Reproducing the UVJ Color Distribution of Star-forming Galaxies at 0.5 < z < 2.5 with a Geometric Model of Dust Attenuation

We analyze the distribution of rest-frame U - V and V - J colors for star-forming galaxies at 0.5 < z < 2.5. Using stellar population synthesis, stochastic star formation histories, and a simple prescription for the dust attenuation that accounts for the shape and inclination of galaxies, we construct a model for the distribution of galaxy colors. With only two free parameters, this model is able to reproduce the observed galaxy colors as a function of redshift and stellar mass remarkably well. Our analysis suggests that the wide range of dust attenuation values measured for star-forming galaxies at a given redshift and stellar mass is almost entirely due to the effect of inclination; if all galaxies at a given stellar mass were observed edge-on, they would show very similar dust attenuation. This result has important implications for the interpretation of dust attenuation measurements, the treatment of UV and IR luminosity, and the comparison between numerical simulations and observations

Patient-Reported Outcomes After Complex Adult Spinal Deformity Surgery: 5-Year Results of the Scoli-Risk-1 Study

Adult spinal deformity; Patient reported outcomes; Spinal deformity surgeryDeformidad espinal en el adulto; Resultados informados por el paciente; Cirugía de deformidad espinalDeformitat espinal de l'adult; Resultats informats pel pacient; Cirurgia de deformitat espinalStudy Design: Prospective cohort. Objective: To prospectively evaluate PROs up to 5-years after complex ASD surgery. Methods: The Scoli-RISK-1 study enrolled 272 ASD patients undergoing surgery from 15 centers. Inclusion criteria was Cobb angle of >80°, corrective osteotomy for congenital or revision deformity, and/or 3-column osteotomy. The following PROs were measured prospectively at intervals up to 5-years postoperative: ODI, SF36-PCS/MCS, SRS-22, NRS back/leg. Among patients with 5-year follow-up, comparisons were made from both baseline and 2-years postoperative to 5-years postoperative. PROs were analyzed using mixed models for repeated measures. Results: Seventy-seven patients (28.3%) had 5-year follow-up data. Comparing baseline to 5-year data among these 77 patients, significant improvement was seen in all PROs: ODI (45.2 vs. 29.3, P 0.05) and proportion achieving MCID did not differ significantly in patients with major surgery-related complications compared to those without. Conclusions: After complex ASD surgery, significant improvement in PROs were seen at 5-years postoperative in ODI, SF36-PCS/MCS, SRS-22r, and NRS-back/leg pain. No significant changes in PROs occurred during the 2 to 5-year postoperative period. Those with major surgery-related complications had similar PROs and proportion of patients achieving MCID as those without these complications.The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was funded by AO Spine through the AO Spine Knowledge Forum Deformity, the Scoliosis Research Society (SRS), and Norton Healthcare. AO Spine Knowledge Forum Deformity is a focused group of international deformity experts. AO Spine is a clinical division of the AO Foundation, which is an independent medically-guided not-for-profit organization. Study support was provided directly through the AO Spine Research Department and the AO Innovation Translation Center, Clinical Evidence

The magnetic field in the Milky Way filamentary bone G47

Funding: R.J.S. acknowledges funding from an STFC ERF (grant ST/N00485X/1).Star formation primarily occurs in filaments where magnetic fields are expected to be dynamically important. The largest and densest filaments trace the spiral structure within galaxies. Over a dozen of these dense (∼104 cm−3) and long (>10 pc) filaments have been found within the Milky Way, and they are often referred to as "bones." Until now, none of these bones has had its magnetic field resolved and mapped in its entirety. We introduce the SOFIA legacy project FIELDMAPS which has begun mapping ∼10 of these Milky Way bones using the HAWC+ instrument at 214 μm and 18′′.2 resolution. Here we present a first result from this survey on the ∼60 pc long bone G47. Contrary to some studies of dense filaments in the Galactic plane, we find that the magnetic field is often not perpendicular to the spine (i.e., the center line of the bone). Fields tend to be perpendicular in the densest areas of active star formation and more parallel or random in other areas. The average field is neither parallel nor perpendicular to the Galactic plane or the bone. The magnetic field strengths along the spine typically vary from ∼20 to ∼100 μG. Magnetic fields tend to be strong enough to suppress collapse along much of the bone, but for areas that are most active in star formation, the fields are notably less able to resist gravitational collapse.Peer reviewe

Lung function and microbiota diversity in cystic fibrosis

Abstract: Background: Chronic infection and concomitant airway inflammation is the leading cause of morbidity and mortality for people living with cystic fibrosis (CF). Although chronic infection in CF is undeniably polymicrobial, involving a lung microbiota, infection surveillance and control approaches remain underpinned by classical aerobic culture-based microbiology. How to use microbiomics to direct clinical management of CF airway infections remains a crucial challenge. A pivotal step towards leveraging microbiome approaches in CF clinical care is to understand the ecology of the CF lung microbiome and identify ecological patterns of CF microbiota across a wide spectrum of lung disease. Assessing sputum samples from 299 patients attending 13 CF centres in Europe and the USA, we determined whether the emerging relationship of decreasing microbiota diversity with worsening lung function could be considered a generalised pattern of CF lung microbiota and explored its potential as an informative indicator of lung disease state in CF. Results: We tested and found decreasing microbiota diversity with a reduction in lung function to be a significant ecological pattern. Moreover, the loss of diversity was accompanied by an increase in microbiota dominance. Subsequently, we stratified patients into lung disease categories of increasing disease severity to further investigate relationships between microbiota characteristics and lung function, and the factors contributing to microbiota variance. Core taxa group composition became highly conserved within the severe disease category, while the rarer satellite taxa underpinned the high variability observed in the microbiota diversity. Further, the lung microbiota of individual patient were increasingly dominated by recognised CF pathogens as lung function decreased. Conversely, other bacteria, especially obligate anaerobes, increasingly dominated in those with better lung function. Ordination analyses revealed lung function and antibiotics to be main explanators of compositional variance in the microbiota and the core and satellite taxa. Biogeography was found to influence acquisition of the rarer satellite taxa. Conclusions: Our findings demonstrate that microbiota diversity and dominance, as well as the identity of the dominant bacterial species, in combination with measures of lung function, can be used as informative indicators of disease state in CF. BBFJdPr3cu-jH3LTAhe361Video Abstrac

sj-docx-1-aut-10.1177_13623613231163056 – Supplemental material for Pediatricians’ role in healthcare for Latino autistic children: Shared decision-making versus “You’ve got to do everything on your own”

Supplemental material, sj-docx-1-aut-10.1177_13623613231163056 for Pediatricians’ role in healthcare for Latino autistic children: Shared decision-making versus “You’ve got to do everything on your own” by Amber M Angell, Olivia J Lindly, Daniella Floríndez, Lucía I Floríndez, Leah I Stein Duker, Katharine E Zuckerman, Larry Yin and Olga Solomon in Autism</p

A Diverse Spectrum of Immune Complex-&nbsp;and Complement-Mediated Kidney Diseases Is Associated With Mantle Cell Lymphoma.

INTRODUCTION: There are limited reports on kidney biopsy findings in patients with mantle cell lymphoma (MCL). METHODS: We initiated a multi-institutional, retrospective review of kidney biopsy findings in patients with active and treated MCL. RESULTS: A total of 30 patients with MCL and kidney biopsies were identified, with a median age of 67 (range 48-87) years, 73% of whom were men. A total of 20 patients had active MCL at the time of biopsy, of whom 14 (70%) presented with acute kidney injury (AKI), proteinuria and/or hematuria, and biopsy findings potentially attributable to lymphoma. Of the 14, 11 had immune complex (IC) or complement-mediated (C3) disease including proliferative glomerulonephritis (GN) with monotypic Ig deposits (PGNMID [2]), C3GN, (2), secondary membranous nephropathy (MN [3]), tubular basement membrane (TBM) deposits (2), and modest lupus-like GN (2). Lymphomatous infiltration was present in 8 of the 20 patients, 5 with coincident IC or C3 lesions. A total of 6 patients with available follow-up were treated for MCL, all with clinical remission of GN (2 PGNMID, 2 C3GN, and 2 MN). CONCLUSION: MCL is associated with diverse monoclonal and polyclonal glomerular and extra-glomerular IC and C3 disease. For patients with active MCL and kidney dysfunction requiring biopsy, 70% had findings due or potentially due to lymphoma, including 55% with IC or C3 disease and 40% had lymphomatous kidney infiltration. IC and C3GN in the setting of active MCL was responsive to lymphoma-directed therapy

The ratting of North America: A 350-year retrospective on <i>Rattus</i> species compositions and competition

While the impacts of black (Rattus rattus) and brown (Rattus norvegicus) rats on human society are well documented—including the spread of disease, broad-scale environmental destruction, and billions spent annually on animal control—little is known about their ecology and behavior in urban areas due to the challenges of studying animals in city environments. We use isotopic and ZooMS analysis of archaeological (1550s–1900 CE) rat remains from eastern North America to provide a large-scale framework for species arrival, interspecific competition, and dietary ecology. Brown rats arrived earlier than expected and rapidly outcompeted black rats in coastal urban areas. This replacement happened despite evidence that the two species occupy different trophic positions. Findings include the earliest molecularly confirmed brown rat in the Americas and show a deep ecological structure to how rats exploit human-structured areas, with implications for understanding urban zoonosis, rat management, and ecosystem planning as well as broader themes of rat dispersal, phylogeny, evolutionary ecology, and climate impacts

The magnetic field in the Milky Way filamentary bone G47

Star formation primarily occurs in filaments where magnetic fields are expected to be dynamically important. The largest and densest filaments trace the spiral structure within galaxies. Over a dozen of these dense (∼104 cm−3) and long (&gt;10 pc) filaments have been found within the Milky Way, and they are often referred to as "bones." Until now, none of these bones has had its magnetic field resolved and mapped in its entirety. We introduce the SOFIA legacy project FIELDMAPS which has begun mapping ∼10 of these Milky Way bones using the HAWC+ instrument at 214 μm and 18′′.2 resolution. Here we present a first result from this survey on the ∼60 pc long bone G47. Contrary to some studies of dense filaments in the Galactic plane, we find that the magnetic field is often not perpendicular to the spine (i.e., the center line of the bone). Fields tend to be perpendicular in the densest areas of active star formation and more parallel or random in other areas. The average field is neither parallel nor perpendicular to the Galactic plane or the bone. The magnetic field strengths along the spine typically vary from ∼20 to ∼100 μG. Magnetic fields tend to be strong enough to suppress collapse along much of the bone, but for areas that are most active in star formation, the fields are notably less able to resist gravitational collapse