518 research outputs found
Discontinuities without discontinuity: The Weakly-enforced Slip Method
Tectonic faults are commonly modelled as Volterra or Somigliana dislocations
in an elastic medium. Various solution methods exist for this problem. However,
the methods used in practice are often limiting, motivated by reasons of
computational efficiency rather than geophysical accuracy. A typical
geophysical application involves inverse problems for which many different
fault configurations need to be examined, each adding to the computational
load. In practice, this precludes conventional finite-element methods, which
suffer a large computational overhead on account of geometric changes. This
paper presents a new non-conforming finite-element method based on weak
imposition of the displacement discontinuity. The weak imposition of the
discontinuity enables the application of approximation spaces that are
independent of the dislocation geometry, thus enabling optimal reuse of
computational components. Such reuse of computational components renders
finite-element modeling a viable option for inverse problems in geophysical
applications. A detailed analysis of the approximation properties of the new
formulation is provided. The analysis is supported by numerical experiments in
2D and 3D.Comment: Submitted for publication in CMAM
Morphology and function of dog arterial grafts preserved in UW-solution
Objectives:To assess the function of arterial grafts after prolonged preservation in the University of Wisconsin solution (UW), in vitro and in vivo.Methods:Carotid arteries were harvested from dogs and stored for 1–21 days at 4°C in UW (n = 10) or in PBS (0.9% NaCl, pH 7.4), (PBS) (n = 10). Slices were examined by lightmicroscopy (LM) and scanning electron microscopy (SEM). For viability testing, specimens were connected to an isometric force transducer (2 × n = 9). Contractile and relaxation responses were examined by adding phenylephrine (200μM) and metacholine (200μM), respectively. For in vivo studies (n = 41), 2.5cm carotid artery segments were implanted orthotopically, as autografts and allografts, after 14 days of storage in UW or in PBS. Autologous veins were used as controls. After 28 days or 56 days, arteriography was performed and the grafts were excised for LM and SEM.Results:The arterial endothelial layer remained intact after up to 14 days of storage in UW. In PBS, the endothelium was lost after 3 days. The functional response after 14 days storage in UW was approximately 50% vs. 0% after 14 days in PBS. In the autografts, total patencies (28 days + 56 days) were 100% (8/8) and 63% (5/8) for UW and PBS stored grafts, respectively. In the allografts, the UW and PBS preserved grafts showed total patencies of 86% (12/14) and 83% (5/6), respectively. Microscopically, the allografts showed fibrotic degeneration.Conclusions:Arteries are well preserved in UW up to 14 days of storage. Arterial autografts preserved in UW showed good patency and better integrity of the vessel wall after implantation, than grafts stored in PBS or allografts (without immunosuppressive therapy)
Nile perch distribution in south-east Lake Victoria is more strongly driven by abiotic factors, than by prey densities
Abstract We studied the effects of environmental driving factors (maximum depth, visibility, oxygen, temperature, and prey densities) on the distribution and diet composition of Nile perch (Lates niloticus) in south-east Lake Victoria from 2009 to 2011. We tested the hypotheses that (i) Nile perch distribution is regulated by the same environmental factors on a local scale (Mwanza Gulf) and on a regional scale (Mwanza Gulf, Speke Gulf and the open lake in Sengerema district), and (ii) driving factors act differently on different Nile perch size classes. Fish were sampled with gillnets. Nile perch densities were highest in the shallow part of the Mwanza Gulf and during the wet seasons, mainly caused by high densities of juveniles. The environmental driving factors explained Nile perch distributions on both regional and local scales in a similar way, often showing non-linear relationships. Maximum depth and temperature were the best predictors of Nile perch densities. Prey densities of shrimp and haplochromines did not strongly affect Nile perch distributions, but did explain Nile perch diet on a local and regional scale. We conclude that abiotic variables drive Nile perch distributions more strongly than prey densities and that feeding takes place opportunistically
First LOFAR results on galaxy clusters
Deep radio observations of galaxy clusters have revealed the existence of
diffuse radio sources related to the presence of relativistic electrons and
weak magnetic fields in the intracluster volume. The role played by this
non-thermal intracluster component on the thermodynamical evolution of galaxy
clusters is debated, with important implications for cosmological and
astrophysical studies of the largest gravitationally bound structures of the
Universe. The low surface brightness and steep spectra of diffuse cluster radio
sources make them more easily detectable at low-frequencies. LOFAR is the first
instrument able to detect diffuse radio emission in hundreds of massive galaxy
clusters up to their formation epoch. We present the first observations of
clusters imaged by LOFAR and the huge perspectives opened by this instrument
for non-thermal cluster studies.Comment: Proceedings of the 2012 week of the French Society of Astronomy and
Astrophysics (SF2A) held in Nice, June 5th-8t
Optimized Trigger for Ultra-High-Energy Cosmic-Ray and Neutrino Observations with the Low Frequency Radio Array
When an ultra-high energy neutrino or cosmic ray strikes the Lunar surface a
radio-frequency pulse is emitted. We plan to use the LOFAR radio telescope to
detect these pulses. In this work we propose an efficient trigger
implementation for LOFAR optimized for the observation of short radio pulses.Comment: Submitted to Nuclear Instruments and Methods in Physics Research
Section
First LOFAR observations at very low frequencies of cluster-scale non-thermal emission: the case of Abell 2256
Abell 2256 is one of the best known examples of a galaxy cluster hosting
large-scale diffuse radio emission that is unrelated to individual galaxies. It
contains both a giant radio halo and a relic, as well as a number of head-tail
sources and smaller diffuse steep-spectrum radio sources. The origin of radio
halos and relics is still being debated, but over the last years it has become
clear that the presence of these radio sources is closely related to galaxy
cluster merger events. Here we present the results from the first LOFAR Low
band antenna (LBA) observations of Abell 2256 between 18 and 67 MHz. To our
knowledge, the image presented in this paper at 63 MHz is the deepest ever
obtained at frequencies below 100 MHz in general. Both the radio halo and the
giant relic are detected in the image at 63 MHz, and the diffuse radio emission
remains visible at frequencies as low as 20 MHz. The observations confirm the
presence of a previously claimed ultra-steep spectrum source to the west of the
cluster center with a spectral index of -2.3 \pm 0.4 between 63 and 153 MHz.
The steep spectrum suggests that this source is an old part of a head-tail
radio source in the cluster. For the radio relic we find an integrated spectral
index of -0.81 \pm 0.03, after removing the flux contribution from the other
sources. This is relatively flat which could indicate that the efficiency of
particle acceleration at the shock substantially changed in the last \sim 0.1
Gyr due to an increase of the shock Mach number. In an alternative scenario,
particles are re-accelerated by some mechanism in the downstream region of the
shock, resulting in the relatively flat integrated radio spectrum. In the radio
halo region we find indications of low-frequency spectral steepening which may
suggest that relativistic particles are accelerated in a rather inhomogeneous
turbulent region.Comment: 13 pages, 13 figures, accepted for publication in A\&A on April 12,
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The influence of medical testing on patients' health: an overview from the gynecologists' perspective
Background: A medical tests may influence the health of patients by guiding clinical decisions, such as treatment in case of a positive test result. However, a medical test can influence the health of patients through other mechanisms as well, like giving reassurance. To make a clinical recommendation about a medical test, we should be aware of the full range of effects of that test on patients. This requires an understanding of the range of effects that medical testing can have on patients. This study evaluates the mechanisms through which medical testing can influence patients’ health, other than the effect on clinical management, from a gynecologist’s perspective. Methods: A qualitative study in which explorative focus groups were conducted with gynecologists, gynecological residents and gynecological M.D. researchers (n = 43). Discussions were transcribed verbatim. Transcriptions were coded inductively and analyzed by three researchers. Results: All participants contributed various clinical examples in which medical testing had influenced patients’ health. Clinical examples illustrated that testing, in itself or in interaction with contextual factors, may provoke a wide range of effects on patients. Our data showed that testing can influence the doctor’s perceptions of the patients’ appraisal of their illness, their perceived control, or the doctor-patient relationship. This may lead to changes in psychological, behavioral, and/or medical outcomes, both favorably or unfavorably. The data were used to construct a conceptual framework of effects of medical testing on patients. Conclusions: Besides supporting clinical decision making, medical testing may have favorable or unfavorable effects on patients’ health though several mechanisms.Jolande Y Vis, Myra CB van Zwieten, Patrick MM Bossuyt, Karel GM Moons, Marcel GW Dijkgraaf, Kirsten J McCaffery, Ben Willem J Mol and Brent C Opmee
Rapid diagnosis of hereditary haemolytic anaemias using automated rheoscopy and supervised machine learning
The Nile perch invasion in Lake Victoria: cause or consequence of the haplochromine decline?
We review alternative hypotheses and associated mechanisms to explain Lake Victoria’s Nile perch takeover and concurrent reduction in haplochromines through a (re)analysis of long term climate, limnological and stock observations in comparison with size-spectrum model predictions of co-existence, extinction and demographic change. The empirical observations are in agreement with the outcomes of the model containing two interacting species with life-histories matching Nile perch and a generalized haplochromine. The dynamic interactions may have depended on size related differences in early juvenile mortality: mouth-brooding haplochromines escape predation mortality in early life stages, unlike Nile perch that have miniscule planktonic eggs and larvae. In our model predation on the latter by planktivorous haplochromine fry act as a stabilizing factor for co-existence,
but external mortality on the haplochromines would disrupt this balance in favor of Nile perch. To explain the observed switch, mortality on haplochromines would need to be much higher than the fishing mortality that can be realistically re-constructed from observations. Abrupt concomitant changes in algal and zooplankton composition, decreased water column transparency, and widespread hypoxia from increased eutrophication most likely caused haplochromine biomass decline. We hypothesize that the shift to Nile perch was a consequence of an externally caused, climate triggered, decrease in haplochromine biomass and associated recruitment failure rather than a direct cause of the introduction
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East Africa’s Lake Victoria provides resources and services to millions of people on the lake’s shores and abroad. In particular, the lake’s fisheries are an important source of protein, employment, and international economic connections for the whole region. Nonetheless, stock dynamics are poorly understood and currently unpredictable. Furthermore, fishery dynamics are intricately connected to other supporting services of the lake as well as to lakeshore societies and economies. Much research has been carried out piecemeal on different aspects of Lake Victoria’s system; e.g., societies, biodiversity, fisheries, and eutrophication. However, to disentangle drivers and dynamics of change in this complex system, we need to put these pieces together and analyze the system as a whole. We did so by first building a qualitative model of the lake’s social-ecological system. We then investigated the model system through a qualitative loop analysis, and finally examined effects of changes on the system state and structure. The model and its contextual analysis allowed us to investigate system-wide chain reactions resulting from disturbances. Importantly, we built a tool that can be used to analyze the cascading effects of management options and establish the requirements for their success. We found that high connectedness of the system at the exploitation level, through fisheries having multiple target stocks, can increase the stocks’ vulnerability to exploitation but reduce society’s vulnerability to variability in individual stocks. We describe how there are multiple pathways to any change in the system, which makes it difficult to identify the root cause of changes but also broadens the management toolkit. Also, we illustrate how nutrient enrichment is not a self-regulating process, and that explicit management is necessary to halt or reverse eutrophication. This model is simple and usable to assess system-wide effects of management policies, and can serve as a paving stone for future quantitative analyses of system dynamics at local scales
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