt, Marc de Manuel, Tomas Marques-Bonet, Sergi Castellano, Aida M. André