Design of engine manipiulator

Tato diplomová práce se zabývá rozborem manipulátorů. Na základě z nich získaných informací je navrhnuto konstrukční řešení manipulátoru motoru. Navržený manipulátor bude sloužit k závěrečné kontrole klikových skříní traktorů Zetor.This master thesis deals with analysis of manipulators. After proposing several possibilities of some manipulator that are contemporary being used, there is suggested structural design for demanded motor manipulator. The proposed manipulator will be used for final control of crankcase for Zetor´s tractor.

Optimization of 1st-line antituberculosis dosing regimens using a population pharmacokinetic approach: food effects, drug combinations and pharmacological effects

Includes bibliographical references.The aim of this thesis was to evaluate optimal doses of 1st-line antituberculosis dosing regimens using a population pharmacokinetic approach, quantify food effects, drug combinations and pharmacological effects. The population pharmacokinetics of rifampicin, isoniazid and pyrazinamide in 76 children with tuberculosis were described using a population pharmacokinetic approach, and then Monte Carlo simulation were performed to evaluate adequacy of newly recommended weight band based doses in World Health Organisation (WHO) guidelines. Food effect (breakfast) was evaluated on rifapentine pharmacokinetic data in 35 healthy male volunteers. Effect of co-administered intermittent rifapentine on the pharmacokinetics of moxifloxacin was evaluated in 28 patients with pulmonary tuberculosis, who participated in a multicenter controlled clinical trial evaluating high dose rifapentine in combination with moxifloxacin. The moxifloxacin pharmacokinetic model, together with a previously published ofloxacin pharmacokinetic model, was used to evaluate the efficacy between moxifloxacin and ofloxacin. Furthermore, pharmacokinetic summary variables of rifapentine and moxifloxacin were evaluated as predictors of treatment outcome. Simulations based on the final models suggested that with the new guidelines, and utilizing available paediatric fixed dose combinations, children will receive adequate rifampicin exposures when compared to adults, but with a larger degree of variability. However, pyrazinamide and isoniazid exposures in many children will be lower than in adults. For food effect, all meals compared with the fasting state, high fat meal had the greatest effect on rifapentine oral bioavailability, increasing it by 86%; bulky low-fat, bulky-high-fat, and chicken soup resulted in 33%, 46%, and 49% increases in rifapentine oral bioavailability, respectively. Similar trends were observed for the metabolite 25-desacetyl rifapentine. For drug-resistant tuberculosis, using a target ratio of ≥100 for multidrug-resistant strains (without resistance to injectable agents or fluoroquinolones), the cumulative fraction of response (CFR) was 88% for moxifloxacin and only 43% for ofloxacin. The higher dose of 800 mg moxifloxacin was needed to achieve a CFR target of ≥90%. In terms of drug-interaction, rifapentine increased the clearance of moxifloxacin by 8% during antituberculosis treatment compared to that after treatment completion without rifapentine. Also, the effect moxifloxacin and rifapentine pharmacokinetics indices on outcome treatment outcome support that combined effect of longer treatment duration and higher rifapentine exposures are associated with better treatment response. In summary, the newer WHO doses for children may give lower pyrazinamide and isoniazid exposures in many children than in adults. Meals have a substantial impact on rifapentine exposure. Rifapentine did not result in a clinically significant change in moxifloxacin exposure. Moxifloxacin is more efficacious than ofloxacin in the treatment of MDR-TB. The combined effect of longer treatment duration, higher rifapentine exposures are associated with better treatment outcome, but could not differentiate which major factor needed for favourable outcome

On Gender and Illiberalism: Lessons From Slovak Parliamentary Debates

This study offers a comprehensive, in-depth analysis of Slovak illiberal anti-gender parliamentary discourse based on a unique dataset consisting of 85 parliamentary speeches. It presents who the main actors are in terms of the illiberal anti-gender discourse in Slovakia and which narratives they postulate. It also considers if there is any variation in the identified narratives. The qualitative content analysis covered several critical anti-gender narratives in the rhetoric of illiberal parties. I argue that the occurrence and range of anti-gender narratives within the Slovak parliamentary illiberal discourse are diverse, and this diversity varies in the ideological background of the analysed parties. While some of the more traditional Christian conservative parties, such as the KDH, and new populist parties such as OĽaNO or Sme Rodina, have articulated gender primarily as a threat to Slovak Catholics, Christianity, traditional marriage, and families, others like the nationally conservative-oriented SNS or the Smer-SD have stressed the loss of national sovereignty and legal aspects around the Istanbul Convention, and utilized this topic to strengthen their Eurosceptic rhetoric. Finally, the far-right K-ĽSNS has used an eclectic approach combining all found anti-gender narratives while using the most abusive language towards transgender persons and other sexual minorities

Using decision trees to infer semantic functions of attribute grammars

In this paper we present a learning method called LAG (Learning of Attribute Grammar) which infers semantic functions for simple classes of attribute grammars by means of examples and background knowledge. This method is an improvement on the AGLEARN approach as it generates the training examples on its own via the effective use of background knowledge. The background knowledge is given in the form of attribute grammars. In addition, the LAG method employs the decision tree learner C4.5 during the learning process. Treating the specification of an attribute grammar as a learning task gives rise to the application of attribute grammars to new sorts of problems such as the Part-of-Speech (PoS) tagging of Hungarian sentences. Here we inferred context rules for selecting the correct annotations for ambiguous words with the help of a background attribute grammar. This attribute grammar detects structural correspondences of the sentences. The rules induced this way were found to be more precise than those rules learned without this information

Michael Kelly, Hilary Footitt, Myriam Salama-Carr (eds.): The Palgrave Handbook of Languages and Conflict

This Handbook maps the contours of an exciting and burgeoning interdisciplinary field concerned with the role of language and languages in situations of conflict. It explores conceptual approaches, sources of information that are available, and the institutions and actors that mediate language encounters. It examines case studies of the role that languages have played in specific conflicts, from colonial times through to the Middle East and Africa today. The contributors provide vibrant evidence to challenge the monolingual assumptions that have affected traditional views of war and conflict. They show that languages are woven into every aspect of the making of war and peace, and demonstrate how language shapes public policy and military strategy, setting frameworks and expectations. The Handbook's 22 chapters powerfully illustrate how the encounter between languages is integral to almost all conflicts, to every phase of military operations and to the lived experiences of those on the ground, who meet, work and fight with speakers of other languages. This comprehensive work will appeal to scholars from across the disciplines of linguistics, translation studies, history, and international relations; and provide fresh insights for a broad range of practitioners interested in understanding the role and implications of foreign languages in war

Online tudatosság a Z-generációban = Online awareness in the Z generation

Learning as a process consists of conscious planning and unconscious process. Our brain stores not only the information we want deliberately, but all that we hear, see and experience in our environment. For both adults and children informal learning is part of our lives, but in the case of adults, information is filtered through their experiences children do not have such filters in their existing knowledge network. Considering that students spend more and more time in the online space and due to this fact it becomes the social medium from which students learn in an informal way, the question arises as to what content the child encounters where information is almost infinite, but anyone can edit it. According to the previously mentioned phenomenon, it is an important question whether children are able to handle the stimuli they receive

Description of rotary drive systems of machine tools

Tato bakalárská práce pojednává o konstrukčním řešením rotačních náhonových soustav a jejich vhodnost u obrábecích stroju. Práce je rozdelena do čtyř základních částí podle aplikace rotačních náhonových soustav.The bachelor´s thesis deals with a constructional solution of rotary drive systems and their useful for machine tools. The bachelor is divide in to four base parts for application rotary drive system.

Karel Černý: Velká blízkovýchodní nestabilita: Arabské jaro, porevoluční chaos a nerovnoměrná modernizace 1950-2015

Současná nestabilita arabského světa se projevuje různě: revolucemi, politickým islámem, terorismem, migrací a hroucením celých států. Kniha vysvětluje kořeny nestability s pomocí teoreticky původní a empiricky podložené historicko-sociologické srovnávací analýzy. Ta vychází z teze o vysoce nerovnoměrném tempu změn v jednotlivých dimenzích modernizace. Jedná se tak o důsledek rychlých socio-demografických změn, jako je populační růst, urbanizace, expanze médií a vzdělanosti, pomalejšího vývoje hospodářství, neznatelné či regresivní politické změny projevující se erozí schopnosti států vládnout či absencí demokratizace. Výsledkem je kumulace společenského napětí, jež se manifestuje trojím deficitem: prosperity, demokracie a bezpečí