Processos de mudança em organizações públicas: um estudo à luz das capacidades dinâmicasChange processes in public organizations: a study in the light of dynamic capabilities

As capacidades dinâmicas relacionam-se a cenários de mudanças e consistem no desenvolvimento de competências que permitam às organizações atuarem em ambientes diversos. No setor público, as capacidades dinâmicas são um tema em exploração. Este artigo analisou como organizações do setor público desenvolvem capacidades dinâmicas de processo em contexto de mudança, identificando as capacidades que foram afetadas por essa mudança. O processo de implementação do Sistema Eletrônico de Informações é o evento de mudança escolhido para a análise. Trata-se de uma pesquisa qualitativa, de cunho descritivo e exploratório, tendo o estudo de caso como estratégia de pesquisa com foco na análise documental. Após a análise de relatórios de implementação do SEI de 10 universidades federais, verificou-se que: um grupo alinhou sua estratégia ao uso suas capacidades dinâmicas de modo a enfrentar a mudança, enquanto que outro grupo aplicou suas capacidades dinâmicas de forma incremental, sem relação com sua estratégia; embora a exigência fosse a mesma para todas as universidades, cada uma adaptou a mudança dos processos de acordo com suas necessidades, alcançando benefícios outrora não previstos pela legislação.

Proposta de mapeamento de processos de armazenagem em centro de distribuição de supermercados de Fortaleza/CE utilizando BPMN / Proposal for storage process mapping in a supermarket distribution center in Fortaleza/CE using BPMN

A Logística e seus processos apresentam-se como uma das formas que a empresa possui para reduzir custos e agregar valor aos stakeholders. Este artigo tem como objetivo analisar os processos de armazenagem de um Centros de Distribuição (CD) em Fortaleza/CE e propor melhorias, por meio da metodologia BPMN. Para tal, foram realizadas pesquisas bibliográficas e levantamentos junto ao CD estudado. A análise dos dados coletados permitiu observar diversas oportunidades de alterações nos fluxos de trabalho e de materiais, as quais, muitas vezes, dependiam de simples aplicação prática ou da utilização de tecnologia

Mechanistic Insights into the Anti-angiogenic Activity of Trypanosoma cruzi Protein 21 and its Potential Impact on the Onset of Chagasic Cardiomyopathy

Chronic chagasic cardiomyopathy (CCC) is arguably the most important form of the Chagas Disease, caused by the intracellular protozoan Trypanosoma cruziit is estimated that 10-30% of chronic patients develop this clinical manifestation. The most common and severe form of CCC can be related to ventricular abnormalities, such as heart failure, arrhythmias, heart blocks, thromboembolic events and sudden death. Therefore, in this study, we proposed to evaluate the anti-angiogenic activity of a recombinant protein from T. cruzi named P21 (rP21) and the potential impact of the native protein on CCC. Our data suggest that the anti-angiogenic activity of rP21 depends on the protein's direct interaction with the CXCR4 receptor. This capacity is likely related to the modulation of the expression of actin and angiogenesis-associated genes. Thus, our results indicate that T. cruzi P21 is an attractive target for the development of innovative therapeutic agents against CCC.Univ Fed Sao Paulo, Escola Paulista Med, Departamento Microbiol Imunol Parasitol, BR-05508 Sao Paulo, SP, BrazilUniv Fed Uberlandia, Inst Ciencias Biomed, Dept Imunol, Lab Tripanosomatideos, Uberlandia, MG, BrazilUniv Fed Uberlandia, Inst Genet & Bioquim, Lab Bioquim & Toxinas Animais, Uberlandia, MG, BrazilCeTICS, Inst Butantan, Sao Paulo, BrazilUniv Fed Uberlandia, Fac Med, Centro Referencia Nacl Dermatol Sanitaria Hanseni, Lab Patol Mol & Biotecnol, Uberlandia, MG, BrazilUniv Fed Uberlandia, Inst Ciencias Biomed, Dept Immunol, Lab Osteoimunol & Imunol Tumores, Uberlandia, MG, BrazilUniv Fed Sao Paulo, Escola Paulista Med, Departamento Microbiol Imunol Parasitol, BR-05508 Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Escola Paulista Med, Departamento Microbiol Imunol Parasitol, BR-05508 Sao Paulo, SP, BrazilWeb of Scienc

Ferrugem da folha sobre genótipos de aveia com diferentes níveis de resistência : danos e perdas

The evolution in virulence of Puccinia coronata f. sp. avenae has challenged the genetic resistance to crown rust in oat genotypes. New resistance sources are constantly required for yield stabilization and costs reduction. This study aimed to characterize the crown rust resistance of oat genotypes and the disease´s productive and economic impact. Experiments were conducted in two environments, with and without chemical control. Resistance was measured by disease progress, apparent rate of infection, final severity and pustule size. Damages were based on reduction of yield, 1000 grain mass and hectoliter mass. UFRGS16Q6030-2 was immune. In both environments, UFRGS166091-2 and URS Brava exhibited the greatest level of resistance and the smallest grain yield reduction, while URS 22 was highly susceptible, reducing more than 70% of its grain yield. These results surpass the negative impacts of the disease previously reported in oats, particularly related to grain yield. The data presented in this paper highlighted the importance of genetic resistance, particularly partial resistance, for maintaining oat genetic yield potential, reducing environmental contamination with less fungicides, and increasing economic gains with oat cultivation.A evolução da virulência de Puccinia coronata f. sp. avenae desafia a resistência genética de cultivares de aveia à ferrugem da folha. Novas fontes de resistência são constantemente necessárias para estabilizar a produção e reduzir custos. Os objetivos desse estudo foram caracterizar a resistência de seis genótipos de aveia à ferrugem da folha e avaliar o impacto produtivo e econômico causado pela doença. Foram conduzidos ensaios em dois ambientes com e sem o controle químico. A resistência foi medida via progresso da doença, taxa aparente de infecção, severidade final e tamanho da pústula. As perdas foram avaliadas em rendimento, massa de mil grãos e massa do hectolitro. UFRGS 16Q6030-2 foi imune. Em ambos os ambientes, UFRGS 166091-2 e URS Brava exibiram os maiores níveis de resistência e as menores reduções no rendimento de grãos, enquanto URS 22 teve a maior suscetibilidade, com redução superior a 70% no rendimento de grãos. Os resultados obtidos superam os impactos negativos da doença previamente relatados em aveia, particularmente em relação ao rendimento de grãos. Os dados apresentados neste trabalho ressaltam a importância da resistência genética, particularmente a parcial, na manutenção do potencial genético produtivo, na redução de contaminações ambientais pelo menor uso de fungicidas e na ampliação dos ganhos econômicos com a cultura da aveia

Fauna e Flora do Brasil\ud (especialmente do Mato Grosso)\ud segundo Joseph Barbosa de Sáa (1769): (Dialogos geograficos, coronologicos, polliticos, e naturais, escripos [sic] por Joseph Barbosa\ud de Sáa nesta Villa Reyal do Senhor Bom Jesus do Cuyaba –\ud Manuscrito 235 da Biblioteca Pública do Porto)

Joseph Barbosa de Sáa (? – 1775), mais conhecido por seus escritos sobre a história do estado do Mato\ud Grosso, Brasil, completou em 1769 um volumoso (408 fólios) e erudito manuscrito, intitulado “Dialogos\ud geograficos, coronologicos, polliticos e naturais”, que nunca foi publicado na íntegra. Esse manuscrito está\ud depositado na Biblioteca Pública do Porto (manuscrito no. 235), em Portugal. Dez capítulos desse manuscrito\ud tratam dos produtos naturais do Brasil (acima de mil, quase a metade sendo animais), observados por Sáa ao\ud longo da costa do Rio de Janeiro, em São Paulo, sul de Goiás e especialmente no Mato Grosso, sendo a\ud primeira monografia sobre a história natural deste último estado. Esses capítulos são aqui transcritos e\ud comentados.Joseph Barbosa de Sáa (? – 1775), more known for his writings about the history of the state of Mato Grosso,\ud Brazil, completed in 1769 a voluminous (408 folios) and erudite manuscript entitled “Dialogos geograficos,\ud coronologicos, polliticos e naturais”, which has never been published in its entirety. This manuscript is deposited\ud in the Biblioteca Pública do Porto (Manuscript no. 235), in Portugal. Ten chapters of the manuscript deal with\ud the natural products of Brazil (over a thousand, nearly half being animals), observed by Sáa along the coast\ud of Rio de Janeiro, in São Paulo, southern Goiás and especially Mato Grosso, being the first monograph about\ud the natural history of this last state. Those chapers are here transcribed and commented.Série: Arquivos do Núcleo de apoio à pesquisa em Etimologia e História da Língua Portuguesa (NEHiLP

SARS-CoV-2 recombinant proteins stimulate distinct cellular and humoral immune response profiles in samples from COVID-19 convalescent patients

OBJECTIVES: In this preliminary study we investigated cellular and humoral immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigens in blood samples from 14 recovered coronavirus disease 2019 (COVID-19) patients and compared them to those in samples from 12 uninfected/unvaccinated volunteers. METHODS: Cellular immunity was assessed by intracellular detection of IFN-γ in CD3+ T lymphocytes after stimulation with SARS-CoV-2 spike (S1), nucleocapsid (NC), or receptor-binding domain (RBD) recombinant proteins or overlapping peptide pools covering the sequence of SARS-CoV-2 spike, membrane and nucleocapsid regions. The humoral response was examined by ELISAs and/or chemiluminescence assays for the presence of serum IgG antibodies directed to SARS-CoV-2 proteins. RESULTS: We observed differences between humoral and cellular immune profiles in response to stimulation with the same proteins. Assays of IgG antibodies directed to SARS-CoV-2 NC, RBD and S1/S2 recombinant proteins were able to differentiate convalescent from uninfected/unvaccinated groups. Cellular immune responses to SARS-CoV-2 protein stimuli did not exhibit a specific response, as T cells from both individuals with no history of contact with SARS-CoV-2 and from recovered donors were able to produce IFN-γ. CONCLUSIONS: Determination of the cellular immune response to stimulation with a pool of SARS-CoV-2 peptides but not with SARS-CoV-2 proteins is able to distinguish convalescent individuals from unexposed individuals. Regarding the humoral immune response, the screening for serum IgG antibodies directed to SARS-CoV-2 proteins has been shown to be specific for the response of recovered individuals

Coal emissions adverse human health effects associated with ultrafine/nano-particles role and resultant engineering controls

There are multiple elements which enable coal geochemistry: (1) boiler and pollution control system design parameters, (2) temperature of flue gas at collection point, (3) feed coal and also other fuels like petroleum coke, tires and biomass geochemistry and (4) fuel feed particle size distribution homogeneity distribution, maintenance of pulverisers, etc. Even though there is a large number of hazardous element pollutants in the coal-processing industry, investigations on micrometer and nanometer-sized particles including their aqueous colloids formation reactions and their behaviour entering the environment are relatively few in numbers. X-ray diffraction (XRD), High Resolution-Transmission Electron microscopy (HR-TEM)/ (Energy Dispersive Spectroscopy) EDS/ (selected-area diffraction pattern) SAED, Field Emission-Scanning Electron Microscopy (FE-SEM)/EDS and granulometric distribution analysis were used as an integrated characterization techniques tool box to determine both geochemistry and nanomineralogy for coal fly ashes (CFAs) from Brazil´s largest coal power plant. Ultrafine/nano-particles size distribution from coal combustion emissions was estimated during the tests. In addition the iron and silicon content was determined as 54.6% of the total 390 different particles observed by electron bean, results aimed that these two particles represent major minerals in the environment particles normally. These data may help in future investigations to asses human health actions related with nano-particles

Prevalence of and risk factors for curable sexually transmitted infections on Bubaque Island, Guinea Bissau.

OBJECTIVES: Complications from sexually transmitted infections (STIs) can result in severe morbidity and mortality. To date, no STI population studies have been conducted on the Bijagos Islands, Guinea Bissau. Our objective was to estimate the prevalence of and identify risk factors for Chlamydia trachomatis (Ct), Neisseria gonorrhoea (Ng), Mycoplasma genitalium (Mg), Trichomonas vaginalis (Tv) and Treponema pallidum (Tp) on Bubaque, the most populated island. METHODS: A cross-sectional survey was conducted on the island of Bubaque among people aged 16-49 years. Participants were asked to answer a questionnaire on STI risk factors, to provide urine samples (men and women) and vaginal swabs (women) for PCR testing for Ct, Ng, Mg and Tv, and to provide dry blood spots for Tp particle agglutination assays. Data were analysed to estimate the prevalence of STIs and logistic regression was used to identify risk factors. RESULTS: In total, 14.9% of participants were found to have a curable STI, with the highest prevalence being observed for Tv (5.9%) followed by Ct (3.8%), Ng (3.8%), Mg (1.9%) and Tp (0.8%). Significant risk factors for having any STI included being female, younger age and concurrent partnership. Having had a previous STI that was optimally treated was a protective factor. CONCLUSIONS: This study demonstrates that there is a considerable burden of STI on the Bijagos Islands, stressing the need for diagnostic testing to facilitate early detection and treatment of these pathogens to stop ongoing transmission. Moreover, these results indicate the need to conduct further research into the STI burden on the Bijagos Islands to help inform and develop a national STI control strategy

Adaptability and stability of corn cultivars in the Brazilian northeast

No ano agrícola de 1997, 21 cultivares de milho foram submetidas a 26 diferentes condições ambientais no Nordeste brasileiro, visando conhecer a estabilidade de produção desses materiais para fins de recomendação na região. Foi utilizado o delineamento experimental em blocos casualizados, com três repetições. Foram detectadas diferenças entre os ambientes, as cultivares e comportamento diferencial das cultivares em face das variações ambientais, na análise de variância conjunta. A produtividade média obtida (4.301 kg/ha) mostra o bom potencial para a produtividade das cultivares avaliadas, e boa aptidão do Nordeste brasileiro para a produção de milho. Todas as cultivares mostraram estabilidade de produção nos ambientes considerados. Os híbridos, de melhores rendimentos que as cultivares, constituem excelentes alternativas para exploração na região, destacando-se, entre eles, o BR 3123, Agromen 2003 e Germinal 600, por expressarem respostas positivas à melhoria ambiental. As cultivares BR 106, BR 5011, BR 5004 e BR 5033 têm recomendação justificada, especialmente, para pequenos e médios produtores rurais, onde certamente contribuirão para a melhoria da produtividade do milho.The yield stability of 21 corn cultivars was submitted to 26 different environments of the Brazilian Northeast region during the 1997 year crop, aiming to obtain regionally adapted materials. The experiments were carried out in a completely randomized block design with three replications. Significant differences were detected between environments, cultivars and differential behavior of cultivars facing environmental variations, by the analysis of variance. The obtained mean productivity of 4,301 kg/ha shows the potential of the cultivars and the good potential of the Brazilian Northeast region for corn crop. All the cultivars showed yield stability under the considered environments. The hybrids, which had better performance than cultivars, constitute an excellent alternative for the region, highlighting among them the BR 3123, Agromen 2003 and Germinal 600, with positive responses to improved environment. The cultivars BR 106, BR 5004 and BR 5033 have their recommendation justified, mostly for small and medium size growers, where they surely will contribute for the improvement of corn productivity

Polymeric micelles containing resveratrol: development, characterization, cytotoxicity on tumor cells and antimicrobial activity

Antimicrobial and antitumor activities of resveratrol, a compound found mainly in grapes, have already been demonstrated. However, its low bioavailability is a limiting factor for therapeutic application. Polymeric micelles can be an approach to solve this problem since they can encapsulate hydrophobic substances. We developed and characterized micellar formulations containing resveratrol and evaluated their cytotoxic and antimicrobial effects. The formulations were prepared by the cold dispersion method with different concentrations of F127 (5 or 10% w/w) and resveratrol (500 or 5000 µM). The formulations were characterized according to size, polydispersity index, pH, encapsulation rate and in vitro release. Cytotoxic effect was evaluated on a bladder cancer cell line and antimicrobial effect was evaluated on E. coli, S. aureus and C. albicans. One of the formulations (10% w/w of F127 and 5000 µM of resveratrol) was a monodispersed solution with high encapsulation rate, thus it was chosen for the cytotoxicity and antimicrobial assays. MS10+RES-3 was able to preserve the antimicrobial and cytotoxic activity of resveratrol. This is the first study that evaluated antimicrobial potential and cytotoxicity of micelles containing resveratrol on bladder cancer cells and the results showed that micellar nanostructures could ensure the maintenance of the biological activity of resveratrol